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Conserved domains on  [gi|19075403|ref|NP_587903|]
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separase/separin [Schizosaccharomyces pombe]

Protein Classification

separin( domain architecture ID 10009105)

separin is a caspase-like protease which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ESP1 COG5155
Separase, a protease involved in sister chromatid separation [Cell division and chromosome ...
 38-1828 0e+00

Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 227484 [Multi-domain]  Cd Length: 1622  Bit Score: 2281.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   38 ASVKLKDLKQNISRDAPSWTFEHLFVAFKCAVSNLAKQWAELSTTDKEKTRRMFCTPSRLNTAHRpeVFYLLECCTyILE 117
Cdd:COG5155    1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIR--DFTKIASNN-IDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  118 QMQVVTKnTSHLYDCIRSgvsicnrlldmeifepaisLLMKTHKNLIILLTYRDHDAIPTATLLNPTLDVSEIQLESCLF 197
Cdd:COG5155   78 AIEDITT-VDHSLNSIYS-------------------LLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFN 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  198 VPMVPASYFLNIgtiVVTFQLNVLRCLSLSQINGLSLNTINNLQSEDGPFQWIERSFPsqvqlansrreILARLLTRFSM 277
Cdd:COG5155  138 ETNLFQAHSLKN---ILLADFSTWNDYYLSNLKILALQIILKRKLVDEYLPHILELFS-----------HDKRYLLKDPN 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  278 IQNNALQSFKLLILSIALWLNILSSqraDDKEFDVNQLETRILQLFSKVVQLCKSEdiegsilNKDMTQLHHLLENLSKE 357
Cdd:COG5155  204 LKAHALTKIVLSFFSVTTSCKVLFG---LKFLQYIKQFKLPFKKFISNITVECFSK-------NLLHKNYLEMGPNKIYL 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  358 SrlHILLQLSQLYYKYNDFQLSAAYVIRGYSLSFEDISFKLKFLLFSFRLSIHDNSICFPFNLIQELSSLQQLFVENALP 437
Cdd:COG5155  274 N--SFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNMSENRLLWSCISVDDLNVILENATNFLQNKGK 351

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  438 YSEALHLLDSIERSFRLFNDSTVFDDTVFALNISEILswiLSSVVRDILVEdellNLQLKIRKFLMFTFHIIRSFSELTK 517
Cdd:COG5155  352 HISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIY---INSNIKSINDE----SAAALLSELLGVLSEICIDYKEPKR 424

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  518 FQSSLEGCLNLAAYYEDAEFPQKLSNhlynlcVKSSNVnyareciSLSIKIAVSHKLtndetyllkILKnFQLRYHDSLQ 597
Cdd:COG5155  425 LSNIISVLFNASVLFKSHSFLLKTAN------LEISNV-------LISNDSKTSHRT---------ILK-FEKFISSAQS 481

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  598 LQEKCDVLHTTFNQLDLYVGTTsvgKSSVLDNILKRIFNSLTSINDSNIEKLLESISYSLLKLFFKCANEGSRYNASAAL 677
Cdd:COG5155  482 AQKKIEIFSCLFNVYCMLRNDT---LSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQL 558

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  678 SFKLSLMLHEKEEVLLLKTNVsCVLANHGYNdiKFEEMVLCVIKGDQNLLEHNSNNNAKLALneSLLCSWEnllcyrrAE 757
Cdd:COG5155  559 SRMIFCSLRGIFDLDPLELNN-TFDKLHLLN--KYELLIRIVYLLNLDMSKHLTTNLSKITK--LYINKWL-------QK 626

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  758 DDSRILTIIESWTIFISRFSSVISrcsFTDFEINSILnFFFCFLHtvepsgkltfELAFLEIFYELFNCLLHLQFSKYLV 837
Cdd:COG5155  627 SDEKAERISSFEMDFVKMLLCYLN---FNNFDKLSIE-LSLCIKS----------KEKYYSSIVPYADNYLLEAYLSLYM 692

