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Conserved domains on  [gi|1395447104|ref|NP_505101|]
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G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

G-protein coupled receptor( domain architecture ID 11606548)

G-protein coupled receptor (GPCR) transmits physiological signals from the outside of the cell to the inside by binding to an extracellular agonist, which induces conformational changes that lead to the activation of heterotrimeric G proteins, which then bind to and activate numerous downstream effector proteins

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
24-302 1.41e-50

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


:

Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 170.12  E-value: 1.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  24 FLNSKVLILQIIFGCGGNILNLMVLLSRAMRSRTNLIFAAMAFADLFFLILHIPSVLFFIGTIRDAPWYRNG---FSQVI 100
Cdd:cd14978     1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFyayFLPYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 101 AGMLNWSSAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKT--------------- 165
Cdd:cd14978    81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVvecencnnnsyyyvi 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 166 -----RAANKYARYVVYIHMIFVVIIPMFLSTSLNILLVCALRKNSmplRMLNDSHVHQSLIVQRTRTERKVTAMVTVIL 240
Cdd:cd14978   161 ptllrQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSK---KRRRLLRRRRRLLSRSQRRERRTTIMLIAVV 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1395447104 241 SSFIACNVPGSIVFVMKESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFRALL 302
Cdd:cd14978   238 IVFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
24-302 1.41e-50

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 170.12  E-value: 1.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  24 FLNSKVLILQIIFGCGGNILNLMVLLSRAMRSRTNLIFAAMAFADLFFLILHIPSVLFFIGTIRDAPWYRNG---FSQVI 100
Cdd:cd14978     1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFyayFLPYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 101 AGMLNWSSAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKT--------------- 165
Cdd:cd14978    81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVvecencnnnsyyyvi 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 166 -----RAANKYARYVVYIHMIFVVIIPMFLSTSLNILLVCALRKNSmplRMLNDSHVHQSLIVQRTRTERKVTAMVTVIL 240
Cdd:cd14978   161 ptllrQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSK---KRRRLLRRRRRLLSRSQRRERRTTIMLIAVV 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1395447104 241 SSFIACNVPGSIVFVMKESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFRALL 302
Cdd:cd14978   238 IVFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-287 9.25e-12

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 64.24  E-value: 9.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  40 GNILNLMVLL-SRAMRSRTNLIFAAMAFADLFFLILHIPsvLFFIGTIRDAPW-YRNGFSQVIAGMLNWSSAVSIWFMMY 117
Cdd:pfam00001   1 GNLLVILVILrNKKLRTPTNIFLLNLAVADLLFSLLTLP--FWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 118 ATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAAN---------------KYARYVVYIHMIF 182
Cdd:pfam00001  79 ISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPegnvtvcfidfpedlSKPVSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 183 VVIIPMFLSTSLNILLVCALRKNSMPLRMlndshvhqsliVQRTRTERKVTAMVTVILSSFIACNVPGSIVFVMKESDDT 262
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASKQKS-----------SERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALD 227
                         250       260
                  ....*....|....*....|....*
gi 1395447104 263 FDDSRRHILMQAVCNSLAVTGKVLN 287
Cdd:pfam00001 228 CELSRLLDKALSVTLWLAYVNSCLN 252
 
Name Accession Description Interval E-value
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
24-302 1.41e-50

