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Conserved domains on  [gi|19074277|ref|NP_585783|]
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uncharacterized protein ECU06_0270 [Encephalitozoon cuniculi GB-M1]

Protein Classification

Sedlin_N superfamily protein( domain architecture ID 230253)

Sedlin_N superfamily protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sedlin_N super family cl21566
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 1-123 7.81e-58

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


The actual alignment was detected with superfamily member COG5122:

Pssm-ID: 354875  Cd Length: 134  Bit Score: 175.09  E-value: 7.81e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277   1 MAVEQFFIINKSGGMVFKYER-EGETEINS--LLILTSSLYSVSVILTKTID--GPVPRLVVYFRNRVITIFRTTTGTSF 75
Cdd:COG5122   1 MAVEQFFIINKSGGLIFQREFgEGETELNSneYLILASTLHGVSAILTQTIPlpGSSGRLVLYFRNFVMTIFQTTTGTKF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19074277  76 VFVA-DRPVDALFER--IYSHYCQYVTRNPFHSPEMPIQCSKFKPHL--MFEG 123
Cdd:COG5122  81 VFVAeKRTVNALFQLqkIYSLYSDYVTKNPFYSPEMPIQCSLFDEHLkrMFEG 133
 
Name Accession Description Interval E-value
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
1-123 7.81e-58

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 175.09  E-value: 7.81e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277   1 MAVEQFFIINKSGGMVFKYER-EGETEINS--LLILTSSLYSVSVILTKTID--GPVPRLVVYFRNRVITIFRTTTGTSF 75
Cdd:COG5122   1 MAVEQFFIINKSGGLIFQREFgEGETELNSneYLILASTLHGVSAILTQTIPlpGSSGRLVLYFRNFVMTIFQTTTGTKF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19074277  76 VFVA-DRPVDALFER--IYSHYCQYVTRNPFHSPEMPIQCSKFKPHL--MFEG 123
Cdd:COG5122  81 VFVAeKRTVNALFQLqkIYSLYSDYVTKNPFYSPEMPIQCSLFDEHLkrMFEG 133
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 7-120 5.86e-23

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 86.42  E-value: 5.86e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277   7 FIINKSGGMVFKYE-REGETEI--NSLLILTSSLYSVSVI---LTktidgPVP-----RLVV--YFRnrvITIFRTTTGT 73
Cdd:cd14856   4 YIINKAGGLIYQKDfSDALAKLssNDYLRLASTFHGLHAIaaqLS-----PVPgssgiELLEtdTFR---LHCFQTLTGI 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 19074277  74 SFVFVADR---PVDALFERIYSHYCQYVTRNPFHSPEMPIQCSKFKPHLM 120
Cdd:cd14856  76 KFVLVADPkqpGLDALLRRVYELYADYVLKNPFYELEMPIRCELFDENLQ 125
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 7-119 7.16e-14

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 63.10  E-value: 7.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277     7 FIINKSGGMVFKYE--REGETEI--NSLLILTSSLYSVSVILTKtIDgPVPRL--VVYFR--NRVITIFRTTTGTSFVFV 78
Cdd:pfam04099   5 YIFNRAGGLIYYKEwnRPKKTKLttNEYKLLAGMLHSLHSISSK-IS-PLPGSsgIESLEtdTFKLHCLETLTGIKFVLV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 19074277    79 ADRP----VDALFERIYSHYCQYVTRNPFHSPEMPIQCSKFKPHL 119
Cdd:pfam04099  83 TDPGtginRDSLLRKYYELYSDYVLKNPFYSLGMPIRCELFDEKL 127
 
Name Accession Description Interval E-value
TRS23 COG5122
Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];
1-123 7.81e-58

Transport protein particle (TRAPP) complex subunit [Intracellular trafficking and secretion];


Pssm-ID: 227451  Cd Length: 134  Bit Score: 175.09  E-value: 7.81e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277   1 MAVEQFFIINKSGGMVFKYER-EGETEINS--LLILTSSLYSVSVILTKTID--GPVPRLVVYFRNRVITIFRTTTGTSF 75
Cdd:COG5122   1 MAVEQFFIINKSGGLIFQREFgEGETELNSneYLILASTLHGVSAILTQTIPlpGSSGRLVLYFRNFVMTIFQTTTGTKF 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19074277  76 VFVA-DRPVDALFER--IYSHYCQYVTRNPFHSPEMPIQCSKFKPHL--MFEG 123
Cdd:COG5122  81 VFVAeKRTVNALFQLqkIYSLYSDYVTKNPFYSPEMPIQCSLFDEHLkrMFEG 133
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 7-120 5.86e-23

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 86.42  E-value: 5.86e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277   7 FIINKSGGMVFKYE-REGETEI--NSLLILTSSLYSVSVI---LTktidgPVP-----RLVV--YFRnrvITIFRTTTGT 73
Cdd:cd14856   4 YIINKAGGLIYQKDfSDALAKLssNDYLRLASTFHGLHAIaaqLS-----PVPgssgiELLEtdTFR---LHCFQTLTGI 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 19074277  74 SFVFVADR---PVDALFERIYSHYCQYVTRNPFHSPEMPIQCSKFKPHLM 120
Cdd:cd14856  76 KFVLVADPkqpGLDALLRRVYELYADYVLKNPFYELEMPIRCELFDENLQ 125
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 7-119 7.16e-14

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 63.10  E-value: 7.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277     7 FIINKSGGMVFKYE--REGETEI--NSLLILTSSLYSVSVILTKtIDgPVPRL--VVYFR--NRVITIFRTTTGTSFVFV 78
Cdd:pfam04099   5 YIFNRAGGLIYYKEwnRPKKTKLttNEYKLLAGMLHSLHSISSK-IS-PLPGSsgIESLEtdTFKLHCLETLTGIKFVLV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 19074277    79 ADRP----VDALFERIYSHYCQYVTRNPFHSPEMPIQCSKFKPHL 119
Cdd:pfam04099  83 TDPGtginRDSLLRKYYELYSDYVLKNPFYSLGMPIRCELFDEKL 127
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 67-119 9.46e-05

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 39.07  E-value: 9.46e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19074277  67 FRTTTGTSFVFVADRPVDALFE---RIYSH-YCQYVTRNPFHSPEMPIQCSKFKPHL 119
Cdd:cd14855  73 YETPTGLKFVLLTDPNVGDLRDvlqQIYSNiYVEYVVKNPLYPPGEPITSELFRSKL 129
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 69-115 3.43e-04

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 37.57  E-value: 3.43e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19074277  69 TTTGTSFVFVADRP--------VDALFERIYSHYCQYVtRNPFHSPEMPIQCSKF 115
Cdd:cd14854  73 TNTKVKFILVLEDTntplrdndVRTLFRRLHNAYVDAV-SNPFYPPGTPITSKKF 126
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 4-115 3.21e-03

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 35.15  E-value: 3.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19074277   4 EQFFIINKSGGMVFKYE--REGETEI---NSLLILTSSLYSVSVILTKTIDGPVP--RLVVYFRNRVITIFRTTTGTSFV 76
Cdd:cd14853   1 FYFVVVGHHGNPLYEREftPPGQAEDdneEEYKLLAGMLHSVRSINSKLSPNVEKylKLSDKTNEYKVHAYVTATGLKFV 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19074277  77 FVAD---RPVDALFERIYSH-YCQYVTR--NPFHSPEMPIQCSKF 115
Cdd:cd14853  81 MLTDvlmDRIEDVLKNFFSDlYVLYVKKnpNPFYEPNSPIRSRLF 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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