NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|18403052|ref|NP_565749|]
View 

LEUNIG-like protein [Arabidopsis thaliana]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 12094222)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 502-787 5.80e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 247.63  E-value: 5.80e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 502 EVSCIRKSASKVICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDA 581
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 582 SDpGYFLRTISGHAAPVMSIDFHPKKTeLLCSCDSNNDIRFWDI-NASCVRAVKGAS---TQVRFQPrTGQFLAAAS-EN 656
Cdd:cd00200  81 ET-GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVeTGKCLTTLRGHTdwvNSVAFSP-DGTFVASSSqDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 657 TVSIFDIeNNNKRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSSGDCIHELSNSGNKFHSVVFHPSypDLLV 735
Cdd:cd00200 158 TIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD--GYLL 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18403052 736 IGGY--QAIELWNTMENKCM-TVAGHECVISALAQSPSTGVVASASHDKSVKIWK 787
Cdd:cd00200 235 ASGSedGTIRVWDLRTGECVqTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 103-440 6.16e-08

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 56.17  E-value: 6.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   103 QMQRRDPNHPSLGGPmnaiGSEGMIGQSNASALAAKMyeerMKQPNPMNSETSQPHLDARmallksatNHHGQIVQGN-- 180
Cdd:pfam09606 165 QPGSGTPNQMGPNGG----PGQGQAGGMNGGQQGPMG----GQMPPQMGVPGMPGPADAG--------AQMGQQAQANgg 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   181 ------HQGGVSAALQQiqsrtQQPTEIKTEVNLGTSPRQLpvdpsTVYGQGilqskpgmgsaglNPGVSGLPLKGWPLT 254
Cdd:pfam09606 229 mnpqqmGGAPNQVAMQQ-----QQPQQQGQQSQLGMGINQM-----QQMPQG-------------VGGGAGQGGPGQPMG 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   255 GIEQmRPGLGGPQVQKSFLQNQSQFQLSPQQQQHQMLAQVQAQGNMTNSPMYGGDMDPRRFTGLPRGNLNPKDGQQNANd 334
Cdd:pfam09606 286 PPGQ-QPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGAN- 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   335 gsigsPMQSSSSKHISMP---PVQQSSSQQQDHLLSQQSQQNNRKRKGPSSSGPanSTGTGNTVGPSNSQPStpstHTPv 411
Cdd:pfam09606 364 -----PMQRGQPGMMSSPspvPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPP--QSHPGGMIPSPALIPS----PSP- 431

                         330       340
                  ....*....|....*....|....*....
gi 18403052   412 dgvaiagnmhHVNSMPKGPMMYGSDGIGG 440
Cdd:pfam09606 432 ----------QMSQQPAQQRTIGQDSPGG 450
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 11-35 8.18e-06

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


:

Pssm-ID: 462501  Cd Length: 25  Bit Score: 42.69  E-value: 8.18e-06
                          10        20
                  ....*....|....*....|....*
gi 18403052    11 MLDVYIYDYLVKKKLHNTAKSFMTE 35
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 502-787 5.80e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 247.63  E-value: 5.80e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 502 EVSCIRKSASKVICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDA 581
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 582 SDpGYFLRTISGHAAPVMSIDFHPKKTeLLCSCDSNNDIRFWDI-NASCVRAVKGAS---TQVRFQPrTGQFLAAAS-EN 656
Cdd:cd00200  81 ET-GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVeTGKCLTTLRGHTdwvNSVAFSP-DGTFVASSSqDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 657 TVSIFDIeNNNKRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSSGDCIHELSNSGNKFHSVVFHPSypDLLV 735
Cdd:cd00200 158 TIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD--GYLL 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18403052 736 IGGY--QAIELWNTMENKCM-TVAGHECVISALAQSPSTGVVASASHDKSVKIWK 787
Cdd:cd00200 235 ASGSedGTIRVWDLRTGECVqTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
513-786 7.75e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.01  E-value: 7.75e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 513 VICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDASDpGYFLRTIS 592
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLT 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 593 GHAAPVMSIDFHPKKTeLLCSCDSNNDIRFWDINA-SCVRAVKGASTQVR---FQPrTGQFLAAASE-NTVSIFDIEnNN 667
Cdd:COG2319 202 GHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATgKLLRTLTGHSGSVRsvaFSP-DGRLLASGSAdGTVRLWDLA-TG 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 668 KRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSSGDCIHELSNSGNKFHSVVFHPSyPDLLVIGGY-QAIELW 745
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDdGTVRLW 357