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 170.12  E-value: 1.41e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  24 FLNSKVLILQIIFGCGGNILNLMVLLSRAMRSRTNLIFAAMAFADLFFLILHIPSVLFFIGTIRDAPWYRNG---FSQVI 100
Cdd:cd14978     1 VLYGYVLPVICIFGIIGNILNLVVLTRKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFyayFLPYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 101 AGMLNWSSAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKT--------------- 165
Cdd:cd14978    81 YPLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVvecencnnnsyyyvi 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 166 -----RAANKYARYVVYIHMIFVVIIPMFLSTSLNILLVCALRKNSmplRMLNDSHVHQSLIVQRTRTERKVTAMVTVIL 240
Cdd:cd14978   161 ptllrQNETYLLKYYFWLYAIFVVLLPFILLLILNILLIRALRKSK---KRRRLLRRRRRLLSRSQRRERRTTIMLIAVV 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1395447104 241 SSFIACNVPGSIVFVMKESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFRALL 302
Cdd:cd14978   238 IVFLICNLPAGILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
29-295 1.83e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 86.57  E-value: 1.83e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILQIIFGCGGNILNLMVLL-SRAMRSRTNLIFAAMAFADLFFLILHIPSVLFFIgtIRDAPWYRNGFSQVIAGMLNWS 107
Cdd:cd00637     4 LYILIFVVGLVGNLLVILVILrNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSL--LLGRWWFGDALCKLLGFLQSVS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 108 SAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAANKY------------ARYV 175
Cdd:cd00637    82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYcccclcwpdltlSKAY 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 176 VYIHMIFVVIIPMFLSTSLNILLVCALRKNSMPLRMLNDSHVHQslivQRTRTERKVTAMVTVILSSFIACNVPGSIVFV 255
Cdd:cd00637   162 TIFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRR----RRRRRERKVTKTLLIVVVVFLLCWLPYFILLL 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1395447104 256 MKESDDTFDDSRRHILMqaVCNSLAVTGKVLNFLLFCLSS 295
Cdd:cd00637   238 LDVFGPDPSPLPRILYF--LALLLAYLNSAINPIIYAFFN 275
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
40-287 9.25e-12

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 64.24  E-value: 9.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  40 GNILNLMVLL-SRAMRSRTNLIFAAMAFADLFFLILHIPsvLFFIGTIRDAPW-YRNGFSQVIAGMLNWSSAVSIWFMMY 117
Cdd:pfam00001   1 GNLLVILVILrNKKLRTPTNIFLLNLAVADLLFSLLTLP--FWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTA 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 118 ATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAAN---------------KYARYVVYIHMIF 182
Cdd:pfam00001  79 ISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPegnvtvcfidfpedlSKPVSYTLLISVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 183 VVIIPMFLSTSLNILLVCALRKNSMPLRMlndshvhqsliVQRTRTERKVTAMVTVILSSFIACNVPGSIVFVMKESDDT 262
Cdd:pfam00001 159 GFLLPLLVILVCYTLIIRTLRKSASKQKS-----------SERTQRRRKALKTLAVVVVVFILCWLPYHIVNLLDSLALD 227
                         250       260
                  ....*....|....*....|....*
gi 1395447104 263 FDDSRRHILMQAVCNSLAVTGKVLN 287
Cdd:pfam00001 228 CELSRLLDKALSVTLWLAYVNSCLN 252
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
34-302 8.65e-09

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 55.69  E-value: 8.65e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  34 IIFGCGGNILNLMVLLS-RAMRSRTNLIFAAMAFADLFFLILHIPSVLFfigTIRDAPWYrngFSQVIAGMLNWSSAVSI 112
Cdd:cd15203    11 IVLGVVGNLLVIYVVLRnKSMQTVTNIFILNLAVSDLLLCLVSLPFTLI---YTLTKNWP---FGSILCKLVPSLQGVSI 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 113 ----WFMMYATIERVQVFRSPFRT--SKRSAstrfFITLFSIAFFCLLLTI--------VHFIHPKTR---------AAN 169
Cdd:cd15203    85 fvstLTLTAIAIDRYQLIVYPTRPrmSKRHA----LLIIALIWILSLLLSLplaifqelSDVPIEILPycgyfctesWPS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 170 KYARYvVY--IHMIFVVIIPMFLSTSLNILLVCALRKNS--MPLRMLNDSHVHQSLIVQRTRTERKVTAMVTVilssFIA 245
Cdd:cd15203   161 SSSRL-IYtiSVLVLQFVIPLLIISFCYFRISLKLRKRVkkKRGKRTLSSRRRRSELRRKRRTNRLLIAMVVV----FAV 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447104 246 CNVPGSIVFVMKESDDTFDDSRRHI-LMQAVCNSLAVTGKVLNFLLFCLSSEHFRALL 302
Cdd:cd15203   236 CWLPLNLFNLLRDFEPLPQIDGRHFyLIFLICHLIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
29-253 1.11e-08

