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Conserved domains on  [gi|24642119|ref|NP_573009|]
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uncharacterized protein Dmel_CG5662, isoform A [Drosophila melanogaster]

Protein Classification

metaxin-2( domain architecture ID 10122961)

metaxin-2 associates with mitochondrial membranes through its interaction with metaxin 1 and plays a role in protein translocation into the mitochondrion

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GST_C_Metaxin2 cd03211
C-terminal, alpha helical domain of Metaxin 2; Glutathione S-transferase (GST) C-terminal ...
 138-266 3.04e-64

C-terminal, alpha helical domain of Metaxin 2; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer membrane signal-anchor domain. It associates with mitochondrial membranes through its interaction with metaxin 1, which is a component of the mitochondrial preprotein import complex of the outer membrane. The biological function of metaxin 2 is unknown. It is likely that it also plays a role in protein translocation into the mitochondria. However, this has not been experimentally validated. In a recent proteomics study, it has been shown that metaxin 2 is overexpressed in response to lipopolysaccharide-induced liver injury.


:

Pssm-ID: 198320  Cd Length: 126  Bit Score: 197.87  E-value: 3.04e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119 138 AEIHMSFVDEVNYQLYTATRCAAAHPWPLSTIRRFAKQKDAQKILKVYRWQDLDNDQVIQEVSICADALIAELEEdqaKS 217
Cdd:cd03211   1 AELYISWCDEETYNEVTKPRYGSVYPWPLNHILAYRKQREVLRKLKALGWSDKSLDQVFDEVEKCCQALSEKLGT---NQ 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 24642119 218 YFGGSRPCKLDALVFGHVVAIMTTKLPNMELAAVLATYPRLLAHCRRID 266
Cdd:cd03211  78 YFFGDQPTELDALVFGHLFTILTTPLPNDELAAIVKKYPNLVEFCRRIE 126
GST_N_Metaxin2 cd03079
GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a ...
 29-106 1.40e-35

GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer membrane signal-anchor domain. It associates with mitochondrial membranes through its interaction with metaxin 1, which is a component of the mitochondrial preprotein import complex of the outer membrane. The biological function of metaxin 2 is unknown. It is likely that it also plays a role in protein translocation into the mitochondria. However, this has not been experimentally validated. In a recent proteomics study, it has been shown that metaxin 2 is overexpressed in response to lipopolysaccharide-induced liver injury.


:

Pssm-ID: 239377  Cd Length: 74  Bit Score: 122.53  E-value: 1.40e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24642119  29 AHLHQPAEANQLLLPERSSCLAVKTFLRMCNLPFTEHISDNAEFMSPGGrltHLPLLRLGpVKTFAEFEPIVAQVEAV 106
Cdd:cd03079   1 AALYQPYEEEQILLPDNASCLAVQTFLKMCNLPFNVRCRANAEFMSPSG---KVPFIRVG-NQIVSEFGPIVQFVEAK 74
 
Name Accession Description Interval E-value
GST_C_Metaxin2 cd03211
C-terminal, alpha helical domain of Metaxin 2; Glutathione S-transferase (GST) C-terminal ...
 138-266 3.04e-64

C-terminal, alpha helical domain of Metaxin 2; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer membrane signal-anchor domain. It associates with mitochondrial membranes through its interaction with metaxin 1, which is a component of the mitochondrial preprotein import complex of the outer membrane. The biological function of metaxin 2 is unknown. It is likely that it also plays a role in protein translocation into the mitochondria. However, this has not been experimentally validated. In a recent proteomics study, it has been shown that metaxin 2 is overexpressed in response to lipopolysaccharide-induced liver injury.


