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Conserved domains on  [gi|17544182|ref|NP_502851|]
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Putative T-box protein 39 [Caenorhabditis elegans]

Protein Classification

T-box-containing protein( domain architecture ID 10075811)

T-box-containing protein may act as a transcriptional regulator involved in developmental processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 9-180 3.31e-53

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


:

Pssm-ID: 410312  Cd Length: 176  Bit Score: 174.70  E-value: 3.31e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYPN-MEMIVNNKGpKLIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVrhATKKEQ 87
Cdd:cd00182   3 VSLRNEELWKKFHELgTEMIVTKSG-RRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGK--AEPPPE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EIKYFLHPDGTKLGKELMKETIKFDTVRITNHKKfMDKDNVFFVETMHKYVPVLTVKNITNVESAN---HSMRMEVAQFF 164
Cdd:cd00182  80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKE-DKKEGHILLHSMHKYIPVLTIYEVDDNGLLSklvKEFRFPETEFI 158

                       170
                ....*....|....*.
gi 17544182 165 PVTVYNQESIGNWKSK 180
Cdd:cd00182 159 AVTAYQNDEITQLKID 174
 
Name Accession Description Interval E-value
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 9-180 3.31e-53

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 174.70  E-value: 3.31e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYPN-MEMIVNNKGpKLIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVrhATKKEQ 87
Cdd:cd00182   3 VSLRNEELWKKFHELgTEMIVTKSG-RRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGK--AEPPPE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EIKYFLHPDGTKLGKELMKETIKFDTVRITNHKKfMDKDNVFFVETMHKYVPVLTVKNITNVESAN---HSMRMEVAQFF 164
Cdd:cd00182  80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKE-DKKEGHILLHSMHKYIPVLTIYEVDDNGLLSklvKEFRFPETEFI 158

                       170
                ....*....|....*.
gi 17544182 165 PVTVYNQESIGNWKSK 180
Cdd:cd00182 159 AVTAYQNDEITQLKID 174
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 9-172 2.94e-35

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 128.06  E-value: 2.94e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182     9 VTMAEEDRWKQWYPN-MEMIVNNKGPKlIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPskvrhATKKEQ 87
Cdd:pfam00907   1 VSLENKELWKKFHELgTEMIITKSGRR-MFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVV-----AGKAEP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182    88 EI--KYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVA---- 161
Cdd:pfam00907  75 HSppRVYIHPDSPATGSHWMKQPVSFDKLKLTNNK--EDKNGHIILNSMHKYQPRLHIVRVGGDEPSLPEENVKTFvfpe 152

                         170
                  ....*....|...
gi 17544182   162 -QFFPVTVY-NQE 172
Cdd:pfam00907 153 tEFIAVTAYqNEE 165
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
9-174 4.87e-28

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 108.89  E-value: 4.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182      9 VTMAEEDRWKQWYP-NMEMIVNNKGPKlIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVrhaTKKEQ 87
Cdd:smart00425   3 VSLEDKELWRKFHElGTEMIVTKSGRR-MFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGK---AEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182     88 EIKYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDN--VFFVETMHKYVPVLTVKNITNVE----SANHSMRMEVA 161
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQ--SDKNGhlQIILNSMHKYQPRLHIVEVDDISkeilSQFKTFVFPET 156

                          170
                   ....*....|...
gi 17544182    162 QFFPVTVYNQESI 174
Cdd:smart00425 157 QFIAVTAYQNQKI 169
 
Name Accession Description Interval E-value
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 9-180 3.31e-53

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 174.70  E-value: 3.31e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYPN-MEMIVNNKGpKLIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVrhATKKEQ 87
Cdd:cd00182   3 VSLRNEELWKKFHELgTEMIVTKSG-RRMFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKFNNGKWVPSGK--AEPPPE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EIKYFLHPDGTKLGKELMKETIKFDTVRITNHKKfMDKDNVFFVETMHKYVPVLTVKNITNVESAN---HSMRMEVAQFF 164
Cdd:cd00182  80 PSRIYVHPDGPQTGSFWMKKGVSFDKVKITNNKE-DKKEGHILLHSMHKYIPVLTIYEVDDNGLLSklvKEFRFPETEFI 158

                       170
                ....*....|....*.
gi 17544182 165 PVTVYNQESIGNWKSK 180
Cdd:cd00182 159 AVTAYQNDEITQLKID 174
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 9-172 2.94e-35

