|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
266-925 |
8.89e-40 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 158.48 E-value: 8.89e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 266 IIVVVLKVTMWNGA-ENRDFYDDLIDKLKDHLERNPHTRMAGIAlnMKNKVFQERIQTD-SLFAAFSALLVFSCFLIYSR 343
Cdd:COG1033 163 LIVVTLDPDPLSSDlDRKEVVAEIRAIIAKYEDPGVEVYLTGFP--VLRGDIAEAIQSDlAIFFPLALLLILLLLFLFFR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 344 SIIFTCIILMVVTLSSGVAFFIyTVVLGIDFFPfINLLVVVILISIGADDAFLLLVYYRREVERMSH----LEYKVGSIY 419
Cdd:COG1033 241 SLRGVLLPLLVVLLAVIWTLGL-MGLLGIPLSP-LTILVPPLLLAIGIDYGIHLLNRYREERRKGLDkreaLREALRKLG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 420 IPlyresdllsrslrlslhhslvsMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLILPgAIILSRPIR 499
Cdd:COG1033 319 PP----------------------VLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP-ALLSLLPRP 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 500 KKLSRGDEEPEKIEShsyFASKITETTHYFRFGIFICSLIMTGLSLFIIFQNPglktpqtnptkllVDSNIHEYFDNNvH 579
Cdd:COG1033 376 KPKTRRLKKPPELGR---LLAKLARFVLRRPKVILVVALVLAVVSLYGISRLK-------------VEYDFEDYLPED-S 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 580 HFNfqwQRSARLVKNF------VFGVDAIKETSTLSPynkpsknfsqahysldtdklDFYRRIVNLES--KKYQLVNYTh 651
Cdd:COG1033 439 PIR---QDLDFIEENFggsdplEVVVDTGEPDGLKDP--------------------EVLKEIDRLQDylESLPEVGKV- 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 652 VSWADKILQANEScfsenktiIHECILSASV--RNKNLIHQFPDDFSVIPGD--GPFIDQDLKVVGYFISIPSnqklqVD 727
Cdd:COG1033 495 LSLADLVKELNQA--------LNEGDPKYYAlpESRELLAQLLLLLSSPPGDdlSRFVDEDYSAARVTVRLKD-----LD 561
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 728 TEMIGSFFQEIEESCKQIKNATSDSVLCLSSTEItrFYDIVSQLRSSSFTSVAISLGICLIVIIACTRVIKLSIISSVII 807
Cdd:COG1033 562 SEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVL--FAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPN 639
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 808 FFVILWTVASLILLGWQLSVVESTILIITIGLSFDYTLHYVVAIRD--TKCVPASEKLTSAHSTAGIACVFGSLTLFLAG 885
Cdd:COG1033 640 LLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREerRKGGDLEEAIRRALRTTGKAILFTSLTLAAGF 719
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 71988521 886 CPLLFSQTASFYQIGTMLVILGITSLFGASIVLPSFLMVF 925
Cdd:COG1033 720 GVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
266-924 |
1.70e-12 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 71.41 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 266 IIVVVLkvtmwNGAENRDFYDDLIDKLKDHLERN--PHTRMA----GIALNMKnkvFQERIQTD--SLFAAFSALLVFSC 337
Cdd:TIGR00921 139 IIIVQL-----KSDADYKQVVPIYNDVERSLERTnpPSGKFLdvtgSPAINYD---IEREFGKDmgTTMAISGILVVLVL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 338 FLIYSRSI---IFTCIILMVVTLSSGVAFFiytvvLGIDFFpFINLLVVVILISIGADDAFLLLVYYRREvermshleyk 414
Cdd:TIGR00921 211 LLDFKRWWrplLPLVIILFGVAWVLGIMGW-----LGIPLY-ATTLLAVPMLIGVGIDYGIQTLNRYEEE---------- 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 415 vgsiyiplYRESDLLSRSLRLSLHHSLVSMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLILPGAIIL 494
Cdd:TIGR00921 275 --------RDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQS 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 495 SRPIRKKLSRGDE----EPEKIESHSyfaSKITETTHYFRFGIFICSLIMTGLSLFiifQNPGLKtPQTNPTKLL-VDSN 569
Cdd:TIGR00921 347 IDIGREKVKKEIIaiggKSSEIEEEL---SKVLSITVRHPVPALVAALIITGLGLY---GAAGIK-PEVNIEKFIpQDLP 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 570 IHEYFDNNVHHFNFQWQRSARLVKnfvfgVDAIKETSTLSPYNKPSKNFSQAHYSldtDKLDFYRRIVNLESKKYQLVNY 649
Cdd:TIGR00921 420 SLQARKVIESHMGGSHDFATILVK-----ADDVRDPELVRFMDELSRDIKATGVA---ARVFGAPSIIDLVKEVEGLPAP 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 650 THvSWADKILQANESCFSENKTIiheCILSASVRNKnlihqfPDDFSVIpgdGPFIDQDLKvvgyFISIPSNQKLQVdte 729
Cdd:TIGR00921 492 ER-SALEPIPEDEEGGYISGGQI---KVAVIQVQLK------QGEPKVQ---GRKILRDVQ----HEHPPPGVKVGV--- 551
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 730 migsffqeieesckqiknaTSDSVLclssteitrFYDIVSQLRSSSFTSVAISLGICLIVIIACTRVIKLSIISSVIIFF 809
Cdd:TIGR00921 552 -------------------TGLPVA---------FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGS 603
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 810 VILWTVASLILLGWQLSVVESTILIITIGLSFDYTLHYVVAIRDT-KCVPASEKLTSAHSTAGIACVFGSLTLFLAGCPL 888
Cdd:TIGR00921 604 GILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEErKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSL 683
|
650 660 670
....*....|....*....|....*....|....*.
gi 71988521 889 LFSQTASFYQIGTMLVILGITSLFGASIVLPSFLMV 924
Cdd:TIGR00921 684 LLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
329-926 |
2.12e-06 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 51.59 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 329 FSALLVFSCFLIY---SRSI----------IFTCIILMVVTLSSGVAFFIytvvLGidfFPFINLLVVV--ILISIGADD 393
Cdd:pfam02460 223 FFLLLTFSIIVSVtlsSYTIdwvrskpilaALGLLSPVMAIVSSFGLLFW----MG---FPFNSIVCVTpfLVLAIGVDD 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 394 AFLLLVYYRREV------ERMSHLEYKVGsiyiplyresdllsrslrlslhhslVSMFVTSLTTASTFLTNLSSPVIVLR 467
Cdd:pfam02460 296 MFLMVAAWQRTTatlsvkKRMGEALSEAG-------------------------VSITITSLTDVLSFGIGTYTPTPAIQ 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 468 CFGVYAALTVTVNYILVVLILPG--AIILSRPIRKKLS---RGDEEPEKIESHSYFASK----ITETTHYFR--FGIFIC 536
Cdd:pfam02460 351 LFCAYTAVAIFFDFIYQITFFAAimAICAKPEAEGRHClfvWATSSPQRIDSEGSEPDKshniEQLKSRFFLdiYCPFLL 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 537 S-----------LIMTGLSLFIIFQ-NPGLktpqtNPTKLLV-DSNIHEYFDNNVHHFnfqWQRSARlVKNFVFGVDAIK 603
Cdd:pfam02460 431 NpsvrvcmlvlfVVYIAIAIYGCVNiKEGL-----EPDKLVLeDSPLVEYLSLREKHF---WPEGLQ-IQVAVNNPPNLT 501
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 604 ETSTLSPYNKPSKNFSQAHYSLdtdkldfyrrivNLESKKYQLVNYTHVSWADKILQANESCFSENKTIIHECILSASVR 683
Cdd:pfam02460 502 IPESRDRMNEMVDEFENTPYSL------------GPNSTLFWLREYENFLSTLNMEEEEDEEKEWSYGNLPSFLKAPGNS 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 684 NKNLIHQFPDDfsvipgDGPFIDQDLKVVGYFISIPSNQKLQVDTemigsfFQEIEESCKQIKNATSDsvlclsstEITR 763
Cdd:pfam02460 570 HWAGDLVWDDN------TTMVTKFRFTLAGKGLSTWNDRTRALQE------WRSIADQYPEFNVTVFD--------EDAP 629
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 764 FYDIVSQLRSSSFTSVAISLgICLIVIIACtrviklsIISSVIIFFVILWTVAS--------LILLGWQLSVVESTILII 835
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITL-ICMFIVCFL-------FIPNPPCVFVITLAIASidigvfgfLSLWGVDLDPISMITIIM 701
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 836 TIGLSFDYTLHYVVAIRDTKCVPASEKLTSAHSTAGIACVFGSLTLFLAGCPLLFSQTasfYQI----GTMLVILGItSL 911
Cdd:pfam02460 702 SIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPS---YMVvvffKTVFLVVAI-GL 777
|
650
....*....|....*
gi 71988521 912 FGASIVLPSFLMVFS 926
Cdd:pfam02460 778 LHGLFILPIILSLFV 792
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
266-925 |
8.89e-40 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 158.48 E-value: 8.89e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 266 IIVVVLKVTMWNGA-ENRDFYDDLIDKLKDHLERNPHTRMAGIAlnMKNKVFQERIQTD-SLFAAFSALLVFSCFLIYSR 343
Cdd:COG1033 163 LIVVTLDPDPLSSDlDRKEVVAEIRAIIAKYEDPGVEVYLTGFP--VLRGDIAEAIQSDlAIFFPLALLLILLLLFLFFR 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 344 SIIFTCIILMVVTLSSGVAFFIyTVVLGIDFFPfINLLVVVILISIGADDAFLLLVYYRREVERMSH----LEYKVGSIY 419
Cdd:COG1033 241 SLRGVLLPLLVVLLAVIWTLGL-MGLLGIPLSP-LTILVPPLLLAIGIDYGIHLLNRYREERRKGLDkreaLREALRKLG 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 420 IPlyresdllsrslrlslhhslvsMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLILPgAIILSRPIR 499
Cdd:COG1033 319 PP----------------------VLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLLP-ALLSLLPRP 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 500 KKLSRGDEEPEKIEShsyFASKITETTHYFRFGIFICSLIMTGLSLFIIFQNPglktpqtnptkllVDSNIHEYFDNNvH 579
Cdd:COG1033 376 KPKTRRLKKPPELGR---LLAKLARFVLRRPKVILVVALVLAVVSLYGISRLK-------------VEYDFEDYLPED-S 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 580 HFNfqwQRSARLVKNF------VFGVDAIKETSTLSPynkpsknfsqahysldtdklDFYRRIVNLES--KKYQLVNYTh 651
Cdd:COG1033 439 PIR---QDLDFIEENFggsdplEVVVDTGEPDGLKDP--------------------EVLKEIDRLQDylESLPEVGKV- 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 652 VSWADKILQANEScfsenktiIHECILSASV--RNKNLIHQFPDDFSVIPGD--GPFIDQDLKVVGYFISIPSnqklqVD 727
Cdd:COG1033 495 LSLADLVKELNQA--------LNEGDPKYYAlpESRELLAQLLLLLSSPPGDdlSRFVDEDYSAARVTVRLKD-----LD 561
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 728 TEMIGSFFQEIEESCKQIKNATSDSVLCLSSTEItrFYDIVSQLRSSSFTSVAISLGICLIVIIACTRVIKLSIISSVII 807
Cdd:COG1033 562 SEEIKALVEEVRAFLAENFPPDGVEVTLTGSAVL--FAAINESVIESQIRSLLLALLLIFLLLLLAFRSLRLGLISLIPN 639
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 808 FFVILWTVASLILLGWQLSVVESTILIITIGLSFDYTLHYVVAIRD--TKCVPASEKLTSAHSTAGIACVFGSLTLFLAG 885
Cdd:COG1033 640 LLPILLTFGLMGLLGIPLNIATAVVASIALGIGVDYTIHFLSRYREerRKGGDLEEAIRRALRTTGKAILFTSLTLAAGF 719
|
650 660 670 680
....*....|....*....|....*....|....*....|
gi 71988521 886 CPLLFSQTASFYQIGTMLVILGITSLFGASIVLPSFLMVF 925
Cdd:COG1033 720 GVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLL 759
|
|
| MMPL |
COG1033 |
Predicted exporter protein, RND superfamily [General function prediction only]; |
285-503 |
4.30e-14 |
|
Predicted exporter protein, RND superfamily [General function prediction only];
Pssm-ID: 440656 [Multi-domain] Cd Length: 767 Bit Score: 76.44 E-value: 4.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 285 YDDLIDKLKDHLERN-PHTR-------MAGIALNMKNKVFQERIQtdSLFAAFSALLVFsCFLIYsRSIIFTCIILMVVT 356
Cdd:COG1033 565 IKALVEEVRAFLAENfPPDGvevtltgSAVLFAAINESVIESQIR--SLLLALLLIFLL-LLLAF-RSLRLGLISLIPNL 640
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 357 LSSGVAFFIyTVVLGIDFFPfINLLVVVILISIGADDAFLLLVYYRREvermshleYKVGSIYIPLYRESdllsrslrls 436
Cdd:COG1033 641 LPILLTFGL-MGLLGIPLNI-ATAVVASIALGIGVDYTIHFLSRYREE--------RRKGGDLEEAIRRA---------- 700
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71988521 437 LHHSLVSMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLILPGAIILSRPIRKKLS 503
Cdd:COG1033 701 LRTTGKAILFTSLTLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLLLDPRIAKKR 767
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
266-924 |
1.70e-12 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 71.41 E-value: 1.70e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 266 IIVVVLkvtmwNGAENRDFYDDLIDKLKDHLERN--PHTRMA----GIALNMKnkvFQERIQTD--SLFAAFSALLVFSC 337
Cdd:TIGR00921 139 IIIVQL-----KSDADYKQVVPIYNDVERSLERTnpPSGKFLdvtgSPAINYD---IEREFGKDmgTTMAISGILVVLVL 210
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 338 FLIYSRSI---IFTCIILMVVTLSSGVAFFiytvvLGIDFFpFINLLVVVILISIGADDAFLLLVYYRREvermshleyk 414
Cdd:TIGR00921 211 LLDFKRWWrplLPLVIILFGVAWVLGIMGW-----LGIPLY-ATTLLAVPMLIGVGIDYGIQTLNRYEEE---------- 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 415 vgsiyiplYRESDLLSRSLRLSLHHSLVSMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLILPGAIIL 494
Cdd:TIGR00921 275 --------RDIGRAKGEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPALLQS 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 495 SRPIRKKLSRGDE----EPEKIESHSyfaSKITETTHYFRFGIFICSLIMTGLSLFiifQNPGLKtPQTNPTKLL-VDSN 569
Cdd:TIGR00921 347 IDIGREKVKKEIIaiggKSSEIEEEL---SKVLSITVRHPVPALVAALIITGLGLY---GAAGIK-PEVNIEKFIpQDLP 419
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 570 IHEYFDNNVHHFNFQWQRSARLVKnfvfgVDAIKETSTLSPYNKPSKNFSQAHYSldtDKLDFYRRIVNLESKKYQLVNY 649
Cdd:TIGR00921 420 SLQARKVIESHMGGSHDFATILVK-----ADDVRDPELVRFMDELSRDIKATGVA---ARVFGAPSIIDLVKEVEGLPAP 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 650 THvSWADKILQANESCFSENKTIiheCILSASVRNKnlihqfPDDFSVIpgdGPFIDQDLKvvgyFISIPSNQKLQVdte 729
Cdd:TIGR00921 492 ER-SALEPIPEDEEGGYISGGQI---KVAVIQVQLK------QGEPKVQ---GRKILRDVQ----HEHPPPGVKVGV--- 551
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 730 migsffqeieesckqiknaTSDSVLclssteitrFYDIVSQLRSSSFTSVAISLGICLIVIIACTRVIKLSIISSVIIFF 809
Cdd:TIGR00921 552 -------------------TGLPVA---------FAEMHELVNEGMRRMTIAGAILVLMILLAVFRNPIKAVFPLIAIGS 603
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 810 VILWTVASLILLGWQLSVVESTILIITIGLSFDYTLHYVVAIRDT-KCVPASEKLTSAHSTAGIACVFGSLTLFLAGCPL 888
Cdd:TIGR00921 604 GILWAIGLMGLRGIPSFLAMATTISIILGLGMDYSIHLAERYFEErKEHGPKEAITHTMERTGPGILFSGLTTAGGFLSL 683
|
650 660 670
....*....|....*....|....*....|....*.
gi 71988521 889 LFSQTASFYQIGTMLVILGITSLFGASIVLPSFLMV 924
Cdd:TIGR00921 684 LLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
|
|
| Patched |
pfam02460 |
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ... |
329-926 |
2.12e-06 |
|
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.
Pssm-ID: 308203 [Multi-domain] Cd Length: 793 Bit Score: 51.59 E-value: 2.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 329 FSALLVFSCFLIY---SRSI----------IFTCIILMVVTLSSGVAFFIytvvLGidfFPFINLLVVV--ILISIGADD 393
Cdd:pfam02460 223 FFLLLTFSIIVSVtlsSYTIdwvrskpilaALGLLSPVMAIVSSFGLLFW----MG---FPFNSIVCVTpfLVLAIGVDD 295
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 394 AFLLLVYYRREV------ERMSHLEYKVGsiyiplyresdllsrslrlslhhslVSMFVTSLTTASTFLTNLSSPVIVLR 467
Cdd:pfam02460 296 MFLMVAAWQRTTatlsvkKRMGEALSEAG-------------------------VSITITSLTDVLSFGIGTYTPTPAIQ 350
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 468 CFGVYAALTVTVNYILVVLILPG--AIILSRPIRKKLS---RGDEEPEKIESHSYFASK----ITETTHYFR--FGIFIC 536
Cdd:pfam02460 351 LFCAYTAVAIFFDFIYQITFFAAimAICAKPEAEGRHClfvWATSSPQRIDSEGSEPDKshniEQLKSRFFLdiYCPFLL 430
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 537 S-----------LIMTGLSLFIIFQ-NPGLktpqtNPTKLLV-DSNIHEYFDNNVHHFnfqWQRSARlVKNFVFGVDAIK 603
Cdd:pfam02460 431 NpsvrvcmlvlfVVYIAIAIYGCVNiKEGL-----EPDKLVLeDSPLVEYLSLREKHF---WPEGLQ-IQVAVNNPPNLT 501
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 604 ETSTLSPYNKPSKNFSQAHYSLdtdkldfyrrivNLESKKYQLVNYTHVSWADKILQANESCFSENKTIIHECILSASVR 683
Cdd:pfam02460 502 IPESRDRMNEMVDEFENTPYSL------------GPNSTLFWLREYENFLSTLNMEEEEDEEKEWSYGNLPSFLKAPGNS 569
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 684 NKNLIHQFPDDfsvipgDGPFIDQDLKVVGYFISIPSNQKLQVDTemigsfFQEIEESCKQIKNATSDsvlclsstEITR 763
Cdd:pfam02460 570 HWAGDLVWDDN------TTMVTKFRFTLAGKGLSTWNDRTRALQE------WRSIADQYPEFNVTVFD--------EDAP 629
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 764 FYDIVSQLRSSSFTSVAISLgICLIVIIACtrviklsIISSVIIFFVILWTVAS--------LILLGWQLSVVESTILII 835
Cdd:pfam02460 630 FADQYLTILPSTIQNIVITL-ICMFIVCFL-------FIPNPPCVFVITLAIASidigvfgfLSLWGVDLDPISMITIIM 701
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 836 TIGLSFDYTLHYVVAIRDTKCVPASEKLTSAHSTAGIACVFGSLTLFLAGCPLLFSQTasfYQI----GTMLVILGItSL 911
Cdd:pfam02460 702 SIGFSVDFSAHIAYHFVRSRGDTPAERVVDALEALGWPVFQGGLSTILGVLVLLFVPS---YMVvvffKTVFLVVAI-GL 777
|
650
....*....|....*
gi 71988521 912 FGASIVLPSFLMVFS 926
Cdd:pfam02460 778 LHGLFILPIILSLFV 792
|
|
| 2A067 |
TIGR00921 |
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ... |
765-925 |
6.21e-06 |
|
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]
Pssm-ID: 273340 [Multi-domain] Cd Length: 719 Bit Score: 50.22 E-value: 6.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 765 YDIVSQLRSSSFTSVAISLGICLIVIIACTRVIKLSIISSVIIFFVILWTVASLILLGWQLSVVESTILIITIGLSFDYT 844
Cdd:TIGR00921 185 YDIEREFGKDMGTTMAISGILVVLVLLLDFKRWWRPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYG 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 845 LH----YVVAIRDTKCVpaSEKLTSAHSTAGIACVFGSLTLFLAGCPLLFSQTASFYQIGTMLVILGITSLFGASIVLPS 920
Cdd:TIGR00921 265 IQtlnrYEEERDIGRAK--GEAIVTAVRRTGRAVLIALLTTSAGFAALALSEFPMVSEFGLGLVAGLITAYLLTLLVLPA 342
|
....*
gi 71988521 921 FLMVF 925
Cdd:TIGR00921 343 LLQSI 347
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
318-489 |
9.94e-05 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 46.38 E-value: 9.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 318 ERIQTD-SLFAAFSALLVFSCFLIYSRSIifTCIILMVVTLSSGVAFFIYTVVLGidfFPFINLLVVVI---LISIGADD 393
Cdd:COG4258 245 QQIKHDiSTIGLISLLGILLLLLLVFRSL--RPLLLGLLPVAVGALAGLAAVSLV---FGSVHGITLGFgssLIGVAVDY 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 394 AFLLLVyyrrevERMSHLEYKVGsiyiPLYREsdllsrslrlslhhSLVSMFVTSLTTASTFLTNLSSPVIVLRCFGVYA 473
Cdd:COG4258 320 SLHYLT------HRRAAGEWDPR----AALRR--------------IWPTLLLGLLTTVLGYLALLFSPFPGLRQLGVFA 375
|
170
....*....|....*.
gi 71988521 474 ALTVTVNYILVVLILP 489
Cdd:COG4258 376 AAGLLAAALTTLLWLP 391
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
316-405 |
1.19e-04 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 45.36 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 316 FQERIQTDSLFAAFSAL-LVFSCFLIYSRSIIFTCIILMVVTLSSGVAFFIYTVVLGIDFFP---FINLLVVVILISIGA 391
Cdd:pfam03176 136 LRDAGDRDLGLIEAVTLvVIFIILLIVYRSVVAALLPLLTVGLSLGAAQGLVAILAHILGIGlstFALNLLVVLLIAVGT 215
|
90
....*....|....
gi 71988521 392 DDAFLLLVYYRREV 405
Cdd:pfam03176 216 DYALFLVSRYREEL 229
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
350-504 |
1.95e-04 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 45.26 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 350 IILMVVTLSSGVAFfiyTVVLGIDFFPFINLLVVVILISIGADDAFLLLVYYRrEVERMSHLEYKVGSIyipLYRESdll 429
Cdd:TIGR00918 434 VLLVALSVAAGLGL---CALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFS-ETGQNIPFEERTGEC---LKRTG--- 503
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 71988521 430 srslrlslhhslVSMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLILPGaiILSRPIRKKLSR 504
Cdd:TIGR00918 504 ------------ASVVLTSISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPA--ILSLDLRRREDR 564
|
|
| Sterol-sensing |
pfam12349 |
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ... |
350-503 |
2.04e-04 |
|
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.
Pssm-ID: 463544 [Multi-domain] Cd Length: 153 Bit Score: 42.57 E-value: 2.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 350 IILMVVTLSSGVAFFiytvvLGIDFFPFINLLVVVILISIGADDAFLLLVYYRR------EVERMSHLEYKVGsiyiply 423
Cdd:pfam12349 15 IVLASVASSLGLCAY-----FGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRtprsldVSERIAEALGEVG------- 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 424 resdllsrslrlslhhslVSMFVTSLTTASTFLTNLSSPVIVLRCFGVYAALTVTVNYILVVLILPGaiILSRPIRKKLS 503
Cdd:pfam12349 83 ------------------PSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVA--VLSLDIRRLES 142
|
|
| COG4258 |
COG4258 |
Predicted exporter [General function prediction only]; |
760-920 |
2.79e-04 |
|
Predicted exporter [General function prediction only];
Pssm-ID: 443400 [Multi-domain] Cd Length: 783 Bit Score: 44.84 E-value: 2.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 760 EITRFYdivSQLRSSSFTSVAISLGICLIVIIACTRVIKLSIISSVIIFFVILWTVASLILLGWQLSVVESTILIITIGL 839
Cdd:COG4258 629 ESSSLF---GRYRNDALWLLLLALLLILLLLLLRLRSLRRALRVLLPPLLAVLLTLAILGLLGIPLNLFHLIALLLVLGI 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 840 SFDYTLhYVVAIRDTKCVPASEKLT---SAHSTAGiacVFGSltlflagcpLLFSQTASFYQIGTMlVILGI-TSLFGAS 915
Cdd:COG4258 706 GIDYAL-FFTEGLLDKGELARTLLSillAALTTLL---GFGL---------LAFSSTPALRSFGLT-VLLGIlLALLLAP 771
|
....*
gi 71988521 916 IVLPS 920
Cdd:COG4258 772 LLAPR 776
|
|
| 2A060602 |
TIGR00918 |
The Eukaryotic (Putative) Sterol Transporter (EST) Family; |
764-925 |
1.12e-03 |
|
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
Pssm-ID: 273338 [Multi-domain] Cd Length: 1145 Bit Score: 42.95 E-value: 1.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 764 FYDIVSQLRSSSFTSVAISLgICLIVIIActrVIKLSIISSVIIFFVILWTVASLI----LLGWQLSVVESTILIITIGL 839
Cdd:TIGR00918 956 FWEQYMGLRHWLLLSISVVL-ACTFLVCA---LLLLNPWTAGLIVLVLALMTVELFgmmgLLGIKLSAIPVVILIASVGI 1031
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 840 SFDYTLHYVVAI------RDTKCVPASEkltsaHSTAGIacVFGSLT-----LFLAGCPLLFSqTASFYQIGTMLVILGi 908
Cdd:TIGR00918 1032 GVEFTVHIALGFltaigdRNRRAVLALE-----HMFAPV--LDGALStllgvLMLAGSEFDFI-VRYFFAVLAVLTCLG- 1102
|
170
....*....|....*..
gi 71988521 909 tsLFGASIVLPSFLMVF 925
Cdd:TIGR00918 1103 --VLNGLVLLPVLLSMF 1117
|
|
| MMPL |
pfam03176 |
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ... |
779-926 |
2.38e-03 |
|
MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.
Pssm-ID: 308676 [Multi-domain] Cd Length: 332 Bit Score: 41.12 E-value: 2.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 779 VAISLGICLIVIIActrvikLSIISSVIIFFVILWTVA-SL-----ILLGWQ------LSVVESTIL-IITIGLSFDYTL 845
Cdd:pfam03176 146 LIEAVTLVVIFIIL------LIVYRSVVAALLPLLTVGlSLgaaqgLVAILAhilgigLSTFALNLLvVLLIAVGTDYAL 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 846 HYVVAIRDTkcVPASEK-----LTSAHSTAGiACVFGSLTLFLAGCPLLFSQTASFYQIGTMlviLGITSLFGASIVL-- 918
Cdd:pfam03176 220 FLVSRYREE--LRAGEDreeavIRAVRGTGK-VVTAAGLTVAIAMLALSFARLPVFAQVGPT---IAIGVLVDVLAALtl 293
|
....*....
gi 71988521 919 -PSFLMVFS 926
Cdd:pfam03176 294 lPALLALLG 302
|
|
| HpnN |
TIGR03480 |
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing ... |
788-922 |
3.07e-03 |
|
hopanoid biosynthesis associated RND transporter like protein HpnN; The genomes containing members of this family share the machinery for the biosynthesis of hopanoid lipids. Furthermore, the genes of this family are usually located proximal to other components of this biological process. The proteins appear to be related to the RND family of export proteins, particularly the hydrophobe/amphiphile efflux-3 (HAE3) family represented by TIGR00921.
Pssm-ID: 274598 [Multi-domain] Cd Length: 862 Bit Score: 41.52 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 71988521 788 IVIIACTRVIKLSIISSVIIFFVIL--WTVASLILLGWQLSVVESTILIITIGLSF----------------DYTLHYVV 849
Cdd:TIGR03480 709 TVVGAFLQAFIYALVAITVLLLLTLrrVRDVLLVLAPLLLAGLLTVAAMVLLGIPFnfaniialplllglgvDFGIYMVH 788
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 71988521 850 AIRdtkcvpASEKLTSA-HSTAGIACVFGSLTLFLAGCPLLFSQ---TASfyqIGTMLVILGITSLFGASIVLPSFL 922
Cdd:TIGR03480 789 RWR------NGVDSGNLlQSSTARAVFFSALTTATAFGSLAVSShpgTAS---MGILLSLGLGLTLLCTLIFLPALL 856
|
|
| |
