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Conserved domains on  [gi|17542892|ref|NP_502063|]
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C2H2-type domain-containing protein [Caenorhabditis elegans]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10442881)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270|GO:0003700
PubMed:  11179890|12665246|11361095|10940247|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 44-65 3.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|..
gi 17542892    44 KCSMCDKVFPRLSHLQRHQMTH 65
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
PLN03086 super family cl29366
PRLI-interacting factor K; Provisional
 107-167 8.94e-03

PRLI-interacting factor K; Provisional


The actual alignment was detected with superfamily member PLN03086:

Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 38.31  E-value: 8.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542892  107 CDKCGQLFKTTyEMRIHRQTYHE--------------------------LHKCKQCQEVIEAGSD---------GLRKHH 151
Cdd:PLN03086 456 CEKCGQAFQQG-EMEKHMKVFHEplqcpcgvvlekeqmvqhqastcplrLITCRFCGDMVQAGGSamdvrdrlrGMSEHE 534

                         90
                 ....*....|....*.
gi 17542892  152 MQCRKYSNVCDECGAS 167
Cdd:PLN03086 535 SICGSRTAPCDSCGRS 550
 
Name Accession Description Interval E-value
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 44-65 3.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|..
gi 17542892    44 KCSMCDKVFPRLSHLQRHQMTH 65
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 107-167 8.94e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 38.31  E-value: 8.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542892  107 CDKCGQLFKTTyEMRIHRQTYHE--------------------------LHKCKQCQEVIEAGSD---------GLRKHH 151
Cdd:PLN03086 456 CEKCGQAFQQG-EMEKHMKVFHEplqcpcgvvlekeqmvqhqastcplrLITCRFCGDMVQAGGSamdvrdrlrGMSEHE 534

                         90
                 ....*....|....*.
gi 17542892  152 MQCRKYSNVCDECGAS 167
Cdd:PLN03086 535 SICGSRTAPCDSCGRS 550
 
Name Accession Description Interval E-value
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 44-65 3.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.00e-03
                          10        20
                  ....*....|....*....|..
gi 17542892    44 KCSMCDKVFPRLSHLQRHQMTH 65
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
PLN03086 PLN03086
PRLI-interacting factor K; Provisional
 107-167 8.94e-03

PRLI-interacting factor K; Provisional


Pssm-ID: 178635 [Multi-domain]  Cd Length: 567  Bit Score: 38.31  E-value: 8.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17542892  107 CDKCGQLFKTTyEMRIHRQTYHE--------------------------LHKCKQCQEVIEAGSD---------GLRKHH 151
Cdd:PLN03086 456 CEKCGQAFQQG-EMEKHMKVFHEplqcpcgvvlekeqmvqhqastcplrLITCRFCGDMVQAGGSamdvrdrlrGMSEHE 534

                         90
                 ....*....|....*.
gi 17542892  152 MQCRKYSNVCDECGAS 167
Cdd:PLN03086 535 SICGSRTAPCDSCGRS 550
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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