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  838 IIGTLLsdkyMTLGFSGKAHLFYTKCYSYLRQCKSSPFINFWNVSYGKYLILTGntdkgilqlKKYSLSSEEDFNSNgls 917
Cdd:COG5155  693 IDDALM----MKNQLQKTMNLSTAKIEQALLHASSLINVHLWDSDLTAFQIYFG---------KTLPAMKPELFDIN--- 756

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  918 rtvslNLLLYEriqlsdalfqlgyTTVSLGFIMQNLKvikgLFSKSSKEHFNGGKYITWRLFAVSAHSNVCAARIYEHMG 997
Cdd:COG5155  757 -----NDHNLP-------------MSLYIKVILLNIK----MFTESQKEFLEKGRFIGKPCRATSTRRNTEAIRMVNSIL 814

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  998 QAREAEFFYRQACSISEKMPFSCFSATFQLRLCSLLTRagklEKGEKILFDLTEAMKSTDTYHKLLWNYGAAE-VCATKS 1076
Cdd:COG5155  815 KAPTRSLGLFGLESVSCLYIYEPMLGIPRYRLCKALVS----LCSKVIVRDLYEEIERRIKLHLLRMLYRDVEsICESMG 890

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1077 ELDGAICHYSECVKLLEIIKSEYYLFFNRNREKSLTKGIKRLSLSSQPTFVTESNttefdDWSILQNTAANLLRLISMFE 1156
Cdd:COG5155  891 FLDYADSSLDEIIVGYLIIRYKEYLEYNKEAWKIVERVGPRLKAKAKRTFASLLN-----GWVGSCLLEEKIERLLSSRR 965

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1157 LKRGNLEIAKALMTDSTKCSIASFFNIvsANILKSKLIVCEADstlfgdPVLRTLPDSVISLPgISHKFQKNQSKTKALG 1236
Cdd:COG5155  966 RKAAVSVEKKNITHVLTRDEVEYFFEN--YPLVSSFLNIPEDL------PVIGTVPYLDLRRP-FNHEYFDEVCCWNGFT 1036

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1237 ENTGFRKGSKRLDYLRERLKINLQNVRLSCEIIFSNAYERssvcvcREVNELISYSTIMQSALTTIGETTDVDSSSASFF 1316
Cdd:COG5155 1037 ENTSMRGGASREKLLRDLGLLKLICFRMCREREYDLELMR------HELSKIKSSSSFERAFLEGITKVVCQESSAAKEF 1110

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1317 LEIPKALGFHRRREAQKFRN-QHKELHFSSLEQILNSRLSIPDVRtFQDNFIDSLPSIWNVVSITINNSGEDLFISKIRK 1395
Cdd:COG5155 1111 TLRPMVLEIIRGMGMASIHNiQLCEYDLSSLSHMFNGEYFESVFR-LNRGVEDSCKSRLNFVAITILNCTGKLVVSKIGG 1189

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1396 GHSPLIFRLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQ-MAQNGKHYTRREDKETWWKERRHLDQCLQQLLENIEI 1474
Cdd:COG5155 1190 VHGPTHLRLPLIRSNSRDLDEMILPFHVAVNELKVIINRSNQnLALKDEMSNLREIRKTWWLERFALDRPSQQLLDNIEI 1269

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1475 SWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKKTPVPTLSPEILELFITLGkPGYEGYEQLLEDLIYFILDIF 1554
Cdd:COG5155 1270 SWRLGRYGVFSPYCIDGSLFIKFFKGFIRIDKDNFRGAKTRMNPILARWVIELFLKLN-PQEIDSRDILEDLIYFGLDIA 1348

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1555 QFRGLHFAYDEIDTDQLSMDLQDALNAYFNNYVSEeNRSHTVLVLDKSVHQFPWESLPCLNRQSVSRVPSLSILRDILSQ 1634
Cdd:COG5155 1349 RFWGQRNAYDEIDLDALLGKLLSDIGSYFNGLSVG-SIKHTILVLDESTHEFPWESLPVLRNKSVYRVPSLEYLENALSS 1427

