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Conserved domains on  [gi|17539090|ref|NP_502514|]
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Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

Protein Classification

cuticular collagen family protein( domain architecture ID 10661013)

cuticular collagen family protein is a structural macromolecule of the extracellular matrix containing triple helix domains that form tight interactions and stabilize supramolecular aggregates

Gene Ontology:  GO:0042302|GO:0005581
PubMed:  1916105|21421911

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
gly_rich_SclB super family cl45768
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-219 3.19e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


The actual alignment was detected with superfamily member NF038329:

Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 3.19e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIReiGMPGAPGAPGVAGAEGLPGKD 219
Cdd:NF038329 243 PTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGKDGER--GPVGPAGKDGQNGKDGLPGKD 301
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 8-56 5.27e-09

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


:

Pssm-ID: 198156  Cd Length: 53  Bit Score: 51.31  E-value: 5.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 17539090      8 AAVSVSSILVVGYITAGLLIFADFRTFYSTALDDVAEFNKFATEAWDDM 56
Cdd:smart01088   5 VAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
 
Name Accession Description Interval E-value
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-219 3.19e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 3.19e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIReiGMPGAPGAPGVAGAEGLPGKD 219
Cdd:NF038329 243 PTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGKDGER--GPVGPAGKDGQNGKDGLPGKD 301
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 8-56 5.27e-09

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 198156  Cd Length: 53  Bit Score: 51.31  E-value: 5.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 17539090      8 AAVSVSSILVVGYITAGLLIFADFRTFYSTALDDVAEFNKFATEAWDDM 56
Cdd:smart01088   5 VAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 161-219 1.44e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 54.91  E-value: 1.44e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17539090  161 GHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIReiGMPGAPGAPGVAGAEGLPGKD 219
Cdd:NF038329 123 GPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGER--GEKGPAGPQGEAGPQGPAGKD 179
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 161-219 1.21e-07

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 52.21  E-value: 1.21e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17539090  161 GHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGirEIGMPGAPGAPGVAGAEGLPGKD 219
Cdd:NF038329 233 GQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRG--EAGPDGPDGKDGERGPVGPAGKD 289
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 161-208 1.40e-07

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 1.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 17539090   161 GHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIreigmPGAPGAPG 208
Cdd:pfam01391  13 GPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGP-----PGAPGAPG 55
Col_cuticle_N pfam01484
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 8-56 1.64e-07

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see pfam01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 460226  Cd Length: 50  Bit Score: 47.07  E-value: 1.64e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17539090     8 AAVSVSSILVVGYITAGLLIFADFRTFYSTALDDVAEFNKFATEAWDDM 56
Cdd:pfam01484   2 VAVAFSTVAILSSLITLPSIYNDIQELQSEVLDEMDEFKARSDDAWNEM 50
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-222 2.45e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 48.36  E-value: 2.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIR------------EIGMPGAPGAPGVAGAEGLPGKD---GEP 222
Cdd:NF038329 187 PAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDgpagpagdgqqgPDGDPGPTGEDGPQGPDGPAGKDgprGDR 265
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-212 3.07e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 47.98  E-value: 3.07e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIReiGMPGAPGAPGVAGA 212
Cdd:NF038329 121 EPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGER--GEKGPAGPQGEAGP 172
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-245 4.36e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 47.59  E-value: 4.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIR-EIGMPGAPGAPGVAGAEGLPGKDGEPGIPGPEGEEGPPGAA 237
Cdd:NF038329 169 EAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQgPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDG 248

                         90
                 ....*....|....*.
gi 17539090  238 G--------LDGERGD 245
Cdd:NF038329 249 PqgpdgpagKDGPRGD 264
 
Name Accession Description Interval E-value
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-219 3.19e-09

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 57.22  E-value: 3.19e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIReiGMPGAPGAPGVAGAEGLPGKD 219
Cdd:NF038329 243 PTGEDGPQGPDGPAGKDGPRGDRGEAGPDGPDGKDGER--GPVGPAGKDGQNGKDGLPGKD 301
Col_cuticle_N smart01088
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 8-56 5.27e-09

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 198156  Cd Length: 53  Bit Score: 51.31  E-value: 5.27e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 17539090      8 AAVSVSSILVVGYITAGLLIFADFRTFYSTALDDVAEFNKFATEAWDDM 56
Cdd:smart01088   5 VAVAVSTVAVLSALVTLPSIYNDIQSFQSELLDEMDEFKARADDAWNEM 53
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 161-219 1.44e-08

