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Conserved domains on  [gi|24640486|ref|NP_524793|]
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myospheroid, isoform A [Drosophila melanogaster]

Protein Classification

integrin beta-8; vWA domain-containing protein( domain architecture ID 10640637)

integrin beta-8 is a component of integrin alpha-V:beta-8 (ITGAV:ITGB8), which is a receptor for fibronectin| vWA (von Willebrand factor type A) domain-containing protein may be involved in one of a wide variety of important cellular functions, including basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and immune defenses

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 45-505 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


:

Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 649.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486     45 KCHTCIQTE-GCAWCMQPDFKGQ--SRCYQNTSSL---CPEEFAYSPITVEQILVNNKLTNQYkaelaaggggsamsgss 118
Cdd:smart00187   1 SCEECIQSGpNCAWCTDENFTSGgsARCDTRANLLakgCSPESIENPASSAEVLEDKPLSDKG----------------- 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    119 sssyssssssssfysqsssgsssasgyeeySAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSME 198
Cdd:smart00187  64 ------------------------------SGGQAVQVSPQRVRLKLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMK 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    199 DDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCEN----CKAPYGYQNHMPLNNNTESFSNE 274
Cdd:smart00187 114 DDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKLENPCPNynktCEPPYGFKHVLSLTDDTDEFNEE 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    275 VKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTL 354
Cdd:smart00187 194 VGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTT 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    355 QDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNA-TGDV 433
Cdd:smart00187 274 QDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVGELSEDSSNVVELIKDAYNKISSRVELEDNAlPEGV 353

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24640486    434 KITYFSSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPedPRDWTQTIHISPVGINEVMQIQLTMLCSC 505
Cdd:smart00187 354 SVTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTATKCP--PEDQEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 692-775 1.68e-25

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 100.82  E-value: 1.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   692 CQELKDCVQCQMYKTGELKNgDDCARNCTQFVPVgVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQ--GELHVYAQENK 769
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPLKE-KNCSRNCKFEIIL-VEVLKEDEEPGAVLCSFKDEDDCWFTFTYYEDesGKYVVHVQKER 78


                  ....*.
gi 24640486   770 ECPAKV 775
Cdd:pfam07965  79 ECPPGP 84
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 803-843 2.08e-24

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


:

Pssm-ID: 462580  Cd Length: 41  Bit Score: 96.09  E-value: 2.08e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24640486   803 TTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMY 843
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 45-505 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 649.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486     45 KCHTCIQTE-GCAWCMQPDFKGQ--SRCYQNTSSL---CPEEFAYSPITVEQILVNNKLTNQYkaelaaggggsamsgss 118
Cdd:smart00187   1 SCEECIQSGpNCAWCTDENFTSGgsARCDTRANLLakgCSPESIENPASSAEVLEDKPLSDKG----------------- 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    119 sssyssssssssfysqsssgsssasgyeeySAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSME 198
Cdd:smart00187  64 ------------------------------SGGQAVQVSPQRVRLKLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMK 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    199 DDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCEN----CKAPYGYQNHMPLNNNTESFSNE 274
Cdd:smart00187 114 DDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKLENPCPNynktCEPPYGFKHVLSLTDDTDEFNEE 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    275 VKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTL 354
Cdd:smart00187 194 VGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTT 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    355 QDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNA-TGDV 433
Cdd:smart00187 274 QDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVGELSEDSSNVVELIKDAYNKISSRVELEDNAlPEGV 353

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24640486    434 KITYFSSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPedPRDWTQTIHISPVGINEVMQIQLTMLCSC 505
Cdd:smart00187 354 SVTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTATKCP--PEDQEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 180-423 3.82e-164

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 476.61  E-value: 3.82e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   180 AEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCEN----CKAP 255
Cdd:pfam00362   1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGeneqCDPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   256 YGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIA 335
Cdd:pfam00362  81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGKLAGIVT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   336 PNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEE 415
Cdd:pfam00362 161 PNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIKEA 240


                  ....*...
gi 24640486   416 YRKISSSV 423
Cdd:pfam00362 241 YEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 692-775 1.68e-25

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 100.82  E-value: 1.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   692 CQELKDCVQCQMYKTGELKNgDDCARNCTQFVPVgVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQ--GELHVYAQENK 769
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPLKE-KNCSRNCKFEIIL-VEVLKEDEEPGAVLCSFKDEDDCWFTFTYYEDesGKYVVHVQKER 78


