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Conserved domains on  [gi|17540004|ref|NP_503063|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-307 5.47e-100

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 297.44  E-value: 5.47e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004     4 IYQLVCTAISFLLNCFLVWLILKHSPQHTGKYKWLMMYTTCFEIFWGAFDLPAEIIAHSVGCAFIVFrINQPDAWLDKNS 83
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVF-VDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004    84 SSWIVLVYTAIFGASMALFASHFIYRFGSLDRSFGSRYTSGWKFGVLFFIPLVYSVWWATVVRVWFWPNEDMDEYTRDMI 163
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004   164 MEKVGVRIENISYIGAMFYNSDGNGTKTLNQSAWIGVSQMWFMIMSSMSCIFGFAILCYLRLRAQLSIVSSAVNNLQLQF 243
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17540004   244 FYALVLQTAIPLILMHIPITIYFVCPMLDLDLDIASSFVASTITLYPAIDPLPSFLIIKSFRNA 307
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-307 5.47e-100

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 297.44  E-value: 5.47e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004     4 IYQLVCTAISFLLNCFLVWLILKHSPQHTGKYKWLMMYTTCFEIFWGAFDLPAEIIAHSVGCAFIVFrINQPDAWLDKNS 83
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVF-VDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004    84 SSWIVLVYTAIFGASMALFASHFIYRFGSLDRSFGSRYTSGWKFGVLFFIPLVYSVWWATVVRVWFWPNEDMDEYTRDMI 163
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004   164 MEKVGVRIENISYIGAMFYNSDGNGTKTLNQSAWIGVSQMWFMIMSSMSCIFGFAILCYLRLRAQLSIVSSAVNNLQLQF 243
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17540004   244 FYALVLQTAIPLILMHIPITIYFVCPMLDLDLDIASSFVASTITLYPAIDPLPSFLIIKSFRNA 307
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 4-307 5.47e-100

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 297.44  E-value: 5.47e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004     4 IYQLVCTAISFLLNCFLVWLILKHSPQHTGKYKWLMMYTTCFEIFWGAFDLPAEIIAHSVGCAFIVFrINQPDAWLDKNS 83
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVF-VDLKDLGLSKSV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004    84 SSWIVLVYTAIFGASMALFASHFIYRFGSLDRSFGSRYTSGWKFGVLFFIPLVYSVWWATVVRVWFWPNEDMDEYTRDMI 163
Cdd:pfam10326  82 GQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREEL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004   164 MEKVGVRIENISYIGAMFYNSDGNGTKTLNQSAWIGVSQMWFMIMSSMSCIFGFAILCYLRLRAQLSIVSSAVNNLQLQF 243
Cdd:pfam10326 162 LENYNLDIDEVAYVGPVYYPTDENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQL 241

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17540004   244 FYALVLQTAIPLILMHIPITIYFVCPMLDLDLDIASSFVASTITLYPAIDPLPSFLIIKSFRNA 307
Cdd:pfam10326 242 FKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 11-306 2.50e-30

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 117.34  E-value: 2.50e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004    11 AISFLLNCFLVWLILKHSPQHTGKYKWLMMYTTCFEIFWGAFDLPAEIIAHSVGCAFIVFrinQPDAWLDKNSS--SWIV 88
Cdd:pfam10319  16 VLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVF---VSDGPFFEYSElgQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004    89 LVYTAIFGASMALFASHFIYRFGSL-DRSFGSRYTSGWKFGVLFFIPLVYSVWWATVVRVWFWPNEDMDEYTRDMIMEKV 167
Cdd:pfam10319  93 SARCSFISASYAVLLIHFIYRYLVLfNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004   168 GVRIENISYIGAMFYnsdgNGTKTLNQSAWIGVSQMWFMIMSSMSCIFGFAILCYLRLRAQLSIVSSAVNNLQLQFFYAL 247
Cdd:pfam10319 173 GVDSMDINMLGALYW----EASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKAL 248

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004   248 VLQTAIPLILMHIPITIYFVCPMLDLDLDIASSFVAST-ITLYPAIDPLPSFLIIKSFRN 306
Cdd:pfam10319 249 IVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIaLSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 8-312 1.78e-12

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 66.80  E-value: 1.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004     8 VCTAISFLLNCFLVWLILKHSPQHTGKYKWLMMY----TTCFEIFWGAFDLPAEIIAHSVGCAFIVFrinqpdAWLDKNS 83
Cdd:pfam10318  12 IITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNlhfwSALLDLSLSFLTIPYIFLPALAGYPLGLL------SYLGVPT 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004    84 SSWIVLVYT--AIFGASMALFashFIYRFGSLdrsFGSRYTSGWKFGVLFFIPLVYSVWWATVVRVWFwpNEDMDEYTRD 161
Cdd:pfam10318  86 PIQFYIGVTslALVGVSIILL---FENRYSIL---FTNKKRITWKKTRVLYLIFNYIIALLFLIPIYL--NIPDQEAAKL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004   162 MIMEKVGVRIENISYIGAMFYnsdgngtktLNQSAWIGVSQMWFMIMSSMSCIFGFAILCYLRLRAQLSI-VSSAVNNLQ 240
Cdd:pfam10318 158 KVLKKLPCLPPEFFDNPPVFV---------LAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSsLSKKTRKLQ 228

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17540004   241 LQFFYALVLQTAIPLILMHIPITIYFVCPMLDLDLDIASSFVASTITLYPAIDPLPSFLIIKSFRNATIDVF 312
Cdd:pfam10318 229 KKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLF 300
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 2-307 3.26e-06

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 47.93  E-value: 3.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004     2 FTIYQLVCTAISFLLNCFLVWLILKHSPQHTGKYKWLMMYTTCFEIFWGAFDLPAE--IIAHSVGCAFIVfriNQPDAWL 79
Cdd:pfam10317   1 FSIYYPIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQqrIIPNGVSMALIS---YGPCKYF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004    80 DKNSSSWIVLVY-TAIFGASMALFAShFIYRFGSLDRSFGSRYTSGWKFGVLFFIPLVYSVwwatvvrVWFWPNEDMDEY 158
Cdd:pfam10317  78 GPWFCYSGYSLLqHFLLHSGWSLLLT-FYYRYYILKHVDPKRKKLILLIIIHYIPSLSQLI-------VIFLSPTDFLPV 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17540004   159 TRDMIMEKVGVRIENISYIGAMFYNSDGNGTKTLNqsawigvsqmwFMIMSSMSCIFGFailcYLR------LRAQLSIV 232
Cdd:pfam10317 150 EALTKELHPNYNLTDYTVTGFSDLQSFPALINTLI-----------MTIPVFPIPIIIL----ILRrkilklLNSNSVNM 214

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17540004   233 SSAVNNLQLQFFYALVLQTAIPLILMHIPITIYFVCPMLDLDLDIASSFVASTITLYPAIDPLPSFLIIKSFRNA 307
Cdd:pfam10317 215 SPTTKAQHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRA 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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