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Conserved domains on  [gi|45549297|ref|NP_569876|]
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uncharacterized protein Dmel_CG3690, isoform A [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
synapt_SV2 super family cl31090
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 25-550 6.25e-34

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


The actual alignment was detected with superfamily member TIGR01299:

Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 137.03  E-value: 6.25e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    25 QKEAAADFEAAIDAAGFGMFNILLLVAAVPAAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGY 104
Cdd:TIGR01299 145 EEELAQQYELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   105 LADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIAT 184
Cdd:TIGR01299 225 LADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGG 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   185 LTLPGLAMLILPE-TWNIQIWT-LSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSR- 261
Cdd:TIGR01299 305 IYAAAMAWAIIPHyGWSFQMGSaYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRa 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   262 --KPKDSFPIkllaNEVIVPvkkHAKDETIptelklptecvevqdpENQDSKKSSLRSGFTQLRPL-----------FTK 328
Cdd:TIGR01299 385 kgHPEKVFSV----NHIKTI---HQEDELI----------------EIESDTGTWYQRCFVRALSEgggiwgnflrcFNP 441

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   329 PYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASI--------------NEYENLMSGESQSTSICNILEY---------- 384
Cdd:TIGR01299 442 EVREITIKLMGVWFTLSFGYYGLSVWFPDMIKHLqaddyaaltknfpgDKVAHFSFNFTLENQIHRGGEYdndkfiglkf 521

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   385 -SVNRTQSQLEAVTRNDPTV------ECHVIIT------------------PSTYTNN-----LIVAGAGFVAYMLagFL 434
Cdd:TIGR01299 522 kSVSFEDSLFEECTFDDVTSsntffkNCTFIDTlfentdfeeykfidsefqNCSFLHNkegcpIDFDGDDEGAYMI--YF 599

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   435 VNLVGV------------------KLIMTSGLLIAAGCSIGMYW-SSSAASTVALASLF--VTMGSISATSVIsaSVSLF 493
Cdd:TIGR01299 600 VNFLGTlavlpgnivsallmdkigRLRMLAGSMVLSCISCFFLSfGNSESAMIALLCLFggLSIAAWNALDVL--TVELY 677

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297   494 PTSLRTMIVSLEMMFGRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:TIGR01299 678 PSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLP 734
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 25-550 6.25e-34

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 137.03  E-value: 6.25e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    25 QKEAAADFEAAIDAAGFGMFNILLLVAAVPAAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGY 104
Cdd:TIGR01299 145 EEELAQQYELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   105 LADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIAT 184
Cdd:TIGR01299 225 LADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGG 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   185 LTLPGLAMLILPE-TWNIQIWT-LSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSR- 261
Cdd:TIGR01299 305 IYAAAMAWAIIPHyGWSFQMGSaYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRa 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   262 --KPKDSFPIkllaNEVIVPvkkHAKDETIptelklptecvevqdpENQDSKKSSLRSGFTQLRPL-----------FTK 328
Cdd:TIGR01299 385 kgHPEKVFSV----NHIKTI---HQEDELI----------------EIESDTGTWYQRCFVRALSEgggiwgnflrcFNP 441

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   329 PYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASI--------------NEYENLMSGESQSTSICNILEY---------- 384
Cdd:TIGR01299 442 EVREITIKLMGVWFTLSFGYYGLSVWFPDMIKHLqaddyaaltknfpgDKVAHFSFNFTLENQIHRGGEYdndkfiglkf 521

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   385 -SVNRTQSQLEAVTRNDPTV------ECHVIIT------------------PSTYTNN-----LIVAGAGFVAYMLagFL 434
Cdd:TIGR01299 522 kSVSFEDSLFEECTFDDVTSsntffkNCTFIDTlfentdfeeykfidsefqNCSFLHNkegcpIDFDGDDEGAYMI--YF 599

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   435 VNLVGV------------------KLIMTSGLLIAAGCSIGMYW-SSSAASTVALASLF--VTMGSISATSVIsaSVSLF 493
Cdd:TIGR01299 600 VNFLGTlavlpgnivsallmdkigRLRMLAGSMVLSCISCFFLSfGNSESAMIALLCLFggLSIAAWNALDVL--TVELY 677

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297   494 PTSLRTMIVSLEMMFGRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:TIGR01299 678 PSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLP 734
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 55-550 4.67e-28

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 117.33  E-value: 4.67e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd17438   7 ALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPE-TWNIQIWT-LSLTSWQ 212
Cdd:cd17438  87 YGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHyGWGFSMGTnYHFHSWR 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 213 FFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSRkpkdsfpikllanevivpvkkhAKDEtipte 292
Cdd:cd17438 167 VFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMR----------------------AKGT----- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 293 lklPTECVEVQDPEnqdsKKSSLRSGFTQLRPLFTkpYLGLSLWV-----YLLNFCVLLGQNTMRLWLPQLFASINEYEN 367
Cdd:cd17438 220 ---PEKVFTVSNIK----RKNTLFLAVVWFTMAFS--YYGLTVWFpdmirYLQKHVTFEDSLFDECYFEDVTSTDTYFKN 290

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 368 LMsgeSQSTSICNILEYSVNRTQSQLEAVTRNDPTVECHVIITPStytNNLIVAGAGFVAYM-------LAGFLVNLVGV 440
Cdd:cd17438 291 CT---IESTIFYNTDLYEHKFIDCRFINSTFLEQKEGCHMDFEED---NDFLIYLVSFLGSLsvlpgniISALLMDKIGR 364

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 441 KLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMgSISATSVISA-SVSLFPTSLRTMIVSLEMMFGRLGSLLGNIF 519
Cdd:cd17438 365 IKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGT-SIAAWNALDViTVELYPTNKRATAFGILNGLCKFAAILGNSI 443

                       490       500       510
                ....*....|....*....|....*....|.
gi 45549297 520 FPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:cd17438 444 FASFVGITKVIPILLASTALVGGGLISLRLP 474
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 47-195 8.74e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 69.07  E-value: 8.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  47 LLLVAAVPAAMgTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICV 126
Cdd:COG0477  15 ALLALALGTFL-EGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45549297 127 LGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLIL 195
Cdd:COG0477  94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
MFS_1 pfam07690
Major Facilitator Superfamily;
76-195 6.02e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.89  E-value: 6.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    76 DLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAV 155
Cdd:pfam07690  26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPA 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 45549297   156 LMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLIL 195
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA 145
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
93-210 1.51e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 44.14  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   93 AGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRI 172
Cdd:PRK11102  37 LGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRM 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 45549297  173 MMMVGIMFSIATLTLP--GLAMLILpETWNIQIWTLSLTS 210
Cdd:PRK11102 117 MSFVTLVMTIAPLLAPiiGGWLLVW-FSWHAIFWVLALAA 155
 
Name Accession Description Interval E-value
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 25-550 6.25e-34

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 137.03  E-value: 6.25e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    25 QKEAAADFEAAIDAAGFGMFNILLLVAAVPAAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGY 104
Cdd:TIGR01299 145 EEELAQQYELIIQECGHGRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGG 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   105 LADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIAT 184
Cdd:TIGR01299 225 LADKLGRKQCLLICLSVNGFFAFFSSFVQGYGFFLFCRLLSGFGIGGAIPIVFSYFAEFLAQEKRGEHLSWLCMFWMIGG 304