                  ....*.
gi 24640486   770 ECPAKV 775
Cdd:pfam07965  79 ECPPGP 84
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 803-843 2.08e-24

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


Pssm-ID: 462580  Cd Length: 41  Bit Score: 96.09  E-value: 2.08e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24640486   803 TTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMY 843
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 45-505 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 649.77  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486     45 KCHTCIQTE-GCAWCMQPDFKGQ--SRCYQNTSSL---CPEEFAYSPITVEQILVNNKLTNQYkaelaaggggsamsgss 118
Cdd:smart00187   1 SCEECIQSGpNCAWCTDENFTSGgsARCDTRANLLakgCSPESIENPASSAEVLEDKPLSDKG----------------- 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    119 sssyssssssssfysqsssgsssasgyeeySAGEIVQIQPQSMRLALRVNEKHNIKISYSQAEGYPVDLYYLMDLSKSME 198
Cdd:smart00187  64 ------------------------------SGGQAVQVSPQRVRLKLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMK 113

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    199 DDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCEN----CKAPYGYQNHMPLNNNTESFSNE 274
Cdd:smart00187 114 DDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHPEKLENPCPNynktCEPPYGFKHVLSLTDDTDEFNEE 193

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    275 VKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIAPNDGECHLSPKGEYTHSTL 354
Cdd:smart00187 194 VGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARRLLVFSTDAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTT 273

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486    355 QDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEEYRKISSSVEMKDNA-TGDV 433
Cdd:smart00187 274 QDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSVGELSEDSSNVVELIKDAYNKISSRVELEDNAlPEGV 353

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24640486    434 KITYFSSCLSNGPEVQTSKCDNLKEGQQVSFTAQIQLLKCPedPRDWTQTIHISPVGINEVMQIQLTMLCSC 505
Cdd:smart00187 354 SVTYTSSCPGGVTGPGTRKCEGVKIGDTVSFEVTVTATKCP--PEDQEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 180-423 3.82e-164

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 476.61  E-value: 3.82e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   180 AEGYPVDLYYLMDLSKSMEDDKAKLSTLGDKLSETMKRITNNFHLGFGSFVDKVLMPYVSTIPKKLEHPCEN----CKAP 255
Cdd:pfam00362   1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGeneqCDPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   256 YGYQNHMPLNNNTESFSNEVKNATVSGNLDAPEGGFDAIMQAIACRSQIGWREQARRLLVFSTDAGFHYAGDGKLGGVIA 335
Cdd:pfam00362  81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNEARRLLVFSTDAGFHYAGDGKLAGIVT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   336 PNDGECHLSPKGEYTHSTLQDYPSISQINQKVKDNAINIIFAVTASQLSVYEKLVEHIQGSSAAKLDNDSSNVVELVKEE 415
Cdd:pfam00362 161 PNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIKEA 240


                  ....*...
gi 24640486   416 YRKISSSV 423
Cdd:pfam00362 241 YEKIRSKV 248
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 692-775 1.68e-25

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 100.82  E-value: 1.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24640486   692 CQELKDCVQCQMYKTGELKNgDDCARNCTQFVPVgVEKVEIDETKDEQMCKFFDEDDCKFMFKYSEQ--GELHVYAQENK 769
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPLKE-KNCSRNCKFEIIL-VEVLKEDEEPGAVLCSFKDEDDCWFTFTYYEDesGKYVVHVQKER 78


                  ....*.
gi 24640486   770 ECPAKV 775
Cdd:pfam07965  79 ECPPGP 84
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 803-843 2.08e-24

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


Pssm-ID: 462580  Cd Length: 41  Bit Score: 96.09  E-value: 2.08e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 24640486   803 TTIHDRREFARFEKERMNAKWDTGENPIYKQATSTFKNPMY 843
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 38-76 3.90e-03

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 35.99  E-value: 3.90e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 24640486    38 STCASKEK-CHTCIQT-EGCAWCMQPDFKGQS-RCYQNTSSL 76
Cdd:pfam17205   1 NRCTSASTsCEECIQSgPDCAWCTDENFTSGSpRCDTRENLL 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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