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Conserved domains on  [gi|19075480|ref|NP_587980|]
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WD repeat-containing protein [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-180 8.11e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 8.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  47 EIFKVPKAHT-NITGIISCDQLNGVITCGSEGEIHLWDIRSQAKsaVRSWTQQSTPFTCIALNKKNQFATGSeltRSLAS 125
Cdd:cd00200  42 ELLRTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGEC--VRTLTGHTSYVSSVAFSPDGRILSSS---SRDKT 116

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19075480 126 VQLWDVRSEQKLIRQwnDAHNDDITHLQFHPkDNELLLTGSVDGLVSLLDTTKEE 180
Cdd:cd00200 117 IKVWDVETGKCLTTL--RGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGK 168
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-180 8.11e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 8.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  47 EIFKVPKAHT-NITGIISCDQLNGVITCGSEGEIHLWDIRSQAKsaVRSWTQQSTPFTCIALNKKNQFATGSeltRSLAS 125
Cdd:cd00200  42 ELLRTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGEC--VRTLTGHTSYVSSVAFSPDGRILSSS---SRDKT 116

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19075480 126 VQLWDVRSEQKLIRQwnDAHNDDITHLQFHPkDNELLLTGSVDGLVSLLDTTKEE 180
Cdd:cd00200 117 IKVWDVETGKCLTTL--RGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGK 168
WD40 COG2319
WD40 repeat [General function prediction only];
70-177 8.82e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 8.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  70 VITCGSEGEIHLWDIRSQAksAVRSWTQQSTPFTCIALNKKNQF-ATGSEltrsLASVQLWDVRSeQKLIRQWnDAHNDD 148
Cdd:COG2319 135 LASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLlASGSD----DGTVRLWDLAT-GKLLRTL-TGHTGA 206

                        90       100
                ....*....|....*....|....*....
gi 19075480 149 ITHLQFHPkDNELLLTGSVDGLVSLLDTT 177
Cdd:COG2319 207 VRSVAFSP-DGKLLASGSADGTVRLWDLA 234
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-180 8.11e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.89  E-value: 8.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  47 EIFKVPKAHT-NITGIISCDQLNGVITCGSEGEIHLWDIRSQAKsaVRSWTQQSTPFTCIALNKKNQFATGSeltRSLAS 125
Cdd:cd00200  42 ELLRTLKGHTgPVRDVAASADGTYLASGSSDKTIRLWDLETGEC--VRTLTGHTSYVSSVAFSPDGRILSSS---SRDKT 116

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19075480 126 VQLWDVRSEQKLIRQwnDAHNDDITHLQFHPkDNELLLTGSVDGLVSLLDTTKEE 180
Cdd:cd00200 117 IKVWDVETGKCLTTL--RGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGK 168
WD40 COG2319
WD40 repeat [General function prediction only];
70-177 8.82e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 8.82e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  70 VITCGSEGEIHLWDIRSQAksAVRSWTQQSTPFTCIALNKKNQF-ATGSEltrsLASVQLWDVRSeQKLIRQWnDAHNDD 148
Cdd:COG2319 135 LASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPDGKLlASGSD----DGTVRLWDLAT-GKLLRTL-TGHTGA 206

                        90       100
                ....*....|....*....|....*....
gi 19075480 149 ITHLQFHPkDNELLLTGSVDGLVSLLDTT 177
Cdd:COG2319 207 VRSVAFSP-DGKLLASGSADGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
70-177 2.17e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 2.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  70 VITCGSEGEIHLWDIRSqaKSAVRSWTQQSTPFTCIALNKKNQF-ATGSELTrslaSVQLWDVRSeQKLIRQWnDAHNDD 148
Cdd:COG2319 261 LASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSPDGKLlASGSDDG----TVRLWDLAT-GKLLRTL-TGHTGA 332

                        90       100
                ....*....|....*....|....*....
gi 19075480 149 ITHLQFHPkDNELLLTGSVDGLVSLLDTT 177
Cdd:COG2319 333 VRSVAFSP-DGKTLASGSDDGTVRLWDLA 360
WD40 COG2319
WD40 repeat [General function prediction only];
70-177 4.71e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 4.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  70 VITCGSEGEIHLWDIRSQAksAVRSWTQQSTPFTCIALNKKNQF-ATGSELTrslaSVQLWDVRSeQKLIRQWnDAHNDD 148
Cdd:COG2319 177 LASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLlASGSADG----TVRLWDLAT-GKLLRTL-TGHSGS 248

                        90       100
                ....*....|....*....|....*....
gi 19075480 149 ITHLQFHPkDNELLLTGSVDGLVSLLDTT 177
Cdd:COG2319 249 VRSVAFSP-DGRLLASGSADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
70-177 2.22e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.84  E-value: 2.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  70 VITCGSEGEIHLWDIRSQAksAVRSWTQQSTPFTCIALNKKNQF-ATGSeltrSLASVQLWDVRSEQKLIRQwnDAHNDD 148
Cdd:COG2319 303 LASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKTlASGS----DDGTVRLWDLATGELLRTL--TGHTGA 374

                        90       100
                ....*....|....*....|....*....
gi 19075480 149 ITHLQFHPkDNELLLTGSVDGLVSLLDTT 177
Cdd:COG2319 375 VTSVAFSP-DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 53-171 6.60e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 6.60e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  53 KAHTN-ITGIISCDQLNGVITCGSEGEIHLWDIRSQAKSAVRswTQQSTPFTCIALNKKNQFATGSELTRslaSVQLWDV 131
Cdd:cd00200 174 TGHTGeVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTL--RGHENGVNSVAFSPDGYLLASGSEDG---TIRVWDL 248

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19075480 132 RSEQKLIRQWndAHNDDITHLQFHPkDNELLLTGSVDGLV 171
Cdd:cd00200 249 RTGECVQTLS--GHTNSVTSLAWSP-DGKRLASGSADGTI 285
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 103-180 9.84e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.40  E-value: 9.84e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19075480 103 TCIALNKKNQF-ATGSELtrslASVQLWDVRSEQKLIRQWNdaHNDDITHLQFHPkDNELLLTGSVDGLVSLLDTTKEE 180
Cdd:cd00200  13 TCVAFSPDGKLlATGSGD----GTIKVWDLETGELLRTLKG--HTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84
WD40 COG2319
WD40 repeat [General function prediction only];
54-177 3.39e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 3.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19075480  54 AHTNITGIISCDQLNGVITCGSEGEIHLWDIRSQAKSAVRSWTQQSTPFTCIALNKKNQFATGSeltrSLASVQLWDVRS 133
Cdd:COG2319  34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASAS----ADGTVRLWDLAT 109

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 19075480 134 EQKLIRQWndAHNDDITHLQFHPkDNELLLTGSVDGLVSLLDTT 177
Cdd:COG2319 110 GLLLRTLT--GHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLA 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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