|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
452-1075 |
3.73e-119 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 390.98 E-value: 3.73e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 452 QLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD-NWFFRALqlpakenlphveIICTQPRRLSAIGVAERVA 530
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElGWGAGGR------------IGMLEPRRLAARAAAERMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 531 AERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFlllil-knllRERKD 609
Cdd:COG1643 77 EELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLllallldlqpALRPD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 610 LKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVqqlfledilemsdfvmeyDTKYcrklkkQEQEILERELEYADVQAS 689
Cdd:COG1643 157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPV------------------EVRY------RPLPADERDLEDAVADAV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 690 GEApgkkikdekltLAETyqryaeyskptcksiylmepmtinpeliesvlkyivegshdwprEGTILIFLPGFGEIQSVH 769
Cdd:COG1643 213 REA-----------LAEE--------------------------------------------PGDILVFLPGEREIRRTA 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 770 DSLldnalfSPRAGKFILV-PLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRN 848
Cdd:COG1643 238 EAL------RGRLPPDTEIlPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSG 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 849 MESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTsyRYQYHIL-AQPVPEIQRVPLEQIVLRIKTL-----QTFAsrntl 922
Cdd:COG1643 312 VTRLPTERISQASANQRAGRAGRLAPGICYRLWS--EEDFARRpAFTDPEILRADLASLILELAAWglgdpEDLP----- 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 923 svlleTLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFv 1002
Cdd:COG1643 385 -----FLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR- 458
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24641139 1003 splnkRTEADkckrmfalgnSDHLTVLNAYRKWLDvarrgnyaasrnyASEHFLSLNTLETIADLKYQYLELL 1075
Cdd:COG1643 459 -----RGAAG----------SDLLARLNLWRRLRE-------------QQREFLSYLRLREWRDLARQLRRLL 503
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
453-636 |
1.57e-95 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 303.30 E-value: 1.57e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALqlpakenLPHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPP-------LPVANIICTQPRRISAISVAERVAQE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKV 612
Cdd:cd17985 74 RAERVGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKV 153
|
170 180
....*....|....*....|....
gi 24641139 613 ILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17985 154 ILMSATLNAELFSDYFNSCPVIHI 177
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
453-1000 |
4.03e-79 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 278.96 E-value: 4.03e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDnwffralqlpakENLPHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLD------------APGIGGKIIMLEPRRLAARSAAQRLASQ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRE-RKDLK 611
Cdd:TIGR01970 69 LGEAVGQTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 612 VILMSATLNAALFSDYFGGAPVLDIPGRTFPVqqlfledilemsdfvmeyDTKYcrkLKKQEQEILEreleyadvqasge 691
Cdd:TIGR01970 149 ILAMSATLDGERLSSLLPDAPVVESEGRSFPV------------------EIRY---LPLRGDQRLE------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 692 apgkkikdekltlaetyqryaeyskptcksiylmepmtinPELIESVLKYIVEGShdwpreGTILIFLPGFGEIQSVHDS 771
Cdd:TIGR01970 195 ----------------------------------------DAVSRAVEHALASET------GSILVFLPGQAEIRRVQEQ 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 772 LLDnALFSpragKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMES 851
Cdd:TIGR01970 229 LAE-RLDS----DVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITR 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 852 LDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQyHILAQPVPEIQRVPLEQIVLRiktLQTFASRNTLSVLLetLEA 931
Cdd:TIGR01970 304 LETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQ-RLPAQDEPEILQADLSGLALE---LAQWGAKDPSDLRW--LDA 377
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24641139 932 PTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSP 1000
Cdd:TIGR01970 378 PPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERGL 446
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
432-1030 |
6.19e-71 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 260.76 E-value: 6.19e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 432 QQFVERRKEERyqKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDnwffraLQLPAKENLPHve 511
Cdd:PRK11131 54 AQRVLLREAAR--PEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE------LGRGVKGLIGH-- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 512 iicTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSE 591
Cdd:PRK11131 124 ---TQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 592 ESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVqqlfledilemsdfvmeyDTKYcRKLKK 671
Cdd:PRK11131 201 NIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPV------------------EVRY-RPIVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 672 QEQEILERELEyadvqasgeapgkkikdekltlaetyqryaeyskptcksiylmepmtinpELIESVLKYIVEGShdwpr 751
Cdd:PRK11131 262 EADDTERDQLQ--------------------------------------------------AIFDAVDELGREGP----- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 752 eGTILIFLPGFGEIQSVHDSLLDNALFSPRagkfiLVPLHSALSGEDQALVFKkaPPGKRKIVLSTNIAETSVTIDDCVF 831
Cdd:PRK11131 287 -GDILIFMSGEREIRDTADALNKLNLRHTE-----ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKY 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 832 VVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYqyhiLAQPV---PEIQRVPLEQIVL 908
Cdd:PRK11131 359 VIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDF----LSRPEftdPEILRTNLASVIL 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 909 RIKTL-----QTFAsrntlsvlleTLEAPTEDSVLGALTRLRDVGALDAED-----QLTPLGHHLAALPVDVRIGKLMLY 978
Cdd:PRK11131 435 QMTALglgdiAAFP----------FVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLE 504
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 24641139 979 GAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLN 1030
Cdd:PRK11131 505 AQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVN 556
|
|
| RWD_DHX57 |
cd23825 |
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ... |
175-367 |
2.97e-42 |
|
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.
