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Conserved domains on  [gi|19114087|ref|NP_593175|]
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coronin Crn1 [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 9-463 1.62e-88

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member PTZ00421:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 493  Bit Score: 282.94  E-value: 1.62e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087    9 SKYRHIFGQTCKKELCYDNIKLSNNAWD-SNLLSVNPFYLSVNWNAGagGALAVIPLNERGKLPDQVNLFRGHTAAVLDT 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQL--GSTAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   88 DWNPFHDQVLASGGDDSKIMIWKVPEDYTVMEPYEdvhPIAELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKG 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISD---PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  168 VAHVSLK-MDVMCQSMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNPRVVWLGSLDRFATTGFSKMSDRQ 246
Cdd:PTZ00421 159 KAVEVIKcHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  247 IALWDPTNLSEPIgGFTTLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEYENDVFHYLSEFKSVDPQRGIAFLPKRGV 326
Cdd:PTZ00421 239 IMLWDTRKMASPY-STVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCSSYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  327 NVSENEVMRAYKSVNDSIIePISFIVPRRS--ESFQSDIYPPAPSGKPSLTAEEWASGKDAQPDLLDMSTLYESKGTVEK 404
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTSPELM 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19114087  405 AVSATVPSAgaqvqkhneekvetpKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKV 463
Cdd:PTZ00421 397 GASALSPSG---------------KPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGV 440
PTZ00121 super family cl31754
MAEBL; Provisional
 376-598 1.00e-07

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   376 AEEWASGKDAQPDLLDMSTLYESKGTVEKAVSATVPSAGA-QVQKHNEEK---VETPKPEAQPVSKPKE--SAEEQKPSK 449
Cdd:PTZ00121 1583 AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAeELKKAEEEKkkvEQLKKKEAEEKKKAEElkKAEEENKIK 1662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   450 EPEVKPTTPSASKVEEPSKKRDEDNHQKEETVTQPKREKTPVEKsFPKPASSPVTFSEDVKKEpSEEKKLEVSD---EAP 526
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE-LKKKEAEEKKKAEELKKA-EEENKIKAEEakkEAE 1740

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114087   527 KAAPLAESKKVEEKEPFYVSKDKKDISAVNLADLNKRF----EGFEKRYEEELAIRDWKIAQLEDKLAKLTEAIKE 598
Cdd:PTZ00121 1741 EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEavieEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKE 1816
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-463 1.62e-88

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 282.94  E-value: 1.62e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087    9 SKYRHIFGQTCKKELCYDNIKLSNNAWD-SNLLSVNPFYLSVNWNAGagGALAVIPLNERGKLPDQVNLFRGHTAAVLDT 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQL--GSTAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   88 DWNPFHDQVLASGGDDSKIMIWKVPEDYTVMEPYEdvhPIAELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKG 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISD---PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  168 VAHVSLK-MDVMCQSMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNPRVVWLGSLDRFATTGFSKMSDRQ 246
Cdd:PTZ00421 159 KAVEVIKcHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  247 IALWDPTNLSEPIgGFTTLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEYENDVFHYLSEFKSVDPQRGIAFLPKRGV 326
Cdd:PTZ00421 239 IMLWDTRKMASPY-STVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCSSYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  327 NVSENEVMRAYKSVNDSIIePISFIVPRRS--ESFQSDIYPPAPSGKPSLTAEEWASGKDAQPDLLDMSTLYESKGTVEK 404
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTSPELM 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19114087  405 AVSATVPSAgaqvqkhneekvetpKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKV 463
Cdd:PTZ00421 397 GASALSPSG---------------KPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGV 440
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.12e-33

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 122.61  E-value: 1.12e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114087     4 RFVRASKYRHIFGQTCKKELCYDNIKLSNNAWDSNLLSVNPFYLSVNWNAGAGGALAVIPLNERGK 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-324 1.82e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 1.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  77 FRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWKvpedytvmepYEDVHPIAELKGHSRKVGLVQYHPtAANVLASSSAD 156
Cdd:cd00200   5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWD----------LETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 157 NTIKLWDCEKGVAHVSLKM---DVMCqsMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAknprvVWLGSLDR 233
Cdd:cd00200  73 KTIRLWDLETGECVRTLTGhtsYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW-----VNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 234 FATTGFSKMSDRQIALWDPTNLSEpiggFTTLD--TGSGILMPFWDDGTKVIylAGKGDGNIRYYEyendvfhyLSEFKS 311
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDLRTGKC----VATLTghTGEVNSVAFSPDGEKLL--SSSSDGTIKLWD--------LSTGKC 211

                       250       260
                ....*....|....*....|
gi 19114087 312 VDPQRG-------IAFLPKR 324
Cdd:cd00200 212 LGTLRGhengvnsVAFSPDG 231
WD40 COG2319
WD40 repeat [General function prediction only];
51-294 1.13e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 1.13e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  51 WNAGAGGALAViplnergklpdqvnlFRGHTAAVLDTDWNPfhD-QVLASGGDDSKIMIWKVPEDytvmepyedvHPIAE 129
Cdd:COG2319 147 WDLATGKLLRT---------------LTGHSGAVTSVAFSP--DgKLLASGSDDGTVRLWDLATG----------KLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 130 LKGHSRKVGLVQYHPTAaNVLASSSADNTIKLWDCEKGVAHVSLKM-DVMCQSMSFNADGTRLVTTSRDKKVRVWDPRTD 208
Cdd:COG2319 200 LTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 209 KPVSVGNGHAGAKNpRVVWLGSLDRFATTGfskmSDRQIALWDPTNlSEPIGGFTTlDTGSGILMPFWDDGTKVIylAGK 288
Cdd:COG2319 279 ELLRTLTGHSGGVN-SVAFSPDGKLLASGS----DDGTVRLWDLAT-GKLLRTLTG-HTGAVRSVAFSPDGKTLA--SGS 349


                ....*.
gi 19114087 289 GDGNIR 294
Cdd:COG2319 350 DDGTVR 355
PTZ00121 PTZ00121
MAEBL; Provisional
 376-598 1.00e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   376 AEEWASGKDAQPDLLDMSTLYESKGTVEKAVSATVPSAGA-QVQKHNEEK---VETPKPEAQPVSKPKE--SAEEQKPSK 449
Cdd:PTZ00121 1583 AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAeELKKAEEEKkkvEQLKKKEAEEKKKAEElkKAEEENKIK 1662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   450 EPEVKPTTPSASKVEEPSKKRDEDNHQKEETVTQPKREKTPVEKsFPKPASSPVTFSEDVKKEpSEEKKLEVSD---EAP 526
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE-LKKKEAEEKKKAEELKKA-EEENKIKAEEakkEAE 1740

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114087   527 KAAPLAESKKVEEKEPFYVSKDKKDISAVNLADLNKRF----EGFEKRYEEELAIRDWKIAQLEDKLAKLTEAIKE 598
Cdd:PTZ00121 1741 EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEavieEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKE 1816
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 411-563 1.56e-06

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 50.92  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  411 PSAGAQVQKHNEE---KVETPKPEAQP-VSKPKESAEEQKPSKEPEVKPtTPSASKVE---EPSKKRDEDNHQKE----E 479
Cdd:NF033839 341 PEVKPQLETPKPEvkpQPEKPKPEVKPqPEKPKPEVKPQPETPKPEVKP-QPEKPKPEvkpQPEKPKPEVKPQPEkpkpE 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  480 TVTQPKREKTPV----EKSFPKPASSPVTFSEDVKKEPSEEK----------KLEVSDEAPKAAPLAESKKVEEKEPFYV 545
Cdd:NF033839 420 VKPQPEKPKPEVkpqpEKPKPEVKPQPEKPKPEVKPQPETPKpevkpqpekpKPEVKPQPEKPKPDNSKPQADDKKPSTP 499

                        170
                 ....*....|....*...
gi 19114087  546 SKDKKDISAVNLADLNKR 563
Cdd:NF033839 500 NNLSKDKQPSNQASTNEK 517
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-110 4.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 19114087     73 QVNLFRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWK 110
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
Caldesmon pfam02029
Caldesmon;
397-594 1.91e-05

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 47.55  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   397 ESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQ 476
Cdd:pfam02029 131 EETEIREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   477 KEETVTQPKREKtpvEKSFPKPASSPVTFSEDVKKEPSEEKKLEvsdeapkaaPLAESKKVEEKEPFYVSKDKKDISAVN 556
Cdd:pfam02029 211 NGEEEVTKLKVT---TKRRQGGLSQSQEREEEAEVFLEAEQKLE---------ELRRRRQEKESEEFEKLRQKQQEAELE 278

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 19114087   557 LADLNKRFEGFEKRYEEElaiRDWKIAQLEDKLAKLTE 594
Cdd:pfam02029 279 LEELKKKREERRKLLEEE---EQRRKQEEAERKLREEE 313
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 398-554 1.21e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.45  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   398 SKGTVEKAVSATVPSAGAQVQKHNE---EKVETPKPEAQPVSKPKESAEEQKPSKEPE--------VKPTTPSASKVEEP 466
Cdd:TIGR02794  30 EPGGGAEIIQAVLVDPGAVAQQANRiqqQKKPAAKKEQERQKKLEQQAEEAEKQRAAEqarqkeleQRAAAEKAAKQAEQ 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   467 SKKRDEDNHQKEETvtqpKREKTPVEKSFPKPASSPVTFSEDVKKEPSEEKKLEVSDEAPKAAPLAESKKVEEKepfyvs 546
Cdd:TIGR02794 110 AAKQAEEKQKQAEE----AKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEA------ 179


                  ....*...
gi 19114087   547 KDKKDISA 554
Cdd:TIGR02794 180 KAKAEAEA 187
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 424-540 1.57e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.76  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  424 KVETPKPEAQP---VSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQ----KEETVTQPKREKTPV----E 492
Cdd:NF033839 291 KPSAPKPGMQPspqPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQletpKPEVKPQPEKPKPEVkpqpE 370

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19114087  493 KSFPKPASSPVTFSEDVKKEPSEEK---KLEVSDEAPKAAPLAESKKVEEK 540
Cdd:NF033839 371 KPKPEVKPQPETPKPEVKPQPEKPKpevKPQPEKPKPEVKPQPEKPKPEVK 421
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 373-540 7.28e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.45  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  373 SLTAEEWASGKDAQPDLLDMSTLYESKGTVEKaVSATVPSAGAQVQKHNEEkvETPKPEAQPvsKPKESAEEQKPSKEPE 452
Cdd:NF033839 232 ALIKELDELKKQALSEIDNVNTKVEIENTVHK-IFADMDAVVTKFKKGLTQ--DTPKEPGNK--KPSAPKPGMQPSPQPE 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  453 VKPTTPSASKVE-----EPSKKRDEDNHQKE----ETVTQPKREKTPVEK--SFPKPASSPV--TFSEDVKKEPSEEK-- 517
Cdd:NF033839 307 KKEVKPEPETPKpevkpQLEKPKPEVKPQPEkpkpEVKPQLETPKPEVKPqpEKPKPEVKPQpeKPKPEVKPQPETPKpe 386

                        170       180
                 ....*....|....*....|....
gi 19114087  518 -KLEVSDEAPKAAPLAESKKVEEK 540
Cdd:NF033839 387 vKPQPEKPKPEVKPQPEKPKPEVK 410
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 422-497 3.04e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.77  E-value: 3.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114087  422 EEKV-ETPKPEAQPVSKPKESAEEQKPSKEPEV-KPTTPSASKVEEPSKKRDEDNHQKeETVTQPKREKTPVEKSFPK 497
Cdd:NF033838 409 EDKVkEKPAEQPQPAPAPQPEKPAPKPEKPAEQpKAEKPADQQAEEDYARRSEEEYNR-LTQQQPPKTEKPAQPSTPK 485
 
Name Accession Description Interval E-value
PTZ00421 PTZ00421
coronin; Provisional
 9-463 1.62e-88

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 282.94  E-value: 1.62e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087    9 SKYRHIFGQTCKKELCYDNIKLSNNAWD-SNLLSVNPFYLSVNWNAGagGALAVIPLNERGKLPDQVNLFRGHTAAVLDT 87
Cdd:PTZ00421   4 SRFRHTQGVPARPDRHFLNVTPSTALWDcSNTIACNDRFIAVPWQQL--GSTAVLKHTDYGKLASNPPILLGQEGPIIDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   88 DWNPFHDQVLASGGDDSKIMIWKVPEDYTVMEPYEdvhPIAELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKG 167
Cdd:PTZ00421  82 AFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNISD---PIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERG 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  168 VAHVSLK-MDVMCQSMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNPRVVWLGSLDRFATTGFSKMSDRQ 246
Cdd:PTZ00421 159 KAVEVIKcHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGCSKSQQRQ 238

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  247 IALWDPTNLSEPIgGFTTLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEYENDVFHYLSEFKSVDPQRGIAFLPKRGV 326
Cdd:PTZ00421 239 IMLWDTRKMASPY-STVDLDQSSALFIPFFDEDTNLLYIGSKGEGNIRCFELMNERLTFCSSYSSVEPHKGLCMMPKWSL 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  327 NVSENEVMRAYKSVNDSIIePISFIVPRRS--ESFQSDIYPPAPSGKPSLTAEEWASGKDAQPDLLDMSTLYESKGTVEK 404
Cdd:PTZ00421 318 DTRKCEIARFYALTYHSLY-TIQMLLPRKQadSELQVDVYPPTFADHPAITADEYFSGGNAEPLVYDMSAVFDGTSPELM 396

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19114087  405 AVSATVPSAgaqvqkhneekvetpKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKV 463
Cdd:PTZ00421 397 GASALSPSG---------------KPRHSGVSVPASTSAMTHSFDDNTSKHADPCAMGV 440
PTZ00420 PTZ00420
coronin; Provisional
 25-397 2.35e-70

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 237.54  E-value: 2.35e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   25 YDNIKLSNNAWDSNLLSVNPFYLSVNWNAGAGGALAVIPLNERGKLPDQVNLfRGHTAAVLDTDWNPFHDQVLASGGDDS 104
Cdd:PTZ00420  19 FDDLRICSRVIDSCGIACSSGFVAVPWEVEGGGLIGAIRLENQMRKPPVIKL-KGHTSSILDLQFNPCFSEILASGSEDL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  105 KIMIWKVP-EDYTVMEPYEdvhPIAELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKGVAHVSLKMDVMCQSMS 183
Cdd:PTZ00420  98 TIRVWEIPhNDESVKEIKD---PQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMPKKLSSLK 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  184 FNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNPRVVW---LGSLDRFA-TTGFSKMSDRQIALWDPTNLSEPI 259
Cdd:PTZ00420 175 WNIKGNLLSGTCVGKHMHIIDPRKQEIASSFHIHDGGKNTKNIWidgLGGDDNYIlSTGFSKNNMREMKLWDLKNTTSAL 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  260 GGFTtLDTGSGILMPFWDDGTKVIYLAGKGDGNIRYYEYENDVFHYLSEFKSVDPQRGIAFLPKRGVNVSENEVMRAYKS 339
Cdd:PTZ00420 255 VTMS-IDNASAPLIPHYDESTGLIYLIGKGDGNCRYYQHSLGSIRKVNEYKSCSPFRSFGFLPKQICDVYKCEIGRVYKN 333

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 19114087  340 VNDSIIEPISFIVPRRSES-FQSDIYPPAPSGKPSLTAEEWASGKDAQPDLLDMSTLYE 397
Cdd:PTZ00420 334 ENNSSIRPISFYVPRKNPTkFQEDLYPPILMHDPERSSRNWIDGKDNKMKRINIKDLTE 392
DUF1899 pfam08953
Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic ...
 4-69 1.12e-33

Domain of unknown function (DUF1899); This set of domains is found in various eukaryotic proteins. Function is unknown.


Pssm-ID: 462645 [Multi-domain]  Cd Length: 66  Bit Score: 122.61  E-value: 1.12e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114087     4 RFVRASKYRHIFGQTCKKELCYDNIKLSNNAWDSNLLSVNPFYLSVNWNAGAGGALAVIPLNERGK 69
Cdd:pfam08953   1 RFVRASKFRHVYGKPAKKELCYDNIKVTKNAWDSNFIAANPKFLAVNWESSGGGAFAVLPLNQTGR 66
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-324 1.82e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.43  E-value: 1.82e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  77 FRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWKvpedytvmepYEDVHPIAELKGHSRKVGLVQYHPtAANVLASSSAD 156
Cdd:cd00200   5 LKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWD----------LETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSD 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 157 NTIKLWDCEKGVAHVSLKM---DVMCqsMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAknprvVWLGSLDR 233
Cdd:cd00200  73 KTIRLWDLETGECVRTLTGhtsYVSS--VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDW-----VNSVAFSP 145

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 234 FATTGFSKMSDRQIALWDPTNLSEpiggFTTLD--TGSGILMPFWDDGTKVIylAGKGDGNIRYYEyendvfhyLSEFKS 311
Cdd:cd00200 146 DGTFVASSSQDGTIKLWDLRTGKC----VATLTghTGEVNSVAFSPDGEKLL--SSSSDGTIKLWD--------LSTGKC 211

                       250       260
                ....*....|....*....|
gi 19114087 312 VDPQRG-------IAFLPKR 324
Cdd:cd00200 212 LGTLRGhengvnsVAFSPDG 231
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-300 2.52e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 2.52e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  77 FRGHTAAVLDTDWNPFHDQvLASGGDDSKIMIWKVpedytvmepyEDVHPIAELKGHSRKVGLVQYHPTaANVLASSSAD 156
Cdd:cd00200  47 LKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDL----------ETGECVRTLTGHTSYVSSVAFSPD-GRILSSSSRD 114

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 157 NTIKLWDCEKGVAHVSLK---MDVMCqsMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNpRVVWLGSLDR 233
Cdd:cd00200 115 KTIKVWDVETGKCLTTLRghtDWVNS--VAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVN-SVAFSPDGEK 191

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 234 FATTGfskmSDRQIALWDPTnlsepigGFTTLDTGSGILMPFWD---DGTKVIYLAGKGDGNIRYYEYEN 300
Cdd:cd00200 192 LLSSS----SDGTIKLWDLS-------TGKCLGTLRGHENGVNSvafSPDGYLLASGSEDGTIRVWDLRT 250
WD40 COG2319
WD40 repeat [General function prediction only];
51-294 1.13e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 1.13e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  51 WNAGAGGALAViplnergklpdqvnlFRGHTAAVLDTDWNPfhD-QVLASGGDDSKIMIWKVPEDytvmepyedvHPIAE 129
Cdd:COG2319 147 WDLATGKLLRT---------------LTGHSGAVTSVAFSP--DgKLLASGSDDGTVRLWDLATG----------KLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 130 LKGHSRKVGLVQYHPTAaNVLASSSADNTIKLWDCEKGVAHVSLKM-DVMCQSMSFNADGTRLVTTSRDKKVRVWDPRTD 208
Cdd:COG2319 200 LTGHTGAVRSVAFSPDG-KLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 209 KPVSVGNGHAGAKNpRVVWLGSLDRFATTGfskmSDRQIALWDPTNlSEPIGGFTTlDTGSGILMPFWDDGTKVIylAGK 288
Cdd:COG2319 279 ELLRTLTGHSGGVN-SVAFSPDGKLLASGS----DDGTVRLWDLAT-GKLLRTLTG-HTGAVRSVAFSPDGKTLA--SGS 349


                ....*.
gi 19114087 289 GDGNIR 294
Cdd:COG2319 350 DDGTVR 355
WD40 COG2319
WD40 repeat [General function prediction only];
73-254 9.03e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.92  E-value: 9.03e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  73 QVNLFRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWKVPEDytvmepyedvHPIAELKGHSRKVGLVQYHPTAaNVLAS 152
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATG----------ELLRTLTGHSGGVNSVAFSPDG-KLLAS 305

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 153 SSADNTIKLWDCEKGVAHVSLKMDV-MCQSMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNpRVVWLGSL 231
Cdd:COG2319 306 GSDDGTVRLWDLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVT-SVAFSPDG 384

                       170       180
                ....*....|....*....|...
gi 19114087 232 DRFATTGFskmsDRQIALWDPTN 254
Cdd:COG2319 385 RTLASGSA----DGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 77-297 1.97e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 1.97e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  77 FRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWKVPEDYtvmepyedvhPIAELKGHSRKVGLVQYHPTAaNVLASSSAD 156
Cdd:cd00200  89 LTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGK----------CLTTLRGHTDWVNSVAFSPDG-TFVASSSQD 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 157 NTIKLWDCEKG------VAHvslKMDVmcQSMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNpRVVWLGS 230
Cdd:cd00200 157 GTIKLWDLRTGkcvatlTGH---TGEV--NSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVN-SVAFSPD 230

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19114087 231 lDRFATTGFskmSDRQIALWDPTN------LSEPIGGFTTLDtgsgilmpFWDDGTKVIylAGKGDGNIRYYE 297
Cdd:cd00200 231 -GYLLASGS---EDGTIRVWDLRTgecvqtLSGHTNSVTSLA--------WSPDGKRLA--SGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
76-253 3.92e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 3.92e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  76 LFRGHTAAVLDTDWNPfhD-QVLASGGDDSKIMIWKVpedytvmepyEDVHPIAELKGHSRKVGLVQYHPTAaNVLASSS 154
Cdd:COG2319 115 TLTGHTGAVRSVAFSP--DgKTLASGSADGTVRLWDL----------ATGKLLRTLTGHSGAVTSVAFSPDG-KLLASGS 181

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 155 ADNTIKLWDCEKGVAHVSLK-MDVMCQSMSFNADGTRLVTTSRDKKVRVWDPRTDKPVSVGNGHAGAKNpRVVWlgSLD- 232
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR-SVAF--SPDg 258

                       170       180
                ....*....|....*....|..
gi 19114087 233 -RFATTGfskmSDRQIALWDPT 253
Cdd:COG2319 259 rLLASGS----ADGTVRLWDLA 276
WD40 COG2319
WD40 repeat [General function prediction only];
47-254 4.02e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 95.75  E-value: 4.02e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  47 LSVNWNAGAGGALAVIPLNERGKLPDQVNLFRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWKVpedytvmepyEDVHP 126
Cdd:COG2319  44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDL----------ATGLL 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 127 IAELKGHSRKVGLVQYHPTaANVLASSSADNTIKLWDCEKGVAHVSLKM-DVMCQSMSFNADGTRLVTTSRDKKVRVWDP 205
Cdd:COG2319 113 LRTLTGHTGAVRSVAFSPD-GKTLASGSADGTVRLWDLATGKLLRTLTGhSGAVTSVAFSPDGKLLASGSDDGTVRLWDL 191

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 19114087 206 RTDKPVSVGNGHAGAKNpRVVWlgSLD--RFATTGfskmSDRQIALWDPTN 254
Cdd:COG2319 192 ATGKLLRTLTGHTGAVR-SVAF--SPDgkLLASGS----ADGTVRLWDLAT 235
WD40_4 pfam16300
Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at ...
 345-387 2.41e-19

Type of WD40 repeat; Most members of this family form part of the 7-bladed beta-propeller at the N-terminus of coronin proteins.


