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Conserved domains on  [gi|17535739|ref|NP_496076|]
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Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase sqv-8 [Caenorhabditis elegans]

Protein Classification

glycosyltransferase family 43 protein( domain architecture ID 10083049)

glycosyltransferase family 43 protein similar to Arabidopsis thaliana beta-1,4-xylosyltransferase IRX9H and human galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GlcAT-I cd00218
Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan ...
97-327 5.13e-127

Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis; Beta1,3-glucuronyltransferase I (GlcAT-I) domain; GlcAT-I is a Key enzyme involved in the initial steps of proteoglycan synthesis. GlcAT-I catalyzes the transfer of a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region of trisaccharide Gal-beta-(1-3)-Gal-beta-(1-4)-Xyl of proteoglycans. The enzyme has two subdomains that bind the donor and acceptor substrate separately. The active site is located at the cleft between both subdomains in which the trisaccharide molecule is oriented perpendicular to the UDP. This family has been classified as Glycosyltransferase family 43 (GT-43).


:

Pssm-ID: 132995  Cd Length: 223  Bit Score: 363.15  E-value: 5.13e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739  97 PFIYFITPTHFRAAQRADLTRLSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDqkmryddPNWTL 176
Cdd:cd00218   1 PTIYVVTPTYARPVQKAELTRLAHTLRLVPPLHWIVVEDSEEKTPLVAELLRRSGLMYTHLNAKTPSD-------PTWLK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739 177 PRGVEQRNRALLWIQNQLSGVKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILEkNGSISHFNAVW 256
Cdd:cd00218  74 PRGVEQRNLALRWIREHLSAKLDGVVYFADDDNTYDLELFEEMRKIKRVGVWPVGLVGGLRVEGPVCE-NGKVVGWHTAW 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17535739 257 KPERPFPIDMAAFAVNISLVLSNANALFSFDVPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTEK 327
Cdd:cd00218 153 KPERPFPIDMAGFAFNSKLLWDPPRAVFPYSAKRGYQESSFLEQLVLDRKELEPLANNCSKVLVWHTRTEK 223
FtsB super family cl42746
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
9-88 1.06e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG2919:

Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 37.94  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   9 KWWLRAF-IALVIFFVWQLFYAIN---RVQSLEEERATLQATIEVLTRKSDGLRTQIfekernlVRLNGKVEEIDTQIRD 84
Cdd:COG2919   3 RLLRTLVlLLLLAYLQYHLWFGDGgllAYRELRQEIAELEAENAKLKARNAELEAEV-------ADLKDGPDYIEERARE 75

                ....
gi 17535739  85 HLSL 88
Cdd:COG2919  76 ELGM 79
 
Name Accession Description Interval E-value
GlcAT-I cd00218
Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan ...
97-327 5.13e-127

Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis; Beta1,3-glucuronyltransferase I (GlcAT-I) domain; GlcAT-I is a Key enzyme involved in the initial steps of proteoglycan synthesis. GlcAT-I catalyzes the transfer of a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region of trisaccharide Gal-beta-(1-3)-Gal-beta-(1-4)-Xyl of proteoglycans. The enzyme has two subdomains that bind the donor and acceptor substrate separately. The active site is located at the cleft between both subdomains in which the trisaccharide molecule is oriented perpendicular to the UDP. This family has been classified as Glycosyltransferase family 43 (GT-43).


Pssm-ID: 132995  Cd Length: 223  Bit Score: 363.15  E-value: 5.13e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739  97 PFIYFITPTHFRAAQRADLTRLSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDqkmryddPNWTL 176
Cdd:cd00218   1 PTIYVVTPTYARPVQKAELTRLAHTLRLVPPLHWIVVEDSEEKTPLVAELLRRSGLMYTHLNAKTPSD-------PTWLK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739 177 PRGVEQRNRALLWIQNQLSGVKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILEkNGSISHFNAVW 256
Cdd:cd00218  74 PRGVEQRNLALRWIREHLSAKLDGVVYFADDDNTYDLELFEEMRKIKRVGVWPVGLVGGLRVEGPVCE-NGKVVGWHTAW 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17535739 257 KPERPFPIDMAAFAVNISLVLSNANALFSFDVPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTEK 327
Cdd:cd00218 153 KPERPFPIDMAGFAFNSKLLWDPPRAVFPYSAKRGYQESSFLEQLVLDRKELEPLANNCSKVLVWHTRTEK 223
Glyco_transf_43 pfam03360
Glycosyltransferase family 43;
118-326 1.13e-100