Pssm-ID: 467661 Cd Length: 115 Bit Score: 150.04 E-value: 2.97e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 175 QEILDMRADEKEALESIFDKAYEEREANRVWNLKFRIDHLLahspsevrkareavlaaaaaaaqaaldkkkkpplrcrnf 254
Cdd:cd23825 1 DELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYLP--------------------------------------- 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 255 drdgtckygpkcrfahlpqqptesdttkkdsvdendnelWFHVEVRFPPGSRYPYEAPFIYLKTTCHDIPHELRLRYARH 334
Cdd:cd23825 42 ---------------------------------------WFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITER 82
|
170 180 190
....*....|....*....|....*....|...
gi 24641139 335 LYKEAKEICRDGIPCVYSICDLLQSNEQLAGRL 367
Cdd:cd23825 83 LMEEALELAEDGEPVVFSLVSLLEDEEEILELL 115
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
940-1028 |
6.92e-26 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 103.09 E-value: 6.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 940 ALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLN------------- 1006
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 24641139 1007 KRTEADKCKRMFA--LGNSDHLTV 1028
Cdd:pfam04408 81 RRAADEKARAKFArlDLEGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
948-1029 |
4.67e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 100.04 E-value: 4.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 948 GALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFvsPLNKRTEADKCKRMFALGNSDHLT 1027
Cdd:smart00847 3 GALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDHLT 80
|
..
gi 24641139 1028 VL 1029
Cdd:smart00847 81 LL 82
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1114-1212 |
6.96e-18 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 79.60 E-value: 6.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 1114 LTSLLCAALYPNIVKiMTPDRVYIQTAggavprepshhdlrfktRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAI 1193
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTTL-----------------SDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKV 62
|
90
....*....|....*....
gi 24641139 1194 YIRDCSMLPLIAMVLFAGS 1212
Cdd:pfam07717 63 YIRTVTAISPEWLLLFAPH 81
|
|
| RWD |
pfam05773 |
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
283-360 |
9.96e-09 |
|
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Pssm-ID: 399058 Cd Length: 111 Bit Score: 54.25 E-value: 9.96e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24641139 283 KDSVDENDNELWFHVEVRFPPGsrYPYEAPFIYLKTTcHDIPHELRLRYARHLYKEAKEICrdGIPCVYSICDLLQSN 360
Cdd:pfam05773 38 DSDESDSSHLPPLVLKFTLPED--YPDEPPKISLSSP-WNLSDEQVLSLLEELEELAEENL--GEVMIFELIEWLQEN 110
|
|
| zf-CCCH |
pfam00642 |
Zinc finger C-x8-C-x5-C-x3-H type (and similar); |
245-272 |
1.02e-06 |
|
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
Pssm-ID: 459885 [Multi-domain] Cd Length: 27 Bit Score: 46.03 E-value: 1.02e-06
10 20
....*....|....*....|....*...
gi 24641139 245 KKPPLrCRNFDRDGTCKYGPKCRFAHLP 272
Cdd:pfam00642 1 YKTEL-CRFFLRTGYCKYGDRCKFAHGQ 27
|
|
| ZnF_C3H1 |
smart00356 |
zinc finger; |
246-270 |
1.09e-04 |
|
zinc finger;
Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 40.31 E-value: 1.09e-04
|
| UBA_VP13D |
cd14306 |
UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar ... |
123-154 |
2.03e-03 |
|
UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins; VP13D is a chorea-acanthocytosis (CHAC)-similar protein encoded by gene VPS13D. it contains two putative domains, ubiquitin-associated (UBA) domain and lectin domain of ricin B chain profile (ricin-B-lectin), suggesting it may interact with, and be involved in the trafficking of, proteins modified with ubiquitin and/or carbohydrate molecules. Further investigation is required.
Pssm-ID: 270491 Cd Length: 36 Bit Score: 37.04 E-value: 2.03e-03
10 20 30
....*....|....*....|....*....|..
gi 24641139 123 LAKLENYGFQAVHCLEAYEHCSGDTEAALLLL 154
Cdd:cd14306 1 VAKLMELGFPEEDCIRALRACGGNVEEAANWL 32
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
452-1075 |
3.73e-119 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 390.98 E-value: 3.73e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 452 QLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD-NWFFRALqlpakenlphveIICTQPRRLSAIGVAERVA 530
Cdd:COG1643 9 DLPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLElGWGAGGR------------IGMLEPRRLAARAAAERMA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 531 AERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFlllil-knllRERKD 609
Cdd:COG1643 77 EELGEPVGETVGYRVRFEDKVSAATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLllallldlqpALRPD 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 610 LKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVqqlfledilemsdfvmeyDTKYcrklkkQEQEILERELEYADVQAS 689
Cdd:COG1643 157 LKLLVMSATLDAERFARLLGDAPVIESSGRTYPV------------------EVRY------RPLPADERDLEDAVADAV 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 690 GEApgkkikdekltLAETyqryaeyskptcksiylmepmtinpeliesvlkyivegshdwprEGTILIFLPGFGEIQSVH 769
Cdd:COG1643 213 REA-----------LAEE--------------------------------------------PGDILVFLPGEREIRRTA 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 770 DSLldnalfSPRAGKFILV-PLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRN 848
Cdd:COG1643 238 EAL------RGRLPPDTEIlPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDPRSG 311
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 849 MESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTsyRYQYHIL-AQPVPEIQRVPLEQIVLRIKTL-----QTFAsrntl 922
Cdd:COG1643 312 VTRLPTERISQASANQRAGRAGRLAPGICYRLWS--EEDFARRpAFTDPEILRADLASLILELAAWglgdpEDLP----- 384
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 923 svlleTLEAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFv 1002
Cdd:COG1643 385 -----FLDPPPARAIADARALLQELGALDADGRLTPLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR- 458
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24641139 1003 splnkRTEADkckrmfalgnSDHLTVLNAYRKWLDvarrgnyaasrnyASEHFLSLNTLETIADLKYQYLELL 1075
Cdd:COG1643 459 -----RGAAG----------SDLLARLNLWRRLRE-------------QQREFLSYLRLREWRDLARQLRRLL 503
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
453-636 |
1.57e-95 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 303.30 E-value: 1.57e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALqlpakenLPHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLQGPP-------LPVANIICTQPRRISAISVAERVAQE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKV 612
Cdd:cd17985 74 RAERVGQSVGYQIRLESVKSSATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKV 153
|
170 180
....*....|....*....|....