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   185 LTLPGLAMLILPE-TWNIQIWT-LSLTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSR- 261
Cdd:TIGR01299 305 IYAAAMAWAIIPHyGWSFQMGSaYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFLENGKHDEAWMILKLIHDTNMRa 384

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   262 --KPKDSFPIkllaNEVIVPvkkHAKDETIptelklptecvevqdpENQDSKKSSLRSGFTQLRPL-----------FTK 328
Cdd:TIGR01299 385 kgHPEKVFSV----NHIKTI---HQEDELI----------------EIESDTGTWYQRCFVRALSEgggiwgnflrcFNP 441

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   329 PYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASI--------------NEYENLMSGESQSTSICNILEY---------- 384
Cdd:TIGR01299 442 EVREITIKLMGVWFTLSFGYYGLSVWFPDMIKHLqaddyaaltknfpgDKVAHFSFNFTLENQIHRGGEYdndkfiglkf 521

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   385 -SVNRTQSQLEAVTRNDPTV------ECHVIIT------------------PSTYTNN-----LIVAGAGFVAYMLagFL 434
Cdd:TIGR01299 522 kSVSFEDSLFEECTFDDVTSsntffkNCTFIDTlfentdfeeykfidsefqNCSFLHNkegcpIDFDGDDEGAYMI--YF 599

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   435 VNLVGV------------------KLIMTSGLLIAAGCSIGMYW-SSSAASTVALASLF--VTMGSISATSVIsaSVSLF 493
Cdd:TIGR01299 600 VNFLGTlavlpgnivsallmdkigRLRMLAGSMVLSCISCFFLSfGNSESAMIALLCLFggLSIAAWNALDVL--TVELY 677

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297   494 PTSLRTMIVSLEMMFGRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:TIGR01299 678 PSDKRATAFGFLNALCKAAAVLGILIFGSFVGITKAAPILFASAALACGGLLALKLP 734
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 55-550 4.67e-28

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 117.33  E-value: 4.67e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd17438   7 ALMADGVEVFVVGFVLPSAEKDMCLSSSNKGMLGLIVYLGMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPE-TWNIQIWT-LSLTSWQ 212
Cdd:cd17438  87 YGAFLFCRLISGFGIGGSLPIVFAYFSEFLAREKRGEHLSWLCMFWMIGGLYASAMAWSIIPHyGWGFSMGTnYHFHSWR 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 213 FFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSRkpkdsfpikllanevivpvkkhAKDEtipte 292
Cdd:cd17438 167 VFVIICALPCIASIIALKFMPESPRFLLEMGKHDEAWMILKNIHDTNMR----------------------AKGT----- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 293 lklPTECVEVQDPEnqdsKKSSLRSGFTQLRPLFTkpYLGLSLWV-----YLLNFCVLLGQNTMRLWLPQLFASINEYEN 367
Cdd:cd17438 220 ---PEKVFTVSNIK----RKNTLFLAVVWFTMAFS--YYGLTVWFpdmirYLQKHVTFEDSLFDECYFEDVTSTDTYFKN 290

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 368 LMsgeSQSTSICNILEYSVNRTQSQLEAVTRNDPTVECHVIITPStytNNLIVAGAGFVAYM-------LAGFLVNLVGV 440
Cdd:cd17438 291 CT---IESTIFYNTDLYEHKFIDCRFINSTFLEQKEGCHMDFEED---NDFLIYLVSFLGSLsvlpgniISALLMDKIGR 364

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 441 KLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMgSISATSVISA-SVSLFPTSLRTMIVSLEMMFGRLGSLLGNIF 519
Cdd:cd17438 365 IKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGT-SIAAWNALDViTVELYPTNKRATAFGILNGLCKFAAILGNSI 443

                       490       500       510
                ....*....|....*....|....*....|.
gi 45549297 520 FPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:cd17438 444 FASFVGITKVIPILLASTALVGGGLISLRLP 474
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 55-550 5.19e-26

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 111.04  E-value: 5.19e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd17363   7 ALMADGVEVFVVGFVLPSAEKDMCLSNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSFVQG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPE-TWNIQIWT-LSLTSWQ 212
Cdd:cd17363  87 YGFFLFCRLLSGIGIGGSIPIVFSYFAEFLAREKRGEHLSWLCMFWMIGGLYASAMAWAIIPHyGWGFSMGTaYQFHSWR 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 213 FFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSRkpkdsfpikllanevivpvkkhAKDEtipte 292
Cdd:cd17363 167 VFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNMR----------------------AKGH----- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 293 lklPTECVEVqdpeNQDSKKSSLRSGFTQLRPLFTkpYLGLSLW----VYLLNFCVLLGQNTMrlwlpqlfasineYENL 368
Cdd:cd17363 220 ---PERVFTV----SHIKRMNTLFLAIVWFTMSFS--YYGLTVWfpdmIKYLQFEDSLFEECY-------------FEDV 277

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 369 MSGES--QSTSICNILEYSVNRTQSQ------LEAVTRNDPTVECHVIITPST----YTNNLIVAGAGFVAYMLAGFLVN 436
Cdd:cd17363 278 TSTNTffENCTFINTVFYNTDLFEYKfidsrfLNSTFFLKEKCGCHLNDDEENayliYLVSFLGSLSVLPGNIVSALLMD 357

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 437 LVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFPTSLRTMIVSLEMMFGRLGSLLG 516
Cdd:cd17363 358 KIGRLKMIGGSMLLSAVCCFFLFFGNSESAMIGLQCLFCGVSIAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILG 437

                       490       500       510
                ....*....|....*....|....*....|....
gi 45549297 517 NIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:cd17363 438 NSIFGSFVGITKVIPILLASAALVCGGLLALKLP 471
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 55-550 1.01e-22

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 101.26  E-value: 1.01e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd17439   7 ALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRIGRRQCLLISLSVNSVFAFFSSFVQG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPE-TWNIQIWT-LSLTSWQ 212
Cdd:cd17439  87 YGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGIYASAMAWAIIPHyGWSFQMGSaYQFHSWR 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 213 FFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSRkpkdsfpikllanevivpVKKHakdetipte 292
Cdd:cd17439 167 VFVLVCAFPSVFAIGALTTMPESPRFFLENGKHDEAWMVLKQVHDTNMR------------------AKGH--------- 219

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 293 lklptecvevqdPENQDSkksslrsgFTQLRPLFTkpYLGLSLWvyllnFCVLLGQNTMRLWLPQLFASINE---YENLM 369
Cdd:cd17439 220 ------------PERVFS--------VTHIKRRIT--LMMMAVW-----FTMSFSYYGLTVWFPDMIKHLQKsvvFEDSL 272

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 370 SGESQSTSICNilEYSVNRTQSQLEAVTRNDPTVECHVI---ITPSTYTNN----LIVAGAGFVAYMLagFLVNLVGVKL 442
Cdd:cd17439 273 FEECYFEDITS--SNTFFKNCTFISTLFYNTDLFEYKFInskLINSTFLHNkegcLLDFSDENNAYMI--YFVSFLGTLA 348

