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Conserved domains on  [gi|17535117|ref|NP_496159|]
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32 kDa beta-galactoside-binding lectin lec-3 [Caenorhabditis elegans]

Protein Classification

galectin family protein( domain architecture ID 10049222)

galectin family protein may exclusively bind beta-galactosides such as lactose in a manner independent of metal ions

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
158-288 2.22e-49

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 160.11  E-value: 2.22e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117 158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKAngfmcakptpgsVVRNSLVNGEWGNEEREGKNPFER 237
Cdd:cd00070   9 GLKPGSTLTVKGRVLPNAKRFSINLGTGSSDIALHFNPRFDENV------------IVRNSFLNGNWGPEERSGGFPFQP 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 17535117 238 LTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 288
Cdd:cd00070  77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
10-140 1.38e-47

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


:

Pssm-ID: 238025  Cd Length: 127  Bit Score: 155.48  E-value: 1.38e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117  10 PYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSpdfsgNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAK-NPIK 88
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGS-----SDIALHFNPRFDENVIVRNSFLNGNWGPEERSGgFPFQ 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 17535117  89 KGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:cd00070  76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
158-288 2.22e-49

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 160.11  E-value: 2.22e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117 158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKAngfmcakptpgsVVRNSLVNGEWGNEEREGKNPFER 237
Cdd:cd00070   9 GLKPGSTLTVKGRVLPNAKRFSINLGTGSSDIALHFNPRFDENV------------IVRNSFLNGNWGPEERSGGFPFQP 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 17535117 238 LTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 288
Cdd:cd00070  77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
158-288 1.13e-47

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 155.44  E-value: 1.13e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117    158 GLVPGKTLVVYGTPEKKAKKFNINLLKK-NGDIALHFNPRFDEKAngfmcakptpgsVVRNSLVNGEWGNEEREGKNPFE 236
Cdd:smart00908   3 GLSPGSSITIRGIVLPDAKRFSINLQCGpNADIALHFNPRFDEGT------------IVRNSKQNGKWGKEERSGGFPFQ 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17535117    237 RLTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 288
Cdd:smart00908  71 PGQPFELEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
10-140 1.38e-47

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 155.48  E-value: 1.38e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117  10 PYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSpdfsgNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAK-NPIK 88
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGS-----SDIALHFNPRFDENVIVRNSFLNGNWGPEERSGgFPFQ 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 17535117  89 KGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:cd00070  76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
11-141 3.94e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 151.61  E-value: 3.94e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117     11 YRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDspdfsGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKK 89
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTG-----GDDIALHFNPRFNENKIVCNSKLNGSWGSEEReGGFPFQP 75
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17535117     90 GDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQW 141
Cdd:smart00276  76 GQPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
158-288 1.15e-43

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 145.09  E-value: 1.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117   158 GLVPGKTLVVYGTPEKKAKKFNINLLK---KNGDIALHFNPRFDEkangfmcakptpGSVVRNSLVNGEWGNEEREGKNP 234
Cdd:pfam00337   3 GLQPGSSLTIKGIVLPDAQRFSINLQTgvgPSDDIALHFNPRFDE------------NVIVRNSRQNGQWGQEEREGGFP 70
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17535117   235 FERLTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 288
Cdd:pfam00337  71 FQPGQPFELTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
20-140 3.48e-37

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 128.53  E-value: 3.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117    20 EPGQTLIIRGKTIDESKRFNINLHKDspDFSGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKKGDDFDIRIR 98
Cdd:pfam00337   5 QPGSSLTIKGIVLPDAQRFSINLQTG--VGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEReGGFPFQPGQPFELTIL 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 17535117    99 AHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Name Accession Description Interval E-value
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
158-288 2.22e-49

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 160.11  E-value: 2.22e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117 158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEKAngfmcakptpgsVVRNSLVNGEWGNEEREGKNPFER 237
Cdd:cd00070   9 GLKPGSTLTVKGRVLPNAKRFSINLGTGSSDIALHFNPRFDENV------------IVRNSFLNGNWGPEERSGGFPFQP 76
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 17535117 238 LTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 288
Cdd:cd00070  77 GQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
158-288 1.13e-47

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 155.44  E-value: 1.13e-47
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117    158 GLVPGKTLVVYGTPEKKAKKFNINLLKK-NGDIALHFNPRFDEKAngfmcakptpgsVVRNSLVNGEWGNEEREGKNPFE 236
Cdd:smart00908   3 GLSPGSSITIRGIVLPDAKRFSINLQCGpNADIALHFNPRFDEGT------------IVRNSKQNGKWGKEERSGGFPFQ 70
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17535117    237 RLTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 288
Cdd:smart00908  71 PGQPFELEILVEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
GLECT cd00070
Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as ...
10-140 1.38e-47

Galectin/galactose-binding lectin. This domain exclusively binds beta-galactosides, such as lactose, and does not require metal ions for activity. GLECT domains occur as homodimers or tandemly repeated domains. They are developmentally regulated and may be involved in differentiation, cell-cell interaction and cellular regulation.