Pssm-ID: 465087 [Multi-domain]  Cd Length: 44  Bit Score: 81.41  E-value: 2.41e-19
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 19114087   345 IEPISFIVPRRS-ESFQSDIYPPAPSGKPSLTAEEWASGKDAQP 387
Cdd:pfam16300   1 IEPISFTVPRKSkEDFQDDLYPDTAGTEPALTAEEWLSGKNAEP 44
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-204 1.27e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 1.27e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  74 VNLFRGHTAAVLDTDWNPfhD-QVLASGGDDSKIMIWKVPEDytvmepyedvHPIAELKGHSRKVGLVQYHPTaANVLAS 152
Cdd:cd00200 170 VATLTGHTGEVNSVAFSP--DgEKLLSSSSDGTIKLWDLSTG----------KCLGTLRGHENGVNSVAFSPD-GYLLAS 236

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 19114087 153 SSADNTIKLWDCEKGVAHVSLKM-DVMCQSMSFNADGTRLVTTSRDKKVRVWD 204
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 126-251 3.82e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 3.82e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 126 PIAELKGHSRKVGLVQYHPTAaNVLASSSADNTIKLWDCEKGVAHVSLK---MDVmcQSMSFNADGTRLVTTSRDKKVRV 202
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKghtGPV--RDVAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 19114087 203 WDPRTDKPVSVGNGHAGAknprvVWlgSLD-----RFATTGfskMSDRQIALWD 251
Cdd:cd00200  78 WDLETGECVRTLTGHTSY-----VS--SVAfspdgRILSSS---SRDKTIKVWD 121
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-163 1.66e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.13  E-value: 1.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  72 DQVNLFRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWKVpedytvmepyEDVHPIAELKGHSRKVGLVQYHPTaANVLA 151
Cdd:cd00200 210 KCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDL----------RTGECVQTLSGHTNSVTSLAWSPD-GKRLA 277

                        90
                ....*....|..
gi 19114087 152 SSSADNTIKLWD 163
Cdd:cd00200 278 SGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 89-318 6.17e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.41  E-value: 6.17e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   89 WNPFHDQVLASGGDDSKIMIWKVPEDYTVmepyedvhpiAELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKGV 168
Cdd:PLN00181 540 WNSYIKSQVASSNFEGVVQVWDVARSQLV----------TEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGV 609

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  169 AHVSLKMDVMCQSMSFNAD-GTRLVTTSRDKKVRVWDPRTDK-PVSVGNGHAGAknprVVWLGSLDrfATTGFSKMSDRQ 246
Cdd:PLN00181 610 SIGTIKTKANICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKT----VSYVRFVD--SSTLVSSSTDNT 683

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  247 IALWDptnLSEPIGGF--TTLDTGSGilmpfwddGTKVIYLAG--KGDGNIRYYEYENDVFHY--------LS-EFKSVD 313
Cdd:PLN00181 684 LKLWD---LSMSISGIneTPLHSFMG--------HTNVKNFVGlsVSDGYIATGSETNEVFVYhkafpmpvLSyKFKTID 752


                 ....*
gi 19114087  314 PQRGI 318
Cdd:PLN00181 753 PVSGL 757
WD40 COG2319
WD40 repeat [General function prediction only];
127-294 6.57e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 6.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 127 IAELKGHSRKVGLVQYHPTAANVLASSSADNTIKLWDCEKGVAHVSLKMDVMCQSMSFNADGTRLVTTSRDKKVRVWDPR 206
Cdd:COG2319  29 LLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087 207 TDKPVSVGNGHAGAKNpRVVWlgSLD--RFATTGfskmSDRQIALWDPTN------LSEPIGGFTTLDtgsgilmpFWDD 278
Cdd:COG2319 109 TGLLLRTLTGHTGAVR-SVAF--SPDgkTLASGS----ADGTVRLWDLATgkllrtLTGHSGAVTSVA--------FSPD 173

                       170
                ....*....|....*.
gi 19114087 279 GTKVIylAGKGDGNIR 294
Cdd:COG2319 174 GKLLA--SGSDDGTVR 187
PTZ00121 PTZ00121
MAEBL; Provisional
 376-598 1.00e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 55.53  E-value: 1.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   376 AEEWASGKDAQPDLLDMSTLYESKGTVEKAVSATVPSAGA-QVQKHNEEK---VETPKPEAQPVSKPKE--SAEEQKPSK 449
Cdd:PTZ00121 1583 AEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAeELKKAEEEKkkvEQLKKKEAEEKKKAEElkKAEEENKIK 1662

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   450 EPEVKPTTPSASKVEEPSKKRDEDNHQKEETVTQPKREKTPVEKsFPKPASSPVTFSEDVKKEpSEEKKLEVSD---EAP 526
Cdd:PTZ00121 1663 AAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEE-LKKKEAEEKKKAEELKKA-EEENKIKAEEakkEAE 1740

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114087   527 KAAPLAESKKVEEKEPFYVSKDKKDISAVNLADLNKRF----EGFEKRYEEELAIRDWKIAQLEDKLAKLTEAIKE 598
Cdd:PTZ00121 1741 EDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEavieEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKE 1816
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 411-563 1.56e-06

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 50.92  E-value: 1.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  411 PSAGAQVQKHNEE---KVETPKPEAQP-VSKPKESAEEQKPSKEPEVKPtTPSASKVE---EPSKKRDEDNHQKE----E 479
Cdd:NF033839 341 PEVKPQLETPKPEvkpQPEKPKPEVKPqPEKPKPEVKPQPETPKPEVKP-QPEKPKPEvkpQPEKPKPEVKPQPEkpkpE 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  480 TVTQPKREKTPV----EKSFPKPASSPVTFSEDVKKEPSEEK----------KLEVSDEAPKAAPLAESKKVEEKEPFYV 545
Cdd:NF033839 420 VKPQPEKPKPEVkpqpEKPKPEVKPQPEKPKPEVKPQPETPKpevkpqpekpKPEVKPQPEKPKPDNSKPQADDKKPSTP 499

                        170
                 ....*....|....*...
gi 19114087  546 SKDKKDISAVNLADLNKR 563
Cdd:NF033839 500 NNLSKDKQPSNQASTNEK 517
PTZ00121 PTZ00121
MAEBL; Provisional
 415-598 3.94e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 50.14  E-value: 3.94e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   415 AQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQKEEtVTQPKREKTPVEKS 494
Cdd:PTZ00121 1345 AEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE-LKKAAAAKKKADEA 1423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   495 fpKPASSPVTFSEDVKKEPSEEKKlevSDEAPKAAplAESKKVEEKEPFYVSKDKKDisavnlaDLNKRFEgfEKRYEEE 574
Cdd:PTZ00121 1424 --KKKAEEKKKADEAKKKAEEAKK---ADEAKKKA--EEAKKAEEAKKKAEEAKKAD-------EAKKKAE--EAKKADE 1487

                         170       180
                  ....*....|....*....|....
gi 19114087   575 LAIRDWKIAQLEDKLAKLTEAIKE 598
Cdd:PTZ00121 1488 AKKKAEEAKKKADEAKKAAEAKKK 1511
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-110 4.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 4.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 19114087     73 QVNLFRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIWK 110
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-163 6.68e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.68e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 19114087    125 HPIAELKGHSRKVGLVQYHPTAaNVLASSSADNTIKLWD 163
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 353-536 9.43e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.93  E-value: 9.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   353 PRRSESFQSDIYPPAPSGKPSLTAEEWASGKDAQPDLLDMSTLYESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEA 432
Cdd:PRK10263  400 PVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQ 479

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   433 QPVSKPKESAEEQKPSKEpEVKPTTPSASKVEEPSKKRDEDNHQKE---ETVTQPKREKTPVEKSFPKPASSPVTfsedv 509
Cdd:PRK10263  480 QPQPVEQQPVVEPEPVVE-ETKPARPPLYYFEEVEEKRAREREQLAawyQPIPEPVKEPEPIKSSLKAPSVAAVP----- 553

                         170       180
                  ....*....|....*....|....*..
gi 19114087   510 kkePSEekklevsdEAPKAAPLAESKK 536
Cdd:PRK10263  554 ---PVE--------AAAAVSPLASGVK 569
Caldesmon pfam02029
Caldesmon;
397-594 1.91e-05

Caldesmon;


Pssm-ID: 460421 [Multi-domain]  Cd Length: 495  Bit Score: 47.55  E-value: 1.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   397 ESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQ 476
Cdd:pfam02029 131 EETEIREKEYQENKWSTEVRQAEEEGEEEEDKSEEAEEVPTENFAKEEVKDEKIKKEKKVKYESKVFLDQKRGHPEVKSQ 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   477 KEETVTQPKREKtpvEKSFPKPASSPVTFSEDVKKEPSEEKKLEvsdeapkaaPLAESKKVEEKEPFYVSKDKKDISAVN 556
Cdd:pfam02029 211 NGEEEVTKLKVT---TKRRQGGLSQSQEREEEAEVFLEAEQKLE---------ELRRRRQEKESEEFEKLRQKQQEAELE 278

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 19114087   557 LADLNKRFEGFEKRYEEElaiRDWKIAQLEDKLAKLTE 594
Cdd:pfam02029 279 LEELKKKREERRKLLEEE---EQRRKQEEAERKLREEE 313
DUF4045 pfam13254
Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. ...
 406-530 2.31e-05

Domain of unknown function (DUF4045); This presumed domain is functionally uncharacterized. This domain family is found in bacteria and eukaryotes, and is typically between 384 and 430 amino acids in length.


Pssm-ID: 433066 [Multi-domain]  Cd Length: 415  Bit Score: 47.08  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   406 VSATVPSAGAQVQKHNEEKVETPKPEAQPVSKP------KESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQKEE 479
Cdd:pfam13254 230 SSPTKEEPSEEADTLSTDKEQSPAPTSASEPPPktkelpKDSEEPAAPSKSAEASTEKKEPDTESSPETSSEKSAPSLLS 309

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 19114087   480 TVTQPKREKTPVEKSF------PKPASSPVTFSEDVKKEPSeekkleVSDEAPKAAP 530
Cdd:pfam13254 310 PVSKASIDKPLSSPDRdplspkPKPQSPPKDFRANLRSREV------PKDKSKKDEP 360
PTZ00121 PTZ00121
MAEBL; Provisional
 416-588 2.44e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 2.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   416 QVQKHNEEK--VETPKPEAQPVSKP---KESAEEQKpsKEPEVKPTTPSASKVEEPSKKRDEdnHQKEETVTQPKREKTP 490
Cdd:PTZ00121 1409 ELKKAAAAKkkADEAKKKAEEKKKAdeaKKKAEEAK--KADEAKKKAEEAKKAEEAKKKAEE--AKKADEAKKKAEEAKK 1484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   491 VEKSfPKPASSPVTFSEDVKKEPSEEKKLEVSDEAPKAAPLAESKKVEEK---EPFYVSKDKKDISAVNLADLNKRFEGF 567
Cdd:PTZ00121 1485 ADEA-KKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAkkaDEAKKAEEKKKADELKKAEELKKAEEK 1563

                         170       180
                  ....*....|....*....|....*....
gi 19114087   568 ----EKRYEEE---LAIRDWKIA-QLEDK 588
Cdd:PTZ00121 1564 kkaeEAKKAEEdknMALRKAEEAkKAEEA 1592
WD40 pfam00400
WD domain, G-beta repeat;
126-163 3.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 3.26e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19114087   126 PIAELKGHSRKVGLVQYHPTAaNVLASSSADNTIKLWD 163
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
73-109 8.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 8.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 19114087    73 QVNLFRGHTAAVLDTDWNPfHDQVLASGGDDSKIMIW 109
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
PTZ00121 PTZ00121
MAEBL; Provisional
 416-599 9.95e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.52  E-value: 9.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   416 QVQKHNEEKVETPKPEAQPVSKPKESAEEQKpsKEPEVKPTTPSASKVEEPSKKRDEDNHQKEETVTQPKREKTPVEKSF 495
Cdd:PTZ00121 1596 EVMKLYEEEKKMKAEEAKKAEEAKIKAEELK--KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEED 1673

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   496 PKPASspvtfsEDVKKEPSEEKKLE-VSDEAPKAAPLAESKKVEEKEPFYVSKDKKDISAVNL-ADLNKRFEGFEKRYEE 573
Cdd:PTZ00121 1674 KKKAE------EAKKAEEDEKKAAEaLKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIkAEEAKKEAEEDKKKAE 1747

