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Conserved domains on  [gi|18424785|ref|NP_568984|]
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Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein [Arabidopsis thaliana]

Protein Classification

protease inhibitor/seed storage/LTP family protein( domain architecture ID 10028580)

Protease inhibitor/seed storage/LTP family protein belongs to a protein family that is unique to higher plants and includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, among others

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAI_LTSS cd00010
AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein ...
 50-113 3.85e-12

AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein family; a protein family unique to higher plants that includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, and similar proteins. Proteins in this family are known to play important roles, in defending plants from insects and pathogens, lipid transport between intracellular membranes, and nutrient storage. Many proteins of this family have been identified as allergens in humans. These proteins contain a common pattern of eight cysteines that form four disulfide bridges.


:

Pssm-ID: 237980  Cd Length: 63  Bit Score: 58.59  E-value: 3.85e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18424785  50 MADCLSFVSSGGTvaKPEGTCCSGLKTVLKADSQCLCEAFKSSASLGVTL-NITKASTLPAACKL 113
Cdd:cd00010   1 LAPCLSYLTGGAT--APPSDCCSGLKSVVKSDPKCLCAALNGPGASLLGLkNATRALALPAACGL 63
 
Name Accession Description Interval E-value
AAI_LTSS cd00010
AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein ...
 50-113 3.85e-12

AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein family; a protein family unique to higher plants that includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, and similar proteins. Proteins in this family are known to play important roles, in defending plants from insects and pathogens, lipid transport between intracellular membranes, and nutrient storage. Many proteins of this family have been identified as allergens in humans. These proteins contain a common pattern of eight cysteines that form four disulfide bridges.


Pssm-ID: 237980  Cd Length: 63  Bit Score: 58.59  E-value: 3.85e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18424785  50 MADCLSFVSSGGTvaKPEGTCCSGLKTVLKADSQCLCEAFKSSASLGVTL-NITKASTLPAACKL 113
Cdd:cd00010   1 LAPCLSYLTGGAT--APPSDCCSGLKSVVKSDPKCLCAALNGPGASLLGLkNATRALALPAACGL 63
Tryp_alpha_amyl pfam00234
Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase ...
 43-121 1.30e-11

Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase inhibitors, seed storage proteins and lipid transfer proteins from plants.


Pssm-ID: 425543  Cd Length: 74  Bit Score: 57.58  E-value: 1.30e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18424785    43 CSTLILNMADCLSFVssGGTVAKPEGTCCSGLKTVlkaDSQCLCEAFKSSASLGVTLNITKASTLPAACKLHAPSIATC 121
Cdd:pfam00234   1 CGQVLLCLAPCLGYL--QGGCQVPSQQCCSQLRQL---QAQCRCTAIRAIVLGIEGINPQAAASLPSMCGVNVPYGIDC 74
AAI smart00499
Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain ...
 43-118 1.17e-10

Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain family;


Pssm-ID: 214698  Cd Length: 79  Bit Score: 55.08  E-value: 1.17e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18424785     43 CSTLILNMADCLSFVSSGGTVAKPEGTCCSGLKTVlkADSQCLCEAFKSSA---SLGVTLNITKASTLPAACKLHAPSI 118
Cdd:smart00499   1 CGQVLLQLAPCLSYLVGGSRGAPPSQQCCSQLRGL--NSAQCRCLALRAAVlgiLEIPGLNAQNAASLPSACGVPPPYT 77
 
Name Accession Description Interval E-value
AAI_LTSS cd00010
AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein ...
 50-113 3.85e-12

AAI_LTSS: Alpha-Amylase Inhibitors (AAI), Lipid Transfer (LT) and Seed Storage (SS) Protein family; a protein family unique to higher plants that includes cereal-type alpha-amylase inhibitors, lipid transfer proteins, seed storage proteins, and similar proteins. Proteins in this family are known to play important roles, in defending plants from insects and pathogens, lipid transport between intracellular membranes, and nutrient storage. Many proteins of this family have been identified as allergens in humans. These proteins contain a common pattern of eight cysteines that form four disulfide bridges.


Pssm-ID: 237980  Cd Length: 63  Bit Score: 58.59  E-value: 3.85e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18424785  50 MADCLSFVSSGGTvaKPEGTCCSGLKTVLKADSQCLCEAFKSSASLGVTL-NITKASTLPAACKL 113
Cdd:cd00010   1 LAPCLSYLTGGAT--APPSDCCSGLKSVVKSDPKCLCAALNGPGASLLGLkNATRALALPAACGL 63
Tryp_alpha_amyl pfam00234
Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase ...
 43-121 1.30e-11

Protease inhibitor/seed storage/LTP family; This family is composed of trypsin-alpha amylase inhibitors, seed storage proteins and lipid transfer proteins from plants.