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 18403052 746 NTMENKCM-TVAGHECVISALAQSPSTGVVASASHDKSVKIW 786
Cdd:COG2319 358 DLATGELLrTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 509-741 8.34e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 75.51  E-value: 8.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  509 SASKVICC-SFSYDGKLLASAGHDKKVFIWNMETLqVESTPEEHaHIITDVRFRP-------NS---TQLATSSFDKTIK 577
Cdd:PLN00181 481 NSSNLVCAiGFDRDGEFFATAGVNKKIKIFECESI-IKDGRDIH-YPVVELASRSklsgicwNSyikSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  578 IWDASDpGYFLRTISGHAAPVMSIDFHPKKTELLCSCDSNNDIRFWDINASC-VRAVKGASTQ--VRFQPRTGQFLA-AA 653
Cdd:PLN00181 559 VWDVAR-SQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVsIGTIKTKANIccVQFPSESGRSLAfGS 637

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  654 SENTVSIFDIENNNKRVNIFKGHSSNVHSVCWSPNGELVASVSEDAVKLWSLSsgdciheLSNSG---NKFHSVVFH--- 727
Cdd:PLN00181 638 ADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLS-------MSISGineTPLHSFMGHtnv 710

                        250
                 ....*....|....
gi 18403052  728 PSYPDLLVIGGYQA 741
Cdd:PLN00181 711 KNFVGLSVSDGYIA 724
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 103-440 6.16e-08

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 56.17  E-value: 6.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   103 QMQRRDPNHPSLGGPmnaiGSEGMIGQSNASALAAKMyeerMKQPNPMNSETSQPHLDARmallksatNHHGQIVQGN-- 180
Cdd:pfam09606 165 QPGSGTPNQMGPNGG----PGQGQAGGMNGGQQGPMG----GQMPPQMGVPGMPGPADAG--------AQMGQQAQANgg 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   181 ------HQGGVSAALQQiqsrtQQPTEIKTEVNLGTSPRQLpvdpsTVYGQGilqskpgmgsaglNPGVSGLPLKGWPLT 254
Cdd:pfam09606 229 mnpqqmGGAPNQVAMQQ-----QQPQQQGQQSQLGMGINQM-----QQMPQG-------------VGGGAGQGGPGQPMG 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   255 GIEQmRPGLGGPQVQKSFLQNQSQFQLSPQQQQHQMLAQVQAQGNMTNSPMYGGDMDPRRFTGLPRGNLNPKDGQQNANd 334
Cdd:pfam09606 286 PPGQ-QPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGAN- 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   335 gsigsPMQSSSSKHISMP---PVQQSSSQQQDHLLSQQSQQNNRKRKGPSSSGPanSTGTGNTVGPSNSQPStpstHTPv 411
Cdd:pfam09606 364 -----PMQRGQPGMMSSPspvPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPP--QSHPGGMIPSPALIPS----PSP- 431

                         330       340
                  ....*....|....*....|....*....
gi 18403052   412 dgvaiagnmhHVNSMPKGPMMYGSDGIGG 440
Cdd:pfam09606 432 ----------QMSQQPAQQRTIGQDSPGG 450
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 666-704 1.11e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18403052    666 NNKRVNIFKGHSSNVHSVCWSPNGELVASVSEDA-VKLWS 704
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGtIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
667-704 2.84e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.84e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18403052   667 NKRVNIFKGHSSNVHSVCWSPNGELVASVSEDA-VKLWS 704
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGtVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 11-35 8.18e-06