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1635 sFVVNGEYVEVRKEAGSYILNPSLDLKHTQEMFE-HKLVEGGWKG-LIASQPSNRDFIKMLSGNDFFLYFGHGGGEQYTT 1712
Cdd:COG5155 1428 -FHYQLPLQGASGRSFSYILNPENDLPKTQERFAgQKFLESSGITnLVTGRPPSDLECKMLDGCDVFLYFGHGGGEQYLK 1506

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1713 SYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDIDRFSLKMLESWGLFENKAPFVN 1792
Cdd:COG5155 1507 SSEIKKCGEGATMLLFGCSSVALLCMGNYEPNGTILKYLRRGCPMVVGNLWDVTDKDIDSFSARIIESLGSGCNSLGELN 1586

                       1770      1780      1790
                 ....*....|....*....|....*....|....*.
gi 19075403 1793 STSICTAVSESRSCCHLRYLNGAAPVIYGIPAYIIP 1828
Cdd:COG5155 1587 SLSVSYAVSRSRDGCHLRYLNGAAPVIYGLPIKFVS 1622
 
Name Accession Description Interval E-value
ESP1 COG5155
Separase, a protease involved in sister chromatid separation [Cell division and chromosome ...
 38-1828 0e+00

Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227484 [Multi-domain]  Cd Length: 1622  Bit Score: 2281.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   38 ASVKLKDLKQNISRDAPSWTFEHLFVAFKCAVSNLAKQWAELSTTDKEKTRRMFCTPSRLNTAHRpeVFYLLECCTyILE 117
Cdd:COG5155    1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIR--DFTKIASNN-IDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  118 QMQVVTKnTSHLYDCIRSgvsicnrlldmeifepaisLLMKTHKNLIILLTYRDHDAIPTATLLNPTLDVSEIQLESCLF 197
Cdd:COG5155   78 AIEDITT-VDHSLNSIYS-------------------LLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFN 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  198 VPMVPASYFLNIgtiVVTFQLNVLRCLSLSQINGLSLNTINNLQSEDGPFQWIERSFPsqvqlansrreILARLLTRFSM 277
Cdd:COG5155  138 ETNLFQAHSLKN---ILLADFSTWNDYYLSNLKILALQIILKRKLVDEYLPHILELFS-----------HDKRYLLKDPN 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  278 IQNNALQSFKLLILSIALWLNILSSqraDDKEFDVNQLETRILQLFSKVVQLCKSEdiegsilNKDMTQLHHLLENLSKE 357
Cdd:COG5155  204 LKAHALTKIVLSFFSVTTSCKVLFG---LKFLQYIKQFKLPFKKFISNITVECFSK-------NLLHKNYLEMGPNKIYL 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  358 SrlHILLQLSQLYYKYNDFQLSAAYVIRGYSLSFEDISFKLKFLLFSFRLSIHDNSICFPFNLIQELSSLQQLFVENALP 437
Cdd:COG5155  274 N--SFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNMSENRLLWSCISVDDLNVILENATNFLQNKGK 351

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  438 YSEALHLLDSIERSFRLFNDSTVFDDTVFALNISEILswiLSSVVRDILVEdellNLQLKIRKFLMFTFHIIRSFSELTK 517
Cdd:COG5155  352 HISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIY---INSNIKSINDE----SAAALLSELLGVLSEICIDYKEPKR 424

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  518 FQSSLEGCLNLAAYYEDAEFPQKLSNhlynlcVKSSNVnyareciSLSIKIAVSHKLtndetyllkILKnFQLRYHDSLQ 597
Cdd:COG5155  425 LSNIISVLFNASVLFKSHSFLLKTAN------LEISNV-------LISNDSKTSHRT---------ILK-FEKFISSAQS 481

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  598 LQEKCDVLHTTFNQLDLYVGTTsvgKSSVLDNILKRIFNSLTSINDSNIEKLLESISYSLLKLFFKCANEGSRYNASAAL 677
Cdd:COG5155  482 AQKKIEIFSCLFNVYCMLRNDT---LSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQL 558