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 443 IMTSGLLIA------------AGCSIG-------MYWSSSAASTVALASLF--VTMGSISATSVIsaSVSLFPTSLRTMI 501
Cdd:cd17439 349 VLPGNIVSAllmdkigrlrmlAGSSVMscvscffLSFGNSESAMIALLCLFggVSIASWNALDVL--TVELYPSDKRTTA 426

                       490       500       510       520
                ....*....|....*....|....*....|....*....|....*....
gi 45549297 502 VSLEMMFGRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:cd17439 427 FGFLNALCKLAAVLGISIFTSFVGITKAVPILLASAALAAGSSLALKLP 475
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 55-550 3.29e-21

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 96.91  E-value: 3.29e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd17440   7 ALMADGVEVFVVGFVLPSAETDMCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRRQSLLICMSVNGFFAFLSSFVQG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPE-TWNIQIWT-LSLTSWQ 212
Cdd:cd17440  87 YGLFLFCRLLSGFGIGGAVPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHyGWSFSMGSaYQFHSWR 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 213 FFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFMYHLNSRKPKDSfpikllanEVIVPVKKHAKDETIPTE 292
Cdd:cd17440 167 VFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKQIHDTNMRARGQP--------EKVFTVNRIKKDNTIKLT 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 293 LKLPTecvevqdpenqdskksslrsgftqlrplFTKPYLGLSLW----VYLLNFCVLLGQNTmrlwlpqLFASInEYENL 368
Cdd:cd17440 239 IVWLT----------------------------LSFGYYGLSVWfpdvIKHLQFKSVTFEDS-------LFKSC-FFEDV 282

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 369 MSGES--QSTSICNILEYSVNR-----TQSQLEAVTRNDPTVECHVIITPS-----TYTNNLIVAGAGFVAYMLAGFLVN 436
Cdd:cd17440 283 TSVNTyfRNCTFIETVFYNTDLedykfIDSDFINCTFFHNKTGCQITFDDDysaywIYFVNFLGTLAVLPGNIVSALLMD 362

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 437 LVGvKLIMTSGLLIAAGCSIGMYW-SSSAASTVALASLFVTMgSISA-TSVISASVSLFPTSLRTMIVSLEMMFGRLGSL 514
Cdd:cd17440 363 RIG-RLTMLGGSMVLSGISCFFLWfGTSESMMIGMLCLYNGL-TISAwNSLDVVTVELYPTDRRATGFGFLNALCKAAAV 440

                       490       500       510
                ....*....|....*....|....*....|....*.
gi 45549297 515 LGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:cd17440 441 LGNLIFGSLVGITKAIPILLASTVLVCGGLVGLRLP 476
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 84-557 7.74e-21

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 95.85  E-value: 7.74e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    84 KGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTEL 163
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNTEF 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   164 HGRKHRQRIMMMVGIMFSIATLTLPGLAMLIlpetwniqiwtlslTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKG 243
Cdd:TIGR00898 209 LPKKQRAIVGTLIQVFFSLGLVLLPLVAYFI--------------PDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQG 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   244 RNREALDAFKFMYHLNSRkpkdsfpiKLLANEVIVPVKKHAkdetiptelklptecvevqdpenqdskkSSLRSGFTQLR 323
Cdd:TIGR00898 275 RIEEALKILQRIAKINGK--------KLPAEVLSLSLEKDL----------------------------SSSKKQYSFLD 318

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   324 PLFTKPYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASIneyenlmsgesqstsicnileysvnrtqsqleavtrndptv 403
Cdd:TIGR00898 319 LFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNI----------------------------------------- 357

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   404 echviitpstYTNNLIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISA- 482
Cdd:TIGR00898 358 ----------YLDLFISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSa 427

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297   483 -TSVISASVSLFPTSLRTMIVSLEMMFGRLGSLLGNIFFpALMGLGCVPPF-LMISAFMLAGCFmAAFLPLKNKAAL 557
Cdd:TIGR00898 428 fQMVYLYTAELYPTVVRNLGVGVCSTMARVGSIISPFLV-YLGEKWLFLPLvLFGGLALLAGIL-TLFLPETKGVPL 502
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 61-548 2.57e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 74.56  E-value: 2.57e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  61 YETSTMSYILP--SAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQL 138
Cdd:cd17316  13 YDFFLIGFVAPvlAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILL 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 139 MVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPetwniqiWTLSLTSWQFFVAVT 218
Cdd:cd17316  93 LVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIP-------LLSGDWGWRILFLIG 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 219 ALPsllsfvlffffpespkflmskgrnrealdafkfmyhlnsrkpkdsfpikllanevivpvkkhakdetiptelklpte 298
Cdd:cd17316 166 ALP----------------------------------------------------------------------------- 168

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 299 cvevqdpenqdskksslrsgftqlrPLFTKPYLGLSLWVYLLNFCVLLGQNTMRLWLPQLFASINEYenlmsgesqstsi 378
Cdd:cd17316 169 -------------------------ALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGL------------- 210

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 379 cnileysvnrtqsqleavtrndptvechviITPSTYTNNLIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGM 458
Cdd:cd17316 211 ------------------------------SPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPL 260

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 459 YWSSSAASTVALASLFVTMGSISATSVISASVS--LFPTSLRTMIVSLEMMFGRLGSLLGNIFFPALMG-LGCVPPFLMI 535
Cdd:cd17316 261 FYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLaeLFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAsTGGTGVPALI 340

                       490
                ....*....|...
gi 45549297 536 SAFMLAGCFMAAF 548
Cdd:cd17316 341 LALLAIVALIVAL 353
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 47-195 8.74e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 69.07  E-value: 8.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  47 LLLVAAVPAAMgTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICV 126
Cdd:COG0477  15 ALLALALGTFL-EGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLAS 93

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45549297 127 LGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLIL 195
Cdd:COG0477  94 LLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
44-195 9.95e-13

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 69.62  E-value: 9.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  44 FNILLLVAAVPAAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADT 123
Cdd:COG2814   7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45549297 124 ICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLIL 195
Cdd:COG2814  87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 61-243 2.33e-11

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 65.84  E-value: 2.33e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    61 YETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMV 140
Cdd:TIGR00895  31 YDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLI 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   141 FKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLtlpgLAMLILPetwniqiWTLSLTSWQ-FFVAVTA 219
Cdd:TIGR00895 111 LRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAA----VGGFLAG-------WLIPVFGWRsLFYVGGI 179

                         170       180
                  ....*....|....*....|....
gi 45549297   220 LPSLLSFVLFFFFPESPKFLMSKG 243
Cdd:TIGR00895 180 APLLLLLLLMRFLPESIDFLVSKR 203
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 60-254 6.35e-11

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 64.25  E-value: 6.35e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  60 VYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLL---IVGYAadtICVLGGALSQSRI 136
Cdd:cd17371  12 GFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLvitILLFA---VFTLLCGFAQNYW 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 137 QLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPetwniqiWTLSLTSWQFFVA 216
Cdd:cd17371  89 QLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFP-------LLPPEIAWRVLFL 161

