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Conserved domains on  [gi|17564226|ref|NP_506789|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-324 1.74e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 288.97  E-value: 1.74e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    10 TYYVECICFGVAVFLNTILLILIREKPRLAFGKYKYLMMVFSILEILYAIMYFWCKPNAHVTQTSFTIFTILENSHVSKD 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    90 IGVIAVTIWCSFYAMMLSLLSIHFFYRYTSVTAPILLmKRFSCRYIFKYTLYILTFSSIWGLSCYFLCGPTENKDYELKL 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   170 EFEEAYCLEPDEYSYVGPQYFYEhrkiidsnEEIREKIFHLPSFLGIGIIAVLMVGILVSSALFGAETY-KILNAQGLAC 248
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPT--------DENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYfKMKKLKSLGS 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564226   249 YAAKELQKQLFKTLVIQSSIPMIFMVLPITCMFLLPFFGVKVGEVANLIPMCAAIYPCLNPMIAMIFIKDFSNRII 324
Cdd:pfam10326 232 EKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-324 1.74e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 288.97  E-value: 1.74e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    10 TYYVECICFGVAVFLNTILLILIREKPRLAFGKYKYLMMVFSILEILYAIMYFWCKPNAHVTQTSFTIFTILENSHVSKD 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    90 IGVIAVTIWCSFYAMMLSLLSIHFFYRYTSVTAPILLmKRFSCRYIFKYTLYILTFSSIWGLSCYFLCGPTENKDYELKL 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   170 EFEEAYCLEPDEYSYVGPQYFYEhrkiidsnEEIREKIFHLPSFLGIGIIAVLMVGILVSSALFGAETY-KILNAQGLAC 248
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPT--------DENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYfKMKKLKSLGS 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564226   249 YAAKELQKQLFKTLVIQSSIPMIFMVLPITCMFLLPFFGVKVGEVANLIPMCAAIYPCLNPMIAMIFIKDFSNRII 324
Cdd:pfam10326 232 EKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 10-324 1.74e-96

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 288.97  E-value: 1.74e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    10 TYYVECICFGVAVFLNTILLILIREKPRLAFGKYKYLMMVFSILEILYAIMYFWCKPNAHVTQTSFTIFTILENSHVSKD 89
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    90 IGVIAVTIWCSFYAMMLSLLSIHFFYRYTSVTAPILLmKRFSCRYIFKYTLYILTFSSIWGLSCYFLCGPTENKDYELKL 169
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKL-KYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLRE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   170 EFEEAYCLEPDEYSYVGPQYFYEhrkiidsnEEIREKIFHLPSFLGIGIIAVLMVGILVSSALFGAETY-KILNAQGLAC 248
Cdd:pfam10326 160 ELLENYNLDIDEVAYVGPVYYPT--------DENGSKVIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYfKMKKLKSLGS 231

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564226   249 YAAKELQKQLFKTLVIQSSIPMIFMVLPITCMFLLPFFGVKVGEVANLIPMCAAIYPCLNPMIAMIFIKDFSNRII 324
Cdd:pfam10326 232 EKTRKLQKQLFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 11-323 6.69e-29

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 113.88  E-value: 6.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    11 YYVECICFGVAVFLNTILLILIREKPRLAFGKYKYLMMVFSILEILYAIMYFWCKPNAHVTQTSFTIFTILENSHVSKDI 90
Cdd:pfam10319   8 YYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSEL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    91 GVIAVTIWCSFYAMMLSLLSIHFFYRYTSVTAPILLMKRFSCRYIFKYTLYILTFSSIWGLSCYFLCGPT-ENKDYeLKL 169
Cdd:pfam10319  88 GQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTRHYFRPWGILISILFFLFHGSVWTAICYFLLRANdEIRDY-IRE 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   170 EFEEAYCLEPDEYSYVGPQYFyehrkiiDSNEEIREKifhlpSFLGIGIIAVLMVGILVSSALFGAET-YKILNAQGLAC 248
Cdd:pfam10319 167 DFRETYGVDSMDINMLGALYW-------EASDETVFR-----SWLGILLLTVISVYSIILYIVLGYKImRKLNKMSVTMS 234

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17564226   249 YAAKELQKQLFKTLVIQSSIPMIFMVLPITCMFLLPFFGVKVGEVANLIPMCA-AIYPCLNPMIAMIFIKDFSNRI 323
Cdd:pfam10319 235 KKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLEVIAlSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 15-324 9.12e-11