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 55.29  E-value: 1.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILQIIFGCGGNILNLMVLL-SRAMRSRTNLIFAAMAFADLFFLILHIPsvLFFIGTIRDApWYRNGFSQVIAGMLN-W 106
Cdd:cd14969     6 YLSLIGVLGVVLNGLVIIVFLkKKKLRTPLNLFLLNLALADLLMSVVGYP--LSFYSNLSGR-WSFGDPGCVIYGFAVtF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 107 SSAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFS--IAFFCLLLTIV---HFIH--PKTRAANKYAR------ 173
Cdd:cd14969    83 LGLVSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIwlYGLFWALPPLFgwsSYVPegGGTSCSVDWYSkdpnsl 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 174 -YVVYIhMIFVVIIPMFLSTSLNILLVCALRKNSmplrmLNDSHVHQSLIVQRT-RTERKVTAMVTVILSSFIACNVPGS 251
Cdd:cd14969   163 sYIVSL-FVFCFFLPLAIIIFCYYKIYRTLRKMS-----KRAARRKNSAITKRTkKAEKKVAKMVLVMIVAFLIAWTPYA 236

                  ..
gi 1395447104 252 IV 253
Cdd:cd14969   237 VV 238
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
30-299 7.29e-08

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 52.85  E-value: 7.29e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  30 LILQIIF--GCGGNILNLMVLL-SRAMRSRTNLIFAAMAFADLFFLILHIPsvlfFIGTIRDAP-WYRNGF-SQVIAGML 104
Cdd:cd14971     5 LFFALIFllGLVGNSLVILVVArNKPMRSTTNLFILNLAVADLTFLLFCVP----FTATIYPLPgWVFGDFmCKFVHYFQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 105 NWSSAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRaaNKYARYVVYIHMIF-- 182
Cdd:cd14971    81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLR--NYTPGNRTVCSEAWps 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 183 -----VVIIPMFLSTSLNILLVCALRKNSMpLRMLNDSHVHQSLIVQRTRTERKVTAMVTVILSSFIACNVPGSIVFVMK 257
Cdd:cd14971   159 rahrrAFALCTFLFGYLLPLLLICVCYAAM-LRHLWRVAVRPVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLV 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1395447104 258 ESdDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd14971   238 AL-GPFPLTYATYALRIWAHCLAYSNSAVNPVLYAFLSEHFR 278
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
29-299 8.78e-08

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 52.72  E-value: 8.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILQIIFGCGGNILNLMVLL-SRAMRSRTNLIFAAMAFADLFFLILHIPsvLFFIGTIRDAPWYRNGFSQVIAGMLNWS 107
Cdd:cd15083     6 FILIIGLIGVVGNGLVIYAFCrFKSLRTPANYLIINLAISDFLMCILNCP--LMVISSFSGRWIFGKTGCDMYGFSGGLF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 108 SAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLL-----------------LTIVHFIHPKTRAANK 170
Cdd:cd15083    84 GIMSINTLAAIAVDRYLVITRPMKASVRISHRRALIVIAVVWLYSLLwvlpplfgwsryvleglLTSCSFDYLSRDDANR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 171 YarYVVYIhMIFVVIIPMFLSTSLNILLVCALRKNSMPLRMLNDSHVHQSLIVQRTRTERKV-TAMVTVILSS-FIACNV 248
Cdd:cd15083   164 S--YVICL-LIFGFVLPLLIIIYCYSFIFRAVRRHEKAMKEMAKRFSKSELSSPKARRQAEVkTAKIALLLVLlFCLAWT 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1395447104 249 PGSIVFVMKESDdtfDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd15083   241 PYAVVALIGQFG---YLEVLTPLATAIPAAFAKTSAIYNPVIYAFSHPKFR 288
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
34-299 2.33e-07

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 51.53  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  34 IIFGCGGNILNLMVLLSRA-MRSRTNLIFAAMAFADLFFLILHIPsvlfFIGTIRDAP-W-YRNGFSQVIAGMLNWSSAV 110
Cdd:cd15096    11 FIVGLIGNSLVILVVLSNQqMRSTTNILILNLAVADLLFVVFCVP----FTATDYVLPtWpFGDVWCKIVQYLVYVTAYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 111 SIWFMMYATIER----VQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAANKY------------ARY 174
Cdd:cd15096    87 SVYTLVLMSLDRylavVHPITSMSIRTERNTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYsyctfltevgtaAQT 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 175 VVYIHMIFVVIIPMFLSTSLNILLVCALRKNSMPlrmlndsHVHQSliVQRTRTERKVTAMVTVILSSFIACNVPGSIVF 254
Cdd:cd15096   167 FFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSP-------GGRRS--AESQRGKRRVTRLVVVVVVVFAICWLPIHIIL 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1395447104 255 VMKeSDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd15096   238 LLK-YYGVLPETVLYVVIQILSNCLAYGNSCVNPILYAFLSQNFR 281
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
29-299 3.36e-06

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 47.56  E-value: 3.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILQIIFGCGGNILNLM-VLLSRAMRSRTNLIFAAMAFADLFFLILHIPsvlFFIGTIRDAPWYrngFSQVIAGMLNWS 107
Cdd:cd14967     5 FLSLIILVTVFGNLLVILaVYRNRRLRTVTNYFIVSLAVADLLVALLVMP---FSAVYTLLGYWP---FGPVLCRFWIAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 108 ----SAVSIWFMMYATIERVQVFRSPFR-----TSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAANKYARYVVYI 178
Cdd:cd14967    79 dvlcCTASILNLCAISLDRYLAITRPLRyrqlmTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 179 HMIFVVIIPMFLstSLNILLVCALRknsmplrmlndshvhqslIVQRTRTERKVTAMVTVILSSFIACNVPGSIVFVMKE 258
Cdd:cd14967   159 YVLVSSVISFFI--PLLIMIVLYAR------------------IFRVARRELKAAKTLAIIVGAFLLCWLPFFIIYLVSA 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1395447104 259 SDDTFDDSRrhiLMQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd14967   219 FCPPDCVPP---ILYAVFFWLGYLNSALNPIIYALFNRDFR 256
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
29-299 2.10e-05

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 45.50  E-value: 2.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILQIIFGCG-GNILNLMVLLS-RAMRSRTNLIFAAMAFADLFFLILHIPsvlFFIGTIRDAPWYRNGF-SQVIAGMLN 105
Cdd:cd14992     5 VALVVIILVSVvGNFIVIAALARhKNLRGATNYFIASLAISDLLMALFCTP---FNFTYVVSLSWEYGHFlCKIVNYLRT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 106 WSSAVSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAA----------------- 168
Cdd:cd14992    82 VSVYASSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLfsvknqekifccqippv 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 169 -NKYARYvVYIHMIFVVI--IPMFLSTSLNILLVCALRKNSMPLRMLNDShvhqslIVQRTRTERKVTAMVTVILSSFIA 245
Cdd:cd14992   162 dNKTYEK-VYFLLIFVVIfvLPLIVMTLAYARISRELWFRKVPGFSIKEV------ERKRLKCKRRVIKMLVCVVVLFVI 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1395447104 246 CNVPGSIVFVMKESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd14992   235 CWLPFHLFFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
34-299 2.54e-05

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 45.28  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  34 IIFGCGGNILNLMVLL-SRAMRSRTNLIFAAMAFADLFFLILHIPSVLffIGTIRDAPWYRNGFSQVIAGMLNWSSAVSI 112
Cdd:cd14993    11 FLLALVGNSLVIAVVLrNKHMRTVTNYFLVNLAVADLLVSLFCMPLTL--LENVYRPWVFGEVLCKAVPYLQGVSVSASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 113 WFMMYATIERVQVFRSPFRTSKRSASTRFFIT-----LFSIAFFCLLL-----TIVHFIHPKTRAA---------NKYAR 173
Cdd:cd14993    89 LTLVAISIDRYLAICYPLKARRVSTKRRARIIivaiwVIAIIIMLPLLvvyelEEIISSEPGTITIyictedwpsPELRK 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 174 YVVYIHMIFVVIIPMFLSTSLNILLVCALRKNSMPLRMLNdSHVHQSLIVQRTRteRKVTAMVTVILSSFIACNVPGSIV 253
Cdd:cd14993   169 AYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPPGDRGS-ANSTSSRRILRSK--KKVARMLIVVVVLFALSWLPYYVL 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1395447104 254 FVMKESDDTFDDSR----RHILMQAVCnsLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd14993   246 SILLDFGPLSSEESdenfLLILPFAQL--LGYSNSAINPIIYCFMSKKFR 293
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
100-301 3.33e-05