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 45549297 217 VTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKF 254
Cdd:cd17371 162 LGALPALLVLFIRRFVKEPPQWQAARAARRHFADRPSL 199
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 414-550 1.68e-10

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 62.60  E-value: 1.68e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 414 YTNNLIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISAT-SVISA-SVS 491
Cdd:cd17317 194 YLNFFLSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAfSVIYLyTAE 273

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 45549297 492 LFPTSLRTMIVSLEMMFGRLGSLLGNiFFPALMGLGCVPPFLMISAFMLAGCFMAAFLP 550
Cdd:cd17317 274 LYPTVVRNTGVGLCSTVARVGAILAP-FIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_1 pfam07690
Major Facilitator Superfamily;
76-195 6.02e-10

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 60.89  E-value: 6.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    76 DLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAV 155
Cdd:pfam07690  26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPA 105

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 45549297   156 LMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLIL 195
Cdd:pfam07690 106 ALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA 145
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 61-244 2.40e-09

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 59.50  E-value: 2.40e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  61 YETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMV 140
Cdd:cd17359  15 YDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFII 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 141 FKYLGGFCMSGPFAVLMTYLTELHGRKHR------QRIMMMVGIMFSIATLTLPGLAMlilPETWNIQiwtlslTSWQFF 214
Cdd:cd17359  95 ARIIGGLAVGGASALVPMYIAEVAPAEIRgrlvslNQLMIVFGQLLAYIVNYLIANAG---GADWLGA------EGWRWM 165

                       170       180       190
                ....*....|....*....|....*....|
gi 45549297 215 VAVTALPSLLSFVLFFFFPESPKFLMSKGR 244
Cdd:cd17359 166 LGLEAIPAILFLLGMLFIPESPRWLVSKGK 195
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
418-554 6.61e-09

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 57.96  E-value: 6.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 418 LIVAGAGFVAYMLAGFLVNLVG--VKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFPT 495
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPK 302

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 496 SLRTMIVSLEMMFGRLGSLLGNIFFPALMGL-GCVPPFLMISAFMLAGCFMAAFLPLKNK 554
Cdd:COG2271 303 KARGTASGLVNTFGFLGGALGPLLVGYLLDAtGYQAAFLLLAALALLAALLALLLLRETR 362
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 55-221 8.63e-09

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 57.54  E-value: 8.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd17372   7 GWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPN 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSGpFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPEtwniqiwtlslTSWQFF 214
Cdd:cd17372  87 YMWLIILRCLVGLGLGG-GPQLASWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPR-----------LGWRWL 154


                ....*..
gi 45549297 215 VAVTALP 221
Cdd:cd17372 155 LAFSSVP 161
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 10-163 2.27e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 56.16  E-value: 2.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  10 PKPHKTAEHQIGdpPQKEAAADFEAAIDAAGF-GMFNILLLVAAVpaAMGTVYETSTmsyILPS-AECDLKLSLLDKGIL 87
Cdd:cd17371 178 KEPPQWQAARAA--RRHFADRPSLRELFSPPLlRTTLLASLLATG--ALGGYYGITT---WLPSyLTGERGLSFEGSAGY 250

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45549297  88 NAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLggALSQSRIQLMVFKYLG---GFCMSGPFAVLMTYLTEL 163
Cdd:cd17371 251 LVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISIL--LYFFLPLSPTLILILGfplGFFASGPFSGMGAYLTEL 327
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 94-221 8.74e-08

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 54.45  E-value: 8.74e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  94 GMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIM 173
Cdd:cd17373  37 GLIFGYLILGCIADRFGRRPVLLFSLILILIFGLTVALAVSVTMFSTLRFLEGFCLAGIILTLYLLRLELCDPGKRLMIT 116

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 45549297 174 MMVGIMFSIATLTLPGLAMLIlpetwniqiwtlslTSWQFFVAVTALP 221
Cdd:cd17373 117 MVASLVAVAGQFLMPGLAALC--------------RDWRVLQALIICP 150
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
47-203 9.13e-08

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 54.50  E-value: 9.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  47 LLLVAAVPAAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICV 126
Cdd:COG2223   5 RVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGL 84

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297 127 LGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILpETWNIQI 203
Cdd:COG2223  85 LLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLI-AAFGWRN 160
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
48-183 9.75e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 54.21  E-value: 9.75e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  48 LLVAAVPAAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVL 127
Cdd:COG2814 209 LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLL 288

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 45549297 128 GGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIA 183
Cdd:COG2814 289 LLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 93-221 1.74e-07

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 53.45  E-value: 1.74e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  93 AGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRI 172
Cdd:cd17374  46 AGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEWTTPRHRALA 125

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 45549297 173 MMMVGIMFSIATLTLPGLAMLIlpETWNIQIWTLSLTSWQFFVAVTALP 221
Cdd:cd17374 126 ITLTSCFFSIGQMLLAGLAYAI--RDWRLLQLVVSVPFFLFFLYSWWLP 172
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 42-549 1.79e-07

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 53.88  E-value: 1.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    42 GMFNILLLVAAVPAAMgTVYETSTMSYILPSAECDLKLSLLDK--------GILNAITYAGMISSAVLWGYLADIKGRRN 113
Cdd:TIGR00879  24 WKVALLSLIAAIGGLM-FGYDTGVIGGALALPAFEFKFTSANSdsyssslwGLVVSIFLVGGFIGALFAGWLSDRFGRKK 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   114 -LLIVGYAAdticVLGGALSQ------SRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLT 186
Cdd:TIGR00879 103 sLLIIALLF----VIGAILMGlaafalSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLYQLAITFGILV 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   187 LPGLAMLILPETWNIQiwtlsltsWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKFmyhlnSRKPKDS 266
Cdd:TIGR00879 179 AYGFGSGKVSLNNTLG--------WRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLAR-----LRGTSGE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   267 FPIKLLANEVIVPvkkhakDETIPTELKLPTEcvevqdpenqDSKKSSLRSgftqlrplftkpylglSLWVYLLNFCVLL 346
Cdd:TIGR00879 246 DKELLDELELIDI------KRSIEKRSVQPSW----------GSLFSSTRR----------------IRRRLFLGVVLQW 293

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   347 GQntmrlwlpqlfasineyenlmsgesQSTSICNILEYSVNRTQSqleavtrndptvechVIITPST-YTNNLIVAGAGF 425
Cdd:TIGR00879 294 FQ-------------------------QFTGINAIMYYSPTIFEN---------------AGVSTDHaFLVSIIVGAVNF 333

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   426 VAYMLAGFLVNLVGVKLIMTSGlliAAGCSIGMYW-----------SSSAASTVALAS--LFVTMGSISATSVISASVS- 491
Cdd:TIGR00879 334 AFTFVAIFLVDRFGRRPLLLIG---AAGMAICLFVlgilgasfvtgSSKSSGNVAIVFilLFIAFFAMGWGPVPWVIVSe 410

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 45549297   492 LFPTSLRTMIVSLEMMFGRLGSLLGNIFFP-ALMGLGCVPPFLMISAFMLAGCFMAAFL 549
Cdd:TIGR00879 411 IFPLSLRPKGISIAVAANWLANFIVGFLFPtMLESIGVGGVFIFFGGLNVLGLIFVYFF 469
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 51-194 2.88e-07