gi 24641139 613 ILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17985 154 ILMSATLNAELFSDYFNSCPVIHI 177
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
453-1000 |
4.03e-79 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 278.96 E-value: 4.03e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDnwffralqlpakENLPHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVPLALLD------------APGIGGKIIMLEPRRLAARSAAQRLASQ 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRE-RKDLK 611
Cdd:TIGR01970 69 LGEAVGQTVGYRVRGENKVSRRTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLK 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 612 VILMSATLNAALFSDYFGGAPVLDIPGRTFPVqqlfledilemsdfvmeyDTKYcrkLKKQEQEILEreleyadvqasge 691
Cdd:TIGR01970 149 ILAMSATLDGERLSSLLPDAPVVESEGRSFPV------------------EIRY---LPLRGDQRLE------------- 194
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 692 apgkkikdekltlaetyqryaeyskptcksiylmepmtinPELIESVLKYIVEGShdwpreGTILIFLPGFGEIQSVHDS 771
Cdd:TIGR01970 195 ----------------------------------------DAVSRAVEHALASET------GSILVFLPGQAEIRRVQEQ 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 772 LLDnALFSpragKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMES 851
Cdd:TIGR01970 229 LAE-RLDS----DVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPKTGITR 303
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 852 LDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQyHILAQPVPEIQRVPLEQIVLRiktLQTFASRNTLSVLLetLEA 931
Cdd:TIGR01970 304 LETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQ-RLPAQDEPEILQADLSGLALE---LAQWGAKDPSDLRW--LDA 377
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24641139 932 PTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSP 1000
Cdd:TIGR01970 378 PPSVALAAARQLLQRLGALDAQGRLTAHGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLEERGL 446
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
471-636 |
4.56e-78 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 253.92 E-value: 4.56e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 471 VVVISGETGCGKSTQVPQFILDNWFfralqlpakENLPHVEIICTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENK 550
Cdd:cd17917 3 VVVIVGETGSGKTTQVPQFLLEDGL---------AKGGKGRIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 551 VSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGG 630
Cdd:cd17917 74 TSSKTRIKFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGG 153
|
....*.
gi 24641139 631 APVLDI 636
Cdd:cd17917 154 APVIHI 159
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
432-1030 |
6.19e-71 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 260.76 E-value: 6.19e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 432 QQFVERRKEERyqKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDnwffraLQLPAKENLPHve 511
Cdd:PRK11131 54 AQRVLLREAAR--PEITYPENLPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLE------LGRGVKGLIGH-- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 512 iicTQPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSE 591
Cdd:PRK11131 124 ---TQPRRLAARTVANRIAEELETELGGCVGYKVRFNDQVSDNTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 592 ESDFLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDIPGRTFPVqqlfledilemsdfvmeyDTKYcRKLKK 671
Cdd:PRK11131 201 NIDFILGYLKELLPRRPDLKVIITSATIDPERFSRHFNNAPIIEVSGRTYPV------------------EVRY-RPIVE 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 672 QEQEILERELEyadvqasgeapgkkikdekltlaetyqryaeyskptcksiylmepmtinpELIESVLKYIVEGShdwpr 751
Cdd:PRK11131 262 EADDTERDQLQ--------------------------------------------------AIFDAVDELGREGP----- 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 752 eGTILIFLPGFGEIQSVHDSLLDNALFSPRagkfiLVPLHSALSGEDQALVFKkaPPGKRKIVLSTNIAETSVTIDDCVF 831
Cdd:PRK11131 287 -GDILIFMSGEREIRDTADALNKLNLRHTE-----ILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKY 358
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 832 VVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYqyhiLAQPV---PEIQRVPLEQIVL 908
Cdd:PRK11131 359 VIDPGTARISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDF----LSRPEftdPEILRTNLASVIL 434
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 909 RIKTL-----QTFAsrntlsvlleTLEAPTEDSVLGALTRLRDVGALDAED-----QLTPLGHHLAALPVDVRIGKLMLY 978
Cdd:PRK11131 435 QMTALglgdiAAFP----------FVEAPDKRNIQDGVRLLEELGAITTDEqasayKLTPLGRQLAQLPVDPRLARMVLE 504
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 24641139 979 GAIFQCLDSVLTIAACLSNKSPFVSPLNKRTEADKCKRMFALGNSDHLTVLN 1030
Cdd:PRK11131 505 AQKHGCVREVMIITSALSIQDPRERPMDKQQASDEKHRRFADKESDFLAFVN 556
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
725-881 |
3.15e-70 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 232.42 E-value: 3.15e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 725 MEPMTINPELIESVLKYIVEGSHDWPrEGTILIFLPGFGEIQSVHDSLLDNALFsPRAGKFILVPLHSALSGEDQALVFK 804
Cdd:cd18791 17 ISSEKEDPDYVDAAVRLILQIHRTEE-PGDILVFLPGQEEIERLCELLREELLS-PDLGKLLVLPLHSSLPPEEQQRVFE 94
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24641139 805 KAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNMESLDLVWVSRANAKQRKGRAGRVMPGVCIHLY 881
Cdd:cd18791 95 PPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRAGRAGRTRPGKCYRLY 171
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
452-995 |
1.44e-69 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 250.61 E-value: 1.44e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 452 QLPAFAEIERILALIESSPVVVISGETGCGKSTQVPqfildnwffraLQLPAKENLPHvEIICTQPRRLSAIGVAERVAA 531
Cdd:PRK11664 3 SLPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLP-----------LQLLQHGGING-KIIMLEPRRLAARNVAQRLAE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 532 ERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRE-RKDL 610
Cdd:PRK11664 71 QLGEKPGETVGYRMRAESKVGPNTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDL 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 611 KVILMSATLNAALFSDYFGGAPVLDIPGRTFPVqqlfledilemsdfvmeydtkycrklkkqeqeilEReleyadvqasg 690
Cdd:PRK11664 151 KLLIMSATLDNDRLQQLLPDAPVIVSEGRSFPV----------------------------------ER----------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 691 eapgkkikdekltlaetyqRYAeyskptcksiylmePMTINPELIESVLKYIvegSHDWPRE-GTILIFLPGFGEIQSVH 769
Cdd:PRK11664 186 -------------------RYQ--------------PLPAHQRFDEAVARAT---AELLRQEsGSLLLFLPGVGEIQRVQ 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 770 DsLLDNALfsprAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLMKEKCFDSNRNM 849
Cdd:PRK11664 230 E-QLASRV----ASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPKTGL 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 850 ESLDLVWVSRANAKQRKGRAGRVMPGVCIHLYTSYRYQyHILAQPVPEIQRVPLEQIVLRIktLQTFASRntlSVLLETL 929
Cdd:PRK11664 305 TRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAE-RAAAQSEPEILHSDLSGLLLEL--LQWGCHD---PAQLSWL 378
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24641139 930 EAPTEDSVLGALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAifQCLDSVLTIAACL 995
Cdd:PRK11664 379 DQPPAAALAAAKRLLQQLGALDGQGRLTARGRKMAALGNDPRLAAMLVAAK--EDDEAALATAAKL 442
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
453-636 |
3.95e-62 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 209.69 E-value: 3.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFfralqlpaKENLPhVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCY--------ANGIP-CRIFCTQPRRLAAIAVAERVAAE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRL-ASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLK 611
Cdd:cd17987 72 RGEKIGQTVGYQIRLESRVSPKTLLTFCTNGVLLRTLmAGDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLK 151
|
170 180
....*....|....*....|....*
gi 24641139 612 VILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17987 152 LILSSAALDVNLFIRYFGSCPVIYI 176
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
453-636 |
1.29e-59 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 202.38 E-value: 1.29e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQLPAKenlphveIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFILDDAIERGKGSSCR-------IVCTQPRRISAISVAERVAAE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLD--RIGQLVGYQIRLENKVSQS-TRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKD 609
Cdd:cd17981 74 RAEscGLGNSTGYQIRLESRKPRKqGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSD 153
|
170 180
....*....|....*....|....*..
gi 24641139 610 LKVILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17981 154 LKVILMSATLNAEKFSDYFNNCPMIHI 180
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
453-636 |
4.47e-54 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 186.11 E-value: 4.47e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRalqlpakenlphveIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH--------------IACTQPRRIACISLAKRVAFE 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKV 612
Cdd:cd17979 67 SLNQYGSKVAYQIRFERTRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKL 146
|
170 180
....*....|....*....|....
gi 24641139 613 ILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17979 147 ILMSATINIELFSGYFEGAPVVQV 170
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
453-636 |
3.29e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 184.35 E-value: 3.29e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQlPAKENlphveIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEDLLLNGGT-AQKCN-----IVCTQPRRISAMSLATRVCEE 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIG-----QLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRER 607
Cdd:cd17975 75 LGCESGpggknSLCGYQIRMESRTGEATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKR 154
|
170 180
....*....|....*....|....*....
gi 24641139 608 KDLKVILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17975 155 SDLHLILMSATVDCEKFSSYFTHCPILRI 183
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
453-636 |
6.09e-53 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 183.32 E-value: 6.09e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQlpakenlphveIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAGFARGGM-----------IGITQPRRVAAVSVAKRVAEE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKD--- 609
Cdd:cd17978 70 MGVELGQLVGYSVRFDDVTSEETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEqkl 149
|
170 180
....*....|....*....|....*....