Pssm-ID: 198320  Cd Length: 126  Bit Score: 197.87  E-value: 3.04e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119 138 AEIHMSFVDEVNYQLYTATRCAAAHPWPLSTIRRFAKQKDAQKILKVYRWQDLDNDQVIQEVSICADALIAELEEdqaKS 217
Cdd:cd03211   1 AELYISWCDEETYNEVTKPRYGSVYPWPLNHILAYRKQREVLRKLKALGWSDKSLDQVFDEVEKCCQALSEKLGT---NQ 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 24642119 218 YFGGSRPCKLDALVFGHVVAIMTTKLPNMELAAVLATYPRLLAHCRRID 266
Cdd:cd03211  78 YFFGDQPTELDALVFGHLFTILTTPLPNDELAAIVKKYPNLVEFCRRIE 126
GST_N_Metaxin2 cd03079
GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a ...
 29-106 1.40e-35

GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer membrane signal-anchor domain. It associates with mitochondrial membranes through its interaction with metaxin 1, which is a component of the mitochondrial preprotein import complex of the outer membrane. The biological function of metaxin 2 is unknown. It is likely that it also plays a role in protein translocation into the mitochondria. However, this has not been experimentally validated. In a recent proteomics study, it has been shown that metaxin 2 is overexpressed in response to lipopolysaccharide-induced liver injury.


Pssm-ID: 239377  Cd Length: 74  Bit Score: 122.53  E-value: 1.40e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24642119  29 AHLHQPAEANQLLLPERSSCLAVKTFLRMCNLPFTEHISDNAEFMSPGGrltHLPLLRLGpVKTFAEFEPIVAQVEAV 106
Cdd:cd03079   1 AALYQPYEEEQILLPDNASCLAVQTFLKMCNLPFNVRCRANAEFMSPSG---KVPFIRVG-NQIVSEFGPIVQFVEAK 74
Tom37 pfam10568
Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer ...
 48-167 5.55e-22

Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intra-membrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex.


Pssm-ID: 463150  Cd Length: 126  Bit Score: 88.84  E-value: 5.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119    48 CLAVKTFLRMCNLP--FTEHISDNAEfMSPGGrltHLPLLRLGPVKTFAEFEPIVAQVEAVQGGNCLDSWMSEDQRDNIR 125
Cdd:pfam10568   1 CLAAIAYLKLLALPapFEVVPSNNPD-LSPTG---ELPALIDGDGTWVSGFDSIVEYLRSKGGGYDLDADLSAKQKADSL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 24642119   126 CLVSYVENVFTLAEIHMSFVDEVNYQLYTATRCAAAHPWPLS 167
Cdd:pfam10568  77 AYISLLESKLYPLLLYSLWVDEENYEEVTRPAYSKLLPFPLN 118
GST_N_4 pfam17172
Glutathione S-transferase N-terminal domain; This domain is homologous to pfam02798.
 46-149 1.78e-21

Glutathione S-transferase N-terminal domain; This domain is homologous to pfam02798.


Pssm-ID: 465370 [Multi-domain]  Cd Length: 97  Bit Score: 86.48  E-value: 1.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119    46 SSCLAVKTFLRMCNLPFTEHISDNaEFMSPGGRlthLPLLRLGPvKTFAEFEPIVAQVEAVqgGNCLDSWMSEDQRDNIR 125
Cdd:pfam17172   1 PFCLKVETYLRMAGIPYEVEPSSN-PSASPKGK---LPFIELNG-DLIADSEFIIEFLKEK--GVDLDAGLSPEQKADAR 73

                          90       100
                  ....*....|....*....|....
gi 24642119   126 CLVSYVENVFTLAEIHMSFVDEVN 149
Cdd:pfam17172  74 ALKALVEEHLYWALLYERWLDPEN 97
 
Name Accession Description Interval E-value
GST_C_Metaxin2 cd03211
C-terminal, alpha helical domain of Metaxin 2; Glutathione S-transferase (GST) C-terminal ...
 138-266 3.04e-64

C-terminal, alpha helical domain of Metaxin 2; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer membrane signal-anchor domain. It associates with mitochondrial membranes through its interaction with metaxin 1, which is a component of the mitochondrial preprotein import complex of the outer membrane. The biological function of metaxin 2 is unknown. It is likely that it also plays a role in protein translocation into the mitochondria. However, this has not been experimentally validated. In a recent proteomics study, it has been shown that metaxin 2 is overexpressed in response to lipopolysaccharide-induced liver injury.


