NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|392893886|ref|NP_497144|]
View 

histone acetyltransferase [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 31-100 4.68e-26

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


:

Pssm-ID: 460457  Cd Length: 72  Bit Score: 96.69  E-value: 4.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392893886   31 LSRQLGLMLHAERCQIAE--QCPVPQCSTMKEVIGHMMTCWNGFQCPSEHCTSSRMVIHHWTRCTNAECPIC 100
Cdd:pfam02135   1 LQRWLLLLLHASKCSAPGpgPCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLRHAKNCKDEDCPVC 72
KIX super family cl44390
KIX domain; CBP and P300 bind to the CREB via a domain known as KIX. The KIX domain of CBP ...
 132-194 3.46e-03

KIX domain; CBP and P300 bind to the CREB via a domain known as KIX. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.


The actual alignment was detected with superfamily member pfam02172:

Pssm-ID: 366953  Cd Length: 81  Bit Score: 35.55  E-value: 3.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392893886  132 WHSEVPKTDREAVIERISKHIMLHP-------QRFEpiwKIKEDARAAELQIFEAAGSRDEYYRMVEERA 194
Cdd:pfam02172   6 WHSRVTRDLRNHLVHKLVQAIFPTPdqnamndGRMD---NLIAYARKVEKEMFESANDRDEYYHLLAEKI 72
 
Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 31-100 4.68e-26

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 96.69  E-value: 4.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392893886   31 LSRQLGLMLHAERCQIAE--QCPVPQCSTMKEVIGHMMTCWNGFQCPSEHCTSSRMVIHHWTRCTNAECPIC 100
Cdd:pfam02135   1 LQRWLLLLLHASKCSAPGpgPCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLRHAKNCKDEDCPVC 72
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
30-100 2.35e-17

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 73.94  E-value: 2.35e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392893886    30 TLSRQLGLMLHAERCQ-IAEQCPVPQCSTMKEVIGHMMTCWNGfQCPSEHCTSSRMVIHHWTRCTNAECPIC 100
Cdd:smart00551   6 QLQRWLELLVHARRCKaREAKCQYPNCKTMKKLLRHMDSCKVR-KCKYGYCASCKQLWQHSKHCKDSNCPVC 76
KIX pfam02172
KIX domain; CBP and P300 bind to the CREB via a domain known as KIX. The KIX domain of CBP ...
 132-194 3.46e-03

KIX domain; CBP and P300 bind to the CREB via a domain known as KIX. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.


Pssm-ID: 366953  Cd Length: 81  Bit Score: 35.55  E-value: 3.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392893886  132 WHSEVPKTDREAVIERISKHIMLHP-------QRFEpiwKIKEDARAAELQIFEAAGSRDEYYRMVEERA 194
Cdd:pfam02172   6 WHSRVTRDLRNHLVHKLVQAIFPTPdqnamndGRMD---NLIAYARKVEKEMFESANDRDEYYHLLAEKI 72
 
Name Accession Description Interval E-value
zf-TAZ pfam02135
TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 ...
 31-100 4.68e-26

TAZ zinc finger; The TAZ2 domain of CBP binds to other transcription factors such as the p53 tumour suppressor protein, E1A oncoprotein, MyoD, and GATA-1. The zinc coordinating motif that is necessary for binding to target DNA sequences consists of HCCC.


Pssm-ID: 460457  Cd Length: 72  Bit Score: 96.69  E-value: 4.68e-26
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392893886   31 LSRQLGLMLHAERCQIAE--QCPVPQCSTMKEVIGHMMTCWNGFQCPSEHCTSSRMVIHHWTRCTNAECPIC 100
Cdd:pfam02135   1 LQRWLLLLLHASKCSAPGpgPCSLPNCRKMKRLLRHMATCKRGGGCPYPHCKRSRQLLRHAKNCKDEDCPVC 72
ZnF_TAZ smart00551
TAZ zinc finger, present in p300 and CBP;
30-100 2.35e-17

TAZ zinc finger, present in p300 and CBP;


Pssm-ID: 214717  Cd Length: 79  Bit Score: 73.94  E-value: 2.35e-17
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392893886    30 TLSRQLGLMLHAERCQ-IAEQCPVPQCSTMKEVIGHMMTCWNGfQCPSEHCTSSRMVIHHWTRCTNAECPIC 100
Cdd:smart00551   6 QLQRWLELLVHARRCKaREAKCQYPNCKTMKKLLRHMDSCKVR-KCKYGYCASCKQLWQHSKHCKDSNCPVC 76
KIX pfam02172
KIX domain; CBP and P300 bind to the CREB via a domain known as KIX. The KIX domain of CBP ...
 132-194 3.46e-03

KIX domain; CBP and P300 bind to the CREB via a domain known as KIX. The KIX domain of CBP also binds to transactivation domains of other nuclear factors including Myb and Jun.


Pssm-ID: 366953  Cd Length: 81  Bit Score: 35.55  E-value: 3.46e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392893886  132 WHSEVPKTDREAVIERISKHIMLHP-------QRFEpiwKIKEDARAAELQIFEAAGSRDEYYRMVEERA 194
Cdd:pfam02172   6 WHSRVTRDLRNHLVHKLVQAIFPTPdqnamndGRMD---NLIAYARKVEKEMFESANDRDEYYHLLAEKI 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH