NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17555846|ref|NP_499517|]
View 

Ubiquitin-like domain-containing protein [Caenorhabditis elegans]

Protein Classification

ubiquitin family protein( domain architecture ID 10110346)

ubiquitin family protein belongs to an diverse class of protein modifier and gene expression regulatory proteins that participate in a number of cellular processes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Ubl_ElonginB cd01788
ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar ...
 5-109 8.68e-49

ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar proteins; Elongin B, also termed Elongin 18 kDa subunit, or EloB, or RNA polymerase II transcription factor SIII subunit B (SIII p18), is part of an E3 ubiquitin ligase complex called VEC that activates ubiquitination by the E2 ubiquitin-conjugating enzyme Ubc5. VEC is composed of von Hippel-Lindau tumor suppressor protein (pVHL), elongin C, cullin 2, NEDD8, and Rbx1. ElonginB binds elonginC to form the elonginBC complex which is a positive regulator of RNA polymerase II elongation factor Elongin A. The BC complex then binds VHL (von Hippel-Lindau) tumor suppressor protein to form a VCB ternary complex. Elongin B has a ubiquitin-like (Ubl) domain. Ub has a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair.


:

Pssm-ID: 340486  Cd Length: 101  Bit Score: 150.91  E-value: 8.68e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555846   5 ELFFEVRRNRSHIYLDAEESHSVMELKLMLAGITRDPVNHMELWKLDedgnksQLLHDTATLSDAGFSSTNAKAQCPAAL 84
Cdd:cd01788   1 DVFLMIRRKKTTIFTDAKESTTVFELKKIIEGILKRPPEDQRLYKDD------QLLDDTKTLGDCGFTSQTARAQAPATL 74

                        90       100
                ....*....|....*....|....*..
gi 17555846  85 GLRLTN--AEEHLTISDVSTAPPIPDT 109
Cdd:cd01788  75 GLAFRAdgEFEPLEITPLSSPPELPDV 101
 
Name Accession Description Interval E-value
Ubl_ElonginB cd01788
ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar ...
 5-109 8.68e-49

ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar proteins; Elongin B, also termed Elongin 18 kDa subunit, or EloB, or RNA polymerase II transcription factor SIII subunit B (SIII p18), is part of an E3 ubiquitin ligase complex called VEC that activates ubiquitination by the E2 ubiquitin-conjugating enzyme Ubc5. VEC is composed of von Hippel-Lindau tumor suppressor protein (pVHL), elongin C, cullin 2, NEDD8, and Rbx1. ElonginB binds elonginC to form the elonginBC complex which is a positive regulator of RNA polymerase II elongation factor Elongin A. The BC complex then binds VHL (von Hippel-Lindau) tumor suppressor protein to form a VCB ternary complex. Elongin B has a ubiquitin-like (Ubl) domain. Ub has a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340486  Cd Length: 101  Bit Score: 150.91  E-value: 8.68e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555846   5 ELFFEVRRNRSHIYLDAEESHSVMELKLMLAGITRDPVNHMELWKLDedgnksQLLHDTATLSDAGFSSTNAKAQCPAAL 84
Cdd:cd01788   1 DVFLMIRRKKTTIFTDAKESTTVFELKKIIEGILKRPPEDQRLYKDD------QLLDDTKTLGDCGFTSQTARAQAPATL 74

                        90       100
                ....*....|....*....|....*..
gi 17555846  85 GLRLTN--AEEHLTISDVSTAPPIPDT 109
Cdd:cd01788  75 GLAFRAdgEFEPLEITPLSSPPELPDV 101
 
Name Accession Description Interval E-value
Ubl_ElonginB cd01788
ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar ...
 5-109 8.68e-49

ubiquitin-like (Ubl) domain found in transcription elongation factor B (Elongin B) and similar proteins; Elongin B, also termed Elongin 18 kDa subunit, or EloB, or RNA polymerase II transcription factor SIII subunit B (SIII p18), is part of an E3 ubiquitin ligase complex called VEC that activates ubiquitination by the E2 ubiquitin-conjugating enzyme Ubc5. VEC is composed of von Hippel-Lindau tumor suppressor protein (pVHL), elongin C, cullin 2, NEDD8, and Rbx1. ElonginB binds elonginC to form the elonginBC complex which is a positive regulator of RNA polymerase II elongation factor Elongin A. The BC complex then binds VHL (von Hippel-Lindau) tumor suppressor protein to form a VCB ternary complex. Elongin B has a ubiquitin-like (Ubl) domain. Ub has a beta-grasp Ubl fold, a common structure involved in protein-protein interactions. Ub is a protein modifier in eukaryotes that is involved in various cellular processes, including transcriptional regulation, cell cycle control, and DNA repair.


Pssm-ID: 340486  Cd Length: 101  Bit Score: 150.91  E-value: 8.68e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17555846   5 ELFFEVRRNRSHIYLDAEESHSVMELKLMLAGITRDPVNHMELWKLDedgnksQLLHDTATLSDAGFSSTNAKAQCPAAL 84
Cdd:cd01788   1 DVFLMIRRKKTTIFTDAKESTTVFELKKIIEGILKRPPEDQRLYKDD------QLLDDTKTLGDCGFTSQTARAQAPATL 74

                        90       100
                ....*....|....*....|....*..
gi 17555846  85 GLRLTN--AEEHLTISDVSTAPPIPDT 109
Cdd:cd01788  75 GLAFRAdgEFEPLEITPLSSPPELPDV 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH