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Conserved domains on  [gi|17558734|ref|NP_506307|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 12-310 1.25e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.87  E-value: 1.25e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    12 LASEIGFFSTLIVNSFLVHLIIFYTKQVFGAYKYLVLSFSLMGIVFATAEFIVKPMTHNYKASFTFFTLERPFKCSKETA 91
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    92 MILLAAYSSTYAATISLLAVQFVYRYWAIFHVRRLSFFNGIWILFWIFLAMMFGVDWSCSVYFLGMPDKVSEDYLRLEIS 171
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   172 DQYNLNITRLAYFSAVVY----DSEYHIRWRSVMVMGSVSKVLSIQYAVMIFCGVRMHFKMAEKMEQFSITNRKMHKQLF 247
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYptdeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558734   248 KTLVVQITVPTFTIFMPVMFMFLIPFFDLQLGIPTGVLLCALSLYPFIDGLIVISIVSDYRKA 310
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 12-310 1.25e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.87  E-value: 1.25e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    12 LASEIGFFSTLIVNSFLVHLIIFYTKQVFGAYKYLVLSFSLMGIVFATAEFIVKPMTHNYKASFTFFTLERPFKCSKETA 91
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    92 MILLAAYSSTYAATISLLAVQFVYRYWAIFHVRRLSFFNGIWILFWIFLAMMFGVDWSCSVYFLGMPDKVSEDYLRLEIS 171
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   172 DQYNLNITRLAYFSAVVY----DSEYHIRWRSVMVMGSVSKVLSIQYAVMIFCGVRMHFKMAEKMEQFSITNRKMHKQLF 247
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYptdeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558734   248 KTLVVQITVPTFTIFMPVMFMFLIPFFDLQLGIPTGVLLCALSLYPFIDGLIVISIVSDYRKA 310
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 12-310 1.25e-109

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 322.87  E-value: 1.25e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    12 LASEIGFFSTLIVNSFLVHLIIFYTKQVFGAYKYLVLSFSLMGIVFATAEFIVKPMTHNYKASFTFFTLERPFKCSKETA 91
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    92 MILLAAYSSTYAATISLLAVQFVYRYWAIFHVRRLSFFNGIWILFWIFLAMMFGVDWSCSVYFLGMPDKVSEDYLRLEIS 171
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   172 DQYNLNITRLAYFSAVVY----DSEYHIRWRSVMVMGSVSKVLSIQYAVMIFCGVRMHFKMAEKMEQFSITNRKMHKQLF 247
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYptdeNGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558734   248 KTLVVQITVPTFTIFMPVMFMFLIPFFDLQLGIPTGVLLCALSLYPFIDGLIVISIVSDYRKA 310
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNA 305
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 16-309 6.75e-44

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 153.94  E-value: 6.75e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    16 IGFFSTLIVNSFLVHLIIFYTKQVFGAYKYLVLSFSLMGIVFATAEFIVKPMTHNYKASFTFFTLERPFKCSKETAMILL 95
Cdd:pfam10319  13 IFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHAL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    96 AAYSSTYAATISLLAVQFVYRYWAIFHVRRLS-FFNGIWILFWIFLAMMFGVDWSCSVYFLGMPDKVSEDYLRLEISDQY 174
Cdd:pfam10319  93 SARCSFISASYAVLLIHFIYRYLVLFNPQLTRhYFRPWGILISILFFLFHGSVWTAICYFLLRANDEIRDYIREDFRETY 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   175 NLNITRLAYFSAVVYDSEYHIRWRSVMVMGSVSKVLSIQYAVMIFCGVRMHFKMAEKMEQFSITNRKMHKQLFKTLVVQI 254
Cdd:pfam10319 173 GVDSMDINMLGALYWEASDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQT 252

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17558734   255 TVPTFTIFMPVMFMFLIPFFDLQLGIPTGVL-LCALSLYPFIDGLIVISIVSDYRK 309
Cdd:pfam10319 253 IIPICISFSPCVLAWYSPIFGIDLGRWNNYLeVIALSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 18-310 7.16e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 53.32  E-value: 7.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    18 FFSTLIVNSFLVHLIIFYTKQVFGAYKYLVLSFSLMGIVFATAEFIVKPMTHNYKASFTFFTLERPFKCSKETAMILLAA 97
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSGYSL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    98 YSSTYAATISLLAVQFVYRYWAIFHV---RRLSFFNGIWILFWIFLAMMfgvdwscsVYFLGMPDKVSEDYLRLEISDQY 174
Cdd:pfam10317  89 LQHFLLHSGWSLLLTFYYRYYILKHVdpkRKKLILLIIIHYIPSLSQLI--------VIFLSPTDFLPVEALTKELHPNY 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   175 NLNITRLAYFSAVvydseyhIRWRSVMVMGSVSKVLSIQYAVMIFCGVRMHFKMAEKMEQFSITNRKMHKQLFKTLVVQI 254
Cdd:pfam10317 161 NLTDYTVTGFSDL-------QSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQA 233

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 17558734   255 TVPTFTIFMPVMFMFLIPFFDLQLGIPTGVLLCALSLYPFIDGLIVISIVSDYRKA 310
Cdd:pfam10317 234 LLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRA 289
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 16-271 2.20e-06

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 48.70  E-value: 2.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    16 IGFFStLIVNSFLVHLIIFYTKQVFGaYKYLVLSF---SLMGIVFATaeFIVKPM-------THNYKASFTFFTLerpfk 85
Cdd:pfam10327  18 IGTIS-LILNLLGIYLIIFKSGKIDN-FRYYLLYFqisCTLTDIHLT--FLMQPIplfpiiaGYCNGFLATVFGI----- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    86 cskeTAMILLAAYSSTYAATISLLAVQFVYRYWAIFHVRRLSFFNGIWILFWIFLAMMFGVDWSCSVYFLGMPDKVSEDY 165
Cdd:pfam10327  89 ----SSHYLMTIFVFLLSFQLESLLLCFVRKHQAIAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQLEY 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   166 LRlEISDQYNLNITRLAYFSAVVYDSEYHIRWRSVMVMGSVSkvlsiqYAVMIFCGVRMhFKMAEKME-QFSITNRKMHK 244
Cdd:pfam10327 165 VK-ENYPEYLSQFSSLPNFAIYDYNPWLIVFGILAIFGGSLS------FLILVYLTVDM-FRMLKRLRkKISAQTYQKHR 236

                         250       260
                  ....*....|....*....|....*..
gi 17558734   245 QLFKTLVVQITVPTFTIFMPVMFMFLI 271
Cdd:pfam10327 237 AALRSLIAQFATSPVCILPPFAFVVVV 263
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 16-317 2.18e-05

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 45.61  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    16 IGFFStLIVNSFLVHLIIFYTKQVFGAYKYLVLSFSLMGIVF-ATAEFIVKPMTH-NYKASFTFFTLERPFKCSKETAMI 93
Cdd:pfam10318  13 ITVIS-IPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLdLSLSFLTIPYIFlPALAGYPLGLLSYLGVPTPIQFYI 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734    94 LLAAYSSTYAATISLlavqFVYRYWAIFHVRRLS---FFNGIWILFWIFLAMMFgvdwsCSVYFLGMPDkvsEDYLRLEI 170
Cdd:pfam10318  92 GVTSLALVGVSIILL----FENRYSILFTNKKRItwkKTRVLYLIFNYIIALLF-----LIPIYLNIPD---QEAAKLKV 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   171 SDQY---NLNITRLAYFSAVVYDSEYHIRWRSVMVMgsvskVLSIQYAVMIFCgVRMHFKMAEKMeQFSITNRKMHKQLF 247
Cdd:pfam10318 160 LKKLpclPPEFFDNPPVFVLAIDSTYFLICIVLLIL-----ILIIQILFFVFL-TIYYLFKSVKS-SLSKKTRKLQKKFF 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558734   248 KTLVVQITVPTFTIFMPVMFMFLIPFFDLQLGIPTGVLLCALSLYPFIDGLIVISIVSDYRKAAIEVFRR 317
Cdd:pfam10318 233 IALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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