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Conserved domains on  [gi|17542922|ref|NP_500674|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 27-315 1.89e-84

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 257.38  E-value: 1.89e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922    27 ILLVVTNSPRKMGSYKYLLIYFSALTIVYAANDFVSAPYMFNDDSTVVVLVDLKNNLLKdrPDLLLLAVVSGVSCFGISL 106
Cdd:pfam10326  20 IYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLS--KSVGQILLALYCGFYGVSI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   107 YAIAINFMYRYFAVQREGRLRYFSGCRLVFWISLSIIGGIMTGLTFYAI-GSRQEISHGLRENLETMYDLDMHRTQYWVF 185
Cdd:pfam10326  98 SLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFlGPDEETDEYLREELLENYNLDIDEVAYVGP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   186 LYWQP-KDGNQDLTAKDIMANLGLTTSMVIPILLIVFFGTKTYRKVKNLTTHGkSEYSKRLQMQLYKALVAQIIIPSVFL 264
Cdd:pfam10326 178 VYYPTdENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFKALVIQTLIPTILM 256

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17542922   265 FLPTLLIAAGPLFKLNIPWASLPLSILFSMFSVMDSIPIIFLVDEYRNALF 315
Cdd:pfam10326 257 YIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 27-315 1.89e-84

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 257.38  E-value: 1.89e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922    27 ILLVVTNSPRKMGSYKYLLIYFSALTIVYAANDFVSAPYMFNDDSTVVVLVDLKNNLLKdrPDLLLLAVVSGVSCFGISL 106
Cdd:pfam10326  20 IYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLS--KSVGQILLALYCGFYGVSI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   107 YAIAINFMYRYFAVQREGRLRYFSGCRLVFWISLSIIGGIMTGLTFYAI-GSRQEISHGLRENLETMYDLDMHRTQYWVF 185
Cdd:pfam10326  98 SLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFlGPDEETDEYLREELLENYNLDIDEVAYVGP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   186 LYWQP-KDGNQDLTAKDIMANLGLTTSMVIPILLIVFFGTKTYRKVKNLTTHGkSEYSKRLQMQLYKALVAQIIIPSVFL 264
Cdd:pfam10326 178 VYYPTdENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFKALVIQTLIPTILM 256

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17542922   265 FLPTLLIAAGPLFKLNIPWASLPLSILFSMFSVMDSIPIIFLVDEYRNALF 315
Cdd:pfam10326 257 YIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 27-315 1.89e-84

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 257.38  E-value: 1.89e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922    27 ILLVVTNSPRKMGSYKYLLIYFSALTIVYAANDFVSAPYMFNDDSTVVVLVDLKNNLLKdrPDLLLLAVVSGVSCFGISL 106
Cdd:pfam10326  20 IYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLS--KSVGQILLALYCGFYGVSI 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   107 YAIAINFMYRYFAVQREGRLRYFSGCRLVFWISLSIIGGIMTGLTFYAI-GSRQEISHGLRENLETMYDLDMHRTQYWVF 185
Cdd:pfam10326  98 SLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFlGPDEETDEYLREELLENYNLDIDEVAYVGP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   186 LYWQP-KDGNQDLTAKDIMANLGLTTSMVIPILLIVFFGTKTYRKVKNLTTHGkSEYSKRLQMQLYKALVAQIIIPSVFL 264
Cdd:pfam10326 178 VYYPTdENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLG-SEKTRKLQKQLFKALVIQTLIPTILM 256

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 17542922   265 FLPTLLIAAGPLFKLNIPWASLPLSILFSMFSVMDSIPIIFLVDEYRNALF 315
Cdd:pfam10326 257 YIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 27-314 2.28e-30

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 117.34  E-value: 2.28e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922    27 ILLVVTNSPRKMGSYKYLLIYFSALTIVYAANDFVSAPYMFNDDSTVVVLVdlKNNLLKDRPDLLLLAVVSGVSCFGISL 106
Cdd:pfam10319  26 IYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFV--SDGPFFEYSELGQHALSARCSFISASY 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   107 YAIAINFMYRYFAVQREGRL-RYFsgcrLVFWISLSIIGGIMTGLTFYAI-----GSRQEISHGLRENLETMYDLDMHRT 180
Cdd:pfam10319 104 AVLLIHFIYRYLVLFNPQLTrHYF----RPWGILISILFFLFHGSVWTAIcyfllRANDEIRDYIREDFRETYGVDSMDI 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   181 QYWVFLYWqpkDGNQDLTAKDIMANLGLTTSMVIPILLIVFFGTKTYRKVKNLTTHgKSEYSKRLQMQLYKALVAQIIIP 260
Cdd:pfam10319 180 NMLGALYW---EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVT-MSKKTKRLQKQLLKALIVQTIIP 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 17542922   261 SVFLFLPTLLIAAGPLFKLNIPWASLPLS-ILFSMFSVMDSIPIIFLVDEYRNAL 314
Cdd:pfam10319 256 ICISFSPCVLAWYSPIFGIDLGRWNNYLEvIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 30-319 2.51e-06

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 48.31  E-value: 2.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922    30 VVTNSPRKMGSYKYLL-----------IYFSALTIVYAandFVSAPYMFnddsTVVVLvdlknNLLKDRPDLLLLAVVSG 98
Cdd:pfam10318  28 ILFKTPKKMKSVKWSLlnlhfwsalldLSLSFLTIPYI---FLPALAGY----PLGLL-----SYLGVPTPIQFYIGVTS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922    99 VSCFGISLYAIainFMYRYFAVQREGRLRYFSGCRLVFWISLSIIGGIMTGLTFYAIGSRQEISHGLRENLETMYDLDMH 178
Cdd:pfam10318  96 LALVGVSIILL---FENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVLKKLPCLPPEFFD 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   179 RTQYWVFlywqpkdgNQDLTAKDIMANLGlttsMVIPILLIVFFGTKTYRKVKNLTTHGKSEYSKRLQMQLYKALVAQII 258
Cdd:pfam10318 173 NPPVFVL--------AIDSTYFLICIVLL----ILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17542922   259 IPSVFLFLPTLLIAAGPLFKLNIPWASLPLSILFSMFSVMDSIPIIFLVDEYRNALFEFFG 319
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 27-314 3.53e-06

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 47.93  E-value: 3.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922    27 ILLVVTNSPRKMGSYKYLLIYFSALTIVYAANDFVSAPYMFNDDSTVVVLVDLKNNLLKDRPDLLLLAVVSGVSCfgISL 106
Cdd:pfam10317  20 LYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSLLQHFLL--HSG 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   107 YAIAINFMYRYFAVqregRLRYFSGCRLVFWISLSIIGGIMTGLTFYAIGSRQEISHGLRENLETMYDLDMH------RT 180
Cdd:pfam10317  98 WSLLLTFYYRYYIL----KHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELHPNYNLTDYtvtgfsDL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542922   181 QYWVFLYwqpkdgnqdltakdimaNLGLTTSMVIPILLIVFFGTKTYRKVKNLTTHGKSEYSKRLQMQLYKALVAQIIIP 260
Cdd:pfam10317 174 QSFPALI-----------------NTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLP 236

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 17542922   261 SVFLFLPTLLIAAGPLFKLNIPWASLPLSILFSMFSVMDSIPIIFLVDEYRNAL 314
Cdd:pfam10317 237 LFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAI 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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