Glycosyltransferase family 43;


Pssm-ID: 460898  Cd Length: 202  Bit Score: 295.60  E-value: 1.13e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   118 LSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDqkmryddPNWTL-PRGVEQRNRALLWIQNQLSG 196
Cdd:pfam03360   1 LAHTLRLVPPLHWIVVEDSESKTPLVANLLRRSGLPYTHLNAKKYKP-------PNWTDkPRGVHQRNVALRWIRENKHR 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   197 vKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILeKNGSISHFNAVWKPERPFPIDMAAFAVNISLV 276
Cdd:pfam03360  74 -LDGVVYFADDDNTYDLRLFDEMRKTKKVGVWPVGLVGGLRVEGPVC-NNGKVVGWHTGWKPERPFPIDMAGFAVNSRLL 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17535739   277 LSNANALFSFD-VPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTE 326
Cdd:pfam03360 152 WDPPEAVFSLDsVKRGYQESSFLEQLVEDESDLEPLADNCTKVLVWHTRTE 202
PLN02458 PLN02458
transferase, transferring glycosyl groups
73-276 3.43e-11

transferase, transferring glycosyl groups


Pssm-ID: 215252  Cd Length: 346  Bit Score: 63.78  E-value: 3.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   73 GKVEEIDTQIRDHLSLLPRvnrstPFIYFITPTHFR-AAQRADLTRLSYTLSHVPN-LHWIVVE---DSDEltpsIAGIL 147
Cdd:PLN02458  93 SETASLLEKEEEEPKLAPR-----RLVIIVTPISTKdRYQGVLLRRLANTLRLVPPpLLWIVVEgqsDSEE----VSEML 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739  148 KRSKIPNTHLNArtpsdqKMRYDDPNWTLPrgvEQRNRALLWI-QNQLSGVkegvVYFGDDDNTYDLKIFGEMRKVKNAG 226
Cdd:PLN02458 164 RKTGIMYRHLVF------KENFTDPEAELD---HQRNLALRHIeHHKLSGI----VHFAGLSNVYDLDFFDEIRDIEVFG 230
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17535739  227 VWPVGIVGG----MFVETPILEKNGSIS-HFNAV--WKPERPfPIDMAAFAVNISLV 276
Cdd:PLN02458 231 TWPMALLSAnrnkVIIEGPVCDSSQVIGwHLKKMnnETETRP-PIHISSFAFNSSIL 286
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
9-88 1.06e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 37.94  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   9 KWWLRAF-IALVIFFVWQLFYAIN---RVQSLEEERATLQATIEVLTRKSDGLRTQIfekernlVRLNGKVEEIDTQIRD 84
Cdd:COG2919   3 RLLRTLVlLLLLAYLQYHLWFGDGgllAYRELRQEIAELEAENAKLKARNAELEAEV-------ADLKDGPDYIEERARE 75

                ....
gi 17535739  85 HLSL 88
Cdd:COG2919  76 ELGM 79
 
Name Accession Description Interval E-value
GlcAT-I cd00218
Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan ...
97-327 5.13e-127

Beta1,3-glucuronyltransferase I (GlcAT-I) is involved in the initial steps of proteoglycan synthesis; Beta1,3-glucuronyltransferase I (GlcAT-I) domain; GlcAT-I is a Key enzyme involved in the initial steps of proteoglycan synthesis. GlcAT-I catalyzes the transfer of a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region of trisaccharide Gal-beta-(1-3)-Gal-beta-(1-4)-Xyl of proteoglycans. The enzyme has two subdomains that bind the donor and acceptor substrate separately. The active site is located at the cleft between both subdomains in which the trisaccharide molecule is oriented perpendicular to the UDP. This family has been classified as Glycosyltransferase family 43 (GT-43).