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  678 SFKLSLMLHEKEEVLLLKTNVsCVLANHGYNdiKFEEMVLCVIKGDQNLLEHNSNNNAKLALneSLLCSWEnllcyrrAE 757
Cdd:COG5155  559 SRMIFCSLRGIFDLDPLELNN-TFDKLHLLN--KYELLIRIVYLLNLDMSKHLTTNLSKITK--LYINKWL-------QK 626

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  758 DDSRILTIIESWTIFISRFSSVISrcsFTDFEINSILnFFFCFLHtvepsgkltfELAFLEIFYELFNCLLHLQFSKYLV 837
Cdd:COG5155  627 SDEKAERISSFEMDFVKMLLCYLN---FNNFDKLSIE-LSLCIKS----------KEKYYSSIVPYADNYLLEAYLSLYM 692

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  838 IIGTLLsdkyMTLGFSGKAHLFYTKCYSYLRQCKSSPFINFWNVSYGKYLILTGntdkgilqlKKYSLSSEEDFNSNgls 917
Cdd:COG5155  693 IDDALM----MKNQLQKTMNLSTAKIEQALLHASSLINVHLWDSDLTAFQIYFG---------KTLPAMKPELFDIN--- 756

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  918 rtvslNLLLYEriqlsdalfqlgyTTVSLGFIMQNLKvikgLFSKSSKEHFNGGKYITWRLFAVSAHSNVCAARIYEHMG 997
Cdd:COG5155  757 -----NDHNLP-------------MSLYIKVILLNIK----MFTESQKEFLEKGRFIGKPCRATSTRRNTEAIRMVNSIL 814

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  998 QAREAEFFYRQACSISEKMPFSCFSATFQLRLCSLLTRagklEKGEKILFDLTEAMKSTDTYHKLLWNYGAAE-VCATKS 1076
Cdd:COG5155  815 KAPTRSLGLFGLESVSCLYIYEPMLGIPRYRLCKALVS----LCSKVIVRDLYEEIERRIKLHLLRMLYRDVEsICESMG 890

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1077 ELDGAICHYSECVKLLEIIKSEYYLFFNRNREKSLTKGIKRLSLSSQPTFVTESNttefdDWSILQNTAANLLRLISMFE 1156
Cdd:COG5155  891 FLDYADSSLDEIIVGYLIIRYKEYLEYNKEAWKIVERVGPRLKAKAKRTFASLLN-----GWVGSCLLEEKIERLLSSRR 965

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1157 LKRGNLEIAKALMTDSTKCSIASFFNIvsANILKSKLIVCEADstlfgdPVLRTLPDSVISLPgISHKFQKNQSKTKALG 1236
Cdd:COG5155  966 RKAAVSVEKKNITHVLTRDEVEYFFEN--YPLVSSFLNIPEDL------PVIGTVPYLDLRRP-FNHEYFDEVCCWNGFT 1036

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1237 ENTGFRKGSKRLDYLRERLKINLQNVRLSCEIIFSNAYERssvcvcREVNELISYSTIMQSALTTIGETTDVDSSSASFF 1316
Cdd:COG5155 1037 ENTSMRGGASREKLLRDLGLLKLICFRMCREREYDLELMR------HELSKIKSSSSFERAFLEGITKVVCQESSAAKEF 1110

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1317 LEIPKALGFHRRREAQKFRN-QHKELHFSSLEQILNSRLSIPDVRtFQDNFIDSLPSIWNVVSITINNSGEDLFISKIRK 1395
Cdd:COG5155 1111 TLRPMVLEIIRGMGMASIHNiQLCEYDLSSLSHMFNGEYFESVFR-LNRGVEDSCKSRLNFVAITILNCTGKLVVSKIGG 1189

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1396 GHSPLIFRLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQ-MAQNGKHYTRREDKETWWKERRHLDQCLQQLLENIEI 1474
Cdd:COG5155 1190 VHGPTHLRLPLIRSNSRDLDEMILPFHVAVNELKVIINRSNQnLALKDEMSNLREIRKTWWLERFALDRPSQQLLDNIEI 1269