Pssm-ID: 238025  Cd Length: 127  Bit Score: 155.48  E-value: 1.38e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117  10 PYRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDSpdfsgNDVPLHLSIRFDEGKIVYNAYTKGTWGKEERAK-NPIK 88
Cdd:cd00070   1 PYKLPLPGGLKPGSTLTVKGRVLPNAKRFSINLGTGS-----SDIALHFNPRFDENVIVRNSFLNGNWGPEERSGgFPFQ 75
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 17535117  89 KGDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:cd00070  76 PGQPFELTILVEEDKFQIFVNGQHFFSFPHRLPLESIDYLSINGDVSLTSVE 127
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
11-141 3.94e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 151.61  E-value: 3.94e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117     11 YRSKLTERIEPGQTLIIRGKTIDESKRFNINLHKDspdfsGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKK 89
Cdd:smart00276   1 FTLPIPGGLKPGQTLTVRGIVLPDAKRFSINLLTG-----GDDIALHFNPRFNENKIVCNSKLNGSWGSEEReGGFPFQP 75
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17535117     90 GDDFDIRIRAHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQW 141
Cdd:smart00276  76 GQPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
GLECT smart00276
Galectin; Galectin - galactose-binding lectin
158-289 7.30e-46

Galectin; Galectin - galactose-binding lectin


Pssm-ID: 214596  Cd Length: 128  Bit Score: 150.84  E-value: 7.30e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117    158 GLVPGKTLVVYGTPEKKAKKFNINLLKKNGDIALHFNPRFDEkangfmcakptpGSVVRNSLVNGEWGNEEREGKNPFER 237
Cdd:smart00276   8 GLKPGQTLTVRGIVLPDAKRFSINLLTGGDDIALHFNPRFNE------------NKIVCNSKLNGSWGSEEREGGFPFQP 75
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 17535117    238 LTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQV 289
Cdd:smart00276  76 GQPFDLTIIVQPDHFQIFVNGVHITTFPHRLPLESIDYLSINGDVQLTSVSF 127
Gal-bind_lectin smart00908
Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are ...
20-140 9.96e-45

Galactoside-binding lectin; Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals. Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction.


Pssm-ID: 214904  Cd Length: 122  Bit Score: 147.74  E-value: 9.96e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117     20 EPGQTLIIRGKTIDESKRFNINLHKDSPDfsgnDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKKGDDFDIRIR 98
Cdd:smart00908   5 SPGSSITIRGIVLPDAKRFSINLQCGPNA----DIALHFNPRFDEGTIVRNSKQNGKWGKEERsGGFPFQPGQPFELEIL 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 17535117     99 AHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:smart00908  81 VEEDEFKVAVNGQHFLEFPHRLPLESIDTLEISGDVQLTSVQ 122
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
158-288 1.15e-43

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 145.09  E-value: 1.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117   158 GLVPGKTLVVYGTPEKKAKKFNINLLK---KNGDIALHFNPRFDEkangfmcakptpGSVVRNSLVNGEWGNEEREGKNP 234
Cdd:pfam00337   3 GLQPGSSLTIKGIVLPDAQRFSINLQTgvgPSDDIALHFNPRFDE------------NVIVRNSRQNGQWGQEEREGGFP 70
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17535117   235 FERLTAFDLEIRNEEFAFQIFVNGERFASYAHRVDPHDIAGLQIQGDIELTGIQ 288
Cdd:pfam00337  71 FQPGQPFELTILVGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
Gal-bind_lectin pfam00337
Galactoside-binding lectin; This family contains galactoside binding lectins. The family also ...
20-140 3.48e-37

Galactoside-binding lectin; This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (EC:3.1.1.5).


Pssm-ID: 459768  Cd Length: 124  Bit Score: 128.53  E-value: 3.48e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17535117    20 EPGQTLIIRGKTIDESKRFNINLHKDspDFSGNDVPLHLSIRFDEGKIVYNAYTKGTWGKEER-AKNPIKKGDDFDIRIR 98
Cdd:pfam00337   5 QPGSSLTIKGIVLPDAQRFSINLQTG--VGPSDDIALHFNPRFDENVIVRNSRQNGQWGQEEReGGFPFQPGQPFELTIL 82
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 17535117    99 AHDSKFQVSINHKEVKNFEHRIPLNSVSHLSIDGDVVLNHVQ 140
Cdd:pfam00337  83 VGDDHFKIYVNGQHFTTFKHRLPPEDIDALQVRGDVKLTSVL 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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