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Conserved domains on  [gi|18401322|ref|NP_565635|]
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C2H2 zinc-finger protein SERRATE (SE) [Arabidopsis thaliana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARS2 super family cl20283
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 436-634 6.05e-34

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


The actual alignment was detected with superfamily member pfam04959:

Pssm-ID: 461498  Cd Length: 195  Bit Score: 128.46  E-value: 6.05e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   436 EGKVSDAKGDENESKFDSHWQERLKGQDPL---EVMAAKEKIDAAATEALdphVRKIRDEKYGWKYGCGAKGctKLFHAA 512
Cdd:pfam04959   6 SGRITSAEVVEWQKGFEERLEPLLSEKETLseeEAMKMGKKDPEQEVEKF---VRKNTQELAKDKWLCPLSG--KKFKGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   513 EFVYKHLKLKHTELVTELTTKVReelYFQNYMNDPNAPGGQPATQQSGPRDRPIRRKPSMENRLRDDRGGrrerdgrang 592
Cdd:pfam04959  81 EFVRKHILNKHGDKVEEVRSEVE---FFNNYLADAKRPATPELKPKPPPRPANRRERPGRAFPSQRPQGQ---------- 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 18401322   593 ndrndRSEDQQRGDNDGGN-----------PGEVGYDAFGGQGGVHVPPFLSD 634
Cdd:pfam04959 148 -----MSDGHPRPPMDGPGggppfppnqygGGRGNYDNFRGQGGGGYPPKPRD 195
SERRATE_Ars2_N super family cl13496
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 199-280 1.87e-21

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


The actual alignment was detected with superfamily member pfam12066:

Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 89.99  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   199 KQFIQELEDDILPSEAERRYQEYKSEYITTQKRAFFNTHKEEDWLKNKYHPTNLLSVIERRNDLAQKVAKDFLLDLQSGT 278
Cdd:pfam12066   1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80


                  ..
gi 18401322   279 LD 280
Cdd:pfam12066  81 FD 82
 
Name Accession Description Interval E-value
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 436-634 6.05e-34

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 128.46  E-value: 6.05e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   436 EGKVSDAKGDENESKFDSHWQERLKGQDPL---EVMAAKEKIDAAATEALdphVRKIRDEKYGWKYGCGAKGctKLFHAA 512
Cdd:pfam04959   6 SGRITSAEVVEWQKGFEERLEPLLSEKETLseeEAMKMGKKDPEQEVEKF---VRKNTQELAKDKWLCPLSG--KKFKGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   513 EFVYKHLKLKHTELVTELTTKVReelYFQNYMNDPNAPGGQPATQQSGPRDRPIRRKPSMENRLRDDRGGrrerdgrang 592
Cdd:pfam04959  81 EFVRKHILNKHGDKVEEVRSEVE---FFNNYLADAKRPATPELKPKPPPRPANRRERPGRAFPSQRPQGQ---------- 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 18401322   593 ndrndRSEDQQRGDNDGGN-----------PGEVGYDAFGGQGGVHVPPFLSD 634
Cdd:pfam04959 148 -----MSDGHPRPPMDGPGggppfppnqygGGRGNYDNFRGQGGGGYPPKPRD 195
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 199-280 1.87e-21

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 89.99  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   199 KQFIQELEDDILPSEAERRYQEYKSEYITTQKRAFFNTHKEEDWLKNKYHPTNLLSVIERRNDLAQKVAKDFLLDLQSGT 278
Cdd:pfam12066   1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80


                  ..
gi 18401322   279 LD 280
Cdd:pfam12066  81 FD 82
 
Name Accession Description Interval E-value
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 436-634 6.05e-34

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 128.46  E-value: 6.05e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   436 EGKVSDAKGDENESKFDSHWQERLKGQDPL---EVMAAKEKIDAAATEALdphVRKIRDEKYGWKYGCGAKGctKLFHAA 512
Cdd:pfam04959   6 SGRITSAEVVEWQKGFEERLEPLLSEKETLseeEAMKMGKKDPEQEVEKF---VRKNTQELAKDKWLCPLSG--KKFKGP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   513 EFVYKHLKLKHTELVTELTTKVReelYFQNYMNDPNAPGGQPATQQSGPRDRPIRRKPSMENRLRDDRGGrrerdgrang 592
Cdd:pfam04959  81 EFVRKHILNKHGDKVEEVRSEVE---FFNNYLADAKRPATPELKPKPPPRPANRRERPGRAFPSQRPQGQ---------- 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 18401322   593 ndrndRSEDQQRGDNDGGN-----------PGEVGYDAFGGQGGVHVPPFLSD 634
Cdd:pfam04959 148 -----MSDGHPRPPMDGPGggppfppnqygGGRGNYDNFRGQGGGGYPPKPRD 195
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 199-280 1.87e-21

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 89.99  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18401322   199 KQFIQELEDDILPSEAERRYQEYKSEYITTQKRAFFNTHKEEDWLKNKYHPTNLLSVIERRNDLAQKVAKDFLLDLQSGT 278
Cdd:pfam12066   1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80


                  ..
gi 18401322   279 LD 280
Cdd:pfam12066  81 FD 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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