NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17558972|ref|NP_506891|]
View 

Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 21-320 3.26e-110

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 324.02  E-value: 3.26e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972    21 AQLVAQIGFFTTTVFCGILIFLTVFGGQKNFGSYKNLLVLFSTVGIFFSVVELTLYPNVHSFYAGYFFYSTQRPFGLKIE 100
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   101 IVQVLMAFYTSIYASTICMLAVQFVYRYWAIFNESLLHYFKGWRFLFSIAYSFIVGAQWGLSIYFFDEMDDYTDNYMRNE 180
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   181 MWERYDINISQVAKMALVAY--NDDGS--IRWWNVCCIIDMTVFMIVQYSIVIYCAVVMYQKMEEKLQLVSASLRELHRQ 256
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17558972   257 FFKTLIMQILSPTICLFAPVVFIIYLPIFNFEVSIPTGMFLCAFTLYPALDALIIMYIVKDYRK 320
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRN 304
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 21-320 3.26e-110

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 324.02  E-value: 3.26e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972    21 AQLVAQIGFFTTTVFCGILIFLTVFGGQKNFGSYKNLLVLFSTVGIFFSVVELTLYPNVHSFYAGYFFYSTQRPFGLKIE 100
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   101 IVQVLMAFYTSIYASTICMLAVQFVYRYWAIFNESLLHYFKGWRFLFSIAYSFIVGAQWGLSIYFFDEMDDYTDNYMRNE 180
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   181 MWERYDINISQVAKMALVAY--NDDGS--IRWWNVCCIIDMTVFMIVQYSIVIYCAVVMYQKMEEKLQLVSASLRELHRQ 256
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17558972   257 FFKTLIMQILSPTICLFAPVVFIIYLPIFNFEVSIPTGMFLCAFTLYPALDALIIMYIVKDYRK 320
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRN 304
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 21-320 3.26e-110

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 324.02  E-value: 3.26e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972    21 AQLVAQIGFFTTTVFCGILIFLTVFGGQKNFGSYKNLLVLFSTVGIFFSVVELTLYPNVHSFYAGYFFYSTQRPFGLKIE 100
Cdd:pfam10326   1 LHIIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   101 IVQVLMAFYTSIYASTICMLAVQFVYRYWAIFNESLLHYFKGWRFLFSIAYSFIVGAQWGLSIYFFDEMDDYTDNYMRNE 180
Cdd:pfam10326  81 VGQILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   181 MWERYDINISQVAKMALVAY--NDDGS--IRWWNVCCIIDMTVFMIVQYSIVIYCAVVMYQKMEEKLQLVSASLRELHRQ 256
Cdd:pfam10326 161 LLENYNLDIDEVAYVGPVYYptDENGSkvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQ 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17558972   257 FFKTLIMQILSPTICLFAPVVFIIYLPIFNFEVSIPTGMFLCAFTLYPALDALIIMYIVKDYRK 320
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRN 304
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 14-320 2.37e-30

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 117.73  E-value: 2.37e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972    14 YQNWvtIAQLVAQIGFFTTTVFCGILIFLTVFGGQKNFGSYKNLLVLFSTVGIFFSVVELTLYPNVHSFYAGYFFYSTQR 93
Cdd:pfam10319   2 YINW--AHYYIPKIFGVLSFIVNPIFIYLIFTEKSSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972    94 PFGLKIEIVQVLMAFYTSIYASTICMLAVQFVYRYWAIFNESLL-HYFKGWRFLFSIAYSFIVGAQWGLSIYFFDEMDDY 172
Cdd:pfam10319  80 PFFEYSELGQHALSARCSFISASYAVLLIHFIYRYLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLLRANDE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   173 TDNYMRNEMWERYDINISQVAKMALVAYNDDGSIRWWNVCCIIDMTVFMIvqYSIVIYcaVVMYQKMEEKLQ----LVSA 248
Cdd:pfam10319 160 IRDYIREDFRETYGVDSMDINMLGALYWEASDETVFRSWLGILLLTVISV--YSIILY--IVLGYKIMRKLNkmsvTMSK 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558972   249 SLRELHRQFFKTLIMQILSPTICLFAPVVFIIYLPIFNFEVSIPTGMF-LCAFTLYPALDALIIMYIVKDYRK 320
Cdd:pfam10319 236 KTKRLQKQLLKALIVQTIIPICISFSPCVLAWYSPIFGIDLGRWNNYLeVIALSAFPFIDPLAIILCLPVYRN 308
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 101-327 1.16e-09

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 58.71  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   101 IVQVLMAFyTSIYASTICMLAVqFVYRYWAIFNESLLHYFKGWRFLFSIAYSFIVgaqWGLSIYFFDEMDDytDNYMRNE 180
Cdd:pfam10318  86 PIQFYIGV-TSLALVGVSIILL-FENRYSILFTNKKRITWKKTRVLYLIFNYIIA---LLFLIPIYLNIPD--QEAAKLK 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   181 MWERY---DINISQVAKMALVAYNDdgsirWWNVCCIIDMTVFMIVQysIVIYCAVVMYQKMEEKLQLVSASLRELHRQF 257
Cdd:pfam10318 159 VLKKLpclPPEFFDNPPVFVLAIDS-----TYFLICIVLLILILIIQ--ILFFVFLTIYYLFKSVKSSLSKKTRKLQKKF 231

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   258 FKTLIMQILSPTICLFAPVVFIIYLPIFNFEVSIPTGMFLCAFTLYPALDALIIMYIVKDYRKSAKRILK 327
Cdd:pfam10318 232 FIALIIQVSIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 29-324 1.48e-08

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 55.25  E-value: 1.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972    29 FFTTTVFCGILIFLTVFGGQKNFGSYKNLLVLFSTVGIFFSVVELTLYPNV--HSFYAGYFFYSTQRPFGLkiEIVQVLM 106
Cdd:pfam10317   9 FILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAITQIISCILAFFTQQRIipNGVSMALISYGPCKYFGP--WFCYSGY 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   107 AFYTSIYASTICMLAVQFVYRYWAIFNESLlhYFKGWRFLFSIAY--SFIVGAQWGLSIYFFDEMDDYTDNYMRNemwer 184
Cdd:pfam10317  87 SLLQHFLLHSGWSLLLTFYYRYYILKHVDP--KRKKLILLIIIHYipSLSQLIVIFLSPTDFLPVEALTKELHPN----- 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17558972   185 YDINISQVAkmalvaynddGSIRWWNVCCIID---MTVFMIVQYSIVIYCAVVMYQKMEEKLQLVSASLRELHRQFFKTL 261
Cdd:pfam10317 160 YNLTDYTVT----------GFSDLQSFPALINtliMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGL 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17558972   262 IMQILSPTICLFAPVVFIIYLPIFNFEVSIPTGMFLCAFTLYPALDALIIMYIVKDYRKSAKR 324
Cdd:pfam10317 230 TIQALLPLFSYIPGVTLYLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAILR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH