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Conserved domains on  [gi|19113714|ref|NP_592802|]
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MFS family membrane transporter [Schizosaccharomyces pombe]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 109-537 9.72e-144

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 418.90  E-value: 9.72e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 109 VIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVG 188
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 189 GGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSyLEWRWTFWIN 268
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 269 MIWAAAVIVFVFIFFPethedtildykakylrkttgntayytihererdpknamiqaatqavsliftepIVVCFTLYLTV 348
Cdd:cd17323 160 AIISGFCLILIFLFLP-----------------------------------------------------IVLLLGLYVGL 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 349 VYIINYINFEGYPIVFAK-YGFNKGEQGLSFIGVGVGIVCAGLCTPFIYWHYLK-VNKKRNGVICPEDRLYPLFIGCFLL 426
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEvYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRrLKKKNGGKPEPEARLPPAFIGAFLF 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 427 PISMFWFAWTCYPHhIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSYQHMAPSALAAATLVRYSASGGISMVARPMYLNL 506
Cdd:cd17323 267 PIGLFIFGWTIYPH-IHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 19113714 507 GDHWATSVLGFISVAMVPIPFIFYRFGKSIR 537
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 109-537 9.72e-144

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 418.90  E-value: 9.72e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 109 VIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVG 188
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 189 GGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSyLEWRWTFWIN 268
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 269 MIWAAAVIVFVFIFFPethedtildykakylrkttgntayytihererdpknamiqaatqavsliftepIVVCFTLYLTV 348
Cdd:cd17323 160 AIISGFCLILIFLFLP-----------------------------------------------------IVLLLGLYVGL 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 349 VYIINYINFEGYPIVFAK-YGFNKGEQGLSFIGVGVGIVCAGLCTPFIYWHYLK-VNKKRNGVICPEDRLYPLFIGCFLL 426
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEvYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRrLKKKNGGKPEPEARLPPAFIGAFLF 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 427 PISMFWFAWTCYPHhIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSYQHMAPSALAAATLVRYSASGGISMVARPMYLNL 506
Cdd:cd17323 267 PIGLFIFGWTIYPH-IHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 19113714 507 GDHWATSVLGFISVAMVPIPFIFYRFGKSIR 537
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-492 8.65e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.08  E-value: 8.65e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 101 SHSYKWWIVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLL 180
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 181 IFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLE 260
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 261 WRWTFWINMIWAAAVIVFVFIFFPETHEdtildykakylrkttgntayytiHERERDPknamiqaatQAVSLIFTEPIVV 340
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRP-----------------------AARARLR---------GSLRELLRRPRLL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 341 CFTLYLTVVYIINYINFEGYPIVF-AKYGFNKGEQGLSFIGVGVGIVCAGLCTPFIYWHYlkvnkkrngvicpeDRLYPL 419
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF--------------GRRRLL 276

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113714 420 FIGCFLLPISMFWFAWTcyphhIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSY-QHMAPSALAAATLVRYSAS 492
Cdd:COG2814 277 LIGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
2_A_01_02 TIGR00880
Multidrug resistance protein;
150-286 7.07e-27

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 105.81  E-value: 7.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   150 TFLVGFGVGSLPFAPLS----DIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFT 225
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113714   226 PVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAVIVFVFIFFPET 286
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPFLFLAILALAAFILLAFLLPET 141
MFS_1 pfam07690
Major Facilitator Superfamily;
112-493 2.82e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 98.26  E-value: 2.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   112 VSVITIVVTFASSVYSSGI-IDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGG 190
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   191 CAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITqSYLEWRWTFWINMI 270
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   271 WAAAVIVFVFIFFPETHEDTILDYKAKYLRKTTgntayytihererdpknamiqaatqAVSLIFTEPIVVCFTLYLTVVY 350
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV-------------------------AWKALLRDPVLWLLLALLLFGF 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   351 IINYINFeGYPIVFAKYGFNKgEQGLSFIGVGVGIVCAGlcTPFIYWHYLKVNKKRngvicpedRLYPLFIGCFLLPISM 430
Cdd:pfam07690 215 AFFGLLT-YLPLYQEVLGLSA-LLAGLLLGLGGLLGAIG--RLLLGRLSDRLGRRR--------RLLLALLLLILAALGL 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113714   431 FWFAWTcyphhIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSY-QHMAPSALAAATLVRYSASG 493
Cdd:pfam07690 283 LLLSLT-----LSSLWLLLALLLLGFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGA 341
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
150-287 3.05e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 68.40  E-value: 3.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  150 TFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQR 229
Cdd:PRK11102  34 AYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEF 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19113714  230 TYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAVIVFVFIFFPETH 287
Cdd:PRK11102 114 SRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETL 170
MFS_efflux_LmrB NF000060
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ...
 108-290 5.67e-03

lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.


Pssm-ID: 411077 [Multi-domain]  Cd Length: 479  Bit Score: 39.24  E-value: 5.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  108 IVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVgslpfapLSDIYGRFIIYFVTLLIFT---I 184
Cdd:NF000060  18 IMISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGI-------LVPVSGLLLQWFTTRQLFTvslI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  185 FQVGG----GCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLE 260
Cdd:NF000060  91 FSILGtfiaALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLE-HLN 169

                        170       180       190
                 ....*....|....*....|....*....|
gi 19113714  261 WRWTFWINMIWAAAVIVFVFIFFPETHEDT 290
Cdd:NF000060 170 WHWIFWISLPFLVLALVFGIAYMQNVSETT 199
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 109-537 9.72e-144

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 418.90  E-value: 9.72e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 109 VIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVG 188
Cdd:cd17323   1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 189 GGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSyLEWRWTFWIN 268
Cdd:cd17323  81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQS-LGWRWIFWFL 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 269 MIWAAAVIVFVFIFFPethedtildykakylrkttgntayytihererdpknamiqaatqavsliftepIVVCFTLYLTV 348
Cdd:cd17323 160 AIISGFCLILIFLFLP-----------------------------------------------------IVLLLGLYVGL 186

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 349 VYIINYINFEGYPIVFAK-YGFNKGEQGLSFIGVGVGIVCAGLCTPFIYWHYLK-VNKKRNGVICPEDRLYPLFIGCFLL 426
Cdd:cd17323 187 VYAILYLFLTAFPYVFGEvYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYYYRrLKKKNGGKPEPEARLPPAFIGAFLF 266

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 427 PISMFWFAWTCYPHhIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSYQHMAPSALAAATLVRYSASGGISMVARPMYLNL 506
Cdd:cd17323 267 PIGLFIFGWTIYPH-IHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNL 345

                       410       420       430
                ....*....|....*....|....*....|.
gi 19113714 507 GDHWATSVLGFISVAMVPIPFIFYRFGKSIR 537
Cdd:cd17323 346 GVGWAFTLLAFISLAMIPIPFIFYKYGKKIR 376
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
101-492 8.65e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.08  E-value: 8.65e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 101 SHSYKWWIVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLL 180
Cdd:COG2814   4 TPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 181 IFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLE 260
Cdd:COG2814  84 LFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD-LFG 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 261 WRWTFWINMIWAAAVIVFVFIFFPETHEdtildykakylrkttgntayytiHERERDPknamiqaatQAVSLIFTEPIVV 340
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLRLLPESRP-----------------------AARARLR---------GSLRELLRRPRLL 210

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 341 CFTLYLTVVYIINYINFEGYPIVF-AKYGFNKGEQGLSFIGVGVGIVCAGLCTPFIYWHYlkvnkkrngvicpeDRLYPL 419
Cdd:COG2814 211 LLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF--------------GRRRLL 276

                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113714 420 FIGCFLLPISMFWFAWTcyphhIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSY-QHMAPSALAAATLVRYSAS 492
Cdd:COG2814 277 LIGLLLLALGLLLLALA-----GSLWLLLLALFLLGFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 121-523 2.76e-27

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 113.44  E-value: 2.76e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 121 FASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAI 200
Cdd:cd17320  13 LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLI 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 201 VRFFQGVFGSTPLANAGGTISDLFTPVQRT----YVLPGFCtfpyLGPIIGPIIGDFItQSYLEWRWTFWINMIWAAAVI 276
Cdd:cd17320  93 ARFLQGLGAAAGSVVARAIVRDLYSGAELAkifsLLMMILA----IAPALAPLLGGLL-LLFFGWRAIFVFLALLGLLLL 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 277 VFVFIFFPEThedtildykakylrkttgntayytiheRERDPKNAMIQAATQAVSLIFTEPIVVCFTLYLTVVYIINYIN 356
Cdd:cd17320 168 LLVLLFLPET---------------------------LPEEKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAY 220

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 357 FEGYPIVFAK-YGFNKGEQGLSFIGVGVGIVCAGLCTPFIywhylkVNKkrngviCPEDRLYPLFIGCFLLPISMFWFAW 435
Cdd:cd17320 221 LAAAPFIYIEqLGLSPAQFGLLFALNAIALILGSLLNGRL------VRR------FGPRRLLRLGLLLLLAAALVLLLAA 288

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 436 TCYPHHIHWIVPIIASAFFGFSLLIVffVSYNYIIDSYQHMAPSALAAATLVRYSASGGISMVARPMY----LNLGdhWA 511
Cdd:cd17320 289 LLGGLSLWPLVAPLFLIFFGFGLIFP--NATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPngtaLPMG--LL 364

                       410
                ....*....|..
gi 19113714 512 TSVLGFISVAMV 523
Cdd:cd17320 365 ILVLGLLALLLL 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
150-286 7.07e-27

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 105.81  E-value: 7.07e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   150 TFLVGFGVGSLPFAPLS----DIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFT 225
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113714   226 PVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAVIVFVFIFFPET 286
Cdd:TIGR00880  82 PEERGVALGLMSAGIALGPLLGPPLGGVLAQ-FLGWRAPFLFLAILALAAFILLAFLLPET 141
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 101-286 1.84e-24

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 103.35  E-value: 1.84e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 101 SHSYKWWIVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLL 180
Cdd:COG0477   8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 181 IFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLE 260
Cdd:COG0477  88 LFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA-ALG 166

                       170       180
                ....*....|....*....|....*.
gi 19113714 261 WRWTFWINMIWAAAVIVFVFiFFPET 286
Cdd:COG0477 167 WRWIFLINAPLGLLALVLRL-RLPES 191
MFS_1 pfam07690
Major Facilitator Superfamily;
112-493 2.82e-22

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 98.26  E-value: 2.82e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   112 VSVITIVVTFASSVYSSGI-IDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGG 190
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   191 CAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITqSYLEWRWTFWINMI 270
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLA-SLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   271 WAAAVIVFVFIFFPETHEDTILDYKAKYLRKTTgntayytihererdpknamiqaatqAVSLIFTEPIVVCFTLYLTVVY 350
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV-------------------------AWKALLRDPVLWLLLALLLFGF 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   351 IINYINFeGYPIVFAKYGFNKgEQGLSFIGVGVGIVCAGlcTPFIYWHYLKVNKKRngvicpedRLYPLFIGCFLLPISM 430
Cdd:pfam07690 215 AFFGLLT-YLPLYQEVLGLSA-LLAGLLLGLGGLLGAIG--RLLLGRLSDRLGRRR--------RLLLALLLLILAALGL 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19113714   431 FWFAWTcyphhIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSY-QHMAPSALAAATLVRYSASG 493
Cdd:pfam07690 283 LLLSLT-----LSSLWLLLALLLLGFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGA 341
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 112-529 7.55e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 91.33  E-value: 7.55e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 112 VSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGC 191
Cdd:cd06174   1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 192 AHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPII-GDFITQSYLEWRWTFWINMI 270
Cdd:cd06174  81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLgGILASSLGFGWRAVFLIAAA 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 271 WAAAVIVFVFIFFPETHedtildykakylrkttgntayytiHERERDPKNAMIQAATQAVSLIFTEPIVVCFTLYLTVVY 350
Cdd:cd06174 161 LALLAAILLLLVVPDPP------------------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVN 216

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 351 IINYINFEGYPIVFAKYGFNKGEQG--LSFIGVGVGIVCAGLCTPFIYWHYlkvnkkrngvicpeDRLYPLFIGCFLLPI 428
Cdd:cd06174 217 LAYYSFSTLLPLFLLDLGGLSVAVAglLLSLFGLAGALGSLLLGLLSDRLI--------------GRKPLLLIGLLLMAL 282

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 429 SMFWFAWtcyphHIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSY-QHMAPSALAAATLVRYSASGGISMVArPMYLNLG 507
Cdd:cd06174 283 GLALLLL-----APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFpPEIRGTAFGLLNTFGFLGGAIGPLLA-GFLLAAT 356

                       410       420
                ....*....|....*....|..
gi 19113714 508 DHWATSVLGFISVAMVPIPFIF 529
Cdd:cd06174 357 FGLTGAFLVLAVLLLLAAILLL 378
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 108-489 3.00e-19

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 89.75  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   108 IVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQV 187
Cdd:TIGR00710   6 FALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSL 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   188 GGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWI 267
Cdd:TIGR00710  86 GLALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILV-WLSWHAIFAF 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   268 NMIWAAAVIVFVFIFFPETHedtildykakylrkttgntayytihererdPKNAMIQAATQA--VSLIFTEPIVVCFTLY 345
Cdd:TIGR00710 165 LSLAGILLSALIFFILPETL------------------------------PYEARIQISTYFetFLLLLKSKMFWGYALI 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   346 LTVVYIINYINFEGYPIVF-AKYGFNKGEQGLSFIGVGVGIVCAG-LCTPFI-YWHYLkvNKKRNGVICpedrlypLFIG 422
Cdd:TIGR00710 215 YGASFGGFFAFFSGAPFVYiDIMGVSPSVFGLLFALNIIAMIFGGfLNGRFIkKWGAK--SLLRMGLIL-------FAVS 285

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19113714   423 CFLLPISMFWfawtcypHHIHWIVPIIASAFFGFSLLIVFFVSYNYIIDSYQHMAPSALAAATLVRY 489
Cdd:TIGR00710 286 AVLLEITAIL-------GLGSWAMIIGPMMFVGIGNSMISSIAMAYALEDFPHVAGTASALFGTLRL 345
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 116-279 3.58e-17

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 83.38  E-value: 3.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 116 TIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNV 195
Cdd:cd17321   5 VFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSL 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 196 WTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAV 275
Cdd:cd17321  85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLE-LFGWRWIFLINVPIGLVA 163


                ....
gi 19113714 276 IVFV 279
Cdd:cd17321 164 LLLA 167
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
104-283 1.05e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 78.76  E-value: 1.05e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 104 YKWWIVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFT 183
Cdd:COG2271   7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 184 IFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYlEWRW 263
Cdd:COG2271  87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAF-GWRA 165

                       170       180
                ....*....|....*....|
gi 19113714 264 TFWINMIWAAAVIVFVFIFF 283
Cdd:COG2271 166 AFLILGLPGLLLALLRFWLL 185
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 112-523 1.10e-15

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 78.77  E-value: 1.10e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 112 VSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGC 191
Cdd:cd17474   4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 192 AHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYleWRWTFWINMIW 271
Cdd:cd17474  84 SDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS--WRYPFFLLAAL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 272 AAAVIVFVFIFFPETHEDTILDYKAKylrkttgntayytiherERDPKNAMIQAATQAVSLIFtepIVVCFTLYLTVVYI 351
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKAKSSSATK-----------------LRDLKKALRGRGLLTFLVSA---FLYFFLYFAFLTYL 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 352 INYINFEgypivfakYGFNKGEQGLSFIGVGVGIVcaglCTPFIYWHYLkvnKKRNGvicpedRLYPLFIGCFLLPISMF 431
Cdd:cd17474 222 PFLLELL--------YGISPIIIGLLFAGWSVLLA----LGSLFVGRLL---KKRFG------ARRILVIGLLLYALSLL 280

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 432 WFAWTcypHHIHWIvpIIASAFFGFSLLIVFFVSYNYIIDSyqhmAPSALAAATLVRYSASGGISMVARPM-----YLNL 506
Cdd:cd17474 281 LLGFV---PSLALL--LIAIVLFGLGLGLNLPLLTTLVTEL----APEEERGTASSLYNFVRFLGQAVGPLlfgllLEIF 351

                       410
                ....*....|....*..
gi 19113714 507 GDHWATSVLGFISVAMV 523
Cdd:cd17474 352 GLSAPFLVGAAIALAAA 368
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 112-279 3.24e-15

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 77.23  E-value: 3.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 112 VSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVgSLPFAP-LSDIYGRFIIYFVTLLIFTIFQVGGG 190
Cdd:cd17503   1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAI-MIPLSGwLADRFGTRRLFLTALALFTLGSLLCG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 191 CAHNVWTLAIVRFFQGVFGS--TPLANAggTISDLFTPVQRTYVLpGFCTFPY-LGPIIGPIIGDFITqSYLEWRWTFWI 267
Cdd:cd17503  80 LAPNLASLIIFRILQGFGGGvlIPLAQT--ILLRIYPPEKRGAAM-GLVGLVIlLAPAIGPTLGGWLT-DNLSWRWIFYI 155

                       170
                ....*....|..
gi 19113714 268 NMIWAAAVIVFV 279
Cdd:cd17503 156 NLPIGILALLLA 167
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 115-284 3.42e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 74.12  E-value: 3.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 115 ITIVVTFASSVYSSGII-DIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAH 193
Cdd:cd17324   6 LAAFAIGTTEYVIQGLLpDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 194 NVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAA 273
Cdd:cd17324  86 SFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQ-LLGWRAAFLAIAVLAL 164

                       170
                ....*....|.
gi 19113714 274 AVIVFVFIFFP 284
Cdd:cd17324 165 LAALLLWRLLP 175
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 133-279 4.64e-14

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 73.37  E-value: 4.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 133 IASELHSSIPVSTLGScTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTP 212
Cdd:cd17502  22 IVAEFGGLSLVSWVGT-AYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGL 100

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19113714 213 LANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAVIVFV 279
Cdd:cd17502 101 MSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTD-HLSWRWCFYINLPIGGLALALL 166
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 123-285 9.17e-14

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 73.57  E-value: 9.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   123 SSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVR 202
Cdd:TIGR00711  18 STIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFR 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   203 FFQGVFGS--TPLANAggTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYlEWRWTFWINMIWAAAVIVFVF 280
Cdd:TIGR00711  98 VIQGFGGGplIPLSFS--TLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENY-HWRWIFLINVPIGIIVVVVAF 174


                  ....*
gi 19113714   281 IFFPE 285
Cdd:TIGR00711 175 FILPR 179
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 132-285 7.37e-13

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 70.34  E-value: 7.37e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 132 DIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGV--FG 209
Cdd:cd17328  24 DIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIgeAS 103

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19113714 210 STPLanAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYLEWRWTFWINMIWAAAVIVFVFIFFPE 285
Cdd:cd17328 104 YSPI--APTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVRE 177
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
150-287 3.05e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 68.40  E-value: 3.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  150 TFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQR 229
Cdd:PRK11102  34 AYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASVVINALMRDMFPKEEF 113

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19113714  230 TYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAVIVFVFIFFPETH 287
Cdd:PRK11102 114 SRMMSFVTLVMTIAPLLAPIIGGWLLV-WFSWHAIFWVLALAAILAAALVFFFIPETL 170
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 120-288 1.23e-11

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 66.88  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 120 TFASSVYSSGIIDIASELHSSiPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLA 199
Cdd:cd06179  11 LFGVTLPAAVLPFIVADLGPS-SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLI 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 200 IVRFFQGV-FGSTPLANAGgtISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYLE-WRWTFWINMI-WAAAVI 276
Cdd:cd06179  90 GGQALIGIgAGTQGLGAAV--ASELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgWRWIFYINAIfNALALI 167

                       170
                ....*....|..
gi 19113714 277 VFVFIFFPETHE 288
Cdd:cd06179 168 LLFFFYHPPPRP 179
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 118-288 7.68e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.75  E-value: 7.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 118 VVTFASSVYSSGII----DIASELH-SSIPVSTLGSCTFLVGFgVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCA 192
Cdd:cd17325   3 LALFLDMLGYGIIIpilpLYAESLGaSVAQIGLIVAAYALAQL-LFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 193 HNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYlEWRWTFWINMIWA 272
Cdd:cd17325  82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL-GYRAPFLVCAALA 160

                       170
                ....*....|....*.
gi 19113714 273 AAVIVFVFIFFPETHE 288
Cdd:cd17325 161 LLALVLALLLLPEPRP 176
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 112-279 8.37e-11

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 63.75  E-value: 8.37e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 112 VSVITIVVTFASSVYSSGIIDIASELH-SSIPVSTLGSCTFLVGfGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGG 190
Cdd:cd17504   1 LALAALAVMLVETMLSPALPTIQREFGtSAAAVSWVLTAYLLVG-AVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 191 CAHNVWTLAIVRFFQGVFGST-PLANAggTISDLFTPvQRTYVLPGF--CTFPyLGPIIGPIIGDFITQsYLEWRWTFWI 267
Cdd:cd17504  80 FAPNLPVLIAGRALQGIGGAVfPLAFA--LVREEFPP-ERVPVAQGIlsATFG-IGAGIGLPLGGWIVQ-HLGWRWIFWT 154

                       170
                ....*....|..
gi 19113714 268 NMIWAAAVIVFV 279
Cdd:cd17504 155 AAPVAVLLAALV 166
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 152-353 1.98e-10

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 62.76  E-value: 1.98e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   152 LVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTY 231
Cdd:TIGR00895  62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGT 141

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   232 VLpgfcTFPYLGPIIGPIIGDFITQ---SYLEWRWTFWINMIWAAAVIVFVFIFFPETHEDTILDYKAKYLRKTTGNTAY 308
Cdd:TIGR00895 142 AV----GLMFCGYPIGAAVGGFLAGwliPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQ 217

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 19113714   309 YTIHERERDPKN-AMIQAATQAVSLIFTEP-------IVVCFTLYLTVVYIIN 353
Cdd:TIGR00895 218 MQAEAQSALPEQkSTQGTKRSVFKALFQGKtaritvlLWLLYFMLLVGVYFLT 270
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 143-281 3.82e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 61.45  E-value: 3.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 143 VSTLGSCTfLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISD 222
Cdd:cd17365  36 LGPVGSAA-LFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSE 114

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 223 LFTPVQR-TYVLPGFCTFPyLGPIIGPIIGDFITQSYlEWRWTFWINMIWAAAVIVFVFI 281
Cdd:cd17365 115 YAPARRRsLAVTLMFCGYP-LGAALGGFLAAALIPAF-GWRSVFLLGGVPPLILLPLLRG 172
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 106-284 1.13e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 60.28  E-value: 1.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 106 WWIVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIF 185
Cdd:cd17319   2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 186 QVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITqSYLEWRWTF 265
Cdd:cd17319  82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLL-LLFGWRWAF 160

                       170
                ....*....|....*....
gi 19113714 266 WINMIWAAAVIVFVFIFFP 284
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYLR 179
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
103-289 2.34e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 59.51  E-value: 2.34e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 103 SYKWWIVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIF 182
Cdd:COG2223   1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 183 TIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYlEWR 262
Cdd:COG2223  81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF-GWR 159

                       170       180
                ....*....|....*....|....*..
gi 19113714 263 WTFWINMIWAAAVIVFVFIFFPETHED 289
Cdd:COG2223 160 NAFLILGILLLVVAVLAWLFLRDPPAG 186
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 121-283 2.98e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.69  E-value: 2.98e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 121 FASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFgVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAI 200
Cdd:cd17316  16 FLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRP-IGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLV 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 201 VRFFQGVF--GSTPLANAggTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYLE---WRWTFWInmiwaAAV 275
Cdd:cd17316  95 LRFLQGIGigGEYPGAST--YVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGdwgWRILFLI-----GAL 167


                ....*...
gi 19113714 276 IVFVFIFF 283
Cdd:cd17316 168 PALLALLL 175
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 160-283 1.19e-07

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 53.81  E-value: 1.19e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 160 LPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTP-VQRTYVLPGFCT 238
Cdd:cd17476  51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGA 130

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19113714 239 FPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAVIVFVFIFF 283
Cdd:cd17476 131 TAPLGFALGGVFGGLFAQ-LAWWPWIFWFLAILAAIVAVAAIFWT 174
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 151-283 1.70e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.35  E-value: 1.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 151 FLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRT 230
Cdd:cd17325 244 QGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRG 323

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19113714 231 YVLPGFCTFPYLGPIIGPIIGDFITQSYlEWRWTFWINMIWAAAVIVFVFIFF 283
Cdd:cd17325 324 TAMGLFNTAFSLGMVLGPLLGGFLYDAF-GFATPFLAAAALLLLAAVLFLLLR 375
Sugar_tr pfam00083
Sugar (and other) transporter;
135-286 2.44e-07

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 53.04  E-value: 2.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   135 SELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAH---NVWTLAIVRFFQGVF--G 209
Cdd:pfam00083  39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKgkwSVYQLIVGRVLVGIGvgG 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113714   210 STPLANAggTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFI--TQSYLEWRWTFWINMIWAAAVIVFVFiFFPET 286
Cdd:pfam00083 119 ASVLAPM--YISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLnkTSNSDGWRIPLGLQLVPALLLIIGLL-FLPES 194
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 165-285 6.48e-07

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 51.46  E-value: 6.48e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 165 LSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTpLANAGGTISDLFTPVQRTYVLPGFCTFPYLGP 244
Cdd:cd17390  54 WSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHT-QSLCKAYLSDLVSEQERSRVLGRFNAASSLGF 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19113714 245 IIGPIIGDFITqsylEWRWTFWINMIWAAAVIVF----VFIFFPE 285
Cdd:cd17390 133 ILGPVVGGHLA----ETDGGFYYVALLCSAIFILnaglVWFLLSK 173
emrD PRK11652
multidrug transporter EmrD;
122-286 8.36e-07

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 51.45  E-value: 8.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  122 ASSVYSSGIIDIASELH-SSIPVSTLGSCtFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAI 200
Cdd:PRK11652  23 AQTIYVPAIADMARDLNvREGAVQAVMAA-YLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIA 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  201 VRFFQGVfGStplaNAGGTIS-----DLF--TPVQRTYVLPGFCTFpyLGPIIGPIIGDFITqSYLEWRWTFWINMIWAA 273
Cdd:PRK11652 102 ASAIQGL-GT----GVGGVMArtlprDLYegTQLRHANSLLNMGIL--VSPLLAPLIGGLLT-TLFGWRACYLFLLLLGA 173

                        170
                 ....*....|...
gi 19113714  274 AVIVFVFIFFPET 286
Cdd:PRK11652 174 GVTFSMARWMPET 186
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 140-286 9.59e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 51.07  E-value: 9.59e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 140 SIPVSTLGscTFLVGFGVGSLPFAP----LSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGS--TPL 213
Cdd:cd17329  31 GLSASIVG--LVLALSAVAGIVASLiggrLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGlfEPA 108

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113714 214 ANAGgtISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYLewRWTFWINMIWAAAVIVFVFIFFPET 286
Cdd:cd17329 109 SEAM--IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF--RLLFLAAAVLFLLAALVLLFLLPET 177
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 151-286 9.85e-07

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 51.15  E-value: 9.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 151 FLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGV-FGSTpLANAGGTISDLFTPVQR 229
Cdd:cd17371  43 TLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLgFGGE-WAAGAALMAEYVPARHR 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19113714 230 TYVLPGFCTFPYLGPII-----GPIIGDFITQsyLEWRWTFWINMIwAAAVIVFVFIFFPET 286
Cdd:cd17371 122 GKALGYVQSGWAVGWLLatllaALLFPLLPPE--IAWRVLFLLGAL-PALLVLFIRRFVKEP 180
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 145-283 2.06e-06

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 49.89  E-value: 2.06e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 145 TLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLF 224
Cdd:cd17317  28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIV 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19113714 225 TPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsyleWRWTFWInmIWAAAVIVFVFIFF 283
Cdd:cd17317 108 GPKYRSFVGILFGLFWALGYMLLALLAYLIRD----WRWLQLA--ISLPGLLFLLLLWW 160
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 112-287 2.10e-06

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 50.27  E-value: 2.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 112 VSVITIVVTFASSVYSSGIIDIASELHSSIPV-----STLGSctfLVGFG--VGSLPFAPLSDIYGRFIIYFVTLLIFTI 184
Cdd:cd17358   7 ANLGSFSFGIAVGWSSPALPSLMSDNSLSLPLtvaqfSWFGS---LLTLGalIGALLSGKLADRIGRKRTLLISAIPCIL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 185 FQVGGGCAHNVWTLAIVRFFQGVfgstplanAGGTISdlftpvqrtYVLP-------------GFCTFPYLGPIIGPIIG 251
Cdd:cd17358  84 GWLLIAFAKDVWMLYLGRFLAGF--------GGGAAS---------VVVPvyiaeiapknvrgALGSLNQLLVNIGILLG 146

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 19113714 252 dFITQSYLEWRWTFWINMIwAAAVIVFVFIFFPETH 287
Cdd:cd17358 147 -YVLGSFLPWRTLALIGAI-PPVVFLILLFFIPESP 180
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 141-281 2.85e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.51  E-value: 2.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 141 IPVSTLGSCTFLVGFGVGSL--------PFAP-LSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGvFGST 211
Cdd:cd17489  21 LYAHDLGGSEAVAGLVVGLFtlaallarPFAGrLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHG-IGWG 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113714 212 PLANAGGTISDLFTPVQRT-YVLPGFCTFPYLGPIIGPIIGDFITQsYLEWRWTFWINMIWAAAVIVFVFI 281
Cdd:cd17489 100 AFTTAAATLVADIIPPSRRgEGIGYYGLATTLAMALGPALGLFLYQ-HLGFAVLFIVAAVLALLALLLVFL 169
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 115-284 2.85e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 49.50  E-value: 2.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 115 ITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLpfaplSDIYGRFIIYFVTLLIFTIFQVGGGCAHN 194
Cdd:cd17330  12 FGIVFPVLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRL-----SDRYGRKPVLLLSLAGSAVSYVLLGLSRN 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 195 VWTLAIVRFFQGVFGSTpLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYLEwRWTFWINMIWAAA 274
Cdd:cd17330  87 LWLLFLARFLDGLTGGN-VSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY-ALPFLVAAALALL 164

                       170
                ....*....|
gi 19113714 275 VIVFVFIFFP 284
Cdd:cd17330 165 NLVLVLFFLP 174
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
107-288 1.55e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 107 WIVIQVSVITIVVtFASSVYSSGIID-----IASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRF--IIYFVTL 179
Cdd:COG2271 177 LALLRFWLLALAY-FLVYFALYGFLTwlptyLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGL 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 180 LIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFtPVQRTYVLPGFC-TFPYLGPIIGPIIGDFITQSY 258
Cdd:COG2271 256 LLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF-PKKARGTASGLVnTFGFLGGALGPLLVGYLLDAT 334

                       170       180       190
                ....*....|....*....|....*....|
gi 19113714 259 lEWRWTFWINMIWAAAVIVFVFIFFPETHE 288
Cdd:COG2271 335 -GYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 162-287 1.56e-05

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 47.25  E-value: 1.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 162 FAP----LSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTpLANAGGTISDLFTPVQRT--YVLPG 235
Cdd:cd17388  54 FAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGAT-GAVAAAYIADVTPPEQRArnFGLLG 132