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 128.06  E-value: 2.94e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182     9 VTMAEEDRWKQWYPN-MEMIVNNKGPKlIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPskvrhATKKEQ 87
Cdd:pfam00907   1 VSLENKELWKKFHELgTEMIITKSGRR-MFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKFHNGKWVV-----AGKAEP 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182    88 EI--KYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVA---- 161
Cdd:pfam00907  75 HSppRVYIHPDSPATGSHWMKQPVSFDKLKLTNNK--EDKNGHIILNSMHKYQPRLHIVRVGGDEPSLPEENVKTFvfpe 152

                         170
                  ....*....|...
gi 17544182   162 -QFFPVTVY-NQE 172
Cdd:pfam00907 153 tEFIAVTAYqNEE 165
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
9-174 4.87e-28

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 108.89  E-value: 4.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182      9 VTMAEEDRWKQWYP-NMEMIVNNKGPKlIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVrhaTKKEQ 87
Cdd:smart00425   3 VSLEDKELWRKFHElGTEMIVTKSGRR-MFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKFNNGKWVVAGK---AEPHM 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182     88 EIKYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDN--VFFVETMHKYVPVLTVKNITNVE----SANHSMRMEVA 161
Cdd:smart00425  79 PSRVYVHPDSPATGAHWMKQPVSFDKVKLTNNQ--SDKNGhlQIILNSMHKYQPRLHIVEVDDISkeilSQFKTFVFPET 156

                          170
                   ....*....|...
gi 17544182    162 QFFPVTVYNQESI 174
Cdd:smart00425 157 QFIAVTAYQNQKI 169
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 8-181 4.18e-23

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 95.02  E-value: 4.18e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   8 NVTMAEEDRWKQWYPNM-EMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSkvrhaTKKE 86
Cdd:cd20192   2 RVTLEDRELWKKFHSLTnEMIVTKSGRRM-FPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYVNGEWVPG-----GKAE 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  87 QEIK--YFLHPDGTKLGKELMKETIKFDTVRITNhkKFMDKDNVfFVETMHKYVPVLtvkNITNVESANH-----SMRME 159
Cdd:cd20192  76 PPPPssVYVHPDSPNFGAHWMKGPVSFSKVKLTN--KPNGEGQI-MLNSLHKYEPRV---HIVRVGSNNHerlvsTFSFP 149

                       170       180
                ....*....|....*....|..
gi 17544182 160 VAQFFPVTVYNQESIGNWKSKF 181
Cdd:cd20192 150 ETQFIAVTAYQNEEITALKIKY 171
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 9-139 6.48e-20

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 87.45  E-value: 6.48e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGpKLIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKW----------GPS 77
Cdd:cd20683   3 LLLEDADLWAQFHSvQNEMIITKSG-RCLFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFRNGRWnpidkdqrgdDAF 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17544182  78 KVRHATKKEQEIKYFLHPDGTKLGKELMKETIKFDTVRITN----------------HKKFMDKDNVFFVETMHKYVP 139
Cdd:cd20683  82 SSGTADKSVLLPESYIHPDGPQTGAFWMANGISFAKIKLSNrqpnssdrdgpkenitNSISALPDGHFFLTSFHKYQP 159
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 25-172 1.97e-19

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 85.52  E-value: 1.97e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  25 EMIVNNKGPKlIFPELNFNITGLEEKSRYVVLLSIEKYDN--IRYGYRNGKW---GPSKVRHATKKeqeikyFLHPDGTK 99
Cdd:cd20682  20 EMIITKAGRR-MFPALKVKLTGLDPDKLYIVWVDIVPVDSnrYRYVYHSSKWvvaGSGDVLPPANR------YIHPDSPA 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182 100 LGKELMKETIKFDTVRITNHKKFMDKDNVFFVeTMHKYVPVLTVKNITNVESANHSM--RMEVAQF-FP------VTVY- 169
Cdd:cd20682  93 SGKYWMSQIVSFDKLKLTNNKEPKQKGQISLH-SMHKYQPRIHIQPVEDDGRNVEKAinSSKALSFeFPetsfitVTAYq 171


                ...
gi 17544182 170 NQE 172
Cdd:cd20682 172 NQQ 174
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 9-174 4.84e-19

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 84.30  E-value: 4.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGY-RNGKWGPSKVRHAtKKE 86
Cdd:cd20681   3 VTLKNRDLWQQFHReGTEMIITKSGRRM-FPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYsGNGGWVPAGGAEP-QPP 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  87 QEIKYFLHPDGTKLGKELMKETIKFDTVRITNHkkFMDKDNVFFVETMHKYVPVLTV---KNITNVESA-NHSMRMEVAQ 162
Cdd:cd20681  81 LPRRIYIHPDSPATGDHWMSQPISFSKVKLTNN--TLDPQGNIVLTSMHKYQPRIHIvrcSDTLALPWApTASFTFPETE 158