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 52.81  E-value: 2.88e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  51 AAVPAAMGTVYETSTMSYILpSAECDLklsLLDKGILNAIT----YAGMISSAVLWGYLADIKGRRNLLIVGYAADTICV 126
Cdd:cd17447   4 PVVPCQNGWVYDHSTFSSTI-ATEWDL---VCDRKGLNQATatffFAGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFG 79

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45549297 127 LGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLI 194
Cdd:cd17447  80 LASAFSVSYVMFAITRTLTGFALTGFSIISMVLCVEWVDIEHRTVAGVLISLFWTVGNMLLALVAYLI 147
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 89-213 2.99e-07

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 52.74  E-value: 2.99e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  89 AITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKH 168
Cdd:cd17379  40 SSLNLGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKY 119

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45549297 169 RQRIMMMVGIMFSIATLTLPGLAMLIlpETWNIQIWTLSLTSWQF 213
Cdd:cd17379 120 RRTVGIVYQMFFTLGLLILPGIAYFI--PHWRWLQLAVTLPNFLF 162
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 61-181 9.84e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 51.05  E-value: 9.84e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  61 YETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMV 140
Cdd:cd17365  13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45549297 141 FKYLGGFCMSGPFAVLMTYLTELHGRKHRQrimMMVGIMFS 181
Cdd:cd17365  93 LRFLTGLGLGAAMPNAITLVSEYAPARRRS---LAVTLMFC 130
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 85-195 1.91e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  85 GILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELH 164
Cdd:cd17325  34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIA 113

                        90       100       110
                ....*....|....*....|....*....|.
gi 45549297 165 GRKHRQRIMMMVGIMFSIATLTLPGLAMLIL 195
Cdd:cd17325 114 PPEERGRAMGIFSSAIGLGFLIGPLLGGLLA 144
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
423-549 2.00e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.26  E-value: 2.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 423 AGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFPTSLRTMIV 502
Cdd:COG2223  52 VGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLAL 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 45549297 503 SLEMMFGRLGSLLGNIFFPALMG-LGCVPPFLMISAFMLAGCFMAAFL 549
Cdd:COG2223 132 GLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAWLF 179
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
79-192 2.34e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 2.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  79 LSLLDKGILNAITYAGMISSAVLWGYLAD--IKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVL 156
Cdd:COG2271 213 LSLAQAGLLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLL 292

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45549297 157 MTYLTELHGRKHRQR---IMMMVGIMFSIATLTLPGLAM 192
Cdd:COG2271 293 WALAAELFPKKARGTasgLVNTFGFLGGALGPLLVGYLL 331
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 55-239 3.05e-06

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 49.43  E-value: 3.05e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd17441   7 AWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFIGMMLSSSLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPI 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSG-PFAVlmTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPEtwniqiwtlslTSWQF 213
Cdd:cd17441  87 YSWILVLRGLVGFGIGGvPQSV--TLYAEFLPMKSRAKCILLIEVFWALGTVFEVLLAVFVMPT-----------LGWRW 153

                       170       180
                ....*....|....*....|....*.
gi 45549297 214 FVAVTALPSLLSFVLFFFFPESPKFL 239
Cdd:cd17441 154 LLILSALPLLIFAVLCFWLPESARYW 179
Sugar_tr pfam00083
Sugar (and other) transporter;
52-548 3.61e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.58  E-value: 3.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    52 AVPAAMGTVYETSTMsYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVgyaADTICVLGGAL 131
Cdd:pfam00083  17 GVIGAFLTLIDFFKN-FGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI---ANVLFVIGAVL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   132 S------QSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMM------VGIMFSIATltlpglaMLILPETW 199
Cdd:pfam00083  93 QgaakgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLyqlaitFGILLAYIF-------GLGLNKTS 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   200 NIqiwtlslTSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFkfmyhlnsRKPKDSFPIKLLANEVIVP 279
Cdd:pfam00083 166 NS-------DGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVL--------AKLRGVPDVDRELDEIKDS 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   280 VKKHAKDETIPTelklptecvevqdpenqdskkSSLRSGFTQLRPLFTkpylGLSLWVyLLNFCvllGQNTMRLWLPQLF 359
Cdd:pfam00083 231 LEAGQEAEKASW---------------------KELFSTKTRRQRLLI----GVMLQI-FQQLT---GINAIFYYSTTIF 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   360 ASineyenlmsgesqstsicnileysvnrtqsqleavtrndptvechVIITPSTYTnNLIVAGAGFVAYMLAGFLVNLVG 439
Cdd:pfam00083 282 EN---------------------------------------------LGLSDSFLV-TIIVGVVNFVFTFIAIFLVDRFG 315

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   440 VKLIMTSGLLIAAGC----SIGMYW---SSSAASTVALAS--LFVTMGSISATSVISASVS-LFPTSLRTMIVSLEMMFG 509
Cdd:pfam00083 316 RRPLLLLGAAGMAICfvilGIVALLgvsKSDWAGIVAIVFiaLFIAFFAMGWGPVPWVIVSeLFPLSVRSKAMALATAAN 395

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|
gi 45549297   510 RLGSLLGNIFFPALMG-LGCVPPFLMISAFMLAGCFMAAF 548
Cdd:pfam00083 396 WLANFLIGFLFPIITDaIGLGYTFFIFAGLLVLFIIFVFF 435
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 40-208 6.21e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 48.37  E-value: 6.21e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  40 GFGMFNILLLVAAVPAAMGTVYetSTMSYILPSA-ECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVG 118
Cdd:cd17316 172 ALLLRRRTLLLILLWFFISFGY--YGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIG 249

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 119 YAADTICV--LGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRqriMMMVGIMFSIATL---TLPGLAML 193
Cdd:cd17316 250 LILSGILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVR---ATGVGLSYNLGRLgggGAPPLIAL 326

                       170
                ....*....|....*
gi 45549297 194 ILPETWNIQIWTLSL 208
Cdd:cd17316 327 LLASTGGTGVPALIL 341
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 93-199 7.10e-06

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 48.18  E-value: 7.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  93 AGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRI 172
Cdd:cd17446  44 AGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVEWMPTRVRAVV 123

                        90       100
                ....*....|....*....|....*..
gi 45549297 173 MMMVGIMFSIATLTLPGLAMLILPETW 199
Cdd:cd17446 124 GTLLGYCYTLGQLILAGVAYAIRDWRW 150
MFS_1 pfam07690
Major Facilitator Superfamily;
419-554 7.21e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.18  E-value: 7.21e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   419 IVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFPTSLR 498
Cdd:pfam07690  40 LFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER 119

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 45549297   499 TMIVSLEMMFGRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLPLKNK 554
Cdd:pfam07690 120 GRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPP 175
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
418-551 7.70e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 48.31  E-value: 7.70e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 418 LIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAAstVALASLFVTMGSISA--TSVISASVSLFPT 495
Cdd:COG0738  50 FAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP--LLLLALFLLGLGLGLldVAANPYVAALGPE 127