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 19113714 236 FCtFPyLGPIIGPIIGDFITQSYLewRWTFWINMIWAAAVIVFVFIFFPETH 287
Cdd:cd17388 133 AA-FG-LGFIAGPALGGLLGEISP--RAPFLVAAGLNGLNFLLGLFVLPESL 180
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 147-467 1.82e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.21  E-value: 1.82e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 147 GSCTFLVGFGVGS---------LPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQgvfGSTPLANAG 217
Cdd:cd17472  28 GATPTLIGLALGIygltqaifqIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ---GSGAISSVV 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 218 GT-ISDLFTPVQRT----YVLPGFCTFPYLGPIIGPIIGDFITQSYLewrwtFWINMIWAAAVIVFVFIFFPEThedtil 292
Cdd:cd17472 105 MAlLADLTREENRTkamaLIGASIGIAFAISMVLGPLLAAHLGVSGL-----FLITAILSLVSLLILLFFVPDP------ 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 293 dykakylrkttgntayyTIHERERDPKNAMIQAatqavslIFTEPIVVCFTLYLTVVYIINYINFEGYPIVFAKYGFNKG 372
Cdd:cd17472 174 -----------------PKIVQISEKEKKKLKK-------LLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKG 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 373 EQGLSFIGVGVGIVcaGLCTPFIywhylKVNKKRNgvicpedRLYPLFIGCFLL---PISMFWFAWTcyphhihwivpii 449
Cdd:cd17472 230 QLWKVYLPAILIGF--ILMVPFV-----IYAEKKG-------KMKQVFVSSILLiavGFLLLLFAAT------------- 282

                       330
                ....*....|....*...
gi 19113714 450 aSAFFGFSLLIVFFVSYN 467
Cdd:cd17472 283 -SLWLLIIGLIIFFIGFN 299
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 151-285 2.40e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 46.93  E-value: 2.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   151 FLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVF--GSTPlanAGGTISDLFTPV- 227
Cdd:TIGR00898 136 FFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGigGIWV---QAVVLNTEFLPKk 212

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113714   228 QRTYVLPGFCTFPYLGPIIGPIIGDFITQsyleWRWTfwinMIWAAA--VIVFVFIFF-PE 285
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVLLPLVAYFIPD----WRWL----QLAVSLptFLFFLLSWFvPE 265
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 159-286 3.30e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 46.41  E-value: 3.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 159 SLPFAP-LSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVF--GSTPLANAggTISDLFTPVQRTYVLPG 235
Cdd:cd17473  51 FAPLAGwLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGvaGIMTLATA--LIGDYFEGEERAKMLGL 128

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 19113714 236 FCTFPYLGPIIGPIIGDFITQsyLEWRWTFWInMIWAAAVIVFVFIFFPET 286
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAE--IGWRAPFLV-YLLALPVLILVLLFLPEP 176
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
151-207 5.51e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 45.65  E-value: 5.51e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 19113714  151 FLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGV 207
Cdd:PRK11043  50 FLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAV 106
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 146-283 6.62e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 45.44  E-value: 6.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   146 LGSCtFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFT 225
Cdd:TIGR00881  35 LLSS-FSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFS 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19113714   226 PVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYLEWRWTFwinMIWAAAVIVFVFIFF 283
Cdd:TIGR00881 114 RSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVF---IVPGIIAIIVSLICF 168
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 138-523 6.71e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 45.30  E-value: 6.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 138 HSSIPVSTLGSCTFLVGFgVGSLPFAPLSDIYGR-------FIIYFVTLLIFTIFQVGGGcaHNVWTLAIVRFFQGVFGS 210
Cdd:cd06173  31 GSALLVGLVLAAFFLPFL-LFSPFAGVLADRFDRrrllilaDLLRALLAAVLALLALLGS--LSLWLLLVLAFLLGIASA 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 211 tplanaggtisdLFTPVQRTYV---LPG---------FCTFPYLGPIIGPIIGDFITqSYLEWRWTFWINMIwaAAVIVF 278
Cdd:cd06173 108 ------------FFGPARQALLpelVPKeqlvranalNSLATQLARIIGPALGGLLV-ALLGPGGAFAINAL--SFLLSA 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 279 VFIFFpethedtildykakyLRKTTgntayytiHERERDPKNAMIQAATQAVSLIFTEPIVVcFTLYLTVVYIINYINFE 358
Cdd:cd06173 173 LLLLF---------------IRRPP--------PAAPGESSSLLLRDLREGLRYLRRSPLLR-LLLLALALFALLGGALT 228

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 359 GYPIVFAKYGFNKGEQGLSFI--GVGVGIVCAGLCTPfiywhylKVNKKRNgvicpedRLYPLFIGCFLLPISMFWFAWT 436
Cdd:cd06173 229 VLLPLLAKEVLGGGAAGYGLLlaAFGVGALLGALLLG-------RLSKRRR-------RGRLLLIGALLLGLALLVLGLS 294

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 437 cyphhIHWIVPIIASAFFGFSlLIVFFVSYNYIIDSY--QHMAPSALAAATLVRYSASGGISMVARPMYLNLGDHWATSV 514
Cdd:cd06173 295 -----PSLWLLLAALFLLGLA-GGLFNVPLNTLLQLRvpDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368


                ....*....
gi 19113714 515 LGFISVAMV 523
Cdd:cd06173 369 AGALLLLAA 377
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 150-283 8.34e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.96  E-value: 8.34e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 150 TFLVGFGVGSLPFAPLSDIYGrfIIYFVT--LLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPV 227
Cdd:cd17312  46 AFLIAYAVGKFISGFLSDRSN--IRRFMSagLLLSALANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKK 123

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19113714 228 QRTYVLPGFCTFPYLGPIIGPIIGDFITQSYlEWRWTFWINMIWAAAVIVFVFIFF 283
Cdd:cd17312 124 ERGTVYGIWSTSHNFGGILAPILAASLASYY-GWRAAFLVPGIVGLVVAIILFFFL 178
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 151-394 1.02e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 44.93  E-value: 1.02e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 151 FLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRT 230
Cdd:cd17327  50 FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQA 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 231 YVLPGFCTFPYLGPIIGPIIGDFITQSYLE-----WRWTFWINMIWAAAVIVFVFIFFPETHEdtildyKAKYLRKTtgN 305
Cdd:cd17327 130 KRIAFFYAAAGLGSIFGGLLAYGVFKILGVgglagWRWLFIIEGLITIIIGLVIFFWLPDNPS------KAWFLTEE--E 201

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 306 TAYYTIHERERDPKNAMIQAATQAVSLIFTEPIVVCFTLYLTVVYIINYINFEGYPIVFAKYGFNKGE-QGLSFIGVGVG 384
Cdd:cd17327 202 KELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQtNLLSVPIGALG 281

                       250
                ....*....|
gi 19113714 385 IVCAGLCTPF 394
Cdd:cd17327 282 AVSLLIAALL 291
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
121-290 1.12e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.46  E-value: 1.12e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 121 FASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAI 200
Cdd:COG0738  22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 201 VRFFQGvFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYL--EWRWTFWINM-IWAAAVIV 277
Cdd:COG0738 102 ALFLLG-LGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLslSWHLPYLILAvLLLLLALL 180

                       170
                ....*....|...
gi 19113714 278 FVFIFFPETHEDT 290
Cdd:COG0738 181 FLRSKLPEIEEEE 193
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 139-285 1.69e-04

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 43.85  E-value: 1.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 139 SSIPVSTLGSCTFLVGFG--VGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANA 216
Cdd:cd17333  26 FNLNVADVSVIFSSQNAGylIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGA 105

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113714 217 GGTISDLF--TPVQRTYVLPGFCTFpylGPIIGPIIGDFITQSYLEWRWTFWInmIWAAAVIVFVFIFFPE 285
Cdd:cd17333 106 NTFVGALFeeSSATRLNVLHGFFGL---GALIGPLIATSLLTSELSWSWAYLI--IGLIYLLLAILILLTL 171
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 148-281 2.32e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.41  E-value: 2.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 148 SCTFLVgfgvgSLPFAP----LSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVF-GSTPLANAGGTISd 222
Cdd:cd17391  43 SSTFLV-----SAIFSPiwgrLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFsGYVPNATALIASQ- 116

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 223 lfTPVQRT-YVLPGFCTFPYLGPIIGPIIGDFITQSYlEWRWTFWInmiwAAAVIVFVFI 281
Cdd:cd17391 117 --TPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLF-GIRNVFFI----TGGLLFLAFL 169
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 156-283 2.55e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.41  E-value: 2.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 156 GVGSLPFAP----LSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQG--VFGSTPLANA-------GGTISD 222
Cdd:cd17391 250 GVSSLLSAPrlgkLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGlaTGGLLPAINSllakitpKEVAGR 329

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113714 223 LFTPVQrtyvlpgfcTFPYLGPIIGPIIGDFITqSYLEWRWTFWINMIWAAAVIVFVFIFF 283
Cdd:cd17391 330 IFGYNQ---------SFQYLGNVAGPLLGSAIA-AHFGYRAVFVVTALLVLLNAIWSFIFL 380
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 153-263 6.26e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 41.95  E-value: 6.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 153 VGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYV 232
Cdd:cd17379  44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGGWMTGYVLVTEFVGSKYRRTV 123

                        90       100       110
                ....*....|....*....|....*....|.
gi 19113714 233 LPGFCTFPYLGPIIGPIIGDFITQsyleWRW 263
Cdd:cd17379 124 GIVYQMFFTLGLLILPGIAYFIPH----WRW 150
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 106-280 7.46e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.82  E-value: 7.46e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 106 WWIVIQVSVITIVVTFASSVYSSGIIDI-ASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTI 184
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 185 FQVGGGCAH--NVWTLAIVRFFQGVFGSTPLANAGGTISDLFtPVQRTYVLPGFCT-FPYLGPIIGPIIGDFITQSYLEW 261
Cdd:cd17316 256 LALPLFYLLsgSPTLLLLLLFILSFFVGGVWGALYAYLAELF-PTEVRATGVGLSYnLGRLGGGGAPPLIALLLASTGGT 334

                       170
                ....*....|....*....
gi 19113714 262 RWTFWINMIWAAAVIVFVF 280
Cdd:cd17316 335 GVPALILALLAIVALIVAL 353
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
126-288 2.82e-03

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 40.00  E-value: 2.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  126 YSSGIIDIASELHSSIPVSTLGSCTFLVGFgVGSLPFA-PLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFF 204
Cdd:PRK10473  22 YLVGLPRIAADLNASEAQLHIAFSVYLAGM-AAAMLFAgKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFL 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  205 QGVFGSTPLANAGGTISDLFTPVQRTYVLPGF----CTFPYLGPIIGPIIgdfitQSYLEWRWTFWINMIWAAAVIVFVF 280
Cdd:PRK10473 101 QGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLngitCIIPVLAPVLGHLI-----MLKFPWQSLFYTMAAMGILVLLLSL 175


                 ....*...
gi 19113714  281 IFFPETHE 288
Cdd:PRK10473 176 FILKETRP 183
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 109-283 4.44e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 4.44e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 109 VIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVStlgsctFLVGFGVGSLPFAP----LSDIYGRFIIYFVTLLIFTI 184
Cdd:cd17489 196 VLPPALILFLASIAYGAISTFLPLYAAERGISNAGL------FFTVYAIALLLSRPfsgkLSDRKGPKTVIIPGLLLLAL 269

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 185 FQVGGGCAHNVWTLAIVRFFQGV-FGStpLANAGGT-ISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLEWR 262
Cdd:cd17489 270 GLLLLSFAGSPWMLLLAAVLYGLgFGL--LFPALQAlAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAE-LFGYR 346

                       170       180
                ....*....|....*....|.
gi 19113714 263 WTFwinmIWAAAVIVFVFIFF 283
Cdd:cd17489 347 AMF----LLAAVVVLLALVLY 363
PRK09874 PRK09874
multidrug efflux MFS transporter MdtG;
148-282 5.05e-03

multidrug efflux MFS transporter MdtG;


Pssm-ID: 182127 [Multi-domain]  Cd Length: 408  Bit Score: 39.52  E-value: 5.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  148 SCTFLvgFGVGSLPF-APLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTpLANAGGTISDLFTP 226
Cdd:PRK09874  61 SITFL--FSAIASPFwGGLADRKGRKIMLLRSALGMGIVMVLMGLAQNIWQFLILRALLGLLGGF-VPNANALIATQVPR 137

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 19113714  227 VQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYlEWRWTFWInmiwAAAVIVFVFIF 282
Cdd:PRK09874 138 NKSGWALGTLSTGGVSGALLGPLAGGLLADSY-GLRPVFFI----TASVLFLCFLV 188
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 139-283 5.47e-03

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 39.20  E-value: 5.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 139 SSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVFGSTPLANAGG 218
Cdd:cd17374  32 ESQSLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLI 111

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113714 219 TISDLFTPVQRTYVLpgfcTFPYLGPIIGPIIGDFITQSYLEWRWTFwinmiWAAAVIVFVFIFF 283
Cdd:cd17374 112 LGTEWTTPRHRALAI----TLTSCFFSIGQMLLAGLAYAIRDWRLLQ-----LVVSVPFFLFFLY 167
MFS_efflux_LmrB NF000060
lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters ...
 108-290 5.67e-03

lincomycin efflux MFS transporter Lmr(B); The lin-2 mutant, described in PMID:12499232, alters Lmr(B) expression in Bacillus subtilis and allows Lmr(B) to confer resistance to lincomycin.


