NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|115534959|ref|NP_508476|]
View 

Membrane-associated protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TMEM127 super family cl48670
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 111-214 9.57e-05

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


The actual alignment was detected with superfamily member pfam20517:

Pssm-ID: 466666  Cd Length: 113  Bit Score: 41.09  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534959  111 CITPSTANYFYILIALCFVISATSSLCATMSLLPPPAPFLAWLRSNSILemSNMMLTLCCCTIAI---IAQTDISDQRED 187
Cdd:pfam20517   1 CVTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVG--SILTVIWCVAIVGFcywVTELILDLQRET 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 115534959  188 DI-------VAIGAGVFLVCISGLLSFLAAMASI 214
Cdd:pfam20517  79 KLypgskvqVSFDVGFYLITAAGALSVLATACNL 112
 
Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 111-214 9.57e-05

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


Pssm-ID: 466666  Cd Length: 113  Bit Score: 41.09  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534959  111 CITPSTANYFYILIALCFVISATSSLCATMSLLPPPAPFLAWLRSNSILemSNMMLTLCCCTIAI---IAQTDISDQRED 187
Cdd:pfam20517   1 CVTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVG--SILTVIWCVAIVGFcywVTELILDLQRET 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 115534959  188 DI-------VAIGAGVFLVCISGLLSFLAAMASI 214
Cdd:pfam20517  79 KLypgskvqVSFDVGFYLITAAGALSVLATACNL 112
 
Name Accession Description Interval E-value
TMEM127 pfam20517
Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its ...
 111-214 9.57e-05

Transmembrane protein 127; TMEM127 modulates mTOR function in the endolysosome. Its interaction with early endosomal GTPase Rab5 to inhibit mTOR signalling seems to be related with its tumour-suppressing properties.


Pssm-ID: 466666  Cd Length: 113  Bit Score: 41.09  E-value: 9.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115534959  111 CITPSTANYFYILIALCFVISATSSLCATMSLLPPPAPFLAWLRSNSILemSNMMLTLCCCTIAI---IAQTDISDQRED 187
Cdd:pfam20517   1 CVTNEIVLLMRVIIALCFMAIIFSLFGFLLDLFGPNQRALKVIRRNAVG--SILTVIWCVAIVGFcywVTELILDLQRET 78

                          90       100       110
                  ....*....|....*....|....*....|....
gi 115534959  188 DI-------VAIGAGVFLVCISGLLSFLAAMASI 214
Cdd:pfam20517  79 KLypgskvqVSFDVGFYLITAAGALSVLATACNL 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH