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Conserved domains on  [gi|25148407|ref|NP_500096|]
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CUB_2 domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycoprotein pfam03409
Transmembrane glycoprotein; This family of proteins has some GO annotations for positive ...
 44-376 5.17e-115

Transmembrane glycoprotein; This family of proteins has some GO annotations for positive regulation of growth rate and nematode larval development. This is probably a family of membrane glycoproteins.


:

Pssm-ID: 397466  Cd Length: 351  Bit Score: 341.15  E-value: 5.17e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407    44 ANLYVASDDDPSNLRLIQIITGGNTYSLADLVS------TPQKITISGGLTITSTNPDAVTYALTGYIYVTTAQQAQDPL 117
Cdd:pfam03409   2 AKLYLASSDDNAYLKNITITTGGQTITLDDLKNnfnddgSPKPFPVNSDLTISTTNSDDVTKNLTGVLYITTAKQAKDPN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   118 FKVLVVTGAHTLNANGVQATT-VILNTELEVrTDDADQPTKSSYVSNLKMTSNENLKFHWGIPAANWKQGTTNNTFFMNP 196
Cdd:pfam03409  82 FLVYVVKGSQTIDRSGNKGTTiVFLNTNLQD-GDDNDQPFKSSYVSNINQSPNTSLYFYWGIPADDYEDVNTQNTIFSNP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   197 ----YTDGTNTMFFDHTEPMQIGLDCWYIISSGPVSMGVKNDYVPNHNYTTTAANTTGLLVSgNFLYQEHQVNFLPDPTR 272
Cdd:pfam03409 161 iklfNTDTGDKVFFDNVEPFQISLDYWYITTTGGVNFKIENKYVDNDNYTTTAVTTTGFYMK-QLVDSNHTVNFLRDTTR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   273 SRTVGTFITAYIPQGANVNFTFVAADGSWVQTFDSSKNNSQLASSSPLAAQKLNVKSSRIFAGTFYCQYFGISTAMLPIS 352
Cdd:pfam03409 240 SGTSGANVSGFPNSDANVTVTLNDGDGSISTTFTPTNNVTINPWSTPWIAQTLTINSTNIVPGTFYVQYFVIQGDLLPST 319

                         330       340
                  ....*....|....*....|....
gi 25148407   353 SSSTTVTSPAIITTSQGGKASTTP 376
Cdd:pfam03409 320 TSTTTPGPTTVTTTTPSTSTTTTT 343
KLF3_N super family cl40586
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ...
 371-441 1.20e-04

N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3.


The actual alignment was detected with superfamily member cd21577:

Pssm-ID: 410554 [Multi-domain]  Cd Length: 214  Bit Score: 43.10  E-value: 1.20e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25148407 371 KASTTPSSAPPAPGSSSASPTGTSGSSVSPPASGPTTSMPAQASTTPSGT---MGSTLQTTTKFSRSPSILISS 441
Cdd:cd21577  29 RSSPPSSSSSSSSSSSSSSSPSSRASPPSPYSKSSPPSPPQQRPLSPPLSlppPVAPPPLSPGSVPGGLPVISP 102
 
Name Accession Description Interval E-value
Glycoprotein pfam03409
Transmembrane glycoprotein; This family of proteins has some GO annotations for positive ...
 44-376 5.17e-115

Transmembrane glycoprotein; This family of proteins has some GO annotations for positive regulation of growth rate and nematode larval development. This is probably a family of membrane glycoproteins.


Pssm-ID: 397466  Cd Length: 351  Bit Score: 341.15  E-value: 5.17e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407    44 ANLYVASDDDPSNLRLIQIITGGNTYSLADLVS------TPQKITISGGLTITSTNPDAVTYALTGYIYVTTAQQAQDPL 117
Cdd:pfam03409   2 AKLYLASSDDNAYLKNITITTGGQTITLDDLKNnfnddgSPKPFPVNSDLTISTTNSDDVTKNLTGVLYITTAKQAKDPN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   118 FKVLVVTGAHTLNANGVQATT-VILNTELEVrTDDADQPTKSSYVSNLKMTSNENLKFHWGIPAANWKQGTTNNTFFMNP 196
Cdd:pfam03409  82 FLVYVVKGSQTIDRSGNKGTTiVFLNTNLQD-GDDNDQPFKSSYVSNINQSPNTSLYFYWGIPADDYEDVNTQNTIFSNP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   197 ----YTDGTNTMFFDHTEPMQIGLDCWYIISSGPVSMGVKNDYVPNHNYTTTAANTTGLLVSgNFLYQEHQVNFLPDPTR 272
Cdd:pfam03409 161 iklfNTDTGDKVFFDNVEPFQISLDYWYITTTGGVNFKIENKYVDNDNYTTTAVTTTGFYMK-QLVDSNHTVNFLRDTTR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   273 SRTVGTFITAYIPQGANVNFTFVAADGSWVQTFDSSKNNSQLASSSPLAAQKLNVKSSRIFAGTFYCQYFGISTAMLPIS 352
Cdd:pfam03409 240 SGTSGANVSGFPNSDANVTVTLNDGDGSISTTFTPTNNVTINPWSTPWIAQTLTINSTNIVPGTFYVQYFVIQGDLLPST 319

                         330       340
                  ....*....|....*....|....
gi 25148407   353 SSSTTVTSPAIITTSQGGKASTTP 376
Cdd:pfam03409 320 TSTTTPGPTTVTTTTPSTSTTTTT 343
KLF3_N cd21577
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ...
 371-441 1.20e-04

N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3.


Pssm-ID: 410554 [Multi-domain]  Cd Length: 214  Bit Score: 43.10  E-value: 1.20e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25148407 371 KASTTPSSAPPAPGSSSASPTGTSGSSVSPPASGPTTSMPAQASTTPSGT---MGSTLQTTTKFSRSPSILISS 441
Cdd:cd21577  29 RSSPPSSSSSSSSSSSSSSSPSSRASPPSPYSKSSPPSPPQQRPLSPPLSlppPVAPPPLSPGSVPGGLPVISP 102
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 371-436 2.18e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 43.35  E-value: 2.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25148407   371 KASTTPSSAPPAPGSSSASPTGtsgssvSPPASGPTTSMPAQASTTPSGTMGSTLQTTTKFsRSPS 436
Cdd:TIGR00601  78 KTGTGKVAPPAATPTSAPTPTP------SPPASPASGMSAAPASAVEEKSPSEESATATAP-ESPS 136
AvrBs3 NF041308
type III secretion system effector avirulence protein AvrBs3;
373-443 5.54e-04

type III secretion system effector avirulence protein AvrBs3;


Pssm-ID: 469205 [Multi-domain]  Cd Length: 1179  Bit Score: 42.64  E-value: 5.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25148407   373 STTPSSA-PPAPGSSSASPTGTSGSSVSPPASGPTTSMPAQAsttpsgTMGSTLQTTTKFSrSPSILISSFA 443
Cdd:NF041308    6 SRTPSPArEPQAGSQPDGVQPIAGRLVSTAASSPLDGLPARP------AMSRTRQPATPAP-SPAFSVGSFS 70
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 366-441 1.30e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 41.23  E-value: 1.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25148407  366 TSQGGKASTTPSSAPPApgSSSASPTGTSGSSVSPPASGPTTSMPAQASTTPSGTMGSTLQTTTKFSRSPSILISS 441
Cdd:PLN02217 585 SSDSPSTVVAPSTSPPA--GHLGSPPATPSKIVSPSTSPPASHLGSPSTTPSSPESSIKVASTETASPESSIKVAS 658
 
Name Accession Description Interval E-value
Glycoprotein pfam03409
Transmembrane glycoprotein; This family of proteins has some GO annotations for positive ...
 44-376 5.17e-115

Transmembrane glycoprotein; This family of proteins has some GO annotations for positive regulation of growth rate and nematode larval development. This is probably a family of membrane glycoproteins.


Pssm-ID: 397466  Cd Length: 351  Bit Score: 341.15  E-value: 5.17e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407    44 ANLYVASDDDPSNLRLIQIITGGNTYSLADLVS------TPQKITISGGLTITSTNPDAVTYALTGYIYVTTAQQAQDPL 117
Cdd:pfam03409   2 AKLYLASSDDNAYLKNITITTGGQTITLDDLKNnfnddgSPKPFPVNSDLTISTTNSDDVTKNLTGVLYITTAKQAKDPN 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   118 FKVLVVTGAHTLNANGVQATT-VILNTELEVrTDDADQPTKSSYVSNLKMTSNENLKFHWGIPAANWKQGTTNNTFFMNP 196
Cdd:pfam03409  82 FLVYVVKGSQTIDRSGNKGTTiVFLNTNLQD-GDDNDQPFKSSYVSNINQSPNTSLYFYWGIPADDYEDVNTQNTIFSNP 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   197 ----YTDGTNTMFFDHTEPMQIGLDCWYIISSGPVSMGVKNDYVPNHNYTTTAANTTGLLVSgNFLYQEHQVNFLPDPTR 272
Cdd:pfam03409 161 iklfNTDTGDKVFFDNVEPFQISLDYWYITTTGGVNFKIENKYVDNDNYTTTAVTTTGFYMK-QLVDSNHTVNFLRDTTR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25148407   273 SRTVGTFITAYIPQGANVNFTFVAADGSWVQTFDSSKNNSQLASSSPLAAQKLNVKSSRIFAGTFYCQYFGISTAMLPIS 352
Cdd:pfam03409 240 SGTSGANVSGFPNSDANVTVTLNDGDGSISTTFTPTNNVTINPWSTPWIAQTLTINSTNIVPGTFYVQYFVIQGDLLPST 319