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1475 SWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKKTPVPTLSPEILELFITLGkPGYEGYEQLLEDLIYFILDIF 1554
Cdd:COG5155 1270 SWRLGRYGVFSPYCIDGSLFIKFFKGFIRIDKDNFRGAKTRMNPILARWVIELFLKLN-PQEIDSRDILEDLIYFGLDIA 1348

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1555 QFRGLHFAYDEIDTDQLSMDLQDALNAYFNNYVSEeNRSHTVLVLDKSVHQFPWESLPCLNRQSVSRVPSLSILRDILSQ 1634
Cdd:COG5155 1349 RFWGQRNAYDEIDLDALLGKLLSDIGSYFNGLSVG-SIKHTILVLDESTHEFPWESLPVLRNKSVYRVPSLEYLENALSS 1427

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1635 sFVVNGEYVEVRKEAGSYILNPSLDLKHTQEMFE-HKLVEGGWKG-LIASQPSNRDFIKMLSGNDFFLYFGHGGGEQYTT 1712
Cdd:COG5155 1428 -FHYQLPLQGASGRSFSYILNPENDLPKTQERFAgQKFLESSGITnLVTGRPPSDLECKMLDGCDVFLYFGHGGGEQYLK 1506

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1713 SYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDIDRFSLKMLESWGLFENKAPFVN 1792
Cdd:COG5155 1507 SSEIKKCGEGATMLLFGCSSVALLCMGNYEPNGTILKYLRRGCPMVVGNLWDVTDKDIDSFSARIIESLGSGCNSLGELN 1586

                       1770      1780      1790
                 ....*....|....*....|....*....|....*.
gi 19075403 1793 STSICTAVSESRSCCHLRYLNGAAPVIYGIPAYIIP 1828
Cdd:COG5155 1587 SLSVSYAVSRSRDGCHLRYLNGAAPVIYGLPIKFVS 1622
Peptidase_C50 pfam03568
Peptidase family C50;
1384-1770 5.90e-180

Peptidase family C50;


Pssm-ID: 460974 [Multi-domain]  Cd Length: 389  Bit Score: 547.55  E-value: 5.90e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1384 SGEDLFISKIRKGHSPLIFRLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQMAQNGKHYTRREDKETWWKERRHLDQ 1463
Cdd:pfam03568    2 DRGDLLLSRLEAGSSPFVLRLPLSRHNSRDADEEVLSFEDALDELDEIIEESNESTSSASDIKTKEARKEWWKEREALDK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1464 CLQQLLENIEISWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKK---TPVPTLSPEILELFITLGkpGYEGYE 1540
Cdd:pfam03568   82 RLKELLENIENSWLGGFKGIFSPHPRDPELLARFAKKFQKILDKHLPSRKQkapSPKLTLDDRILELFLGLG--PEDDFD 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1541 QLLEDLIYFILDIFQFRGLHFAYDEIDTDQLSMDLQDALNAYFNNYVSEENRSHTVLVLDKSVHQFPWESLPCLNRQSVS 1620
Cdd:pfam03568  160 ELLEDLLYFVLDILQFHGERNAYDEIDFDQLVVELEDALRKYHSKAAPETKREHTVLVLDKALQSFPWESLPCLRGRSVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1621 RVPSLSILRDILSQSFVVNGEYVEVRKEaGSYILNPSLDLKHTQEMFEHKLV-EGGWKGLIASQPSNRDFIKMLSGNDFF 1699
Cdd:pfam03568  240 RMPSLHSLRDLLEKREAQLKPRIVVDRN-GYYILNPSGDLKRTQERFEDWFEsLPGWKGIVGRAPSEEEFEEALSTSDLF 318

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19075403   1700 LYFGHGGGEQYTTSYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDI 1770
Cdd:pfam03568  319 LYFGHGGGEQYIRSRTIKKLPRCAASLLMGCSSGALKEAGDFEPYGTPLNYLLAGCPAVVGNLWDVTDKDI 389
 
Name Accession Description Interval E-value
ESP1 COG5155
Separase, a protease involved in sister chromatid separation [Cell division and chromosome ...
 38-1828 0e+00

Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227484 [Multi-domain]  Cd Length: 1622  Bit Score: 2281.46  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   38 ASVKLKDLKQNISRDAPSWTFEHLFVAFKCAVSNLAKQWAELSTTDKEKTRRMFCTPSRLNTAHRpeVFYLLECCTyILE 117
Cdd:COG5155    1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIR--DFTKIASNN-IDL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  118 QMQVVTKnTSHLYDCIRSgvsicnrlldmeifepaisLLMKTHKNLIILLTYRDHDAIPTATLLNPTLDVSEIQLESCLF 197
Cdd:COG5155   78 AIEDITT-VDHSLNSIYS-------------------LLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFN 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  198 VPMVPASYFLNIgtiVVTFQLNVLRCLSLSQINGLSLNTINNLQSEDGPFQWIERSFPsqvqlansrreILARLLTRFSM 277
Cdd:COG5155  138 ETNLFQAHSLKN---ILLADFSTWNDYYLSNLKILALQIILKRKLVDEYLPHILELFS-----------HDKRYLLKDPN 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  278 IQNNALQSFKLLILSIALWLNILSSqraDDKEFDVNQLETRILQLFSKVVQLCKSEdiegsilNKDMTQLHHLLENLSKE 357
Cdd:COG5155  204 LKAHALTKIVLSFFSVTTSCKVLFG---LKFLQYIKQFKLPFKKFISNITVECFSK-------NLLHKNYLEMGPNKIYL 273

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  358 SrlHILLQLSQLYYKYNDFQLSAAYVIRGYSLSFEDISFKLKFLLFSFRLSIHDNSICFPFNLIQELSSLQQLFVENALP 437
Cdd:COG5155  274 N--SFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNMSENRLLWSCISVDDLNVILENATNFLQNKGK 351

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  438 YSEALHLLDSIERSFRLFNDSTVFDDTVFALNISEILswiLSSVVRDILVEdellNLQLKIRKFLMFTFHIIRSFSELTK 517
Cdd:COG5155  352 HISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIY---INSNIKSINDE----SAAALLSELLGVLSEICIDYKEPKR 424

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  518 FQSSLEGCLNLAAYYEDAEFPQKLSNhlynlcVKSSNVnyareciSLSIKIAVSHKLtndetyllkILKnFQLRYHDSLQ 597
Cdd:COG5155  425 LSNIISVLFNASVLFKSHSFLLKTAN------LEISNV-------LISNDSKTSHRT---------ILK-FEKFISSAQS 481

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  598 LQEKCDVLHTTFNQLDLYVGTTsvgKSSVLDNILKRIFNSLTSINDSNIEKLLESISYSLLKLFFKCANEGSRYNASAAL 677
Cdd:COG5155  482 AQKKIEIFSCLFNVYCMLRNDT---LSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQL 558

                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  678 SFKLSLMLHEKEEVLLLKTNVsCVLANHGYNdiKFEEMVLCVIKGDQNLLEHNSNNNAKLALneSLLCSWEnllcyrrAE 757
Cdd:COG5155  559 SRMIFCSLRGIFDLDPLELNN-TFDKLHLLN--KYELLIRIVYLLNLDMSKHLTTNLSKITK--LYINKWL-------QK 626

                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  758 DDSRILTIIESWTIFISRFSSVISrcsFTDFEINSILnFFFCFLHtvepsgkltfELAFLEIFYELFNCLLHLQFSKYLV 837
Cdd:COG5155  627 SDEKAERISSFEMDFVKMLLCYLN---FNNFDKLSIE-LSLCIKS----------KEKYYSSIVPYADNYLLEAYLSLYM 692