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 42.69  E-value: 8.18e-06
                          10        20
                  ....*....|....*....|....*
gi 18403052    11 MLDVYIYDYLVKKKLHNTAKSFMTE 35
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 10-40 4.80e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 38.18  E-value: 4.80e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 18403052     10 KMLDVYIYDYLVKKKLHNTAKSFMTEGKVSP 40
Cdd:smart00667   4 SELNRLILEYLLRNGYEETAETLQKESGLSL 34
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 502-787 5.80e-76

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 247.63  E-value: 5.80e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 502 EVSCIRKSASKVICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDA 581
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 582 SDpGYFLRTISGHAAPVMSIDFHPKKTeLLCSCDSNNDIRFWDI-NASCVRAVKGAS---TQVRFQPrTGQFLAAAS-EN 656
Cdd:cd00200  81 ET-GECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVeTGKCLTTLRGHTdwvNSVAFSP-DGTFVASSSqDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 657 TVSIFDIeNNNKRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSSGDCIHELSNSGNKFHSVVFHPSypDLLV 735
Cdd:cd00200 158 TIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD--GYLL 234

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 18403052 736 IGGY--QAIELWNTMENKCM-TVAGHECVISALAQSPSTGVVASASHDKSVKIWK 787
Cdd:cd00200 235 ASGSedGTIRVWDLRTGECVqTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
513-786 7.75e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.01  E-value: 7.75e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 513 VICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDASDpGYFLRTIS 592
Cdd:COG2319 123 VRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT-GKLLRTLT 201

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 593 GHAAPVMSIDFHPKKTeLLCSCDSNNDIRFWDINA-SCVRAVKGASTQVR---FQPrTGQFLAAASE-NTVSIFDIEnNN 667
Cdd:COG2319 202 GHTGAVRSVAFSPDGK-LLASGSADGTVRLWDLATgKLLRTLTGHSGSVRsvaFSP-DGRLLASGSAdGTVRLWDLA-TG 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 668 KRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSSGDCIHELSNSGNKFHSVVFHPSyPDLLVIGGY-QAIELW 745
Cdd:COG2319 279 ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDgTVRLWDLATGKLLRTLTGHTGAVRSVAFSPD-GKTLASGSDdGTVRLW 357

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 18403052 746 NTMENKCM-TVAGHECVISALAQSPSTGVVASASHDKSVKIW 786
Cdd:COG2319 358 DLATGELLrTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
510-786 2.02e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 204.37  E-value: 2.02e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 510 ASKVICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDASDPGyFLR 589
Cdd:COG2319  78 TAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK-LLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 590 TISGHAAPVMSIDFHPKKTELLcSCDSNNDIRFWDI-NASCVRAVKGASTQVR---FQPRtGQFLAAASE-NTVSIFDIE 664
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLA-SGSDDGTVRLWDLaTGKLLRTLTGHTGAVRsvaFSPD-GKLLASGSAdGTVRLWDLA 234

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 665 nNNKRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSSGDCIHELSNSGNKFHSVVFHPSyPDLLVIGGY-QAI 742
Cdd:COG2319 235 -TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADgTVRLWDLATGELLRTLTGHSGGVNSVAFSPD-GKLLASGSDdGTV 312

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 18403052 743 ELWNTMENKCM-TVAGHECVISALAQSPSTGVVASASHDKSVKIW 786
Cdd:COG2319 313 RLWDLATGKLLrTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
510-786 1.91e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 173.56  E-value: 1.91e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 510 ASKVICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDASDpGYFLR 589
Cdd:COG2319  36 AAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLLLR 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 590 TISGHAAPVMSIDFHPKKTELLcSCDSNNDIRFWDI-NASCVRAVKGASTQVR---FQPrTGQFLAAASE-NTVSIFDIE 664
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLaTGKLLRTLTGHSGAVTsvaFSP-DGKLLASGSDdGTVRLWDLA 192

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 665 nNNKRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSSGDCIHELSNSGNKFHSVVFHpsyPD--LLVIGGY-Q 740
Cdd:COG2319 193 -TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADgTVRLWDLATGKLLRTLTGHSGSVRSVAFS---PDgrLLASGSAdG 268