                       170
                ....*....|..
gi 17544182 163 FFPVTVYNQESI 174
Cdd:cd20681 159 FIAVTAYQNERI 170
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 6-182 1.01e-18

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 83.16  E-value: 1.01e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   6 QFNVTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPskvrhATK 84
Cdd:cd20202   1 ELKVSLEESELWLRFKElTNEMIVTKNGRRM-FPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYVNGEWVP-----GGK 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  85 KEQEIK--YFLHPDGTKLGKELMKETIKFDTVRITNHkkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEVAQ 162
Cdd:cd20202  75 PEPQAPscVYIHPDSPNFGAHWMKAPVSFSKVKLTNK---LNGGGQIMLNSLHKYEPRIHIVRVGGPQRMITSHSFPETQ 151

                       170       180
                ....*....|....*....|
gi 17544182 163 FFPVTVYNQESIGNWKSKFH 182
Cdd:cd20202 152 FIAVTAYQNEEITALKIKYN 171
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 9-178 1.82e-18

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 82.61  E-value: 1.82e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDR--WKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVRHATKK 85
Cdd:cd20196   1 VRMSLENAelWKQFSSvGTEMIITKAGRRM-FPQLRVSVSGLDPEARYLLLLDVVPVDGSRYRWQGNSWEASGKAEPRLP 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  86 EqeiKYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESA---NHSMRMEVAQ 162
Cdd:cd20196  80 D---RVYIHPDSPATGAHWMRQPISFHRAKLTNNT--LDPHGHIILHSMHRYQPRVHVVRARDVLSWgggCASFTFPETQ 154

                       170
                ....*....|....*.
gi 17544182 163 FFPVTVYNQESIGNWK 178
Cdd:cd20196 155 FITVTAYQNPKITQLK 170
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 3-182 9.54e-17

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 77.76  E-value: 9.54e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   3 SQAQFNVTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPskvrh 81
Cdd:cd20201   2 TEKQLQVSLEDAELWQRFKEvTNEMIVTKNGRRM-FPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYVNGEWVP----- 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  82 ATKKEQEIK--YFLHPDGTKLGKELMKETIKFDTVRITNHkkfMDKDNVFFVETMHKYVPVLTVKNItnveSANHSMRME 159
Cdd:cd20201  76 AGKPEPHSHscVYIHPDSPNFGAHWMKAPISFSKVKLTNK---LNGGGQIMLNSLHKYEPQIHIVRV----GGPHRMVTN 148

                       170       180
                ....*....|....*....|....*..
gi 17544182 160 VA----QFFPVTVYNQESIGNWKSKFH 182
Cdd:cd20201 149 CSfpetQFIAVTAYQNEEITALKIKYN 175
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 9-178 2.30e-16

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 76.70  E-value: 2.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPskvrhATKKEQ 87
Cdd:cd20189   3 VFLENRELWQKFHEvGTEMIITKAGRRM-FPSIKVKVTGLNPKTKYILLMDIVPADDHRYKFHDSEWVV-----AGKAEP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EI--KYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVP---VLTVKNITNVESANHSMRMEV-- 160
Cdd:cd20189  77 AMpgRLYVHPDSPATGAHWMRQLVSFQKLKLTNNH--LDQFGHIILNSMHKYQPrihIVQADDNNAFGSKNTAFSTHVfp 154

                       170
                ....*....|....*....
gi 17544182 161 -AQFFPVTVYNQESIGNWK 178
Cdd:cd20189 155 eTAFIAVTAYQNHQITQLK 173
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 9-178 7.89e-16

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 75.16  E-value: 7.89e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWgpskvRHATKKEQ 87
Cdd:cd20188   5 VELEAKDLWDQFHKlGTEMVITKSGRRM-FPPFKVRVSGLDKKAKYILLMDIVAADDCRYKFHNSRW-----MVAGKADP 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EI--KYFLHPDGTKLGKELMKETIKFDTVRITNHkkFMDKDNVFFVETMHKYVP---VLTVKNITNVE-SANHSMRMEVA 161
Cdd:cd20188  79 EMpkRMYIHPDSPSTGEQWMQKVVSFHKLKLTNN--ISDKHGFTILNSMHKYQPrfhIVRANDILKLPySTFRTYVFKET 156

                       170
                ....*....|....*..
gi 17544182 162 QFFPVTVYNQESIGNWK 178
Cdd:cd20188 157 EFIAVTAYQNEKITQLK 173
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 9-178 1.35e-15

