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Conserved domains on  [gi|19075479|ref|NP_587979|]
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TAP42-like family protein [Schizosaccharomyces pombe]

Protein Classification

IGBP1/TAP42 family protein( domain architecture ID 10514489)

IGBP1/TAP42 family protein similar to human immunoglobulin-binding protein 1 (IGBP1) that is involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6, and to Saccharomyces cerevisiae type 2A phosphatase-associated protein 42 (TAP42) that is involved in negative regulation of the TOR signaling pathway in response to the available nitrogen source type

CATH:  1.25.40.540
Gene Ontology:  GO:0035303|GO:0051721
PubMed:  11741537|9441740
SCOP:  4004504

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
6-312 6.44e-65

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


:

Pssm-ID: 461209  Cd Length: 305  Bit Score: 206.68  E-value: 6.44e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479     6 LRELWEETEKLKDSSSTDEKTRSEIV--------EGYEKCLKLVLQLRIFSSNEEVDEIKTSELRYLMIDYELAKCVE-- 75
Cdd:pfam04177   1 LSELFDSALKLYEELENSTPTNSPEYqdkvksaiALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQkl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479    76 QWTKGDRLKAVQYAKTHYETFLSICDDYGLKPMQDEK---------------------PKTEADTRTLKIARYRMRQNLE 134
Cdd:pfam04177  81 QTDPEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKllesfssenyselpelfstasTSDAAARREEKIARFKREKELE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   135 KELKALSKDSETN-----EEQERKFWLTKLQIAVEDTLDSLPHIEMEIDLLKRAQAelmksedspekdeetlrreerkqk 209
Cdd:pfam04177 161 QKLEELKKRVESRsgqedEEVVRELYLTQLKLAILKAFQELESIEQELEILEMAPG------------------------ 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   210 egsswrldlntrdkildknnRPLQPFTIVSDRNETRKNVFGFGYNLPTMTVDEYLDEEMKRGNII------SQKDNPPKS 283
Cdd:pfam04177 217 --------------------KPLRPFTILSTREELQAKVFGPGHSLPTMTVDEYLEEERRRGGIIegggeaSAAEPEEEE 276
                         330       340
                  ....*....|....*....|....*....
gi 19075479   284 DSDDEDDYEKLDAKTMKDRYWDEFKEANP 312
Cdd:pfam04177 277 EEDEEDDEEKADEETYKAREWDEFKDDNP 305
 
Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
6-312 6.44e-65

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461209  Cd Length: 305  Bit Score: 206.68  E-value: 6.44e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479     6 LRELWEETEKLKDSSSTDEKTRSEIV--------EGYEKCLKLVLQLRIFSSNEEVDEIKTSELRYLMIDYELAKCVE-- 75
Cdd:pfam04177   1 LSELFDSALKLYEELENSTPTNSPEYqdkvksaiALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQkl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479    76 QWTKGDRLKAVQYAKTHYETFLSICDDYGLKPMQDEK---------------------PKTEADTRTLKIARYRMRQNLE 134
Cdd:pfam04177  81 QTDPEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKllesfssenyselpelfstasTSDAAARREEKIARFKREKELE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   135 KELKALSKDSETN-----EEQERKFWLTKLQIAVEDTLDSLPHIEMEIDLLKRAQAelmksedspekdeetlrreerkqk 209
Cdd:pfam04177 161 QKLEELKKRVESRsgqedEEVVRELYLTQLKLAILKAFQELESIEQELEILEMAPG------------------------ 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   210 egsswrldlntrdkildknnRPLQPFTIVSDRNETRKNVFGFGYNLPTMTVDEYLDEEMKRGNII------SQKDNPPKS 283
Cdd:pfam04177 217 --------------------KPLRPFTILSTREELQAKVFGPGHSLPTMTVDEYLEEERRRGGIIegggeaSAAEPEEEE 276
                         330       340
                  ....*....|....*....|....*....
gi 19075479   284 DSDDEDDYEKLDAKTMKDRYWDEFKEANP 312
Cdd:pfam04177 277 EEDEEDDEEKADEETYKAREWDEFKDDNP 305
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
3-235 2.16e-04

