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Conserved domains on  [gi|32567289|ref|NP_507361|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
24-323 2.31e-92

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 277.50  E-value: 2.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289    24 ATWQAVAYPIHIIQFFSLPFQVLAFYIIMTKTPPRMKPLQLPLFLNHLFGGLLDVCFCSFSTLFFFEPMMAFATVGVFNW 103
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   104 LGLSFVYQGVLGAAMASGVAGSYVFLFESRSSSLLENRFRIHRKSSSFLYYTYFFAPYIAVLVAIYNVAEESDAAKLRAL 183
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   184 EVYPCPTPEFFM-FSVCVFVGNPSNMFLIFAFLLLQATGNIIFHVACLVYYLYVAPPSTLSQATKRDQRTFLISVSIQTS 262
Cdd:pfam10318 161 KKLPCLPPEFFDnPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32567289   263 IPLFVIIAPAMAVLLASWTGTYRQEWMNLSNVCIATHGLAESISIMLVHKPYRAAIRRILG 323
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
24-323 2.31e-92

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 277.50  E-value: 2.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289    24 ATWQAVAYPIHIIQFFSLPFQVLAFYIIMTKTPPRMKPLQLPLFLNHLFGGLLDVCFCSFSTLFFFEPMMAFATVGVFNW 103
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   104 LGLSFVYQGVLGAAMASGVAGSYVFLFESRSSSLLENRFRIHRKSSSFLYYTYFFAPYIAVLVAIYNVAEESDAAKLRAL 183
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   184 EVYPCPTPEFFM-FSVCVFVGNPSNMFLIFAFLLLQATGNIIFHVACLVYYLYVAPPSTLSQATKRDQRTFLISVSIQTS 262
Cdd:pfam10318 161 KKLPCLPPEFFDnPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32567289   263 IPLFVIIAPAMAVLLASWTGTYRQEWMNLSNVCIATHGLAESISIMLVHKPYRAAIRRILG 323
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
24-323 2.31e-92

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 277.50  E-value: 2.31e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289    24 ATWQAVAYPIHIIQFFSLPFQVLAFYIIMTKTPPRMKPLQLPLFLNHLFGGLLDVCFCSFSTLFFFEPMMAFATVGVFNW 103
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   104 LGLSFVYQGVLGAAMASGVAGSYVFLFESRSSSLLENRFRIHRKSSSFLYYTYFFAPYIAVLVAIYNVAEESDAAKLRAL 183
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTNKKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   184 EVYPCPTPEFFM-FSVCVFVGNPSNMFLIFAFLLLQATGNIIFHVACLVYYLYVAPPSTLSQATKRDQRTFLISVSIQTS 262
Cdd:pfam10318 161 KKLPCLPPEFFDnPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVKSSLSKKTRKLQKKFFIALIIQVS 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 32567289   263 IPLFVIIAPAMAVLLASWTGTYRQEWMNLSNVCIATHGLAESISIMLVHKPYRAAIRRILG 323
Cdd:pfam10318 241 IPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFK 301
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
34-315 6.44e-06

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 47.15  E-value: 6.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289    34 HIIQFFSLPFQVLAFYIIMTKTPpRMKPLQLPLFLNHLFGGLLDVCFCSFSTLFFFEPMMAFATVGVF-NWLGLSFVYQG 112
Cdd:pfam10327  16 HIIGTISLILNLLGIYLIIFKSG-KIDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLaTVFGISSHYLM 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   113 VLGAAMASGVAGSYV--FLFESRSSSLLENRFRIhrkSSSFLYYTYFFAPYIAVLVAI-YNVAEESDAAKLRAL-EVYPC 188
Cdd:pfam10327  95 TIFVFLLSFQLESLLlcFVRKHQAIAKILSKHVI---PKWLYIFLYILCHIFPFLTAFlFYQSGLSREEQLEYVkENYPE 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   189 PTPEFFMFSVCVfVGNPSNMFLIFAFLLLQATGNIIFHVACLVYYLYVAPP---STLSQATKRDQRTFLISVSIQTSIPL 265
Cdd:pfam10327 172 YLSQFSSLPNFA-IYDYNPWLIVFGILAIFGGSLSFLILVYLTVDMFRMLKrlrKKISAQTYQKHRAALRSLIAQFATSP 250
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 32567289   266 FVIIAPAMAVLLASWTGTYRQEWMNLSNVCIATHGLAESISIMLVHKPYR 315
Cdd:pfam10327 251 VCILPPFAFVVVVLFPIEYSQEISEILLAIFSTHSSVNSIVLILTTPPYR 300
7TM_GPCR_Srd pfam10317
Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis ...
35-320 4.99e-03

Serpentine type 7TM GPCR chemoreceptor Srd; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srd is part of the larger Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402094  Cd Length: 292  Bit Score: 38.30  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289    35 IIQFFSLPFQVLAFYIIMTKTPPRMKPLQLPLFLNHLFggllDVCFCSFSTLFFFEPM-----MAFATVGVFNWLGLSF- 108
Cdd:pfam10317   7 IFFILGLILNLLLLYLIIFKSPKSLKTYRILLLNTAIT----QIISCILAFFTQQRIIpngvsMALISYGPCKYFGPWFc 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   109 --VYQGVLGAAMASGVAGSYVFLFesRSSSLLENRFRIHRkssSFLYYTYFFAPYIAVLVAIYNVAEESDAAKLRALEVY 186
Cdd:pfam10317  83 ysGYSLLQHFLLHSGWSLLLTFYY--RYYILKHVDPKRKK---LILLIIIHYIPSLSQLIVIFLSPTDFLPVEALTKELH 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   187 PCPTPEFFMFSVCVFVGNPSNMFlifaflllqatgnIIFHVACLVYYLYVA--------------PPSTLSQATKRDQRT 252
Cdd:pfam10317 158 PNYNLTDYTVTGFSDLQSFPALI-------------NTLIMTIPVFPIPIIililrrkilkllnsNSVNMSPTTKAQHRQ 224
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32567289   253 FLISVSIQTSIPLFVIIAPAMAVLLASWTGTYR--QEWMNLSNVCIAThgLAESISIMLVHKPYRAAIRR 320
Cdd:pfam10317 225 LIKGLTIQALLPLFSYIPGVTLYLLSQLTGTEFliLEYFIFVLPALPP--LLDPLITIYFVTPYRRAILR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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