                         330       340
                  ....*....|....*....|....
gi 25148407   353 SSSTTVTSPAIITTSQGGKASTTP 376
Cdd:pfam03409 320 TSTTTPGPTTVTTTTPSTSTTTTT 343
KLF3_N cd21577
N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called ...
 371-441 1.20e-04

N-terminal domain of Kruppel-like factor 3; Kruppel-like factor 3 (KLF3; also called Krueppel-like factor 3 and originally called Basic Kruppel-like Factor/BKLF), was the third member of the KLF family of zinc finger transcription factors to be discovered. KLF3 possesses a wide range of biological impacts on regulating apoptosis, differentiation, and proliferation in various tissues during the entire progression process. It has been proposed as a tumor suppressor in colorectal cancer. It appears to function predominantly as a repressor of transcription, turning genes off by recruiting the C-terminal Binding Protein co-repressors CtBP1 and CtBP2. CtBP docks onto a short motif (residues 61-65) in the N-terminus of KLF3, through the Proline-X-Aspartate-Leucine-Serine (PXDLS) motif. CtBP in turn recruits histone modifying enzymes to alter chromatin and repress gene expression. KLF3 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF3.


Pssm-ID: 410554 [Multi-domain]  Cd Length: 214  Bit Score: 43.10  E-value: 1.20e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 25148407 371 KASTTPSSAPPAPGSSSASPTGTSGSSVSPPASGPTTSMPAQASTTPSGT---MGSTLQTTTKFSRSPSILISS 441
Cdd:cd21577  29 RSSPPSSSSSSSSSSSSSSSPSSRASPPSPYSKSSPPSPPQQRPLSPPLSlppPVAPPPLSPGSVPGGLPVISP 102
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 371-436 2.18e-04

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 43.35  E-value: 2.18e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25148407   371 KASTTPSSAPPAPGSSSASPTGtsgssvSPPASGPTTSMPAQASTTPSGTMGSTLQTTTKFsRSPS 436
Cdd:TIGR00601  78 KTGTGKVAPPAATPTSAPTPTP------SPPASPASGMSAAPASAVEEKSPSEESATATAP-ESPS 136
AvrBs3 NF041308
type III secretion system effector avirulence protein AvrBs3;
373-443 5.54e-04

type III secretion system effector avirulence protein AvrBs3;


Pssm-ID: 469205 [Multi-domain]  Cd Length: 1179  Bit Score: 42.64  E-value: 5.54e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 25148407   373 STTPSSA-PPAPGSSSASPTGTSGSSVSPPASGPTTSMPAQAsttpsgTMGSTLQTTTKFSrSPSILISSFA 443
Cdd:NF041308    6 SRTPSPArEPQAGSQPDGVQPIAGRLVSTAASSPLDGLPARP------AMSRTRQPATPAP-SPAFSVGSFS 70
PLN02217 PLN02217
probable pectinesterase/pectinesterase inhibitor
 366-441 1.30e-03

probable pectinesterase/pectinesterase inhibitor


Pssm-ID: 215130 [Multi-domain]  Cd Length: 670  Bit Score: 41.23  E-value: 1.30e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 25148407  366 TSQGGKASTTPSSAPPApgSSSASPTGTSGSSVSPPASGPTTSMPAQASTTPSGTMGSTLQTTTKFSRSPSILISS 441
Cdd:PLN02217 585 SSDSPSTVVAPSTSPPA--GHLGSPPATPSKIVSPSTSPPASHLGSPSTTPSSPESSIKVASTETASPESSIKVAS 658
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
362-430 3.28e-03

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 39.23  E-value: 3.28e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 25148407  362 AIITTSQGGKASTTPSSAPPAPGSSSAS-----PTGTSgSSVSPPASGPTTSMPAQASTTPSGTMGSTLQT-TTK 430
Cdd:PRK13042  20 VITTTTQAANATTPSSTKVEAPQSTPPStkveaPQSKP-NATTPPSTKVEAPQQTPNATTPSSTKVETPQSpTTK 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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