Pssm-ID: 425543  Cd Length: 74  Bit Score: 57.58  E-value: 1.30e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18424785    43 CSTLILNMADCLSFVssGGTVAKPEGTCCSGLKTVlkaDSQCLCEAFKSSASLGVTLNITKASTLPAACKLHAPSIATC 121
Cdd:pfam00234   1 CGQVLLCLAPCLGYL--QGGCQVPSQQCCSQLRQL---QAQCRCTAIRAIVLGIEGINPQAAASLPSMCGVNVPYGIDC 74
AAI smart00499
Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain ...
 43-118 1.17e-10

Plant lipid transfer protein / seed storage protein / trypsin-alpha amylase inhibitor domain family;


Pssm-ID: 214698  Cd Length: 79  Bit Score: 55.08  E-value: 1.17e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 18424785     43 CSTLILNMADCLSFVSSGGTVAKPEGTCCSGLKTVlkADSQCLCEAFKSSA---SLGVTLNITKASTLPAACKLHAPSI 118
Cdd:smart00499   1 CGQVLLQLAPCLSYLVGGSRGAPPSQQCCSQLRGL--NSAQCRCLALRAAVlgiLEIPGLNAQNAASLPSACGVPPPYT 77
nsLTP1 cd01960
nsLTP1: Non-specific lipid-transfer protein type 1 (nsLTP1) subfamily; Plant nsLTPs are small, ...
 41-116 1.00e-09

nsLTP1: Non-specific lipid-transfer protein type 1 (nsLTP1) subfamily; Plant nsLTPs are small, soluble proteins that facilitate the transfer of fatty acids, phospholipids, glycolipids, and steroids between membranes. In addition to lipid transport and assembly, nsLTPs also play a key role in the defense of plants against pathogens. There are two closely-related types of nsLTPs, types 1 and 2, which differ in protein sequence, molecular weight, and biological properties. nsLTPs contain an internal hydrophobic cavity, which serves as the binding site for lipids. The hydrophobic cavity accommodates various fatty acid ligands containing from ten to 18 carbon atoms. In general, the cavity is larger in nsLTP1 than in nsLTP2. nsLTP1 proteins are located in extracellular layers and in vacuolar structures. They may be involved in the formation of cutin layers on plant surfaces by transporting cutin monomers. Many nsLTP1 proteins have been characterized as allergens in humans.


Pssm-ID: 238926  Cd Length: 89  Bit Score: 52.74  E-value: 1.00e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424785  41 VDCSTLILNMADCLSFVSSGGtvAKPEGTCCSGLKTVL-----KADSQCLCEAFKSSASLGVTLNITKASTLPAACKLHA 115
Cdd:cd01960   1 ISCGQVTSLLAPCLGYLTGGG--PAPSPACCSGVKSLNglaktTADRQAACNCLKSAAAGISGLNPGRAAGLPGKCGVSI 78


                .
gi 18424785 116 P 116
Cdd:cd01960  79 P 79
LTP_2 pfam14368
Probable lipid transfer; The members of this family are probably involved in lipid transfer. ...
 34-121 1.68e-09

Probable lipid transfer; The members of this family are probably involved in lipid transfer. The family has several highly conserved cysteines, paired in various ways.


Pssm-ID: 433909  Cd Length: 100  Bit Score: 52.48  E-value: 1.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18424785    34 ATAPAPSVDCS-TLILNMADCLSFVSSGGTVAKPEGTCCSGLKTVLKADSQCLCEAFKSSASLGVTLNITKASTLPAACK 112
Cdd:pfam14368  12 PPPAPAAASCTlSMLSGLSPCLPYLTGTPAATAPSPACCGALKSAVSTDVTCLCALVTAPLPIGFPINVTRALALPRACG 91


                  ....*....
gi 18424785   113 LHAPSIATC 121
Cdd:pfam14368  92 VKTPPSSKC 100
nsLTP_like cd04660
nsLTP_like: Non-specific lipid-transfer protein (nsLTP)-like subfamily; composed of ...
 43-117 9.45e-06

nsLTP_like: Non-specific lipid-transfer protein (nsLTP)-like subfamily; composed of predominantly uncharacterized proteins with similarity to nsLTPs, including Medicago truncatula MtN5, the root-specific Phaseolus vulgaris PVR3, Antirrhinum majus FIL1, and Lilium longiflorum LIM3. Plant nsLTPs are small, soluble proteins that facilitate the transfer of fatty acids, phospholipids, glycolipids, and steroids between membranes. The MtN5 gene is induced during root nodule development. FIL1 is thought to be important in petal and stamen formation. The LIM3 gene is induced during the early prophase stage of meiosis in lily microsporocytes.


Pssm-ID: 240018  Cd Length: 73  Bit Score: 41.97  E-value: 9.45e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 18424785  43 CSTLILNMADCLSFVSSGGTVAKPEGTCCSGLKtvlKADSQCLCEaFKSSASLGVtLNITKASTLPAACKLHAPS 117
Cdd:cd04660   1 CNMDLDLLAECQPYVTGPNPPPPPSRECCAALR---RADLPCLCR-YKTSLVLQI-IDPDKAVYLPAKCGLPLPP 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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