                         170       180
                  ....*....|....*....|....*....
gi 19114087   574 ELAIRDW---KIAQLEDKLAKLTEAIKEK 599
Cdd:PTZ00121 1748 EAKKDEEekkKIAHLKKEEEKKAEEIRKE 1776
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
 398-554 1.21e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.45  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   398 SKGTVEKAVSATVPSAGAQVQKHNE---EKVETPKPEAQPVSKPKESAEEQKPSKEPE--------VKPTTPSASKVEEP 466
Cdd:TIGR02794  30 EPGGGAEIIQAVLVDPGAVAQQANRiqqQKKPAAKKEQERQKKLEQQAEEAEKQRAAEqarqkeleQRAAAEKAAKQAEQ 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   467 SKKRDEDNHQKEETvtqpKREKTPVEKSFPKPASSPVTFSEDVKKEPSEEKKLEVSDEAPKAAPLAESKKVEEKepfyvs 546
Cdd:TIGR02794 110 AAKQAEEKQKQAEE----AKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEA------ 179


                  ....*...
gi 19114087   547 KDKKDISA 554
Cdd:TIGR02794 180 KAKAEAEA 187
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
401-490 1.34e-04

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 44.35  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  401 TVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEeqkpSKEPEVKPTTPSASKVEEPSKKRDEDNHQkEET 480
Cdd:PRK13335  82 TNEEKTSASKIEKISQPKQEEQKSLNISATPAPKQEQSQTTTE----STTPKTKVTTPPSTNTPQPMQSTKSDTPQ-SPT 156

                         90
                 ....*....|
gi 19114087  481 VTQPKREKTP 490
Cdd:PRK13335 157 IKQAQTDMTP 166
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 424-540 1.57e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 44.76  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  424 KVETPKPEAQP---VSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQ----KEETVTQPKREKTPV----E 492
Cdd:NF033839 291 KPSAPKPGMQPspqPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQletpKPEVKPQPEKPKPEVkpqpE 370

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 19114087  493 KSFPKPASSPVTFSEDVKKEPSEEK---KLEVSDEAPKAAPLAESKKVEEK 540
Cdd:NF033839 371 KPKPEVKPQPETPKPEVKPQPEKPKpevKPQPEKPKPEVKPQPEKPKPEVK 421
PTZ00121 PTZ00121
MAEBL; Provisional
 431-597 1.62e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.13  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   431 EAQPVSKPKESAEEQKPSKEPEvKPTTPSASKVEEPSKKRDEDNHQKEETVTQPKREKTPVEKSFPKPASSPVTFSEDVK 510
Cdd:PTZ00121 1300 EKKKADEAKKKAEEAKKADEAK-KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKK 1378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   511 KEPSEEKKLEVSDEAPKAAPLAES--KKVEEKEPFYVSKDKKDisavnlaDLNKRFEgfEKRYEEELAIRDWKIAQLEDK 588
Cdd:PTZ00121 1379 KADAAKKKAEEKKKADEAKKKAEEdkKKADELKKAAAAKKKAD-------EAKKKAE--EKKKADEAKKKAEEAKKADEA 1449


                  ....*....
gi 19114087   589 LAKLTEAIK 597
Cdd:PTZ00121 1450 KKKAEEAKK 1458
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 181-204 2.06e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 2.06e-04
                           10        20
                   ....*....|....*....|....
gi 19114087    181 SMSFNADGTRLVTTSRDKKVRVWD 204
Cdd:smart00320  17 SVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00121 PTZ00121
MAEBL; Provisional
 397-597 2.43e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.36  E-value: 2.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   397 ESKGTVEKAVSATVPSAGAQVQKHNEEK-VETPKPEAQPVSKP---KESAEEQKpSKEPEVKPTTPSASKVEEPSKKRDE 472
Cdd:PTZ00121 1351 EAEAAADEAEAAEEKAEAAEKKKEEAKKkADAAKKKAEEKKKAdeaKKKAEEDK-KKADELKKAAAAKKKADEAKKKAEE 1429

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   473 DnhQKEETVTQPKREKTPVEKSFPKpasspvtfSEDVKKEPSEEKKLEvsdEAPKAAPLaeSKKVEEKEPFYVSKDKKDI 552
Cdd:PTZ00121 1430 K--KKADEAKKKAEEAKKADEAKKK--------AEEAKKAEEAKKKAE---EAKKADEA--KKKAEEAKKADEAKKKAEE 1494

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 19114087   553 SAVNLADLNKRFEgfEKRYEEELaiRDWKIAQLEDKLAKLTEAIK 597
Cdd:PTZ00121 1495 AKKKADEAKKAAE--AKKKADEA--KKAEEAKKADEAKKAEEAKK 1535
PTZ00121 PTZ00121
MAEBL; Provisional
 397-599 3.17e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 3.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   397 ESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQ 476
Cdd:PTZ00121 1299 EEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKK 1378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   477 KEETVTQPKREKTPVEKSFPKPASSPVTFSEDVKKEPSEEKKLEVSDEAPKAAPLAESKKVEEKEPFYVSKDKKDISAVN 556
Cdd:PTZ00121 1379 KADAAKKKAEEKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKK 1458

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19114087   557 LADLNKRFEgfEKRYEEELAiRDWKIAQLEDKLAKLTEAIKEK 599
Cdd:PTZ00121 1459 AEEAKKKAE--EAKKADEAK-KKAEEAKKADEAKKKAEEAKKK 1498
WD40 pfam00400
WD domain, G-beta repeat;
181-204 4.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 4.82e-04
                          10        20
                  ....*....|....*....|....
gi 19114087   181 SMSFNADGTRLVTTSRDKKVRVWD 204
Cdd:pfam00400  16 SLAFSPDGKLLASGSDDGTVKVWD 39
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 364-542 5.66e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 5.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   364 YPPAPSGKPSLTA--EEWAsgkdaQPdlldmstlYESKGTVEKAVSATVPSAgAQVQKHNEEKVETPKP---EAQPVSKP 438
Cdd:PRK10263  380 YPQQSQYAQPAVQynEPLQ-----QP--------VQPQQPYYAPAAEQPAQQ-PYYAPAPEQPAQQPYYapaPEQPVAGN 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   439 KESAEEQKPSKEPEvkPTTPSASKVEEPSKKrDEDNHQKEETVTQPKREKTPVEKSFpKPASSPVTFSEDVKKEPSEEKK 518
Cdd:PRK10263  446 AWQAEEQQSTFAPQ--STYQTEQTYQQPAAQ-EPLYQQPQPVEQQPVVEPEPVVEET-KPARPPLYYFEEVEEKRARERE 521