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 496 SLRTMIVSLEMMFGrLGSLLGNIFFPALMGLGCVP----PFLMISAFMLAGCFMAAFLPL 551
Cdd:COG0738 128 TAASRLNLLHAFFS-LGALLGPLLGGLLILLGLSLswhlPYLILAVLLLLLALLFLRSKL 186
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 75-256 8.33e-06

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 48.41  E-value: 8.33e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  75 CDLKLSLLdKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAadtICVLGGALS------QSRIQLMVFKYLGGFC 148
Cdd:cd17357  43 SDSELDLL-WSLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNA---LLVVSSLLMflsksaKSPELLIFGRFLVGIA 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 149 MSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLtlpgLAMLI-LPETWNiqiwtlSLTSWQFFVAVTALPSLLSFV 227
Cdd:cd17357 119 CGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGIL----LGQVFgLPSVLG------TETLWPYLLFFPGIPALLQLA 188

                       170       180       190
                ....*....|....*....|....*....|
gi 45549297 228 LFFFFPESPKFLM-SKGRNREALDAFKFMY 256
Cdd:cd17357 189 ALPFFPESPKFLLiSKGDEEEAEKSLKFLR 218
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 85-194 9.82e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 47.97  E-value: 9.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  85 GILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELH 164
Cdd:cd17489  34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADII 113

                        90       100       110
                ....*....|....*....|....*....|
gi 45549297 165 GRKHRQRIMMMVGIMFSIATLTLPGLAMLI 194
Cdd:cd17489 114 PPSRRGEGIGYYGLATTLAMALGPALGLFL 143
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 55-221 1.28e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 47.81  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTVYETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQS 134
Cdd:cd06174   4 GFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 135 RIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQR---IMMMVGIMFSIATLTLPGLAMLILPETWNIQIWTLSLTSW 211
Cdd:cd06174  84 FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRalgLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALAL 163

                       170
                ....*....|
gi 45549297 212 QFFVAVTALP 221
Cdd:cd06174 164 LAAILLLLVV 173
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 418-549 1.38e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.57  E-value: 1.38e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 418 LIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFPTSL 497
Cdd:cd17325 242 GAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG 321

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 45549297 498 RTMIVSLEMMFGRLGSLLGNIFFPALMG-LGCVPPFLMISAFMLAGCFMAAFL 549
Cdd:cd17325 322 RGTAMGLFNTAFSLGMVLGPLLGGFLYDaFGFATPFLAAAALLLLAAVLFLLL 374
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 76-193 1.45e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 47.19  E-value: 1.45e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  76 DLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCmSGPFAV 155
Cdd:cd17330  28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLT-GGNVSV 106

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45549297 156 LMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAML 193
Cdd:cd17330 107 AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGF 144
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
419-526 1.74e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.74e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 419 IVAGAGFVAYML----AGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFP 494
Cdd:COG2271  49 LLASAFFLGYALgqipAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFP 128

                        90       100       110
                ....*....|....*....|....*....|..
gi 45549297 495 TSLRTMIVSLEMMFGRLGSLLGNIFFPALMGL 526
Cdd:COG2271 129 PKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 85-186 1.92e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 47.16  E-value: 1.92e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  85 GILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELH 164
Cdd:cd17324  37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116

                        90       100
                ....*....|....*....|..
gi 45549297 165 GRKHRQRIMMMVGIMFSIATLT 186
Cdd:cd17324 117 PPEKRGRAIGLVFSGLTLGLVL 138
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 48-254 2.19e-05

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 47.18  E-value: 2.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  48 LLVAAVPAAMGTV--YETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVgyaADTIC 125
Cdd:cd17358   5 FVANLGSFSFGIAvgWSSPALPSLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLI---SAIPC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 126 VLGGAL---SQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRI--MMMVGIMFSIATLTLPGLAMlilpetwn 200
Cdd:cd17358  82 ILGWLLiafAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALgsLNQLLVNIGILLGYVLGSFL-------- 153

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 45549297 201 iqiwtlsltSWQFFVAVTALPSLLSFVLFFFFPESPKFLMSKGRNREALDAFKF 254
Cdd:cd17358 154 ---------PWRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQF 198
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
76-220 5.67e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 5.67e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  76 DLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAV 155
Cdd:COG0738  37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVA 116

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45549297 156 LMTYLTELHGRKHRQRIMMMvGIMFSIATLTLPGLAMLILPETWNIQiWTLSLTSWQFFVAVTAL 220
Cdd:COG0738 117 ANPYVAALGPETAASRLNLL-HAFFSLGALLGPLLGGLLILLGLSLS-WHLPYLILAVLLLLLAL 179
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 89-184 9.60e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 44.86  E-value: 9.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  89 AITYAGMIssaVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKH 168
Cdd:cd17321  41 LLAFAALL---LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGER 117

                        90
                ....*....|....*.
gi 45549297 169 RQRIMMMVGIMFSIAT 184
Cdd:cd17321 118 RGRALGLWGAVVGIGA 133
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 419-554 1.21e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 44.34  E-value: 1.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 419 IVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFPTSLR 498
Cdd:cd06174  39 LFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERER 118

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 45549297 499 TMIVSLEMMFGRLGSLLGNIFFPAL--MGLGCVPPFLMISAFMLAGCFMAAFLPLKNK 554
Cdd:cd06174 119 GRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLAAILLLLVVPDP 176
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 93-208 1.31e-04

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 44.30  E-value: 1.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    93 AGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRI 172
Cdd:TIGR00710  51 LGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRI 130

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 45549297   173 MMMVGIMFSIATLTLPGLAMLILPE-TWNIQIWTLSL 208
Cdd:TIGR00710 131 YSILMPVLALAPAVAPLLGGYILVWlSWHAIFAFLSL 167
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 93-195 1.50e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 44.10  E-value: 1.50e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  93 AGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRI 172
Cdd:cd17320  45 LGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKI 124

                        90       100
                ....*....|....*....|...
gi 45549297 173 MMMVGIMFSIATLTLPGLAMLIL 195
Cdd:cd17320 125 FSLLMMILAIAPALAPLLGGLLL 147
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
93-210 1.51e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 44.14  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297   93 AGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRI 172
Cdd:PRK11102  37 LGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEFSRM 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 45549297  173 MMMVGIMFSIATLTLP--GLAMLILpETWNIQIWTLSLTS 210
Cdd:PRK11102 117 MSFVTLVMTIAPLLAPiiGGWLLVW-FSWHAIFWVLALAA 155
MFS_1 pfam07690
Major Facilitator Superfamily;
17-183 1.59e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    17 EHQIGDPPQKEAAADFEAAIDAAGFGMFNILLLVAAVPAAMGTvyetSTMSYILPSAECDLKLSLLDKGILNAITYAGMI 96
Cdd:pfam07690 174 PPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAF----FGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGA 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297    97 SSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLG---GFCMSGPFAVLMTYLTELHGRKHRQRIM 173
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALlllGFGFGLVFPALNALVSDLAPKEERGTAS 329

                         170
                  ....*....|
gi 45549297   174 MMVGIMFSIA 183
Cdd:pfam07690 330 GLYNTAGSLG 339
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
79-188 2.09e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.72  E-value: 2.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  79 LSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLG-GALSQSRIQLMVFKYLGGFCMSGPFAVLM 157
Cdd:COG2223 238 LSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLlALALGSLWLFLVLFLLLGLALGGGNGAVF 317