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 74.53  E-value: 1.35e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKvrhatKKEQ 87
Cdd:cd20190   3 LSLEDRELWKEFSSvGTEMIITKSGRRM-FPACKVSVTGLDPEAKYLFLLDVVPVDNARYKWNKRRWEPSG-----KAEP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EI--KYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESAN----HSMRMEVA 161
Cdd:cd20190  77 HLpdRVYIHPDSPAPGAHWMRQPISFHKLKLTNNT--LDPHGHLILHSMHKYQPRIHLVQSADLCSQHwggmASFRFPET 154

                       170
                ....*....|....*..
gi 17544182 162 QFFPVTVYNQESIGNWK 178
Cdd:cd20190 155 TFIAVTAYQNPQITKLK 171
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 9-178 1.45e-15

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 74.11  E-value: 1.45e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYgyrngKWGPSKVRHATKKEQ 87
Cdd:cd20197   3 ASLEDQDLWKKFHQiGTEMIITKSGRRM-FPQCKIRVSGLLPYAKYVMLVDFVPVDNFRY-----KWNKDQWEVAGKAEP 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EI--KYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTVKNITNVESANHSMRMEV----A 161
Cdd:cd20197  77 QPpcRTYVHPDSPAPGSHWMKQPISFQKLKLTNNT--LDQHGHIILHSMHRYQPRFHIVQADDLFNVRWSLFQVFsfpeT 154

                       170
                ....*....|....*..
gi 17544182 162 QFFPVTVYNQESIGNWK 178
Cdd:cd20197 155 VFTAVTAYQNEKITKLK 171
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 9-174 2.83e-15

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 73.62  E-value: 2.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGpKLIFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKVRHAtkkEQ 87
Cdd:cd20195   3 VTLENNSMWNEFYRcGTEMILTKQG-RRMFPYCRFRISGLDPDRNYILVMDISPVDNFRYRWNGRWWEPSGKAEP---HV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EIKYFLHPDGTKLGKELMKETIKFDTVRITNHkkFMDKDNVFFVETMHKYVP---VLTVKNITNVESAN----HSMRMEV 160
Cdd:cd20195  79 LGRVFIHPESPATGRHWMDQPVSFYKLKLTNN--TLDQEGHIILHSMHRYLPrlhVVPADKEVDVIQLNgpdvHTFTFPQ 156

                       170
                ....*....|....
gi 17544182 161 AQFFPVTVYNQESI 174
Cdd:cd20195 157 TEFFAVTAYQNKQI 170
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 23-178 1.74e-14

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 71.35  E-value: 1.74e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  23 NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKvrHATKKEQEIKYFLHPDGTKLGK 102
Cdd:cd20194  19 QTEMIITKQGRRM-FPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKFQSGKWVPCG--KAEGLPQGNRVYVHPDSPNTGA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182 103 ELMKETIKFDTVRITNHKkfmDKDNVFFV-ETMHKYVPVLTVKNIT----NVESANHSMRMEVAQFFPVTVYNQESIGNW 177
Cdd:cd20194  96 HWMKQEISFSKLKLTNNK---GADQGMIVlNSMHKYQPRIHVIEVGgngpNEQRNLQTHSFPETQFIAVTAYQNTDITQL 172


                .
gi 17544182 178 K 178
Cdd:cd20194 173 K 173
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 3-139 3.86e-14

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 70.30  E-value: 3.86e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   3 SQAQFNVTMAEedRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDN--IRYGYRNGKWgpsKV 79
Cdd:cd20191   1 KEIQVELQGSE--LWKRFHDiGTEMIITKAGRRM-FPAIRVKVSGLDPHAQYIVAMDIVPVDNkrYRYVYHSSKW---MV 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  80 RHATKKEQEIKYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVP 139
Cdd:cd20191  75 AGNADAPVPPRVYIHPDSPASGETWMRQVVSFDKLKLTNNE--MDDQGHIILHSMHKYQP 132
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 25-169 7.38e-14

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 69.38  E-value: 7.38e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  25 EMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDN--IRYGYRNGKWgpskvRHATKKEQEIK--YFLHPDGTKL 100
Cdd:cd20193  20 EMIITKSGRRM-FPTVRVSFSGVDPDAKYIVLMDIVPVDNkrYRYAYHRSSW-----LVAGKADPPLParLYVHPDSPFT 93

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17544182 101 GKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVP----VLTVKNITNVESANHsmrMEVAQF-FPVTVY 169
Cdd:cd20193  94 GEQLLKQMVSFEKVKLTNNE--LDKHGHIILNSMHKYQPrvhiVKKKDHTASLVNLKS---EEFRTFiFPETVF 162
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 25-178 2.72e-13