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 18403052 741 AIELWNTMENKCM-TVAGHECVISALAQSPSTGVVASASHDKSVKIW 786
Cdd:COG2319 269 TVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
513-707 7.67e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 7.67e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 513 VICCSFSYDGKLLASAGHDKKVFIWNMETLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWDAsDPGYFLRTIS 592
Cdd:COG2319 207 VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL-ATGELLRTLT 285

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052 593 GHAAPVMSIDFHPkKTELLCSCDSNNDIRFWDINA-SCVRAVKGASTQVR---FQPrTGQFLAAASE-NTVSIFDIEnNN 667
Cdd:COG2319 286 GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATgKLLRTLTGHTGAVRsvaFSP-DGKTLASGSDdGTVRLWDLA-TG 362

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 18403052 668 KRVNIFKGHSSNVHSVCWSPNGELVASVSED-AVKLWSLSS 707
Cdd:COG2319 363 ELLRTLTGHTGAVTSVAFSPDGRTLASGSADgTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 509-741 8.34e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 75.51  E-value: 8.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  509 SASKVICC-SFSYDGKLLASAGHDKKVFIWNMETLqVESTPEEHaHIITDVRFRP-------NS---TQLATSSFDKTIK 577
Cdd:PLN00181 481 NSSNLVCAiGFDRDGEFFATAGVNKKIKIFECESI-IKDGRDIH-YPVVELASRSklsgicwNSyikSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  578 IWDASDpGYFLRTISGHAAPVMSIDFHPKKTELLCSCDSNNDIRFWDINASC-VRAVKGASTQ--VRFQPRTGQFLA-AA 653
Cdd:PLN00181 559 VWDVAR-SQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVsIGTIKTKANIccVQFPSESGRSLAfGS 637

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  654 SENTVSIFDIENNNKRVNIFKGHSSNVHSVCWSPNGELVASVSEDAVKLWSLSsgdciheLSNSG---NKFHSVVFH--- 727
Cdd:PLN00181 638 ADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLS-------MSISGineTPLHSFMGHtnv 710

                        250
                 ....*....|....
gi 18403052  728 PSYPDLLVIGGYQA 741
Cdd:PLN00181 711 KNFVGLSVSDGYIA 724
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 103-440 6.16e-08

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 56.17  E-value: 6.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   103 QMQRRDPNHPSLGGPmnaiGSEGMIGQSNASALAAKMyeerMKQPNPMNSETSQPHLDARmallksatNHHGQIVQGN-- 180
Cdd:pfam09606 165 QPGSGTPNQMGPNGG----PGQGQAGGMNGGQQGPMG----GQMPPQMGVPGMPGPADAG--------AQMGQQAQANgg 228

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   181 ------HQGGVSAALQQiqsrtQQPTEIKTEVNLGTSPRQLpvdpsTVYGQGilqskpgmgsaglNPGVSGLPLKGWPLT 254
Cdd:pfam09606 229 mnpqqmGGAPNQVAMQQ-----QQPQQQGQQSQLGMGINQM-----QQMPQG-------------VGGGAGQGGPGQPMG 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   255 GIEQmRPGLGGPQVQKSFLQNQSQFQLSPQQQQHQMLAQVQAQGNMTNSPMYGGDMDPRRFTGLPRGNLNPKDGQQNANd 334
Cdd:pfam09606 286 PPGQ-QPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGAN- 363

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   335 gsigsPMQSSSSKHISMP---PVQQSSSQQQDHLLSQQSQQNNRKRKGPSSSGPanSTGTGNTVGPSNSQPStpstHTPv 411
Cdd:pfam09606 364 -----PMQRGQPGMMSSPspvPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPP--QSHPGGMIPSPALIPS----PSP- 431