                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  838 IIGTLLsdkyMTLGFSGKAHLFYTKCYSYLRQCKSSPFINFWNVSYGKYLILTGntdkgilqlKKYSLSSEEDFNSNgls 917
Cdd:COG5155  693 IDDALM----MKNQLQKTMNLSTAKIEQALLHASSLINVHLWDSDLTAFQIYFG---------KTLPAMKPELFDIN--- 756

                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  918 rtvslNLLLYEriqlsdalfqlgyTTVSLGFIMQNLKvikgLFSKSSKEHFNGGKYITWRLFAVSAHSNVCAARIYEHMG 997
Cdd:COG5155  757 -----NDHNLP-------------MSLYIKVILLNIK----MFTESQKEFLEKGRFIGKPCRATSTRRNTEAIRMVNSIL 814

                        970       980       990      1000      1010      1020      1030      1040
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403  998 QAREAEFFYRQACSISEKMPFSCFSATFQLRLCSLLTRagklEKGEKILFDLTEAMKSTDTYHKLLWNYGAAE-VCATKS 1076
Cdd:COG5155  815 KAPTRSLGLFGLESVSCLYIYEPMLGIPRYRLCKALVS----LCSKVIVRDLYEEIERRIKLHLLRMLYRDVEsICESMG 890

                       1050      1060      1070      1080      1090      1100      1110      1120
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1077 ELDGAICHYSECVKLLEIIKSEYYLFFNRNREKSLTKGIKRLSLSSQPTFVTESNttefdDWSILQNTAANLLRLISMFE 1156
Cdd:COG5155  891 FLDYADSSLDEIIVGYLIIRYKEYLEYNKEAWKIVERVGPRLKAKAKRTFASLLN-----GWVGSCLLEEKIERLLSSRR 965

                       1130      1140      1150      1160      1170      1180      1190      1200
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1157 LKRGNLEIAKALMTDSTKCSIASFFNIvsANILKSKLIVCEADstlfgdPVLRTLPDSVISLPgISHKFQKNQSKTKALG 1236
Cdd:COG5155  966 RKAAVSVEKKNITHVLTRDEVEYFFEN--YPLVSSFLNIPEDL------PVIGTVPYLDLRRP-FNHEYFDEVCCWNGFT 1036

                       1210      1220      1230      1240      1250      1260      1270      1280
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1237 ENTGFRKGSKRLDYLRERLKINLQNVRLSCEIIFSNAYERssvcvcREVNELISYSTIMQSALTTIGETTDVDSSSASFF 1316
Cdd:COG5155 1037 ENTSMRGGASREKLLRDLGLLKLICFRMCREREYDLELMR------HELSKIKSSSSFERAFLEGITKVVCQESSAAKEF 1110

                       1290      1300      1310      1320      1330      1340      1350      1360
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1317 LEIPKALGFHRRREAQKFRN-QHKELHFSSLEQILNSRLSIPDVRtFQDNFIDSLPSIWNVVSITINNSGEDLFISKIRK 1395
Cdd:COG5155 1111 TLRPMVLEIIRGMGMASIHNiQLCEYDLSSLSHMFNGEYFESVFR-LNRGVEDSCKSRLNFVAITILNCTGKLVVSKIGG 1189

                       1370      1380      1390      1400      1410      1420      1430      1440
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1396 GHSPLIFRLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQ-MAQNGKHYTRREDKETWWKERRHLDQCLQQLLENIEI 1474
Cdd:COG5155 1190 VHGPTHLRLPLIRSNSRDLDEMILPFHVAVNELKVIINRSNQnLALKDEMSNLREIRKTWWLERFALDRPSQQLLDNIEI 1269

                       1450      1460      1470      1480      1490      1500      1510      1520
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1475 SWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKKTPVPTLSPEILELFITLGkPGYEGYEQLLEDLIYFILDIF 1554
Cdd:COG5155 1270 SWRLGRYGVFSPYCIDGSLFIKFFKGFIRIDKDNFRGAKTRMNPILARWVIELFLKLN-PQEIDSRDILEDLIYFGLDIA 1348