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 67.84  E-value: 2.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  25 EMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWGPSKvrHATKKEQEIKYFLHPDGTKLGKEL 104
Cdd:cd20204  21 EMIITKQGRRM-FPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCG--KADTNVQGNRVYMHPDSPNTGAHW 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182 105 MKETIKFDTVRITNHKKFMDKDNVFFV-ETMHKYVPVLTVKNITN--VESANHSMRMEV-----AQFFPVTVYNQESIGN 176
Cdd:cd20204  98 MRQEISFGKLKLTNNKGASNNNGQMVVlQSLHKYQPRLHVVEVNEdgTEDTSQPGRVQTftfpeTQFIAVTAYQNTDITQ 177


                ..
gi 17544182 177 WK 178
Cdd:cd20204 178 LK 179
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 1-143 7.74e-13

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 66.67  E-value: 7.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   1 MFSQAQFNVTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDN--IRYGYRNGKWgps 77
Cdd:cd20198   1 TSSMEEIQVELQCADLWKRFHDiGTEMIITKAGRRM-FPAMRVKITGLDPHQQYYIAMDIVPVDNkrYRYVYHSSKW--- 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17544182  78 KVRHATKKEQEIKYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTV 143
Cdd:cd20198  77 MVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDKLKLTNNE--LDDQGHIILHSMHKYQPRVHV 140
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 9-178 1.40e-12

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 65.75  E-value: 1.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYPNM-EMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWgpskvRHATKKEQ 87
Cdd:cd20203   4 VLLNNHPLWSKFHKHQtEMIITKQGRRM-FPFLSFNLTGLDPTAHYNVYVDVVLADQHHWRYQGGKW-----VQCGKAEG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  88 EI---KYFLHPDGTKLGKELMKETIKFDTVRITNHKKFMDKDNVFFV-ETMHKYVPVLTVKNITNVE-------SANHSM 156
Cdd:cd20203  78 NMpgnRLYVHPDSPNTGAHWMRQEVSFGKLKLTNNKGASNNVTQMIVlQSLHKYQPRLHIVEVKEGEteeayssSKTHTF 157

                       170       180
                ....*....|....*....|..
gi 17544182 157 RMEVAQFFPVTVYNQESIGNWK 178
Cdd:cd20203 158 TFPETQFIAVTAYQNAEITQLK 179
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 25-178 2.19e-12

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 65.47  E-value: 2.19e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182  25 EMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDNIRYGYRNGKWgpSKVRHATKKEQEIKYFLHPDGTKLGKEL 104
Cdd:cd20205  21 EMIITKQGRRM-FPFLSFNITGLNPTAHYNVFVEVVLADPNHWRFQGGKW--VTCGKADNNMQGNKVYVHPESPNTGAHW 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182 105 MKETIKFDTVRITNHKKFMDKDNVFFV-ETMHKYVPVLTVKNIT-------NVESANHSMRMEVAQFFPVTVYNQESIGN 176
Cdd:cd20205  98 MRQEISFGKLKLTNNKGANNNNTQMIVlQSLHKYQPRLHIVEVSedgvedlNDSSKTQTFTFPENQFIAVTAYQNTDITQ 177


                ..
gi 17544182 177 WK 178
Cdd:cd20205 178 LK 179
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 9-143 2.83e-12

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 65.07  E-value: 2.83e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDN--IRYGYRNGKWgpsKVRHATKK 85
Cdd:cd20199   6 VDLQGADLWKRFHEiGTEMIITKAGRRM-FPAMRVKITGLDPHQQYYIAMDIVPVDNkrYRYVYHSSKW---MVAGNADS 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 17544182  86 EQEIKYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTV 143
Cdd:cd20199  82 PVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNE--LDDQGHIILHSMHKYQPRVHV 137
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 9-143 6.95e-10

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 58.01  E-value: 6.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17544182   9 VTMAEEDRWKQWYP-NMEMIVNNKGPKLiFPELNFNITGLEEKSRYVVLLSIEKYDN--IRYGYRNGKWgpsKVRHATKK 85
Cdd:cd20200   5 VELQGSELWKRFHEiGTEMIITKAGRRM-FPSVRVKVKGLDPLKQYYIAMDVVPVDSkrYRYVYHSSQW---MVAGNTDH 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17544182  86 EQEI-KYFLHPDGTKLGKELMKETIKFDTVRITNHKkfMDKDNVFFVETMHKYVPVLTV 143
Cdd:cd20200  81 SCITpRLYVHPDSPCSGETWMRQIISFDRVKLTNNE--MDDKGHIILQSMHKYKPRVHV 137
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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