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Conserved domains on  [gi|17568683|ref|NP_510374|]
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Fork-head domain-containing protein [Caenorhabditis elegans]

Protein Classification

forkhead box protein( domain architecture ID 165)

forkhead box protein contains a forkhead/winged helix DNA-binding domain and may function as a transcription factor that is involved in regulating diverse biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FH_FOX super family cl00061
Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar ...
 160-285 2.50e-18

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).


The actual alignment was detected with superfamily member smart00339:

Pssm-ID: 469596 [Multi-domain]  Cd Length: 89  Bit Score: 78.05  E-value: 2.50e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17568683    160 KPPNSkYQRRYALIELKSVERSFKLFFDFTWIEKNIFRFRENRRRKQnkrnnvvtvkpmllqkktvqpNVNRPSISFHQC 239
Cdd:smart00339   1 KPPYS-YIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGWQ---------------------NSIRHNLSLNDC 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 17568683    240 LAQALIfptdltedillKETTQTASNeqkTITSQPAASSnVFNRNN 285
Cdd:smart00339  59 FVKVPR-----------EGDRPGKGS---YWTLDPAAEN-MFENGN 89
 
Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 160-285 2.50e-18

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 78.05  E-value: 2.50e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17568683    160 KPPNSkYQRRYALIELKSVERSFKLFFDFTWIEKNIFRFRENRRRKQnkrnnvvtvkpmllqkktvqpNVNRPSISFHQC 239
Cdd:smart00339   1 KPPYS-YIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGWQ---------------------NSIRHNLSLNDC 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 17568683    240 LAQALIfptdltedillKETTQTASNeqkTITSQPAASSnVFNRNN 285
Cdd:smart00339  59 FVKVPR-----------EGDRPGKGS---YWTLDPAAEN-MFENGN 89
 
Name Accession Description Interval E-value
FH smart00339
FORKHEAD; FORKHEAD, also known as a "winged helix"
 160-285 2.50e-18

FORKHEAD; FORKHEAD, also known as a "winged helix"


Pssm-ID: 214627 [Multi-domain]  Cd Length: 89  Bit Score: 78.05  E-value: 2.50e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17568683    160 KPPNSkYQRRYALIELKSVERSFKLFFDFTWIEKNIFRFRENRRRKQnkrnnvvtvkpmllqkktvqpNVNRPSISFHQC 239
Cdd:smart00339   1 KPPYS-YIALIAMAILSSPDKRLTLSEIYKWIEDNFPYYRENRAGWQ---------------------NSIRHNLSLNDC 58

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 17568683    240 LAQALIfptdltedillKETTQTASNeqkTITSQPAASSnVFNRNN 285
Cdd:smart00339  59 FVKVPR-----------EGDRPGKGS---YWTLDPAAEN-MFENGN 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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