gi 24641139 610 --LKVILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17978 150 spLKVIIMSATLDADLFSEYFNGAPVLYI 178
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
453-636 |
2.10e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 178.83 E-value: 2.10e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRAlqlpakeNLPHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEDYVLRG-------RGARCNVVITQPRRISAVSVAQRVAHE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKV-SQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLK 611
Cdd:cd17976 74 LGPNLRRNVGYQVRLESRPpPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELR 153
|
170 180
....*....|....*....|....*
gi 24641139 612 VILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17976 154 VVLMSATGDNQRLSRYFGGCPVVRV 178
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
441-636 |
2.64e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 179.15 E-value: 2.64e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 441 ERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDnwfFRALQLPAKEnlphveIICTQPRRL 520
Cdd:cd17973 1 QRYFEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLD---DELPHQPKKL------VACTQPRRV 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 521 SAIGVAERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLIL 600
Cdd:cd17973 72 AAMSVAQRVAEEMDVKLGEEVGYSIRFEDCSSAKTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLL 151
|
170 180 190
....*....|....*....|....*....|....*.
gi 24641139 601 KNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17973 152 KEVVRRRPDLKLIVMSATLDAGKFQKYFDNAPLLKV 187
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
436-636 |
1.34e-50 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 178.87 E-value: 1.34e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 436 ERRKEERYQKIIDGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFfralqlpAKENLPHVEIICT 515
Cdd:cd17972 42 QREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATGCGKTTQVPQYILDDFI-------QNDRAAECNIVVT 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 516 QPRRLSAIGVAERVAAERLDRIGQLVGYQIRLENKVSQS-TRLSFCTTGILLRRLASDplLGSVTHVIVDEVHERSEESD 594
Cdd:cd17972 115 QPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPhASILFCTVGVLLRKLEAG--IRGISHVIVDEIHERDINTD 192
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 24641139 595 FLLLILKNLLRERKDLKVILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17972 193 FLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYFFNCPVIEV 234
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
453-629 |
2.25e-50 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 176.15 E-value: 2.25e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWffralqlpAKENLPhVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFILDHY--------YKRGKY-CNIVVTQPRRIAAISIARRVSQE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLR-ERKDLK 611
Cdd:cd17988 72 REWTLGSLVGYQVGLERPASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRLLRtNSRHVK 151
|
170
....*....|....*...
gi 24641139 612 VILMSATLNAALFSDYFG 629
Cdd:cd17988 152 IILMSATISCKEFADYFT 169
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
453-628 |
2.05e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 159.17 E-value: 2.05e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILD-NWF--FRAlqlpakenlphveIICTQPRRLSAIGVAERV 529
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEaGWTagGRV-------------VGCTQPRRVAAVTVAGRV 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 530 AAERLDRIGQLVGYQIRLENKVS-QSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERK 608
Cdd:cd17980 68 AEEMGAVLGHEVGYCIRFDDCTDpQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRG 147
|
170 180
....*....|....*....|
gi 24641139 609 DLKVILMSATLNAALFSDYF 628
Cdd:cd17980 148 DLRLIVASATLDAEKFRDFF 167
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
453-636 |
3.63e-44 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 158.05 E-value: 3.63e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRALQlpakenlphvEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGG----------KIGCTQPRRVAAMSVAARVAEE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKV 612
Cdd:cd17974 71 MGVKLGNEVGYSIRFEDCTSEKTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKL 150
|
170 180
....*....|....*....|....
gi 24641139 613 ILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17974 151 LISSATMDAEKFSAFFDDAPIFRI 174
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
453-634 |
1.68e-42 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 153.26 E-value: 1.68e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPqfildnwffraLQLPAKENLPHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVP-----------LALLAELWIAGGKIIVLEPRRVAARAAARRLATL 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRE-RKDLK 611
Cdd:cd17990 70 LGEAPGETVGYRVRGESRVGRRTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQLlRDDLR 149
|
170 180
....*....|....*....|...
gi 24641139 612 VILMSATLNAALFSDYFGGAPVL 634
Cdd:cd17990 150 LLAMSATLDGDGLAALLPEAPVV 172
|
|
| RWD_DHX57 |
cd23825 |
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a ... |
175-367 |
2.97e-42 |
|
RWD domain of DEAH box protein 57 (DHX57) and related proteins; DHX57 (EC 3.6.4.13) is a putative ATP-dependent RNA helicase. A genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identified significant SNPs (single nucleotide polymorphisms) in a loci 2p22.1 inside the DHX57 gene, suggesting that variants in DHX57 are associated with epigenetic age in the cerebellum.
Pssm-ID: 467661 Cd Length: 115 Bit Score: 150.04 E-value: 2.97e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 175 QEILDMRADEKEALESIFDKAYEEREANRVWNLKFRIDHLLahspsevrkareavlaaaaaaaqaaldkkkkpplrcrnf 254
Cdd:cd23825 1 DELLEQRQEEAMALESIYGEAFSERIPNKVWTIKLDLPYLP--------------------------------------- 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 255 drdgtckygpkcrfahlpqqptesdttkkdsvdendnelWFHVEVRFPPGSRYPYEAPFIYLKTTCHDIPHELRLRYARH 334
Cdd:cd23825 42 ---------------------------------------WFELEIRFPKGNKYPYEPPIVAFSSTNENFPKAVCLNITER 82
|
170 180 190
....*....|....*....|....*....|...
