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Conserved domains on  [gi|71982315|ref|NP_498053|]
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JmjC domain-containing protein [Caenorhabditis elegans]

Protein Classification

cupin domain-containing protein( domain architecture ID 1562428)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cupin_8 super family cl46322
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 183-243 3.61e-06

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


The actual alignment was detected with superfamily member pfam13621:

Pssm-ID: 463936  Cd Length: 251  Bit Score: 46.98  E-value: 3.61e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71982315   183 VIHGSKRWFLYP-------YEQRPNWNPDKTTLEWYTYD------YPKLSRDELPLECEMKSGEVIYFPDKWWH 243
Cdd:pfam13621 156 VVRGRKRFTLFPpsdvpnlYPGPLEPTPEGQVFSLVDPLapdferFPRFRDAARPLVVTLNPGDVLYLPALWWH 229
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 183-243 3.61e-06

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 46.98  E-value: 3.61e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71982315   183 VIHGSKRWFLYP-------YEQRPNWNPDKTTLEWYTYD------YPKLSRDELPLECEMKSGEVIYFPDKWWH 243
Cdd:pfam13621 156 VVRGRKRFTLFPpsdvpnlYPGPLEPTPEGQVFSLVDPLapdferFPRFRDAARPLVVTLNPGDVLYLPALWWH 229
 
Name Accession Description Interval E-value
Cupin_8 pfam13621
Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.
 183-243 3.61e-06

Cupin-like domain; This cupin like domain shares similarity to the JmjC domain.


Pssm-ID: 463936  Cd Length: 251  Bit Score: 46.98  E-value: 3.61e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 71982315   183 VIHGSKRWFLYP-------YEQRPNWNPDKTTLEWYTYD------YPKLSRDELPLECEMKSGEVIYFPDKWWH 243
Cdd:pfam13621 156 VVRGRKRFTLFPpsdvpnlYPGPLEPTPEGQVFSLVDPLapdferFPRFRDAARPLVVTLNPGDVLYLPALWWH 229
JmjC pfam02373
JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain ...
 168-247 6.74e-03

JmjC domain, hydroxylase; The JmjC domain belongs to the Cupin superfamily. JmjC-domain proteins may be protein hydroxylases that catalyze a novel histone modification. This is confirmed to be a hydroxylase: the human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation.


Pssm-ID: 396791  Cd Length: 114  Bit Score: 35.74  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71982315   168 GTGVPFHF--HGPGFAEVIH--GSKRWFLYPYE----------QRPNWNPDKTTLEWYTYDYPKLSRDE--LPLECEMKS 231
Cdd:pfam02373   8 FSTTPWHIedQGLYSINYLHfgAPKVWYIIPPEyaekfekvlsDHFGGEQPDDLLHLNTIISPKQLRENgiPVYRFVQKP 87

                          90
                  ....*....|....*.
gi 71982315   232 GEVIYFPDKWWHATLN 247
Cdd:pfam02373  88 GEFVFTFPGWYHQVFN 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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