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 42.97  E-value: 2.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   3 SKSLRELWEETEKLkdssstdEKTRSEIVEGYEKCLKLVLQLRIFSS-NEEVDEIKTSE-----------------LRYL 64
Cdd:COG1269  98 EEELEEIEEEVNEL-------EERLEELEEELEELEELIEALEPWGDlDIDLEELRGTKylsvrvgtvpkenleklKKAL 170
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479  65 MIDYELAKCVEQWTKGDRLKAVQYAKTHYETFLSICDDYGLKPMQ----DEKPKteadtrtlkiaryRMRQNLEKELKAL 140
Cdd:COG1269 171 EILADYVEVVSSDKEDEVYVVVIVPKEDEEEVEEVLRSLGFERLEipelEGTPS-------------EALEELEEEIEEL 237
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479 141 SKDSETNEEQERKF---WLTKLQIAVEdtldslpHIEMEIDLLKrAQAELMKSEDS-------PEKDEETLRREERKQKE 210
Cdd:COG1269 238 EKEIEELEKELEELaekYREDLLALYE-------YLEIEKEKAE-APLKLATTENLfvlegwvPEEEVEELEKALEKATG 309
                       250       260
                ....*....|....*....|....*....
gi 19075479 211 GSSWRLDLNTRDK----ILDKNNRPLQPF 235
Cdd:COG1269 310 GRVYVEEEDPEEDdeppTLLKNPKFVKPF 338
 
Name Accession Description Interval E-value
TAP42 pfam04177
TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to ...
6-312 6.44e-65

TAP42-like family; The TOR signalling pathway activates a cell-growth program in response to nutrients. TIP41 (pfam04176) interacts with TAP42 and negatively regulates the TOR signaling pathway.


Pssm-ID: 461209  Cd Length: 305  Bit Score: 206.68  E-value: 6.44e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479     6 LRELWEETEKLKDSSSTDEKTRSEIV--------EGYEKCLKLVLQLRIFSSNEEVDEIKTSELRYLMIDYELAKCVE-- 75
Cdd:pfam04177   1 LSELFDSALKLYEELENSTPTNSPEYqdkvksaiALLELCTKLVSQLSLFSSNETLEDISTSDLKYLLVPYYLGELTQkl 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479    76 QWTKGDRLKAVQYAKTHYETFLSICDDYGLKPMQDEK---------------------PKTEADTRTLKIARYRMRQNLE 134
Cdd:pfam04177  81 QTDPEDRLEVLKRAREYYEDFLKRLEDYELLPKEDKKllesfssenyselpelfstasTSDAAARREEKIARFKREKELE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   135 KELKALSKDSETN-----EEQERKFWLTKLQIAVEDTLDSLPHIEMEIDLLKRAQAelmksedspekdeetlrreerkqk 209
Cdd:pfam04177 161 QKLEELKKRVESRsgqedEEVVRELYLTQLKLAILKAFQELESIEQELEILEMAPG------------------------ 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   210 egsswrldlntrdkildknnRPLQPFTIVSDRNETRKNVFGFGYNLPTMTVDEYLDEEMKRGNII------SQKDNPPKS 283
Cdd:pfam04177 217 --------------------KPLRPFTILSTREELQAKVFGPGHSLPTMTVDEYLEEERRRGGIIegggeaSAAEPEEEE 276
                         330       340
                  ....*....|....*....|....*....
gi 19075479   284 DSDDEDDYEKLDAKTMKDRYWDEFKEANP 312
Cdd:pfam04177 277 EEDEEDDEEKADEETYKAREWDEFKDDNP 305
NtpI COG1269
Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal ...
3-235 2.16e-04

Archaeal/vacuolar-type H+-ATPase subunit I/STV1 [Energy production and conversion]; Archaeal/vacuolar-type H+-ATPase subunit I/STV1 is part of the Pathway/BioSystem: A/V-type ATP synthase


Pssm-ID: 440880 [Multi-domain]  Cd Length: 645  Bit Score: 42.97  E-value: 2.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479   3 SKSLRELWEETEKLkdssstdEKTRSEIVEGYEKCLKLVLQLRIFSS-NEEVDEIKTSE-----------------LRYL 64
Cdd:COG1269  98 EEELEEIEEEVNEL-------EERLEELEEELEELEELIEALEPWGDlDIDLEELRGTKylsvrvgtvpkenleklKKAL 170
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479  65 MIDYELAKCVEQWTKGDRLKAVQYAKTHYETFLSICDDYGLKPMQ----DEKPKteadtrtlkiaryRMRQNLEKELKAL 140
Cdd:COG1269 171 EILADYVEVVSSDKEDEVYVVVIVPKEDEEEVEEVLRSLGFERLEipelEGTPS-------------EALEELEEEIEEL 237
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075479 141 SKDSETNEEQERKF---WLTKLQIAVEdtldslpHIEMEIDLLKrAQAELMKSEDS-------PEKDEETLRREERKQKE 210
Cdd:COG1269 238 EKEIEELEKELEELaekYREDLLALYE-------YLEIEKEKAE-APLKLATTENLfvlegwvPEEEVEELEKALEKATG 309
                       250       260
                ....*....|....*....|....*....
gi 19075479 211 GSSWRLDLNTRDK----ILDKNNRPLQPF 235
Cdd:COG1269 310 GRVYVEEEDPEEDdeppTLLKNPKFVKPF 338
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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