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 44.89  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 100 IAGMLNWSSA-VSIWFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAANKYARYV--- 175
Cdd:cd15919    77 IIEVLEFSSIhTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWIEDYTSTSMhhv 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 176 -VYIHMIFVVIIPMFLSTSLNILLVCALRKNSMpLRMlndshvhqslivqRTRTERKVTAMVTVILSSFIACNVPGSIVF 254
Cdd:cd15919   157 lIWIHCFTVYLVPCSIFFVLNSIIVYKLRRKSN-FRL-------------RGYSTGKTTAILFTITSIFAILWAPRIIMI 222
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1395447104 255 VMKESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFRAL 301
Cdd:cd15919   223 LYHLYVSPINNSWLVHIVSDIANMLALLNTAINFFLYCFISKRFRTM 269
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
37-299 1.04e-04

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 43.50  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  37 GCGGNILNLMVLLS-RAMRSRTNLIFAAMAFADLFFLILHIPSVLFFIgtIRDAPW-YRNGFSQVIAGMLNWSSAVSIWF 114
Cdd:cd14979    14 GIVGNLLTCIVIARhKSLRTTTNYYLFSLAVSDLLILLVGLPVELYNF--WWQYPWaFGDGGCKLYYFLFEACTYATVLT 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 115 MMYATIERVQVFRSPFR-----TSKRSASTRFFITLFSIA---FFCLLLTIVHFIHPK-------------TRAANKYAR 173
Cdd:cd14979    92 IVALSVERYVAICHPLKaktlvTKRRVKRFILAIWLVSILcaiPILFLMGIQYLNGPLpgpvpdsavctlvVDRSTFKYV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 174 YVVYIHMIFVViiPMFLSTSLNILLVCALRKNSMPLRMLNDSHVHQSLIVQRTRTERKVTAMVTVILSSFIACNVPGSIV 253
Cdd:cd14979   172 FQVSTFIFFVL--PMFVISILYFRIGVKLRSMRNIKKGTRAQGTRNVELSLSQQARRQVVKMLGAVVIAFFVCWLPFHAQ 249
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1395447104 254 FVM--KESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd14979   250 RLMfsYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFR 297
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
35-253 1.24e-04

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 43.05  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  35 IFGCGGNILNLMVLLS-RAMRSRTNLIFAAMAFADLFFLILHIPSVLffIGTIRDAPWYRNGF-SQVIAGMLNWSSAVSI 112
Cdd:cd14997    12 VVGVLGNVLVGIVVWKnKDMRTPTNIFLVNLSVADLLVLLVCMPVAL--VETWAREPWLLGEFmCKLVPFVELTVAHASV 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 113 WFMMYATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTR---------------AANKYARyVVY 177
Cdd:cd14997    90 LTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKeedfndgtpvavcrtPADTFWK-VAY 168
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447104 178 IHMIFVV--IIPMFLSTSLNILLVCALRKNSMPLRMLNDSHVhqsliVQRTRTERKVTAMVTVILSSFIACNVPGSIV 253
Cdd:cd14997   169 ILSTIVVffVVPLAILSGLYSVICRRLVGHPALESRRADAAN-----RHTLRSRRQVVYMLITVVVLFFVCLLPFRVV 241
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
40-299 3.24e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 41.66  E-value: 3.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  40 GNILNLMV-LLSRAMRSRTNLIFAAMAFADLFFLILHIPSVLFFIGTirdAPWYRNGF-SQVIAGMLNWSSAVSIWFMMY 117
Cdd:cd15012    16 GNLLVILVvTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLI---PSWPFGEVlCRMYQFVHSLSYTASIGILVV 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 118 ATIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHFIHPKTRAANKYARyvVYIHMIFVVIIPMFLSTSLNIL 197
Cdd:cd15012    93 ISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQD--GQEEEICVLDREMFNSKLYDTI 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 198 --LVCALrknsMPLRMLNDSHVHQSLIV---QRTRTERKVTAMVTVILSSFIACNVPGSIVFVMKE-SDDTFDDSRRHIL 271
Cdd:cd15012   171 nfIVWYL----IPLLIMTVLYSKISIVLwksSSIEARRKVVRLLVAVVVSFALCNLPYHARKMWQYwSEPYRCDSNWNAL 246
                         250       260
                  ....*....|....*....|....*...
gi 1395447104 272 MQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd15012   247 LTPLTFLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
34-299 5.46e-04

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 41.13  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  34 IIFGCGGNILNL-MVLLSRAMRSRTNLIFAAMAFADLFFLILHIPSVlfFIGTIRDAPWYRNGFSQVIAGMLNWSSAVSI 112
Cdd:cd15390    11 VLVAIGGNLIVIwIVLAHKRMRTVTNYFLVNLAVADLLISAFNTVFN--FTYLLYNDWPFGLFYCKFSNFVAITTVAASV 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 113 WFMMYATIERVQVFRSPF--RTSKRSAstrfFITLFSIAFFCLLLTIVHFIHPKTRAANKYARYV--------------- 175
Cdd:cd15390    89 FTLMAISIDRYIAIVHPLrpRLSRRTT----KIAIAVIWLASFLLALPQLLYSTTETYYYYTGSErtvcfiawpdgpnsl 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 176 ---VYIHMIFVV--IIPMFLSTSLNILLVCALRKNsmplRMLNDSHVHQsliVQRTRTERKVTAMVTVILSSFIACNVPG 250
Cdd:cd15390   165 qdfVYNIVLFVVtyFLPLIIMAVAYTRVGVELWGS----KTIGENTPRQ---LESVRAKRKVVKMMIVVVVIFAICWLPY 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1395447104 251 SIVFVMKESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFR 299
Cdd:cd15390   238 HLYFILTYLYPDINSWKYIQQIYLAIYWLAMSNSMYNPIIYCWMNKRFR 286
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
29-300 1.48e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 39.94  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILQIIFGCGGNILNLMVLLSRA-MRSRTNLIFAAMAFADLFFlILHIP-SVLFFIGtiRDAPWYRNGFSQVIAGMLNW 106
Cdd:cd14982     6 VYSLIFILGLLGNILALWVFLRKMkKRSPTTIYMINLALADLLF-VLTLPfRIYYYLN--GGWWPFGDFLCRLTGLLFYI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 107 SSAVSIWFMMYATIERVQVFRSPFRTskRSASTRFFITLFSIA--FFCLLLTIVHFIHPKTRAANK------------YA 172
Cdd:cd14982    83 NMYGSILFLTCISVDRYLAVVHPLKS--RRLRRKRYAVGVCAGvwILVLVASVPLLLLRSTIAKENnsttcfeflsewLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 173 RYVVYIHMIFVVI--IPMFLSTSLNILLVCALRKNSMPLrmlndshvhqslivQRTRTERKVTAMVTVILSSFIACNVP- 249
Cdd:cd14982   161 SAAPIVLIALVVGflIPLLIILVCYSLIIRALRRRSKQS--------------QKSVRKRKALRMILIVLAVFLVCFLPy 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1395447104 250 --GSIVFVMKESDDTFDDSRRHILMQA--VCNSLAVTGKVLNFLLFCLSSEHFRA 300
Cdd:cd14982   227 hvTRILYLLVRLSFIADCSARNSLYKAyrITLCLASLNSCLDPLIYYFLSKTFRK 281
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
25-81 2.01e-03

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 39.33  E-value: 2.01e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447104  25 LNSKVLILQIIFGCGGNILNLMVLLS-RAMRSRTNLIFAAMAFADLFFLILHIPSVLF 81
Cdd:cd15000     1 IKSSMFLPVVLFGIFGNFVLLYILASnRSLRTPTNLLIGNMALADLLTLLVCPWMFLV 58
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
29-295 2.26e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 39.40  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILQIIFGCGGNILNLMVL-LSRAMRSRTNLIFAAMAFADLFFLILhIPSVLFFIGTIRdaPWyrNGFSQVIAGMLNWS 107
Cdd:cd15928     6 VCSVLMLVGASGNLLTVLVIgRSRDMRTTTNLYLSSLAVSDLLIFLV-LPLDLYRLWRYR--PW--RFGDLLCRLMYFFS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 108 ---SAVSIWFMMYATIERVQVFRSPFRTSK--RSASTRFFI------TLFSIAFFCLLLTIVHFIHPKTRAANKYARYVV 176
Cdd:cd15928    81 etcTYASILHITALSVERYLAICHPLRAKVlvTRGRVKLLIaviwavAIVSAGPALVLVGVEHIQGQQTPRGFECTVVNV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 177 YIHMIFVVI--------IPMFLSTSLNILLVCALRKNSMPLRMLNDShvhqslivQRTRTERKVTAMVTVILSSFIACNV 248
Cdd:cd15928   161 SSGLLSVMLwvstsfffVPMVCLSLLYGLIGRALWDRRQRSRTAGAS--------RRDNNHRQTVRMLAVIVLAFVLCWL 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1395447104 249 P---GSIVFVMKESDDTFddsrRHILMQAVcnslavtgKVLNFLLFCLSS 295
Cdd:cd15928   233 PfhvGRVIFNHSRASTKH----LHYVSQYF--------NLVSFVLFYLSA 270
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
34-302 3.66e-03

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 38.57  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  34 IIFGCGGNILNLMV-LLSRAMRSRTNLIFAAMAFADLFFLILHIPSVLFFIGTIRDapWYRNGF-SQVIAGMLNWSSAVS 111
Cdd:cd15394    11 VLVGVVGNYLLIYViCRTKKMHNVTNFLIGNLAFSDMLMCATCVPLTLAYAFEPRG--WVFGRFmCYFVFLMQPVTVYVS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 112 IWFMMYATIERVQVFRSPFRtskRSASTRFFITLFSIAFFCLLL----TIVHFIH------------------PKTRAAN 169
Cdd:cd15394    89 VFTLTAIAVDRYYVTVYPLR---RRISRRTCAYIVAAIWLLSCGlalpAAAHTYYvefkgldfsiceefwfgqEKQRLAY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 170 KYARYVVYIHMIFVVIIPMFLSTSlnillvCALRKNSMPlrmlndSHVHQSLIVQRTRTERKVTAMVTVILSSFIACNVP 249
Cdd:cd15394   166 ACSTLLITYVLPLLAISLSYLRIS------VKLRNRVVP------GSMTQSQAEWDRARRRKTFRLLVVVVVAFAICWLP 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1395447104 250 GSIVFVMKESDDTFDDSRRHILMQAVCNSLAVTGKVLNFLLFCLSSEHFRALL 302
Cdd:cd15394   234 LHIFNVIRDIDIDLIDKQYFNLIQLLCHWLAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
29-249 6.90e-03

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 37.64  E-value: 6.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  29 VLILqIIFGCG-GNILNLMVLLS-RAMRSRTNLIFAAMAFADLFFLILHIPSVL-FFIgtIRDAPWyrnGFSQVIAGMLN 105
Cdd:cd15204     6 VYVL-IMLVCGvGNLLLIAVLARyKKLRTLTNLLIANLALSDFLVAVFCLPFEMdYYV--VRQRSW---THGDVLCAVVN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 106 WSSAVSIWFMMYA----TIERVQVFRSPFRTSKRSASTRFFITLFSIAFFCLLLTIVHF--IHPKTRAANKY-------- 171
Cdd:cd15204    80 YLRTVSLYVSTNAllviAIDRYLVIVHPLKPRMKRRTACVVIALVWVVSLLLAIPSAVYskTTPYANQGKIFcgqiwpvd 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104 172 --ARYVVYIHMIFVV--IIPMFLSTSLNILLVCALRKNSMPlrmlndsHVHQSLIVQRTRTERKVTAMVTVILSSFIACN 247
Cdd:cd15204   160 qqAYYKAYYLFLFVLefVLPVLIMTLCYLRIVRKVWFRRVP-------GQQTEQIRRRLRRRRRKVRLLVVILTAFVLCW 232

                  ..
gi 1395447104 248 VP 249
Cdd:cd15204   233 AP 234
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
35-162 9.05e-03

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 37.57  E-value: 9.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1395447104  35 IFGCGGNILNLMVLLSRAMR-SRTNLIFAAMAFADLFFLILHIPSVL--FFIGTIRDAPWYRNGFSQVIAGMLNW----- 106
Cdd:pfam10324   8 FIGFIINIFHLIILTRKSMRtSSINIIMIGIAICDIITMLLTIYNFIpeFIISYENSECIPPDSYLKVLLDWILEslqdy 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447104 107 SSAVSIWFMMYATIERVQVFRSPFRTSKRSAST-RF-FITLFSIAFFCLLLTIVHFIH 162
Cdd:pfam10324  88 SRRCSTWLGVFMALIRTLVVKNPMSNKIQKLSKpKFgLIIIIIVFILSLPISIFYYFR 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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