                        90       100       110
                ....*....|....*....|....*....|.
gi 45549297 158 TYLTELHGRKHRQRIMMMVGIMFSIATLTLP 188
Cdd:COG2223 318 ALVPDIFPTKNAGAVYGLVGAAGGLGGFLGP 348
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 418-549 2.19e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 43.71  E-value: 2.19e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 418 LIVAGAGF----VAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLF 493
Cdd:cd17474 238 LLFAGWSVllalGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELA 317

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297 494 PTSLRTMIVSLEMMFGRLGSLLGNIFFPALM-GLGCVPPFLMISAFMLAGCFMAAFL 549
Cdd:cd17474 318 PEEERGTASSLYNFVRFLGQAVGPLLFGLLLeIFGLSAPFLVGAAIALAAAVLLALL 374
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 47-220 2.34e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.57  E-value: 2.34e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  47 LLLVAAVPAAMGTVYeTSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLAD-IKGRRNLLIVGYAADTIC 125
Cdd:cd06174 205 LWLLLLAIFLVNLAY-YSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDrLIGRKPLLLIGLLLMALG 283

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 126 VLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLILPETWNIQIWT 205
Cdd:cd06174 284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAF 363

                       170
                ....*....|....*
gi 45549297 206 LSLTSWQFFVAVTAL 220
Cdd:cd06174 364 LVLAVLLLLAAILLL 378
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 84-221 3.00e-04

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 43.12  E-value: 3.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  84 KGILNAITYAGMISSAVLWGYLADIK-GRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTE 162
Cdd:cd17378  35 VGLPQSSFFVGCLIGSGVLGHLADSSlGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLATE 114

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 45549297 163 LHGRKHRQRIMMMVGIMFSIATLTLPGLAMlilpetwniqiwtLSLTSWQFFVAVTALP 221
Cdd:cd17378 115 PVGPKWRGQVGMSTFFFFVLGFMSLPGIAY-------------LNGSSWRVLYFWTSIP 160
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 94-193 3.32e-04

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 43.23  E-value: 3.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  94 GMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIM 173
Cdd:cd17443  48 GWLLGYIILGAGCDRLGRRAAFVLSLVLATLLGVSVALSASPPTFLVLRLLQGGTLAGVFLSLYIARLELCDPSHRLMVS 127

                        90       100
                ....*....|....*....|
gi 45549297 174 MMVGIMFSIATLTLPGLAML 193
Cdd:cd17443 128 MGAGFFSVAGELLLPGLAVL 147
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 77-191 3.44e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 42.95  E-value: 3.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  77 LKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVL 156
Cdd:cd17325 230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45549297 157 MTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLA 191
Cdd:cd17325 310 LALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLG 344
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 85-199 6.29e-04

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.16  E-value: 6.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  85 GILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELH 164
Cdd:cd17477  34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALA 113

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45549297 165 GRKHRQRIMMMVGIMFSIATLTLPGLAMLILPETW 199
Cdd:cd17477 114 TNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGA 148
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 409-548 7.98e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 42.13  E-value: 7.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 409 ITPSTYTNNLIVAGA-GFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVI- 486
Cdd:cd17369 261 VDRSTVLLAVLIASVvAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFFWLLDTGSTWLIVLAAVVVLGVLHGMMYg 340

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 487 ---SASVSLFPTSLRTMIVSLEMMfgrLGSLLGNIFFP----ALMGL-GCVPPflmISAFMLAGCFMAAF 548
Cdd:cd17369 341 pqaAFLAELFPTRVRYTGASLGYQ---LGAILGGGFAPliatALVAAtGSWWP---VALYLAALAVISLV 404
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 47-169 8.70e-04

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.74  E-value: 8.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  47 LLLVAAVPAAMGTVYETSTmSYILPSAECDLKLSLldkgilNAITYAGMISSAV------LWGYLADIKGRRNLLIVGYA 120
Cdd:cd17369 230 LLLAIGLRLAENVLFYLFT-TFALSYATQTLGVDR------STVLLAVLIASVVaaitipLFGWLSDRVGRRPVYLAGAL 302

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 45549297 121 ADTICVLG--GALSQSRIQLMVFKYL--GGFCMSGPFAVLMTYLTELHGRKHR 169
Cdd:cd17369 303 LAALFAFPffWLLDTGSTWLIVLAAVvvLGVLHGMMYGPQAAFLAELFPTRVR 355
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
419-549 1.13e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 1.13e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 419 IVAGAGFVAYML----AGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFP 494
Cdd:COG2814  49 LVVTAYLLGAALgaplAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVP 128

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 45549297 495 TSLRTMIVSLEMMFGRLGSLLGNIFFPALMG-LGCVPPFLMISAFMLAGCFMAAFL 549
Cdd:COG2814 129 PERRGRALGLLGAGLGLGPALGPLLGGLLADlFGWRWVFLVNAVLALLALLLLLRL 184
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 94-221 1.17e-03

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 41.27  E-value: 1.17e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  94 GMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIM 173
Cdd:cd17375  47 GVLLGAVIFGDIADRIGRRPVLWFTSTGQFVFGIAVAFTFDYYSFVIVRFLLAMVSSGYLVVVFVYVTEFTGIKARTWAS 126

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 45549297 174 MMVGIMFSIATLTLPGLAMLIlpETWNIQIWTLSLTSWQFFVAVTALP 221
Cdd:cd17375 127 MHVHAFFAVGIMVVALVGYLV--RTWWIYQIILSLVTIPFILCCWMLP 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
46-186 1.20e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.20e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  46 ILLLVAAVPAAMGTvyeTSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTIC 125
Cdd:COG2211 231 LLLLLAYLLFFLAL---ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45549297 126 VLGGALSQ--SRIQLMVFKYLGGFCMSGPFAVLMTYLTEL---HGRKHRQRIMmmvGIMFSIATLT 186
Cdd:COG2211 308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLADVvdyDEWKTGRRRE---GLYFGIFTFA 370
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 90-221 1.25e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 41.01  E-value: 1.25e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  90 ITYAGMISSAV---LWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGR 166
Cdd:cd17502  35 VGTAYLLTSTAfqpIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPP 114

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45549297 167 KHRQRIMMMVGIMFSIATL---------------------TLP--GLAMLILPETWNIQIwTLSLTSWQFFVAVTALP 221
Cdd:cd17502 115 RERGKYQGYIGAVFGIASVagpliggaftdhlswrwcfyiNLPigGLALALLRTILLSSI-FGFLFGGALFGLIYYLP 191
MFS_SLC22A23 cd17444
Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier ...
 94-193 1.78e-03

Solute carrier family 22, member 23 of the Major Facilitator Superfamily; Solute carrier family 22, member 23 (SLC22A23) is an orphan member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It is abundantly expressed in brain and is also found in liver. Single-nucleotide polymorphisms in SLC22A23 are associated with inflammatory bowel disease (IBD) in a Canadian white population. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A23 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341002 [Multi-domain]  Cd Length: 364  Bit Score: 40.99  E-value: 1.78e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  94 GMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIM 173
Cdd:cd17444  48 GLIFGYLITGCLADWFGRRPVLLFSVVFILIFGLTVALSVNVTMFSTLRFFEGFCLAGIILSLYALRIELCPPGHRFMIT 127

