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Conserved domains on  [gi|17560050|ref|NP_507050|]
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Seven TM Receptor [Caenorhabditis elegans]

Protein Classification

class R serpentine receptor( domain architecture ID 10563422)

class R serpentine receptor, also known as seven TM receptor (Str), belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 19-319 9.62e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402099  Cd Length: 307  Bit Score: 293.21  E-value: 9.62e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    19 RVAQFGFFATTTSCTMLILLTLYGVKRDFGSYKNLLLMFSGLGIVFATTEVLLFPNLHSYKAGYFFYSMERPFGLDTKNV 98
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    99 SRFLVFYTGLYGSTICLLSVQFVYRYWAVFSESKLKFFKGWRLIFCIMYCAAFGADWGLSIYYFDEMDAYADHYFRAEMH 178
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   179 KRYRLNISEIAGFSLVAYNFDNT----PRWRNISCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSFAIRNLHRQFY 254
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17560050   255 KTLVIQIFTPTIFLFSPLIFIIFHPLFNVEIVVPTGMFLCAITIYPAADAIVIMYVVTDYRNTIK 319
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 19-319 9.62e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 293.21  E-value: 9.62e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    19 RVAQFGFFATTTSCTMLILLTLYGVKRDFGSYKNLLLMFSGLGIVFATTEVLLFPNLHSYKAGYFFYSMERPFGLDTKNV 98
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    99 SRFLVFYTGLYGSTICLLSVQFVYRYWAVFSESKLKFFKGWRLIFCIMYCAAFGADWGLSIYYFDEMDAYADHYFRAEMH 178
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   179 KRYRLNISEIAGFSLVAYNFDNT----PRWRNISCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSFAIRNLHRQFY 254
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17560050   255 KTLVIQIFTPTIFLFSPLIFIIFHPLFNVEIVVPTGMFLCAITIYPAADAIVIMYVVTDYRNTIK 319
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
 
Name Accession Description Interval E-value
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
 19-319 9.62e-99

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 293.21  E-value: 9.62e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    19 RVAQFGFFATTTSCTMLILLTLYGVKRDFGSYKNLLLMFSGLGIVFATTEVLLFPNLHSYKAGYFFYSMERPFGLDTKNV 98
Cdd:pfam10326   3 IIQYIGFFLSILLNSILIYLILFKSPKIFGTYKYLMIYFSIFGIFFSILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSVG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    99 SRFLVFYTGLYGSTICLLSVQFVYRYWAVFSESKLKFFKGWRLIFCIMYCAAFGADWGLSIYYFDEMDAYADHYFRAEMH 178
Cdd:pfam10326  83 QILLALYCGFYGVSISLLAVQFIYRYLALCRPGKLKYFDGKKLILWFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   179 KRYRLNISEIAGFSLVAYNFDNT----PRWRNISCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSFAIRNLHRQFY 254
Cdd:pfam10326 163 ENYNLDIDEVAYVGPVYYPTDENgskvIRWRSLIGLLIMTFIIGISFSIIIYCGIKMYFKMKKLKSLGSEKTRKLQKQLF 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 17560050   255 KTLVIQIFTPTIFLFSPLIFIIFHPLFNVEIVVPTGMFLCAITIYPAADAIVIMYVVTDYRNTIK 319
Cdd:pfam10326 243 KALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIALYPAIDPLPAMFIIKEYRNAIK 307
7TM_GPCR_Srj pfam10319
Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis ...
 44-318 7.76e-23