                         330       340
                  ....*....|....*....|....*....
gi 18403052   412 dgvaiagnmhHVNSMPKGPMMYGSDGIGG 440
Cdd:pfam09606 432 ----------QMSQQPAQQRTIGQDSPGG 450
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 666-704 1.11e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.11e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18403052    666 NNKRVNIFKGHSSNVHSVCWSPNGELVASVSEDA-VKLWS 704
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGtIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 541-580 6.43e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.54  E-value: 6.43e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18403052    541 TLQVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWD 580
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
667-704 2.84e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.64  E-value: 2.84e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 18403052   667 NKRVNIFKGHSSNVHSVCWSPNGELVASVSEDA-VKLWS 704
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGtVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
543-580 5.99e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.49  E-value: 5.99e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 18403052   543 QVESTPEEHAHIITDVRFRPNSTQLATSSFDKTIKIWD 580
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
LisH pfam08513
LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The ...
 11-35 8.18e-06

LisH; The LisH (lis homology) domain mediates protein dimerization and tetramerization. The LisH domain is found in Sif2, a component of the Set3 complex which is responsible for repressing meiotic genes. It has been shown that the LisH domain helps mediate interaction with components of the Set3 complex.


Pssm-ID: 462501  Cd Length: 25  Bit Score: 42.69  E-value: 8.18e-06
                          10        20
                  ....*....|....*....|....*
gi 18403052    11 MLDVYIYDYLVKKKLHNTAKSFMTE 35
Cdd:pfam08513   1 ELNRLIYDYLVKEGYEETAEAFEKE 25
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 499-538 3.89e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 3.89e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 18403052    499 SFNEVSCIRKSASKVICCSFSYDGKLLASAGHDKKVFIWN 538
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 584-624 5.07e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 5.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 18403052    584 PGYFLRTISGHAAPVMSIDFHPKKTeLLCSCDSNNDIRFWD 624
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
Coatomer_WDAD pfam04053
Coatomer WD associated region; This region is composed of WD40 repeats.
 642-700 9.18e-05

Coatomer WD associated region; This region is composed of WD40 repeats.


Pssm-ID: 427679  Cd Length: 439  Bit Score: 45.69  E-value: 9.18e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 18403052   642 FQPRTGQFLAAASENTVSIFDIENNN--KRVNIfkghsSNVHSVCWSPNGELVASVSEDAV 700
Cdd:pfam04053 114 FGGGPGSLLGVKSEGSLSFYDWEQGKlvRRIDV-----SPVKYVIWSDDGELVALLSKDTV 169
WD40 pfam00400
WD domain, G-beta repeat;
585-624 1.04e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 18403052   585 GYFLRTISGHAAPVMSIDFHPKKTeLLCSCDSNNDIRFWD 624
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 750-787 1.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 18403052    750 NKCMTVAGHECVISALAQSPSTGVVASASHDKSVKIWK 787
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 555-738 1.50e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.27  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  555 ITDVRFRP-NSTQLATSSFDKTIKIWDASDPGYFLRTIS------GHAAPVMSIDFHPKKTELLCSCDSNNDIRFWDIN- 626
Cdd:PTZ00421  78 IIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISDpivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVEr 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  627 ASCVRAVKGASTQV---RFQPRTGQFLAAASENTVSIFDiENNNKRVNIFKGHSSNVHSVC-WSPNGELVASV-----SE 697
Cdd:PTZ00421 158 GKAVEVIKCHSDQItslEWNLDGSLLCTTSKDKKLNIID-PRDGTIVSSVEAHASAKSQRClWAKRKDLIITLgcsksQQ 236

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 18403052  698 DAVKLW---SLSSGDCIHELSNSgnkfhSVVFHPSYPD---LLVIGG 738
Cdd:PTZ00421 237 RQIMLWdtrKMASPYSTVDLDQS-----SALFIPFFDEdtnLLYIGS 278
WD40 pfam00400
WD domain, G-beta repeat;
753-786 2.18e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.18e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 18403052   753 MTVAGHECVISALAQSPSTGVVASASHDKSVKIW 786
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
LisH smart00667
Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, ...
 10-40 4.80e-04

Lissencephaly type-1-like homology motif; Alpha-helical motif present in Lis1, treacle, Nopp140, some katanin p60 subunits, muskelin, tonneau, LEUNIG and numerous WD40 repeat-containing proteins. It is suggested that LisH motifs contribute to the regulation of microtubule dynamics, either by mediating dimerisation, or else by binding cytoplasmic dynein heavy chain or microtubules directly.


Pssm-ID: 128913  Cd Length: 34  Bit Score: 38.18  E-value: 4.80e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 18403052     10 KMLDVYIYDYLVKKKLHNTAKSFMTEGKVSP 40
Cdd:smart00667   4 SELNRLILEYLLRNGYEETAETLQKESGLSL 34
WD40 pfam00400
WD domain, G-beta repeat;
511-538 4.98e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.98e-04
                          10        20
                  ....*....|....*....|....*...
gi 18403052   511 SKVICCSFSYDGKLLASAGHDKKVFIWN 538
Cdd:pfam00400  12 GSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 591-693 1.57e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 1.57e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  591 ISGHAAPVMSIDFHPKKTELLCSCDSNNDIRFWDI--NASCVRAVK-------GASTQVR---FQPRTGQFLAAAS-ENT 657
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphNDESVKEIKdpqcilkGHKKKISiidWNPMNYYIMCSSGfDSF 149

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 18403052  658 VSIFDIENNNKRVNIFKghSSNVHSVCWSPNGELVA 693
Cdd:PTZ00420 150 VNIWDIENEKRAFQINM--PKKLSSLKWNIKGNLLS 183
PTZ00420 PTZ00420
coronin; Provisional
 551-625 3.78e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 3.78e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052  551 HAHIITDVRFRP-NSTQLATSSFDKTIKIW----------DASDPGYFLRtisGHAAPVMSIDFHPKKTELLCSCDSNND 619
Cdd:PTZ00420  73 HTSSILDLQFNPcFSEILASGSEDLTIRVWeiphndesvkEIKDPQCILK---GHKKKISIIDWNPMNYYIMCSSGFDSF 149


                 ....*.
gi 18403052  620 IRFWDI 625
Cdd:PTZ00420 150 VNIWDI 155
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 664-787 5.50e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.79  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   664 ENNNKRVNIFKGHSSNV--------HSVCWSPN--------GELVASVSedavkLWSLsSGDCIHELSNsgNKFHSVVFH 727
Cdd:pfam08662  38 ETNLYLIGETGGPDCVVeldkegpiHDVAWSPNgkefaviyGYMPAKVS-----FFDL-KGNVIHSFGE--QPRNTIFWS 109

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18403052   728 PSyPDLLVIGGYQ----AIELWNTMENKCMTVAGHECViSALAQSPS-TGVVASASH-----DKSVKIWK 787
Cdd:pfam08662 110 PF-GRLVLLAGFGnlagDIEFWDVVNKKKIATAEASNA-TLCEWSPDgRYFLTATTAprlrvDNGFKIWH 177
Coatomer_WDAD_beta-like cd22947
Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', ...
 647-700 5.80e-03

Coatomer WD Associated Region from Coatomer Subunit Beta and Beta'; Coatomer subunit beta', also called beta'-coat protein; beta'-COP; p102, is a component of the coatomer, which is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complexes are hetero-oligomers composed of at least an alpha, beta, beta', gamma, delta, epsilon and zeta subunit. It is a heptameric complex that can polymerize into a cage to deform the membrane into a bud. This model corresponds to the WD-associated (WDAD) region found in coatomer subunits beta and beta' and is composed of a beta-propeller and an alpha-solenoid. The WD40 domain is found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. It typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40. Between the GH and WD lies a conserved core. It forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet. Each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure. The residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands allowing them to bind either stably or reversibly.


Pssm-ID: 438572  Cd Length: 475  Bit Score: 40.14  E-value: 5.80e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 18403052 647 GQFLAAASENTVSIFDIENNN--KRVNIfkghssNVHSVCWSPNGELVASVSEDAV 700
Cdd:cd22947 133 GALLGVRSSDFICFYDWETGKlvRRIDV------EAKNVYWSESGELVAIATDDSF 182
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH