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Conserved domains on  [gi|17561280|ref|NP_506418|]
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WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-341 1.29e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 1.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280  39 IVIGGRDRRCEIYKFTSDQQLYasawSNKNDIKFrlaVGTVSDVSVNPCAA-----NKVSIVQLkdETGELVETasFPM- 112
Cdd:cd00200  24 LATGSGDGTIKVWDLETGELLR----TLKGHTGP---VRDVAASADGTYLAsgssdKTIRLWDL--ETGECVRT--LTGh 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 113 EFPANAVGFIPDPDnvypdLIATTSD--CLRLWRVVDGKV------HPDAVMinntnsqygsaLTSFDWNelePRYIGVS 184
Cdd:cd00200  93 TSYVSSVAFSPDGR-----ILSSSSRdkTIKVWDVETGKClttlrgHTDWVN-----------SVAFSPD---GTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 185 SVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAKINGgrdHFATVGADGSARMFDLR-------HLNH 257
Cdd:cd00200 154 SQDGTIKLWDLRTG------------KCVATLTGHTGEVNSVAFSPDGE---KLLSSSSDGTIKLWDLStgkclgtLRGH 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 258 STIVYEdpnkeklqrLSWNKQEPYFMALFAENSqeVQILDIRMpCNILCRLRNHTGPVNGIAWAPHSPhHICTAGDDSQA 337
Cdd:cd00200 219 ENGVNS---------VAFSPDGYLLASGSEDGT--IRVWDLRT-GECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                ....
gi 17561280 338 LIWD 341
Cdd:cd00200 286 RIWD 289
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 308-385 1.34e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 308 LRNHTGPVNGIAWAPHSPHhICTAGDDSQALIWDLQQvprpvDDPILAYS-AGGEVNQIHWGPvHSNWIAIC-FNKTLEI 385
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-----GELLRTLKgHTGPVRDVAASA-DGTYLASGsSDKTIRL 77
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-341 1.29e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 1.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280  39 IVIGGRDRRCEIYKFTSDQQLYasawSNKNDIKFrlaVGTVSDVSVNPCAA-----NKVSIVQLkdETGELVETasFPM- 112
Cdd:cd00200  24 LATGSGDGTIKVWDLETGELLR----TLKGHTGP---VRDVAASADGTYLAsgssdKTIRLWDL--ETGECVRT--LTGh 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 113 EFPANAVGFIPDPDnvypdLIATTSD--CLRLWRVVDGKV------HPDAVMinntnsqygsaLTSFDWNelePRYIGVS 184
Cdd:cd00200  93 TSYVSSVAFSPDGR-----ILSSSSRdkTIKVWDVETGKClttlrgHTDWVN-----------SVAFSPD---GTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 185 SVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAKINGgrdHFATVGADGSARMFDLR-------HLNH 257
Cdd:cd00200 154 SQDGTIKLWDLRTG------------KCVATLTGHTGEVNSVAFSPDGE---KLLSSSSDGTIKLWDLStgkclgtLRGH 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 258 STIVYEdpnkeklqrLSWNKQEPYFMALFAENSqeVQILDIRMpCNILCRLRNHTGPVNGIAWAPHSPhHICTAGDDSQA 337
Cdd:cd00200 219 ENGVNS---------VAFSPDGYLLASGSEDGT--IRVWDLRT-GECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                ....
gi 17561280 338 LIWD 341
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
100-343 1.48e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 1.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 100 ETGELVETASFPmEFPANAVGFIPDPDnvypdLIATTSD--CLRLWRVVDGKV------HPDAVminntnsqygsalTSF 171
Cdd:COG2319 150 ATGKLLRTLTGH-SGAVTSVAFSPDGK-----LLASGSDdgTVRLWDLATGKLlrtltgHTGAV-------------RSV 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 172 DWNeleP--RYIGVSSVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAkiNGGRdHFATVGADGSARM 249
Cdd:COG2319 211 AFS---PdgKLLASGSADGTVRLWDLATG------------KLLRTLTGHSGSVRSVAFS--PDGR-LLASGSADGTVRL 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 250 FDLRhlnhstivyedpNKEKLQRLSWNKQEPYFMA--------LFAENSQEVQILDIRMPcNILCRLRNHTGPVNGIAWA 321
Cdd:COG2319 273 WDLA------------TGELLRTLTGHSGGVNSVAfspdgkllASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFS 339

                       250       260
                ....*....|....*....|..
gi 17561280 322 PHSpHHICTAGDDSQALIWDLQ 343
Cdd:COG2319 340 PDG-KTLASGSDDGTVRLWDLA 360
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-341 2.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17561280    303 NILCRLRNHTGPVNGIAWAPHSpHHICTAGDDSQALIWD 341
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 308-385 1.34e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 308 LRNHTGPVNGIAWAPHSPHhICTAGDDSQALIWDLQQvprpvDDPILAYS-AGGEVNQIHWGPvHSNWIAIC-FNKTLEI 385
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-----GELLRTLKgHTGPVRDVAASA-DGTYLASGsSDKTIRL 77
WD40 pfam00400
WD domain, G-beta repeat;
303-341 1.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17561280   303 NILCRLRNHTGPVNGIAWAPHSPhHICTAGDDSQALIWD 341
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-341 1.29e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.50  E-value: 1.29e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280  39 IVIGGRDRRCEIYKFTSDQQLYasawSNKNDIKFrlaVGTVSDVSVNPCAA-----NKVSIVQLkdETGELVETasFPM- 112
Cdd:cd00200  24 LATGSGDGTIKVWDLETGELLR----TLKGHTGP---VRDVAASADGTYLAsgssdKTIRLWDL--ETGECVRT--LTGh 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 113 EFPANAVGFIPDPDnvypdLIATTSD--CLRLWRVVDGKV------HPDAVMinntnsqygsaLTSFDWNelePRYIGVS 184
Cdd:cd00200  93 TSYVSSVAFSPDGR-----ILSSSSRdkTIKVWDVETGKClttlrgHTDWVN-----------SVAFSPD---GTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 185 SVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAKINGgrdHFATVGADGSARMFDLR-------HLNH 257
Cdd:cd00200 154 SQDGTIKLWDLRTG------------KCVATLTGHTGEVNSVAFSPDGE---KLLSSSSDGTIKLWDLStgkclgtLRGH 218

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 258 STIVYEdpnkeklqrLSWNKQEPYFMALFAENSqeVQILDIRMpCNILCRLRNHTGPVNGIAWAPHSPhHICTAGDDSQA 337
Cdd:cd00200 219 ENGVNS---------VAFSPDGYLLASGSEDGT--IRVWDLRT-GECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                ....
gi 17561280 338 LIWD 341
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
100-343 1.48e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 1.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 100 ETGELVETASFPmEFPANAVGFIPDPDnvypdLIATTSD--CLRLWRVVDGKV------HPDAVminntnsqygsalTSF 171
Cdd:COG2319 150 ATGKLLRTLTGH-SGAVTSVAFSPDGK-----LLASGSDdgTVRLWDLATGKLlrtltgHTGAV-------------RSV 210

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 172 DWNeleP--RYIGVSSVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAkiNGGRdHFATVGADGSARM 249
Cdd:COG2319 211 AFS---PdgKLLASGSADGTVRLWDLATG------------KLLRTLTGHSGSVRSVAFS--PDGR-LLASGSADGTVRL 272

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 250 FDLRhlnhstivyedpNKEKLQRLSWNKQEPYFMA--------LFAENSQEVQILDIRMPcNILCRLRNHTGPVNGIAWA 321
Cdd:COG2319 273 WDLA------------TGELLRTLTGHSGGVNSVAfspdgkllASGSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFS 339

                       250       260
                ....*....|....*....|..
gi 17561280 322 PHSpHHICTAGDDSQALIWDLQ 343
Cdd:COG2319 340 PDG-KTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
95-343 5.83e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 5.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280  95 VQLKDETGELVETASFPMEFPANAVGFipDPDNvypDLIATTSD--CLRLWRVVDGKV------HPDAVminntnsqygs 166
Cdd:COG2319 102 VRLWDLATGLLLRTLTGHTGAVRSVAF--SPDG---KTLASGSAdgTVRLWDLATGKLlrtltgHSGAV----------- 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 167 alTSFDWNeleP--RYIGVSSVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAKiNGGRdhFATVGAD 244
Cdd:COG2319 166 --TSVAFS---PdgKLLASGSDDGTVRLWDLATG------------KLLRTLTGHTGAVRSVAFSP-DGKL--LASGSAD 225

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 245 GSARMFDLRhlnhstivyedpNKEKLQRLSWNKQEPYFMA--------LFAENSQEVQILDIRmPCNILCRLRNHTGPVN 316
Cdd:COG2319 226 GTVRLWDLA------------TGKLLRTLTGHSGSVRSVAfspdgrllASGSADGTVRLWDLA-TGELLRTLTGHSGGVN 292

                       250       260
                ....*....|....*....|....*..
gi 17561280 317 GIAWAPHSpHHICTAGDDSQALIWDLQ 343
Cdd:COG2319 293 SVAFSPDG-KLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 115-386 4.91e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.80  E-value: 4.91e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 115 PANAVGFIPDPDnvypdLIATTSD--CLRLWRVVDG------KVHPDAVminntnsqygSALTSFDWNEleprYIGVSSV 186
Cdd:cd00200  11 GVTCVAFSPDGK-----LLATGSGdgTIKVWDLETGellrtlKGHTGPV----------RDVAASADGT----YLASGSS 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 187 DTTCTIYDVEVGCaigqtkptapftLKTQLIAHDKPVHDIEFakiNGGRDHFATVGADGSARMFDLRHLN-------HST 259
Cdd:cd00200  72 DKTIRLWDLETGE------------CVRTLTGHTSYVSSVAF---SPDGRILSSSSRDKTIKVWDVETGKclttlrgHTD 136

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 260 IVYedpnkeklqRLSWNKQEPYfmALFAENSQEVQILDIRmPCNILCRLRNHTGPVNGIAWAPhSPHHICTAGDDSQALI 339
Cdd:cd00200 137 WVN---------SVAFSPDGTF--VASSSQDGTIKLWDLR-TGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKL 203

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 17561280 340 WDLQqvprpvddpilaysaggEVNQIHWGPVHSNWI-AICFNKTLEIL 386
Cdd:cd00200 204 WDLS-----------------TGKCLGTLRGHENGVnSVAFSPDGYLL 234
WD40 COG2319
WD40 repeat [General function prediction only];
100-343 2.01e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.52  E-value: 2.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 100 ETGELVETASFPmEFPANAVGFIPDPDnvypdLIATTSD--CLRLWRVVDGKV------HPDAVminntnsqygsalTSF 171
Cdd:COG2319 192 ATGKLLRTLTGH-TGAVRSVAFSPDGK-----LLASGSAdgTVRLWDLATGKLlrtltgHSGSV-------------RSV 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 172 DWNeleP--RYIGVSSVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAKiNGgrDHFATVGADGSARM 249
Cdd:COG2319 253 AFS---PdgRLLASGSADGTVRLWDLATG------------ELLRTLTGHSGGVNSVAFSP-DG--KLLASGSDDGTVRL 314

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 250 FDLR-------HLNHSTIVYE---DPNKEKLqrlswnkqepyfmaLFAENSQEVQILDIRMPcNILCRLRNHTGPVNGIA 319
Cdd:COG2319 315 WDLAtgkllrtLTGHTGAVRSvafSPDGKTL--------------ASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVA 379

                       250       260
                ....*....|....*....|....
gi 17561280 320 WAPHSpHHICTAGDDSQALIWDLQ 343
Cdd:COG2319 380 FSPDG-RTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 212-344 9.94e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 9.94e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 212 LKTQLIAHDKPVHDIEFakiNGGRDHFATVGADGSARMFDLRHLNHSTIVYEdpNKEKLQRLSWNKQEPYfMALFAENSQ 291
Cdd:cd00200   1 LRRTLKGHTGGVTCVAF---SPDGKLLATGSGDGTIKVWDLETGELLRTLKG--HTGPVRDVAASADGTY-LASGSSDKT 74

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 17561280 292 eVQILDIRMPCnILCRLRNHTGPVNGIAWAPHSpHHICTAGDDSQALIWDLQQ 344
Cdd:cd00200  75 -IRLWDLETGE-CVRTLTGHTSYVSSVAFSPDG-RILSSSSRDKTIKVWDVET 124
WD40 COG2319
WD40 repeat [General function prediction only];
178-343 1.61e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 1.61e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 178 PRYIGVSSVDTTCTIYDVEVGcaigqtkptapfTLKTQLIAHDKPVHDIEFAKiNGGRdhFATVGADGSARMFDLRhlnh 257
Cdd:COG2319  90 GRLLASASADGTVRLWDLATG------------LLLRTLTGHTGAVRSVAFSP-DGKT--LASGSADGTVRLWDLA---- 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 258 stivyedpNKEKLQRLSWNKQEPYFMAlFAENSQ---------EVQILDIRMPcNILCRLRNHTGPVNGIAWAPHSpHHI 328
Cdd:COG2319 151 --------TGKLLRTLTGHSGAVTSVA-FSPDGKllasgsddgTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDG-KLL 219

                       170
                ....*....|....*
gi 17561280 329 CTAGDDSQALIWDLQ 343
Cdd:COG2319 220 ASGSADGTVRLWDLA 234
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 303-341 2.06e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 2.06e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 17561280    303 NILCRLRNHTGPVNGIAWAPHSpHHICTAGDDSQALIWD 341
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 308-385 1.34e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.48  E-value: 1.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17561280 308 LRNHTGPVNGIAWAPHSPHhICTAGDDSQALIWDLQQvprpvDDPILAYS-AGGEVNQIHWGPvHSNWIAIC-FNKTLEI 385
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-----GELLRTLKgHTGPVRDVAASA-DGTYLASGsSDKTIRL 77
WD40 pfam00400
WD domain, G-beta repeat;
303-341 1.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.15e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 17561280   303 NILCRLRNHTGPVNGIAWAPHSPhHICTAGDDSQALIWD 341
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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