gi 24641139 335 LYKEAKEICRDGIPCVYSICDLLQSNEQLAGRL 367
Cdd:cd23825 83 LMEEALELAEDGEPVVFSLVSLLEDEEEILELL 115
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
453-626 |
1.33e-41 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 151.35 E-value: 1.33e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFfralqlpAKENLPHVEII-CTQPRRLSAIGVAERVAA 531
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGF-------GSPESDNPGMIgITQPRRVAAVSMAKRVAE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 532 ErLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKD-- 609
Cdd:cd17982 74 E-LNVFGKEVSYQIRYDSTVSENTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKly 152
|
170 180
....*....|....*....|....*
gi 24641139 610 --------LKVILMSATLNAALFSD 626
Cdd:cd17982 153 lqdqtvkpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
453-636 |
1.20e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 147.99 E-value: 1.20e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRalqlpakenlpHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTD-----------YGMIGCTQPRRVAAMSVAKRVSEE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKV 612
Cdd:cd17983 70 MGVELGEEVGYAIRFEDCTSENTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKL 149
|
170 180
....*....|....*....|....
gi 24641139 613 ILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17983 150 IVTSATMDADKFADFFGNVPIFTI 173
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
448-637 |
8.27e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 145.70 E-value: 8.27e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 448 DGRKQLPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFIldnwffralqlpAKENLPHVEII-CTQPRRLSAIGVA 526
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYL------------AEAGYTSRGKIgCTQPRRVAAMSVA 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 527 ERVAAERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRE 606
Cdd:cd17971 69 KRVAEEFGCCLGQEVGYTIRFEDCTSPETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQK 148
|
170 180 190
....*....|....*....|....*....|.
gi 24641139 607 RKDLKVILMSATLNAALFSDYFGGAPVLDIP 637
Cdd:cd17971 149 RPDLKLIVTSATLDAVKFSQYFYEAPIFTIP 179
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
453-636 |
3.56e-39 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 143.75 E-value: 3.56e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDnwffraLQLPAKENLPHveiicTQPRRLSAIGVAERVAAE 532
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLE------LGRGIRGLIGH-----TQPRRLAARSVAERIAEE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKV 612
Cdd:cd17989 70 LKTELGGAVGYKVRFTDQTSDETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKV 149
|
170 180
....*....|....*....|....
gi 24641139 613 ILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17989 150 IITSATIDAERFSRHFNNAPIIEV 173
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
453-636 |
3.61e-34 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 129.59 E-value: 3.61e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDNWFFRalqlpakenlpHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQ-----------HGMIGVTQPRRVAAISVAQRVAEE 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESD-----FLLLILKNLLRER 607
Cdd:cd17984 70 MKCTLGSKVGYQVRFDDCSSKETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDilfglLKKLFQEKSPNRK 149
|
170 180
....*....|....*....|....*....
gi 24641139 608 KDLKVILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17984 150 EHLKVVVMSATLELAKLSAFFGNCPVFDI 178
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
453-636 |
5.74e-26 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 106.06 E-value: 5.74e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIESSPVVVISGETGCGKSTQVPQFILDnwFFRALQLPakenlpHVEIICTQPRRLSAIGVAERVAAE 532
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAE--YCLSAHYQ------HGVVVCTQVHKQTAVWLALRVADE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 533 RLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLKV 612
Cdd:cd17977 73 MDVNIGHEVGYVIPFENCCTNETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKL 152
|
170 180
....*....|....*....|....
gi 24641139 613 ILMSATLNAALFSDYFGGAPVLDI 636
Cdd:cd17977 153 VIITCPHLSSKLLSYYGNVPLIEV 176
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
940-1028 |
6.92e-26 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 103.09 E-value: 6.92e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 940 ALTRLRDVGALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFVSPLN------------- 1006
Cdd:pfam04408 1 ALELLYYLGALDEDGELTPLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarrr 80
|
90 100
....*....|....*....|....
gi 24641139 1007 KRTEADKCKRMFA--LGNSDHLTV 1028
Cdd:pfam04408 81 RRAADEKARAKFArlDLEGDHLTL 104
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
453-636 |
2.48e-25 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 104.21 E-value: 2.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 453 LPAFAEIERILALIES-SPVVVISGETGCGKSTQVPQFILDNWFFRALQlpakenlpHVEIICTQPRRLSAIGVAERVAA 531
Cdd:cd17986 1 LPIWAAKFTFLEQLESpSGIVLVSGEPGSGKSTQVPQWCAEFALSRGFQ--------KGQVTVTQPHPLAARSLALRVAD 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 532 ERLDRIGQLVGYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHERSEESDFLLLILKNLLRERKDLK 611
Cdd:cd17986 73 EMDLNLGHEVGYSIPQEDCTGPNTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELR 152
|
170 180
....*....|....*....|....*.
gi 24641139 612 VILM-SATLNAALFSdYFGGAPVLDI 636
Cdd:cd17986 153 VVVVtSPALEPKLRA-FWGNPPVVHV 177
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
948-1029 |
4.67e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 100.04 E-value: 4.67e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 948 GALDAEDQLTPLGHHLAALPVDVRIGKLMLYGAIFQCLDSVLTIAACLSNKSPFvsPLNKRTEADKCKRMFALGNSDHLT 1027
Cdd:smart00847 3 GALDDDGRLTPLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGDPR--PKEKREDADAARRRFADPESDHLT 80
|
..
gi 24641139 1028 VL 1029
Cdd:smart00847 81 LL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
462-642 |
4.07e-19 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 87.16 E-value: 4.07e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 462 ILALIESSPVVVISGETGCGKSTQVPQFILDnwffralqlpAKENLPHVEIICTQPRRLSAIGVAERVAAE----RLDRI 537
Cdd:smart00487 17 IEALLSGLRDVILAAPTGSGKTLAALLPALE----------ALKRGKGGRVLVLVPTRELAEQWAEELKKLgpslGLKVV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 538 GQLVGYQIR--LENKVSQSTRLSFCTTGILLRRLASDPL-LGSVTHVIVDEVHERSeESDFLLLILKNLLRERKDLKVIL 614
Cdd:smart00487 87 GLYGGDSKReqLRKLESGKTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLL-DGGFGDQLEKLLKLLPKNVQLLL 165
|
170 180 190
....*....|....*....|....*....|
gi 24641139 615 MSATLNAAL--FSDYFGGAPVLDIPGRTFP 642
Cdd:smart00487 166 LSATPPEEIenLLELFLNDPVFIDVGFTPL 195
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
1114-1212 |
6.96e-18 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 79.60 E-value: 6.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 1114 LTSLLCAALYPNIVKiMTPDRVYIQTAggavprepshhdlrfktRGDGYVKIHPSSVNSQVSVFQAPFLVFQEKVRTSAI 1193
Cdd:pfam07717 1 LRAALAAGLYPNVAR-RDPKGKGYTTL-----------------SDNQRVFIHPSSVLFNEKTFPPEWVVYQELVETTKV 62
|
90
....*....|....*....
gi 24641139 1194 YIRDCSMLPLIAMVLFAGS 1212
Cdd:pfam07717 63 YIRTVTAISPEWLLLFAPH 81
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
781-871 |
2.82e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 60.69 E-value: 2.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 781 RAGKFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCVFVVDCGLmkekcfdsnrnmesldlvWVSRA 860
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------PWSPA 69
|
90
....*....|.
gi 24641139 861 NAKQRKGRAGR 871
Cdd:smart00490 70 SYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
751-872 |
6.54e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 57.61 E-value: 6.54e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 751 REGTILIFLPGFgeiqsvhdSLLDNALFSPRAGkFILVPLHSALSGEDQALVFKKAPPGKRKIVLSTNIAETSVTIDDCV 830
Cdd:pfam00271 14 RGGKVLIFSQTK--------KTLEAELLLEKEG-IKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVD 84
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 24641139 831 FVVDcglmkekcfdsnrnmesLDLVWvSRANAKQRKGRAGRV 872
Cdd:pfam00271 85 LVIN-----------------YDLPW-NPASYIQRIGRAGRA 108
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
461-882 |
3.20e-09 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 61.15 E-value: 3.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 461 RILALIESSPVVVISGETGCGKSTQVPQFILdnWF---------FRALQLPAKEN-----LPHVEIIctqprRLSAIGVA 526
Cdd:PHA02653 171 KIFEAWISRKPVVLTGGTGVGKTSQVPKLLL--WFnylfggfdnLDKIDPNFIERpivlsLPRVALV-----RLHSITLL 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 527 ERVAAERLD------RIGqlvGYQIRLENKVSQSTRLSFCTTGILLRRLasdpllGSVTHVIVDEVHERSEESDFLLLIL 600
Cdd:PHA02653 244 KSLGFDEIDgspislKYG---SIPDELINTNPKPYGLVFSTHKLTLNKL------FDYGTVIIDEVHEHDQIGDIIIAVA 314
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 601 KNLLRERKDLkvILMSATL--NAALFSDYFGGAPVLDIPGRT-FPVQQLFLEDilemsdfvmEYDTKYCRKLKKQE-QEI 676
Cdd:PHA02653 315 RKHIDKIRSL--FLMTATLedDRDRIKEFFPNPAFVHIPGGTlFPISEVYVKN---------KYNPKNKRAYIEEEkKNI 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 677 LERELEYA-DVQASGeapgkKIKDEKLTLAETYQRYAEYSKPtcksIYLMepmtinpeliesvlkYIVegsHdwpregti 755
Cdd:PHA02653 384 VTALKKYTpPKGSSG-----IVFVASVSQCEEYKKYLEKRLP----IYDF---------------YII---H-------- 428
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 756 liflpgfGEIQSVHDSLLDnalfspragkfilvplhsalsgedqalVFKKAPPgkrKIVLSTNIAETSVTIDDCVFVVDC 835
Cdd:PHA02653 429 -------GKVPNIDEILEK---------------------------VYSSKNP---SIIISTPYLESSVTIRNATHVYDT 471
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 24641139 836 GLMKEKCFDSNRNMesldlvWVSRANAKQRKGRAGRVMPGVCIHLYT 882
Cdd:PHA02653 472 GRVYVPEPFGGKEM------FISKSMRTQRKGRVGRVSPGTYVYFYD 512
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
472-618 |
3.83e-09 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 56.64 E-value: 3.83e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 472 VVISGETGCGKSTQVPQFILDnwffRALQLPAKenlphVEIICtqPRRLSAIGVAERVAAERL--DRIGQLVGYQ--IRL 547
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALL----LLLKKGKK-----VLVLV--PTKALALQTAERLRELFGpgIRVAVLVGGSsaEER 72
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24641139 548 ENKVSQSTRLSFCTTGILLRRLASDPLLGS--VTHVIVDEVHERSEESDFLLLILKNLLR-ERKDLKVILMSAT 618
Cdd:cd00046 73 EKNKLGDADIIIATPDMLLNLLLREDRLFLkdLKLIIVDEAHALLIDSRGALILDLAVRKaGLKNAQVILLSAT 146
|
|
| RWD |
pfam05773 |
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. ... |
283-360 |
9.96e-09 |
|
RWD domain; This domain was identified in WD40 repeat proteins and Ring finger domain proteins. The function of this domain is unknown. GCN2 is the alpha-subunit of the only translation initiation factor (eIF2 alpha) kinase that appears in all eukaryotes. Its function requires an interaction with GCN1 via the domain at its N-terminus, which is termed the RWD domain after three major RWD-containing proteins: RING finger-containing proteins, WD-repeat-containing proteins, and yeast DEAD (DEXD)-like helicases. The structure forms an alpha + beta sandwich fold consisting of two layers: a four-stranded antiparallel beta-sheet, and three side-by-side alpha-helices.