Pssm-ID: 411077 [Multi-domain]  Cd Length: 479  Bit Score: 39.24  E-value: 5.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  108 IVIQVSVITIVVTFASSVYSSGIIDIASELHSSIPVSTLGSCTFLVGFGVgslpfapLSDIYGRFIIYFVTLLIFT---I 184
Cdd:NF000060  18 IMISLLLAGFIGMFSETALNIALTDLMKELNITAATVQWLTTGYLLVLGI-------LVPVSGLLLQWFTTRQLFTvslI 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714  185 FQVGG----GCAHNVWTLAIVRFFQGVFGSTPLANAGGTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQsYLE 260
Cdd:NF000060  91 FSILGtfiaALAPSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTFSGLVLE-HLN 169

                        170       180       190
                 ....*....|....*....|....*....|
gi 19113714  261 WRWTFWINMIWAAAVIVFVFIFFPETHEDT 290
Cdd:NF000060 170 WHWIFWISLPFLVLALVFGIAYMQNVSETT 199
2A0108 TIGR00886
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
 143-282 6.30e-03

nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]


Pssm-ID: 273322 [Multi-domain]  Cd Length: 354  Bit Score: 38.82  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   143 VSTLGSCTFLVGFgVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCA-HNVWTLAIVRFFQGVFGSTpLANAGGTIS 221
Cdd:TIGR00886  39 LGNLVAVPVLAGA-VLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAvQSYSVLLLIRLFIGIAGGS-FASCMPWIS 116

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19113714   222 DLFTPVQRTYVLP----------GFCTFpYLGPIIGPIIGDFITQSYLEWRWTFWI-NMIWAAAVIVFVFIF 282
Cdd:TIGR00886 117 FFFPKKIQGTALGlaagwgnmggGVAQF-VMPPIIGSLIFGGGQPAHLAWGWAFVIvPAGILLLPALLIFFV 187
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 112-282 7.43e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 7.43e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 112 VSVITIVVTFASSVYSSGIIDIASEL-----HSSIPVSTLGSCTFLVGFgVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQ 186
Cdd:cd17473 199 VLPIYFLAFLAMLLFYVIPIQLPFLLqerggGSAALIGLALAIASLAGA-IGALLFGRLKRRLGKRRLLAIGFALMALGF 277

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 187 VGGGCAHNVWTLAIVRFFQGV-FG-STPLANAggTISDLFTPVQRTYVLPGFCTFPYLGPIIGPIIGDFITQSYLEWRWT 264
Cdd:cd17473 278 LLLALASGLWVVLLGAILAGLgFGlLLPTLNS--WAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGA 355

                       170
                ....*....|....*...
gi 19113714 265 FWINMIWAAAVIVFVFIF 282
Cdd:cd17473 356 FLILGVLALVLAIVLLLL 373
2A0112 TIGR00891
putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic ...
 132-431 7.77e-03

putative sialic acid transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273324 [Multi-domain]  Cd Length: 405  Bit Score: 38.71  E-value: 7.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   132 DIASELHSSIPVSTLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAIVRFFQGVfGST 211
Cdd:TIGR00891  37 EVAGEFGLTTVDAASLISAALISRWFGALMFGLWGDRYGRRLPMVTSIVLFSAGTLACGFAPGYITMFIARLVIGI-GMG 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   212 PLANAGGTISDLFTPVQRTYVLPGFCTFPY-LGPIIGPIIGDFITQSY-LEWRWTFWINmIWAAAVIVFVFIFFPEThED 289
Cdd:TIGR00891 116 GEYGSSAAYVIESWPKHLRNKASGLLISGYaVGAVVAAQVYSLVVPVWgDGWRALFFIS-ILPIIFALWLRKNIPEA-ED 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   290 TILDYKAKYLRKTTGNTAYYTIHereRDPKNAMIQAATQAVSLIFTEPIVVCFTLYLTVVYIINYINFEGYPIVF-AKYG 368
Cdd:TIGR00891 194 WKEKHAGKALVRTMVDILYGGEH---RIANIVMTLAAAMVQSAGKRWPTFVYLVVLVLFANLYSHPIQDLLPTYLkADLG 270

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19113714   369 FNKGEQGLSFIGVGVGIVCAGLctpfIYWHYLKVNKKRNGVICPedrlyPLFIGCFLLPISMF 431
Cdd:TIGR00891 271 LSPHTVANIVVFSNIGAIVGGC----VFGFLGDWLGRRKAYVCS-----LLAGQLLIIPVFAI 324
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 203-426 8.11e-03

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 38.94  E-value: 8.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   203 FFQGVfGSTPLANAGGTISDLFTPVQRTYVLPG-FCTFPYLGPIIGPIIGDFITQSYLEW---------------RW--T 264
Cdd:TIGR00805 179 ILRGI-GATPIFPLGISYIDDFAKSKNSPLYIGiLESGSVFGPAFGFLLGSFCLQIYVDTgsvntedliitptdpRWigA 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   265 FWINMIWAAAVIVFV---FIFFPETHEDTIL-----DYKAKYLRKTTGNTAYYTIHERERDPKnamiqaatqAVSLIFTE 336
Cdd:TIGR00805 258 WWIGFLVCGFVALLTsipLFFFPKTLPKEGKrvnvdVHEAEKLEKSRGEDRKKNSGITKDFPK---------FIKRLLCN 328

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714   337 PIVVCFTLY--LTVVYIINYINFegYPIVFAK-YGFNKGEQGLSFIGVGVGIVCAGLCTPFIYWHYLKVNKKRNG--VIC 411
Cdd:TIGR00805 329 KIYMLVILAqvIDVLAFNGYITF--LPKYLENqYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAyfAIC 406

                         250
                  ....*....|....*
gi 19113714   412 PEDRLYPLFIGCFLL 426
Cdd:TIGR00805 407 LSTLEYLLYSPKFLI 421
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 125-207 8.28e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 38.61  E-value: 8.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113714 125 VYSSGIIDIASEL----HSSIPVStLGSCTFLVGFGVGSLPFAPLSDIYGRFIIYFVTLLIFTIFQVGGGCAHNVWTLAI 200
Cdd:cd17377  19 HFSSSFTSIVSEWflvgNAAYKVS-LASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAV 97


                ....*..
gi 19113714 201 VRFFQGV 207
Cdd:cd17377  98 SRFLVGV 104
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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