Pssm-ID: 198320  Cd Length: 126  Bit Score: 197.87  E-value: 3.04e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119 138 AEIHMSFVDEVNYQLYTATRCAAAHPWPLSTIRRFAKQKDAQKILKVYRWQDLDNDQVIQEVSICADALIAELEEdqaKS 217
Cdd:cd03211   1 AELYISWCDEETYNEVTKPRYGSVYPWPLNHILAYRKQREVLRKLKALGWSDKSLDQVFDEVEKCCQALSEKLGT---NQ 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 24642119 218 YFGGSRPCKLDALVFGHVVAIMTTKLPNMELAAVLATYPRLLAHCRRID 266
Cdd:cd03211  78 YFFGDQPTELDALVFGHLFTILTTPLPNDELAAIVKKYPNLVEFCRRIE 126
GST_N_Metaxin2 cd03079
GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a ...
 29-106 1.40e-35

GST_N family, Metaxin subfamily, Metaxin 2; a metaxin 1 binding protein identified through a yeast two-hybrid system using metaxin 1 as the bait. Metaxin 2 shares sequence similarity with metaxin 1 but does not contain a C-terminal mitochondrial outer membrane signal-anchor domain. It associates with mitochondrial membranes through its interaction with metaxin 1, which is a component of the mitochondrial preprotein import complex of the outer membrane. The biological function of metaxin 2 is unknown. It is likely that it also plays a role in protein translocation into the mitochondria. However, this has not been experimentally validated. In a recent proteomics study, it has been shown that metaxin 2 is overexpressed in response to lipopolysaccharide-induced liver injury.


Pssm-ID: 239377  Cd Length: 74  Bit Score: 122.53  E-value: 1.40e-35
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24642119  29 AHLHQPAEANQLLLPERSSCLAVKTFLRMCNLPFTEHISDNAEFMSPGGrltHLPLLRLGpVKTFAEFEPIVAQVEAV 106
Cdd:cd03079   1 AALYQPYEEEQILLPDNASCLAVQTFLKMCNLPFNVRCRANAEFMSPSG---KVPFIRVG-NQIVSEFGPIVQFVEAK 74
Tom37 pfam10568
Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer ...
 48-167 5.55e-22

Outer mitochondrial membrane transport complex protein; The TOM37 protein is one of the outer membrane proteins that make up the TOM complex for guiding cytosolic mitochondrial beta-barrel proteins from the cytosol across the outer mitochondrial membrane into the intra-membrane space. In conjunction with TOM70 it guides peptides without an MTS into TOM40, the protein that forms the passage through the outer membrane. It has homology with Metaxin-1, also part of the outer mitochondrial membrane beta-barrel protein transport complex.


Pssm-ID: 463150  Cd Length: 126  Bit Score: 88.84  E-value: 5.55e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119    48 CLAVKTFLRMCNLP--FTEHISDNAEfMSPGGrltHLPLLRLGPVKTFAEFEPIVAQVEAVQGGNCLDSWMSEDQRDNIR 125
Cdd:pfam10568   1 CLAAIAYLKLLALPapFEVVPSNNPD-LSPTG---ELPALIDGDGTWVSGFDSIVEYLRSKGGGYDLDADLSAKQKADSL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 24642119   126 CLVSYVENVFTLAEIHMSFVDEVNYQLYTATRCAAAHPWPLS 167
Cdd:pfam10568  77 AYISLLESKLYPLLLYSLWVDEENYEEVTRPAYSKLLPFPLN 118
GST_N_4 pfam17172
Glutathione S-transferase N-terminal domain; This domain is homologous to pfam02798.
 46-149 1.78e-21

Glutathione S-transferase N-terminal domain; This domain is homologous to pfam02798.