Serpentine type 7TM GPCR chemoreceptor Srj; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srj is part of the Str superfamily of chemoreceptors. The srj family is designated as the out-group based on its location in preliminary phylogenetic analyses of the entire superfamily. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 370974  Cd Length: 310  Bit Score: 96.16  E-value: 7.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    44 KRDFGSYKNLLLMFSGLGIVFATTEVLLFPNLHSYKAGYFFYSMERPFGLDTKNVSRFLVFYTGLYGSTICLLSVQFVYR 123
Cdd:pfam10319  34 SSQFGNYRYLLLFFAIFNLIYSVVELLVPLDIHSYRYCFVVFVSDGPFFEYSELGQHALSARCSFISASYAVLLIHFIYR 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   124 YWAVFSESKL-KFFKGWRLIFCIMYCAAFGADWGLSIYYF----DEMDAYADHYFRaemhKRYRLNISEIAGFSLVAYNF 198
Cdd:pfam10319 114 YLVLFNPQLTrHYFRPWGILISILFFLFHGSVWTAICYFLlranDEIRDYIREDFR----ETYGVDSMDINMLGALYWEA 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   199 DNTPRWRNISCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSFAIRNLHRQFYKTLVIQIFTPTIFLFSPLIFIIFH 278
Cdd:pfam10319 190 SDETVFRSWLGILLLTVISVYSIILYIVLGYKIMRKLNKMSVTMSKKTKRLQKQLLKALIVQTIIPICISFSPCVLAWYS 269

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 17560050   279 PLFNVEIVVPTGMF-LCAITIYPAADAIVIMYVVTDYRNTI 318
Cdd:pfam10319 270 PIFGIDLGRWNNYLeVIALSAFPFIDPLAIILCLPVYRNRI 310
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
 115-319 8.55e-09

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 55.63  E-value: 8.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   115 LLSVQFVYRYWAVFSESKLKffKGWRLIFCIMYCAAFGAdwgLSIYYFDEMDAYADHYFRAEMHKRYRLNISEIAGFSlv 194
Cdd:pfam10317  99 SLLLTFYYRYYILKHVDPKR--KKLILLIIIHYIPSLSQ---LIVIFLSPTDFLPVEALTKELHPNYNLTDYTVTGFS-- 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   195 aynfdNTPRWRNISCTISLFCIMLIQYTIIIYCATIMYLKMEEKLKLLSFAIRNLHRQFYKTLVIQIFTPTIFLFSPLIF 274
Cdd:pfam10317 172 -----DLQSFPALINTLIMTIPVFPIPIIILILRRKILKLLNSNSVNMSPTTKAQHRQLIKGLTIQALLPLFSYIPGVTL 246

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 17560050   275 IIFHPLFNVEIVVPTGMFLCAITIYPAADAIVIMYVVTDYRNTIK 319
Cdd:pfam10317 247 YLLSQLTGTEFLILEYFIFVLPALPPLLDPLITIYFVTPYRRAIL 291
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
 47-320 5.90e-07

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 50.23  E-value: 5.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050    47 FGSYKNLLL------MFSGLGIVFATTEVLLFPNLHSYKAGYFFYsmerpFGLDTKNVSRFLVFYTGLYGSTICLLsvqF 120
Cdd:pfam10318  36 MKSVKWSLLnlhfwsALLDLSLSFLTIPYIFLPALAGYPLGLLSY-----LGVPTPIQFYIGVTSLALVGVSIILL---F 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   121 VYRYWAVFSESKLKFFKGWRLIF-CIMYCAAFGadWGLSIYYF--DEMDAyadhyfRAEMHKRY-RLNISEIAGFSLVAY 196
Cdd:pfam10318 108 ENRYSILFTNKKRITWKKTRVLYlIFNYIIALL--FLIPIYLNipDQEAA------KLKVLKKLpCLPPEFFDNPPVFVL 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17560050   197 NFDNTprwRNISCTISLFCIMLIQYTIIIYCaTIMYLKMEEKLKLlSFAIRNLHRQFYKTLVIQIFTPTIFLFSPLIFII 276
Cdd:pfam10318 180 AIDST---YFLICIVLLILILIIQILFFVFL-TIYYLFKSVKSSL-SKKTRKLQKKFFIALIIQVSIPLIVILIPLIYIL 254

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 17560050   277 FHPLFNVEIVVPTGMFLCAITIYPAADAIVIMYVVTDYRNTIKS 320
Cdd:pfam10318 255 FSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLS 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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