                       1530      1540      1550      1560      1570      1580      1590      1600
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1555 QFRGLHFAYDEIDTDQLSMDLQDALNAYFNNYVSEeNRSHTVLVLDKSVHQFPWESLPCLNRQSVSRVPSLSILRDILSQ 1634
Cdd:COG5155 1349 RFWGQRNAYDEIDLDALLGKLLSDIGSYFNGLSVG-SIKHTILVLDESTHEFPWESLPVLRNKSVYRVPSLEYLENALSS 1427

                       1610      1620      1630      1640      1650      1660      1670      1680
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1635 sFVVNGEYVEVRKEAGSYILNPSLDLKHTQEMFE-HKLVEGGWKG-LIASQPSNRDFIKMLSGNDFFLYFGHGGGEQYTT 1712
Cdd:COG5155 1428 -FHYQLPLQGASGRSFSYILNPENDLPKTQERFAgQKFLESSGITnLVTGRPPSDLECKMLDGCDVFLYFGHGGGEQYLK 1506

                       1690      1700      1710      1720      1730      1740      1750      1760
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403 1713 SYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDIDRFSLKMLESWGLFENKAPFVN 1792
Cdd:COG5155 1507 SSEIKKCGEGATMLLFGCSSVALLCMGNYEPNGTILKYLRRGCPMVVGNLWDVTDKDIDSFSARIIESLGSGCNSLGELN 1586

                       1770      1780      1790
                 ....*....|....*....|....*....|....*.
gi 19075403 1793 STSICTAVSESRSCCHLRYLNGAAPVIYGIPAYIIP 1828
Cdd:COG5155 1587 SLSVSYAVSRSRDGCHLRYLNGAAPVIYGLPIKFVS 1622
Peptidase_C50 pfam03568
Peptidase family C50;
1384-1770 5.90e-180

Peptidase family C50;


Pssm-ID: 460974 [Multi-domain]  Cd Length: 389  Bit Score: 547.55  E-value: 5.90e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1384 SGEDLFISKIRKGHSPLIFRLPLQRHNSRDADEEILVFTKAQTELFRIISKSNQMAQNGKHYTRREDKETWWKERRHLDQ 1463
Cdd:pfam03568    2 DRGDLLLSRLEAGSSPFVLRLPLSRHNSRDADEEVLSFEDALDELDEIIEESNESTSSASDIKTKEARKEWWKEREALDK 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1464 CLQQLLENIEISWLGGFKGIFNPHKIDTSLFAKFSSQFQNIIAKNFNMDKK---TPVPTLSPEILELFITLGkpGYEGYE 1540
Cdd:pfam03568   82 RLKELLENIENSWLGGFKGIFSPHPRDPELLARFAKKFQKILDKHLPSRKQkapSPKLTLDDRILELFLGLG--PEDDFD 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1541 QLLEDLIYFILDIFQFRGLHFAYDEIDTDQLSMDLQDALNAYFNNYVSEENRSHTVLVLDKSVHQFPWESLPCLNRQSVS 1620
Cdd:pfam03568  160 ELLEDLLYFVLDILQFHGERNAYDEIDFDQLVVELEDALRKYHSKAAPETKREHTVLVLDKALQSFPWESLPCLRGRSVS 239

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075403   1621 RVPSLSILRDILSQSFVVNGEYVEVRKEaGSYILNPSLDLKHTQEMFEHKLV-EGGWKGLIASQPSNRDFIKMLSGNDFF 1699
Cdd:pfam03568  240 RMPSLHSLRDLLEKREAQLKPRIVVDRN-GYYILNPSGDLKRTQERFEDWFEsLPGWKGIVGRAPSEEEFEEALSTSDLF 318

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19075403   1700 LYFGHGGGEQYTTSYDLATLKRCAVTILMGCSSGALYECGSFEPWGTPLDYLSAGCPTLVANLWDVTDKDI 1770
Cdd:pfam03568  319 LYFGHGGGEQYIRSRTIKKLPRCAASLLMGCSSGALKEAGDFEPYGTPLNYLLAGCPAVVGNLWDVTDKDI 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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