                        90       100
                ....*....|....*....|
gi 45549297 174 MMVGIMFSIATLTLPGLAML 193
Cdd:cd17444 128 MVASFIAMAGQFLMPGLAAL 147
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 55-240 1.99e-03

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 40.64  E-value: 1.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  55 AAMGTV---YETSTMSYILPSAECDLKLSL--LDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGG 129
Cdd:cd17315   2 AALGGLlfgYDLGVINGALLYIAKDLGFGLstSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLS 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 130 ALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHR------QRIMMMVGIMFSIATltlpGLAMLILPETWniqi 203
Cdd:cd17315  82 ALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRgalgtlNQLMITFGILLAYLL----GLALSLSPPGW---- 153

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 45549297 204 wtlsltsWQFFVAVTALPSLLSFVLFFFFPESPKFLM 240
Cdd:cd17315 154 -------WRLMFALAAVPALLQLLLMFFLPESRALLV 183
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 79-188 2.50e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 40.25  E-value: 2.50e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  79 LSLLDKGILNAITYAGMISSAVLWGYLADI---KGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAV 155
Cdd:cd17319 212 FSLKQVGLLAAIPFLAGAIGMILGGRLSDRllrGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPV 291

                        90       100       110
                ....*....|....*....|....*....|...
gi 45549297 156 LMTYLTELHGRKHRQRIMMMVGIMFSIATLTLP 188
Cdd:cd17319 292 FWSLPADLLPGEAAATAGGLINSGGNLGGFVAP 324
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 94-221 2.93e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 40.25  E-value: 2.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  94 GMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIM 173
Cdd:cd17323  46 GFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAM 125

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 45549297 174 MmvgiMFSIATLTLPGLAMLI-----LPETWNIQIWTLSLTSWQFFVAVTALP 221
Cdd:cd17323 126 G----VYSLGPLLGPALGPIIggfitQSLGWRWIFWFLAIISGFCLILIFLFL 174
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 46-237 3.01e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 3.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  46 ILLLVAAVPAAMGTvyetSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTIC 125
Cdd:cd17474   2 YAVFFATLLAVLGV----SIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 126 VLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLilpetwniqiwt 205
Cdd:cd17474  78 GLLCGLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGL------------ 145

                       170       180       190
                ....*....|....*....|....*....|..
gi 45549297 206 LSLTSWQFFVAVTALPSLLSFVLFFFFPESPK 237
Cdd:cd17474 146 LAAISWRYPFFLLAALIPVAFLAILFLLPEPK 177
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 419-556 3.68e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.85  E-value: 3.68e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 419 IVAGAGFVAYMLAGF----LVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISASVSLFP 494
Cdd:cd17477  35 LVASAYYLGILLGSPlvprLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESWLNALAT 114

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45549297 495 TSLRTMIVSLEMMFGRLGSLLGNIFFpALMGLGCVPPFLMISAFMLAGCFMAAFLPLKNKAA 556
Cdd:cd17477 115 NENRGRVLGLYSTVLGLGFALGPLLL-ALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEI 175
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
421-556 4.19e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 4.19e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 421 AGAGFVAYMLAGFLVNLVG-VKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATsVISASVSLFPTSlRT 499
Cdd:COG0738 256 WGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPT-IFSLALDGLGKR-TA 333

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45549297 500 MIVSLEMMFGRLGSLLGniffPALMGL-----GCVPPFLMISAFMLAGCFMAAFLPLKNKAA 556
Cdd:COG0738 334 AAVSAVLIMGIVGGAIG----PPLIGFladafGLRAAFLVPLVCYLLILLLALALKRKRRKK 391
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 418-526 4.35e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.46  E-value: 4.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 418 LIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMG---SISATSVISASVSLFP 494
Cdd:cd17321 211 LPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGlglGLFATPLTNAALSSVP 290

                        90       100       110
                ....*....|....*....|....*....|..
gi 45549297 495 TSLRTMIVSLEMMFGRLGSLLGniffPALMGL 526
Cdd:cd17321 291 KEKAGAASGILNTARQLGGALG----VALLGA 318
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 76-195 5.79e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 5.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  76 DLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAV 155
Cdd:cd17329  29 QLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPA 108

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45549297 156 LMTYLTELHGRKHRQRIMMMVGIMFSIATLTLPGLAMLIL 195
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL 148
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 71-147 6.63e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 39.14  E-value: 6.63e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297  71 PSAECDLKLSLLDKGILNAITYAGMISSAVLWGYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGF 147
Cdd:cd17475  20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGA 96
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
24-180 7.39e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.07  E-value: 7.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297  24 PQKEAAADFEAAIDAAGFGMFNILLLVAAVPAAMGTV-YETSTMSYILPSAECDLKLSLLDKGILNAITYAGMISSAVLW 102
Cdd:COG0738 187 PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVgAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLG 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 103 GYLADIKGRRNLLIVGYAADTICVLGGALSQSRIQLMVFKYLGGFCMSGPFAVLMTYLTELHGRKHRQR-----IMMMVG 177
Cdd:COG0738 267 GFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAvsavlIMGIVG 346


                ...
gi 45549297 178 IMF 180
Cdd:COG0738 347 GAI 349
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 430-553 7.69e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.76  E-value: 7.69e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 430 LAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALAsLFVTMGSISATSVIS-ASVSLFPTSLRTMIVSLEMMF 508
Cdd:cd17475  50 PAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYGSVQPGGGrAIMRWFPPRERGLAMGIRQTG 128

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45549297 509 GRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFLPLKN 553
Cdd:cd17475 129 VPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYRE 173
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 419-549 7.93e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 38.71  E-value: 7.93e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 419 IVAGAGFVAYMLAGFLVNLVGV---KLIMTSGLLIAAGCSIGMYWSSSAASTVALASLfVTMGSISATSVISA-SVSLFP 494
Cdd:cd17319 223 IPFLAGAIGMILGGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSL-AGFGIGAASPVFWSlPADLLP 301

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 45549297 495 TSLRTMIVSLEMMFGRLGSLLGNIFFPALMGL--GCVPPFLMISAFMLAGCFMAAFL 549
Cdd:cd17319 302 GEAAATAGGLINSGGNLGGFVAPLLIGYLVDAtgSYTAAFLFLAAVALLAALLVLLL 358
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
417-549 9.74e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.73  E-value: 9.74e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45549297 417 NLIVAGAGFVAYMLAGFLVNLVGVKLIMTSGLLIAAGCSIGMYWSSSAASTVALASLFVTMGSISATSVISAS------- 489
Cdd:COG2211 270 LALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAmladvvd 349

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45549297 490 VSLFPTSLRT--MIVSLEMMFGRLGSLLGNIFFPALMGLGCVPPFLMISAFMLAGCFMAAFL 549
Cdd:COG2211 350 YDEWKTGRRRegLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSALTGIRLLFFL 411
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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