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 61.80  E-value: 9.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    15 CICFGVAVFLNTILLILIREKPRLAFGKYKYLMMVFSILEILYAIMYFWCKPNAHVTQTSFTIFTILENSHVSKDIGVIA 94
Cdd:pfam10317   6 PIFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIIPNGVSMALISYGPCKYFGPWFCYSG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    95 VTIWCSFYAMMLSLLSIHFFYRYTsvtapILLMKRFSCRYIFKYTLYILTFSSIWGLSCYFLCGPTENKDYELKLEFeea 174
Cdd:pfam10317  86 YSLLQHFLLHSGWSLLLTFYYRYY-----ILKHVDPKRKKLILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELH--- 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   175 yclepdeysyvgPQYFYEHRKIIDSneeirEKIFHLPSFLGIGIIAVLMVGILVSSALFGAETYKILNAQGLACYAA-KE 253
Cdd:pfam10317 158 ------------PNYNLTDYTVTGF-----SDLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTtKA 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17564226   254 LQKQLFKTLVIQSSIPMIFMVLPITCMFLLPFFGVKVGEVANLIPMCAAIYPCLNPMIAMIFIKDFSNRII 324
Cdd:pfam10317 221 QHRQLIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 90-329 6.86e-04

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 40.99  E-value: 6.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    90 IGVIAVTIWCSFYAMMLSLLSIhFFYRYTSVTAPILLMKRFSCRYIFKYTLYILTFssiwglsCYFLCGPTENKDYEL-K 168
Cdd:pfam10318  85 TPIQFYIGVTSLALVGVSIILL-FENRYSILFTNKKRITWKKTRVLYLIFNYIIAL-------LFLIPIYLNIPDQEAaK 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   169 LEFEEAY-CLepdeysyvgPQYFYEHRKIIDSNEEIREKIFHLPSFLGIGIIAVLMVGILVSSALFGAETYKIlnaqgla 247
Cdd:pfam10318 157 LKVLKKLpCL---------PPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSL------- 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   248 CYAAKELQKQLFKTLVIQSSIPMIFMVLPITCMFLLPFFGVKVGEVANLIPMCAAIYpCLNPMIAMIFI-KDFSNRIIEI 326
Cdd:pfam10318 221 SKKTRKLQKKFFIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLH-GLLSTIAMLLVhKPYRKFVLSL 299


                  ...
gi 17564226   327 ITC 329
Cdd:pfam10318 300 FKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
 6-315 7.49e-03

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 37.91  E-value: 7.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226     6 WLNVTYYvecICFGVAVFLNTILLILIREKPRlAFGKYKYLMMVFSILEILYAI-MYFWCKP-------NAHVTQTSFTI 77
Cdd:pfam10327  10 WLILYYH---IIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIhLTFLMQPiplfpiiAGYCNGFLATV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226    78 FTIleNSHvskdigvIAVTIWCSFYAMMLSLLSIHFFYRYTSVTapiLLMKRFSCRYIFKYTLYILT--FSSIWGLSCYF 155
Cdd:pfam10327  86 FGI--SSH-------YLMTIFVFLLSFQLESLLLCFVRKHQAIA---KILSKHVIPKWLYIFLYILChiFPFLTAFLFYQ 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   156 LCgptenKDYELKLEF-EEAYclepdeysyvgPQYFYEHRKIidSNEEIREKIFHLPSFLGIGIIAVLMVGILVSsaLFG 234
Cdd:pfam10327 154 SG-----LSREEQLEYvKENY-----------PEYLSQFSSL--PNFAIYDYNPWLIVFGILAIFGGSLSFLILV--YLT 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17564226   235 AETYKILnaqglacyaaKELQKQL-----------FKTLVIQSSIPMIFMVLPITCMFLLPFFGVKVGEVANLIPMCAAI 303
Cdd:pfam10327 214 VDMFRML----------KRLRKKIsaqtyqkhraaLRSLIAQFATSPVCILPPFAFVVVVLFPIEYSQEISEILLAIFST 283

                         330
                  ....*....|..
gi 17564226   304 YPCLNpMIAMIF 315
Cdd:pfam10327 284 HSSVN-SIVLIL 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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