Pssm-ID: 132995  Cd Length: 223  Bit Score: 363.15  E-value: 5.13e-127
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739  97 PFIYFITPTHFRAAQRADLTRLSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDqkmryddPNWTL 176
Cdd:cd00218   1 PTIYVVTPTYARPVQKAELTRLAHTLRLVPPLHWIVVEDSEEKTPLVAELLRRSGLMYTHLNAKTPSD-------PTWLK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739 177 PRGVEQRNRALLWIQNQLSGVKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILEkNGSISHFNAVW 256
Cdd:cd00218  74 PRGVEQRNLALRWIREHLSAKLDGVVYFADDDNTYDLELFEEMRKIKRVGVWPVGLVGGLRVEGPVCE-NGKVVGWHTAW 152
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17535739 257 KPERPFPIDMAAFAVNISLVLSNANALFSFDVPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTEK 327
Cdd:cd00218 153 KPERPFPIDMAGFAFNSKLLWDPPRAVFPYSAKRGYQESSFLEQLVLDRKELEPLANNCSKVLVWHTRTEK 223
Glyco_transf_43 pfam03360
Glycosyltransferase family 43;
118-326 1.13e-100

Glycosyltransferase family 43;


Pssm-ID: 460898  Cd Length: 202  Bit Score: 295.60  E-value: 1.13e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   118 LSYTLSHVPNLHWIVVEDSDELTPSIAGILKRSKIPNTHLNARTPSDqkmryddPNWTL-PRGVEQRNRALLWIQNQLSG 196
Cdd:pfam03360   1 LAHTLRLVPPLHWIVVEDSESKTPLVANLLRRSGLPYTHLNAKKYKP-------PNWTDkPRGVHQRNVALRWIRENKHR 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   197 vKEGVVYFGDDDNTYDLKIFGEMRKVKNAGVWPVGIVGGMFVETPILeKNGSISHFNAVWKPERPFPIDMAAFAVNISLV 276
Cdd:pfam03360  74 -LDGVVYFADDDNTYDLRLFDEMRKTKKVGVWPVGLVGGLRVEGPVC-NNGKVVGWHTGWKPERPFPIDMAGFAVNSRLL 151
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17535739   277 LSNANALFSFD-VPRGYQESTFLENLGIHRYNMEPLAEMCTKVYVWHTRTE 326
Cdd:pfam03360 152 WDPPEAVFSLDsVKRGYQESSFLEQLVEDESDLEPLADNCTKVLVWHTRTE 202
PLN02458 PLN02458
transferase, transferring glycosyl groups
73-276 3.43e-11

transferase, transferring glycosyl groups


Pssm-ID: 215252  Cd Length: 346  Bit Score: 63.78  E-value: 3.43e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   73 GKVEEIDTQIRDHLSLLPRvnrstPFIYFITPTHFR-AAQRADLTRLSYTLSHVPN-LHWIVVE---DSDEltpsIAGIL 147
Cdd:PLN02458  93 SETASLLEKEEEEPKLAPR-----RLVIIVTPISTKdRYQGVLLRRLANTLRLVPPpLLWIVVEgqsDSEE----VSEML 163
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739  148 KRSKIPNTHLNArtpsdqKMRYDDPNWTLPrgvEQRNRALLWI-QNQLSGVkegvVYFGDDDNTYDLKIFGEMRKVKNAG 226
Cdd:PLN02458 164 RKTGIMYRHLVF------KENFTDPEAELD---HQRNLALRHIeHHKLSGI----VHFAGLSNVYDLDFFDEIRDIEVFG 230
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 17535739  227 VWPVGIVGG----MFVETPILEKNGSIS-HFNAV--WKPERPfPIDMAAFAVNISLV 276
Cdd:PLN02458 231 TWPMALLSAnrnkVIIEGPVCDSSQVIGwHLKKMnnETETRP-PIHISSFAFNSSIL 286
FtsB COG2919
Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];
9-88 1.06e-03

Cell division protein FtsB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442163 [Multi-domain]  Cd Length: 96  Bit Score: 37.94  E-value: 1.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535739   9 KWWLRAF-IALVIFFVWQLFYAIN---RVQSLEEERATLQATIEVLTRKSDGLRTQIfekernlVRLNGKVEEIDTQIRD 84
Cdd:COG2919   3 RLLRTLVlLLLLAYLQYHLWFGDGgllAYRELRQEIAELEAENAKLKARNAELEAEV-------ADLKDGPDYIEERARE 75

                ....
gi 17535739  85 HLSL 88
Cdd:COG2919  76 ELGM 79
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
32-83 2.24e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 39.50  E-value: 2.24e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|..
gi 17535739  32 RVQSLEEERATLQATIEVLTRKSDGLRTQIFEKERNLVRLNGKVEEIDTQIR 83
Cdd:COG4372 116 ELEELQKERQDLEQQRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELA 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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