Pssm-ID: 465370 [Multi-domain]  Cd Length: 97  Bit Score: 86.48  E-value: 1.78e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119    46 SSCLAVKTFLRMCNLPFTEHISDNaEFMSPGGRlthLPLLRLGPvKTFAEFEPIVAQVEAVqgGNCLDSWMSEDQRDNIR 125
Cdd:pfam17172   1 PFCLKVETYLRMAGIPYEVEPSSN-PSASPKGK---LPFIELNG-DLIADSEFIIEFLKEK--GVDLDAGLSPEQKADAR 73

                          90       100
                  ....*....|....*....|....
gi 24642119   126 CLVSYVENVFTLAEIHMSFVDEVN 149
Cdd:pfam17172  74 ALKALVEEHLYWALLYERWLDPEN 97
GST_N_Metaxin cd03054
GST_N family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a ...
 29-105 4.36e-14

GST_N family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. Metaxin 2 binds to metaxin 1 and may also play a role in protein translocation into the mitochondria. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken and mammals. Sequence analysis suggests that all three metaxins share a common ancestry and that they possess similarity to GSTs. Also included in the subfamily are uncharacterized proteins with similarity to metaxins, including a novel GST from Rhodococcus with toluene o-monooxygenase and glutamylcysteine synthetase activities.


Pssm-ID: 239352 [Multi-domain]  Cd Length: 72  Bit Score: 65.71  E-value: 4.36e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24642119  29 AHLHQPAEAnQLLLPERSSCLAVKTFLRMCNLPFTEHISDNAeFMSPGGrltHLPLLRLGPvKTFAEFEPIVAQVEA 105
Cdd:cd03054   1 LELYQWGRA-FGLPSLSPECLKVETYLRMAGIPYEVVFSSNP-WRSPTG---KLPFLELNG-EKIADSEKIIEYLKK 71
GST_C_6 pfam17171
Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.
 216-265 9.57e-13

Glutathione S-transferase, C-terminal domain; This domain is closely related to PF00043.


Pssm-ID: 465369  Cd Length: 64  Bit Score: 62.17  E-value: 9.57e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 24642119   216 KSYFGGSRPCKLDALVFGHVVAIMTTKLPNMELAAVLATYPRLLAHCRRI 265
Cdd:pfam17171  15 KPFFFGDKPTSLDALVFGHLALILYTPLPSPALRIHLKEYPNLVAYCERI 64
GST_C_Metaxin1_3 cd03212
C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins; Glutathione ...
 138-270 1.54e-12

C-terminal, alpha helical domain of Metaxin 1, Metaxin 3, and similar proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins. Mammalian metaxin (or metaxin 1) is a component of the preprotein import complex of the mitochondrial outer membrane. Metaxin extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. Like the murine gene, the human metaxin gene is located downstream to the glucocerebrosidase (GBA) pseudogene and is convergently transcribed. Inherited deficiency of GBA results in Gaucher disease, which presents many diverse clinical phenotypes. Alterations in the metaxin gene, in addition to GBA mutations, may be associated with Gaucher disease. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals.


Pssm-ID: 198321 [Multi-domain]  Cd Length: 137  Bit Score: 63.42  E-value: 1.54e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24642119 138 AEIHMSFVDEVNYQlyTATRCAAA----HPWPLSTIRRFAKQKdAQKILKVYRWQDLDNDQVIqEVSICADA------LI 207
Cdd:cd03212   2 ALLYTLWVDEKNYV--EVTRPWYAkalpFPLNFYYPGRYQRRA-KDRLQLLRGLSELDSEEEV-EKELYKDAkeclnlLS 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24642119 208 AELEEDQaksYFGGSRPCKLDALVFGHVVAIMTTKLPNMELAAVLATYPRLLAHCRRIDQSLF 270
Cdd:cd03212  78 ERLGEKK---FFFGDRPTSLDALVFGYLAPLLKAPLPNNKLQNHLKGCPNLVQFVDRILQNYF 137
GST_C_Metaxin cd03193
C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase ...
 193-265 1.77e-11

C-terminal, alpha helical domain of Metaxin and related proteins; Glutathione S-transferase (GST) C-terminal domain family, Metaxin subfamily; composed of metaxins and related proteins. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. Metaxin 2 binds to metaxin 1 and may also play a role in protein translocation into the mitochondria. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken, and mammals. Sequence analysis suggests that all three metaxins share a common ancestry and that they possess similarity to GSTs. Also included in the subfamily are uncharacterized proteins with similarity to metaxins, including a novel GST from Rhodococcus with toluene o-monooxygenase and glutamylcysteine synthetase activities. Other members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.


Pssm-ID: 198302 [Multi-domain]  Cd Length: 88  Bit Score: 59.18  E-value: 1.77e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24642119 193 DQVIQEVSICADALIAELEEdqaKSYFGGSRPCKLDALVFGHVVAIMTTKLPNMELAAVLATYPRLLAHCRRI 265
Cdd:cd03193  18 REIYELALEDLEALSTLLGD---KKFLFGDKPTSVDATVFAHLASILYPPEDSPLLRVLVASSPNLVEYCERI 87
GST_N_Metaxin1_like cd03078
GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and ...
 48-100 4.71e-04

GST_N family, Metaxin subfamily, Metaxin 1-like proteins; composed of metaxins 1 and 3, and similar proteins including Tom37 from fungi. Mammalian metaxin (or metaxin 1) and the fungal protein Tom37 are components of preprotein import complexes of the mitochondrial outer membrane. Metaxin extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. Like the murine gene, the human metaxin gene is located downstream to the glucocerebrosidase (GBA) pseudogene and is convergently transcribed. Inherited deficiency of GBA results in Gaucher disease, which presents many diverse clinical phenotypes. Alterations in the metaxin gene, in addition to GBA mutations, may be associated with Gaucher disease. Genome sequencing shows that a third metaxin gene also exists in zebrafish, Xenopus, chicken and mammals.


Pssm-ID: 239376  Cd Length: 73  Bit Score: 38.02  E-value: 4.71e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 24642119  48 CLAVKTFLRMCNLPFTEHISDNaEFMSPGGrltHLPLLRLGPvKTFAEFEPIV 100
Cdd:cd03078  19 CLAVLAYLKFAGAPLKVVPSNN-PWRSPTG---KLPALLTSG-TKISGPEKII 66
GST_N_Metaxin_like cd03080
GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, ...
 30-79 8.37e-03

GST_N family, Metaxin subfamily, Metaxin-like proteins; a heterogenous group of proteins, predominantly uncharacterized, with similarity to metaxins and GSTs. Metaxin 1 is a component of a preprotein import complex of the mitochondrial outer membrane. It extends to the cytosol and is anchored to the mitochondrial membrane through its C-terminal domain. In mice, metaxin is required for embryonic development. In humans, alterations in the metaxin gene may be associated with Gaucher disease. One characterized member of this subgroup is a novel GST from Rhodococcus with toluene o-monooxygenase and gamma-glutamylcysteine synthetase activities. Also members are the cadmium-inducible lysosomal protein CDR-1 and its homologs from C. elegans, and the failed axon connections (fax) protein from Drosophila. CDR-1 is an integral membrane protein that functions to protect against cadmium toxicity and may also have a role in osmoregulation to maintain salt balance in C. elegans. The fax gene of Drosophila was identified as a genetic modifier of Abelson (Abl) tyrosine kinase. The fax protein is localized in cellular membranes and is expressed in embryonic mesoderm and axons of the central nervous system.


Pssm-ID: 239378 [Multi-domain]  Cd Length: 75  Bit Score: 34.52  E-value: 8.37e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 24642119  30 HLHQPAEANqlLLPERSS-CLAVKTFLRMCNLPFtEHISDNAEFMSPGGRL 79
Cdd:cd03080   3 TLYQFPRAF--GVPSLSPfCLKVETFLRMAGIPY-ENKFGGLAKRSPKGKL 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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