Pssm-ID: 399058 Cd Length: 111 Bit Score: 54.25 E-value: 9.96e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24641139 283 KDSVDENDNELWFHVEVRFPPGsrYPYEAPFIYLKTTcHDIPHELRLRYARHLYKEAKEICrdGIPCVYSICDLLQSN 360
Cdd:pfam05773 38 DSDESDSSHLPPLVLKFTLPED--YPDEPPKISLSSP-WNLSDEQVLSLLEELEELAEENL--GEVMIFELIEWLQEN 110
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
460-623 |
1.83e-07 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 52.24 E-value: 1.83e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 460 ERILALIESSPVVVISGETGCGKSTqvpqfildnwffrALQLPA----KENLPHVEIICTQPRRLSAIGVAERvAAERLD 535
Cdd:pfam00270 5 AEAIPAILEGRDVLVQAPTGSGKTL-------------AFLLPAlealDKLDNGPQALVLAPTRELAEQIYEE-LKKLGK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24641139 536 RIGQLV-----GYQIRLENKVSQSTRLSFCTTGILLRRLASDPLLGSVTHVIVDEVHeRSEESDFLLLILKNLLRERKDL 610
Cdd:pfam00270 71 GLGLKVasllgGDSRKEQLEKLKGPDILVGTPGRLLDLLQERKLLKNLKLLVLDEAH-RLLDMGFGPDLEEILRRLPKKR 149
|
170
....*....|...
gi 24641139 611 KVILMSATLNAAL 623
Cdd:pfam00270 150 QILLLSATLPRNL 162
|
|
| zf-CCCH |
pfam00642 |
Zinc finger C-x8-C-x5-C-x3-H type (and similar); |
245-272 |
1.02e-06 |
|
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
Pssm-ID: 459885 [Multi-domain] Cd Length: 27 Bit Score: 46.03 E-value: 1.02e-06
10 20
....*....|....*....|....*...
gi 24641139 245 KKPPLrCRNFDRDGTCKYGPKCRFAHLP 272
Cdd:pfam00642 1 YKTEL-CRFFLRTGYCKYGDRCKFAHGQ 27
|
|
| ZnF_C3H1 |
smart00356 |
zinc finger; |
246-270 |
1.09e-04 |
|
zinc finger;
Pssm-ID: 214632 [Multi-domain] Cd Length: 27 Bit Score: 40.31 E-value: 1.09e-04
|
| zf_CCCH_4 |
pfam18345 |
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ... |
251-270 |
6.06e-04 |
|
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.
Pssm-ID: 465719 [Multi-domain] Cd Length: 19 Bit Score: 38.17 E-value: 6.06e-04
|
| UBA_VP13D |
cd14306 |
UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar ... |
123-154 |
2.03e-03 |
|
UBA domain found in vacuolar protein sorting-associated protein 13D (VP13D) and similar proteins; VP13D is a chorea-acanthocytosis (CHAC)-similar protein encoded by gene VPS13D. it contains two putative domains, ubiquitin-associated (UBA) domain and lectin domain of ricin B chain profile (ricin-B-lectin), suggesting it may interact with, and be involved in the trafficking of, proteins modified with ubiquitin and/or carbohydrate molecules. Further investigation is required.
Pssm-ID: 270491 Cd Length: 36 Bit Score: 37.04 E-value: 2.03e-03
10 20 30
....*....|....*....|....*....|..
gi 24641139 123 LAKLENYGFQAVHCLEAYEHCSGDTEAALLLL 154
Cdd:cd14306 1 VAKLMELGFPEEDCIRALRACGGNVEEAANWL 32
|
|
| RWD_GCN2 |
cd23823 |
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called ... |
284-359 |
3.52e-03 |
|
RWD domain of eIF-2-alpha kinase GCN2 and related proteins; GCN2 (EC 2.7.11.1), also called eukaryotic translation initiation factor 2-alpha kinase 4 (EIF2AK4), acts as a metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) in response to low amino acid availability. It also plays a role in modulating the adaptive immune response to yellow fever virus infection and promotes dendritic cells to initiate autophagy and antigene presentation to both CD4(+) and CD8(+) T-cells under amino acid starvation.
Pssm-ID: 467659 Cd Length: 117 Bit Score: 38.74 E-value: 3.52e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24641139 284 DSVDENDNELWFHVEVRFPPgsRYPYEAPFIYLKtTCHDIPHELRLRYARHLYKEAKEicRDGIPCVYSICDLLQS 359
Cdd:cd23823 41 QEGESEENHVSVDLHVKFPP--TYPDVPPEIELE-NVKGLSDEQLEELLKELEELAKE--LLGEEMIFELAEAVQE 111
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
812-882 |
7.46e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 36.53 E-value: 7.46e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24641139 812 KIVLSTNIAETSVTIDDCVFVVDCGlmkekcfdsnrnmesldlVWVSRANAKQRKGRAGRVMPGVC-IHLYT 882
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFD------------------PPSSAASYIQRVGRAGRGGKDEGeVILFV 77
|
|
| |