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 54.91  E-value: 1.44e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17539090  161 GHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIReiGMPGAPGAPGVAGAEGLPGKD 219
Cdd:NF038329 123 GPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGER--GEKGPAGPQGEAGPQGPAGKD 179
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 161-219 1.21e-07

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 52.21  E-value: 1.21e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 17539090  161 GHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGirEIGMPGAPGAPGVAGAEGLPGKD 219
Cdd:NF038329 233 GQQGPDGDPGPTGEDGPQGPDGPAGKDGPRGDRG--EAGPDGPDGKDGERGPVGPAGKD 289
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 161-208 1.40e-07

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 47.49  E-value: 1.40e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 17539090   161 GHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIreigmPGAPGAPG 208
Cdd:pfam01391  13 GPPGPPGPPGPPGPPGPPGEPGPPGPPGPPGPPGP-----PGAPGAPG 55
Col_cuticle_N pfam01484
Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is ...
 8-56 1.64e-07

Nematode cuticle collagen N-terminal domain; The function of this domain is unknown. It is found in the N-terminal region of nematode cuticle collagens, see pfam01391. Cuticle is a tough elastic structure secreted by hypodermal cells and is primarily composed of collagen proteins.


Pssm-ID: 460226  Cd Length: 50  Bit Score: 47.07  E-value: 1.64e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17539090     8 AAVSVSSILVVGYITAGLLIFADFRTFYSTALDDVAEFNKFATEAWDDM 56
Cdd:pfam01484   2 VAVAFSTVAILSSLITLPSIYNDIQELQSEVLDEMDEFKARSDDAWNEM 50
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-222 2.45e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 48.36  E-value: 2.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIR------------EIGMPGAPGAPGVAGAEGLPGKD---GEP 222
Cdd:NF038329 187 PAGEKGPQGPRGETGPAGEQGPAGPAGPDGEAGPAGEDgpagpagdgqqgPDGDPGPTGEDGPQGPDGPAGKDgprGDR 265
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-212 3.07e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 47.98  E-value: 3.07e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIReiGMPGAPGAPGVAGA 212
Cdd:NF038329 121 EPGPAGPAGPAGEQGPRGDRGETGPAGPAGPPGPQGER--GEKGPAGPQGEAGP 172
gly_rich_SclB NF038329
LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like ...
 159-245 4.36e-06

LPXTG-anchored collagen-like adhesin Scl2/SclB; SclB (or Scl2 - streptococcal collagen-like protein 2) is an LPXTG-anchored surface-anchored adhesin with a variable-length region of triple helix-forming collagen-like Gly-Xaa-Xaa repeats.


Pssm-ID: 468478 [Multi-domain]  Cd Length: 440  Bit Score: 47.59  E-value: 4.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17539090  159 EVGHDGPPGVEGEPGDAGDQGEDGEPGVDGRPGASGIR-EIGMPGAPGAPGVAGAEGLPGKDGEPGIPGPEGEEGPPGAA 237
Cdd:NF038329 169 EAGPQGPAGKDGEAGAKGPAGEKGPQGPRGETGPAGEQgPAGPAGPDGEAGPAGEDGPAGPAGDGQQGPDGDPGPTGEDG 248

                         90
                 ....*....|....*.
gi 17539090  238 G--------LDGERGD 245
Cdd:NF038329 249 PqgpdgpagKDGPRGD 264
Collagen pfam01391
Collagen triple helix repeat (20 copies); Members of this family belong to the collagen ...
 170-218 7.42e-05

Collagen triple helix repeat (20 copies); Members of this family belong to the collagen superfamily. Collagens are generally extracellular structural proteins involved in formation of connective tissue structure. The alignment contains 20 copies of the G-X-Y repeat that forms a triple helix. The first position of the repeat is glycine, the second and third positions can be any residue but are frequently proline and hydroxy-proline. Collagens are post translationally modified by proline hydroxylase to form the hydroxy-proline residues. Defective hydroxylation is the cause of scurvy. Some members of the collagen superfamily are not involved in connective tissue structure but share the same triple helical structure. The family includes bacterial collagen-like triple-helix repeat proteins.


Pssm-ID: 460189 [Multi-domain]  Cd Length: 57  Bit Score: 39.78  E-value: 7.42e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 17539090   170 GEPGDAGDQGEDGEPGVDGRPGAsgireigmPGAPGAPGVAGAEGLPGK 218
Cdd:pfam01391   1 GPPGPPGPPGPPGPPGPPGPPGP--------PGPPGPPGEPGPPGPPGP 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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