                         170       180
                  ....*....|....*....|....
gi 19114087   519 LEVSDEAPKAAPLAESKKVEEKEP 542
Cdd:PRK10263  522 QLAAWYQPIPEPVKEPEPIKSSLK 545
PTZ00121 PTZ00121
MAEBL; Provisional
 397-599 5.94e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   397 ESKGTVEKAVSATVPSAGAQVQKHNEE---KVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDED 473
Cdd:PTZ00121 1422 EAKKKAEEKKKADEAKKKAEEAKKADEakkKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADE 1501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   474 NHQKEETvtqpKREKTPVEKSFPKPASSPVTFSEDVKKEPSEEKKLEV--SDEAPKAAPL---AESKKVEEKEPFYVSKD 548
Cdd:PTZ00121 1502 AKKAAEA----KKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKkkADELKKAEELkkaEEKKKAEEAKKAEEDKN 1577

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19114087   549 KKDISAVNLADLNK-RFEGFEKRYEEELAIRDWKIAQLEDKLAKLTEAIKEK 599
Cdd:PTZ00121 1578 MALRKAEEAKKAEEaRIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAE 1629
PTZ00121 PTZ00121
MAEBL; Provisional
 397-573 6.87e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 6.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   397 ESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKpEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDNHQ 476
Cdd:PTZ00121 1252 EEIRKFEEARMAHFARRQAAIKAEEARKADELK-KAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKK 1330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   477 KEETV--TQPKREKTPVEKSFPKPASSPVTFSED----VKKEPSEEKKleVSDEAPKAAplAESKKVEEKEPFYVSKDKK 550
Cdd:PTZ00121 1331 ADAAKkkAEEAKKAAEAAKAEAEAAADEAEAAEEkaeaAEKKKEEAKK--KADAAKKKA--EEKKKADEAKKKAEEDKKK 1406

                         170       180
                  ....*....|....*....|...
gi 19114087   551 DISAVNLADLNKRFEGFEKRYEE 573
Cdd:PTZ00121 1407 ADELKKAAAAKKKADEAKKKAEE 1429
PspC_subgroup_2 NF033839
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ...
 373-540 7.28e-04

pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.


Pssm-ID: 468202 [Multi-domain]  Cd Length: 557  Bit Score: 42.45  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  373 SLTAEEWASGKDAQPDLLDMSTLYESKGTVEKaVSATVPSAGAQVQKHNEEkvETPKPEAQPvsKPKESAEEQKPSKEPE 452
Cdd:NF033839 232 ALIKELDELKKQALSEIDNVNTKVEIENTVHK-IFADMDAVVTKFKKGLTQ--DTPKEPGNK--KPSAPKPGMQPSPQPE 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  453 VKPTTPSASKVE-----EPSKKRDEDNHQKE----ETVTQPKREKTPVEK--SFPKPASSPV--TFSEDVKKEPSEEK-- 517
Cdd:NF033839 307 KKEVKPEPETPKpevkpQLEKPKPEVKPQPEkpkpEVKPQLETPKPEVKPqpEKPKPEVKPQpeKPKPEVKPQPETPKpe 386

                        170       180
                 ....*....|....*....|....
gi 19114087  518 -KLEVSDEAPKAAPLAESKKVEEK 540
Cdd:NF033839 387 vKPQPEKPKPEVKPQPEKPKPEVK 410
PRK11633 PRK11633
cell division protein DedD; Provisional
 351-469 9.15e-04

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 41.14  E-value: 9.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  351 IVPRRSESFQSDIYPPA----PSGKPSLTAEEWASGKDAQPdlldmstlyeskgTVEKAVSATVPSAGAQvqkhneEKVE 426
Cdd:PRK11633  43 LVPKPGDRDEPDMMPAAtqalPTQPPEGAAEAVRAGDAAAP-------------SLDPATVAPPNTPVEP------EPAP 103

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 19114087  427 TPKPEAQPVSKPKesaEEQKPSKEPEVKPTTPSASKVEEPSKK 469
Cdd:PRK11633 104 VEPPKPKPVEKPK---PKPKPQQKVEAPPAPKPEPKPVVEEKA 143
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 405-594 1.45e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.39  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  405 AVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRdednhQKEETVTQP 484
Cdd:PRK07994 365 LPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQ-----RAQGATKAK 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  485 KREktPVEKSFPKPASSPVTFSEDVKKEPSEEKKLEVSDEAP--KAAPLAESKKVEEKEPfyvSKDKKDISAVNLADLNK 562
Cdd:PRK07994 440 KSE--PAAASRARPVNSALERLASVRPAPSALEKAPAKKEAYrwKATNPVEVKKEPVATP---KALKKALEHEKTPELAA 514

                        170       180       190
                 ....*....|....*....|....*....|....
gi 19114087  563 RFEgfekryEEELAIRDWK--IAQLedKLAKLTE 594
Cdd:PRK07994 515 KLA------AEAIERDPWAalVSQL--GLPGLVE 540
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 321-470 2.25e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 40.82  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  321 LPKRGVNVSENEVMRAYKSVNDSII--EPISFIvprRSESFQSDIYPPAPSGKPSLTAEEWAS---GKDaqpdlldmstL 395
Cdd:PTZ00144  49 VPTMGDSISEGTVVEWKKKVGDYVKedEVICII---ETDKVSVDIRAPASGVITKIFAEEGDTvevGAP----------L 115

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114087  396 YESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPK-ESAEEQKPSKEPEVKPTTPSASKVEEPSKKR 470
Cdd:PTZ00144 116 SEIDTGGAPPAAAPAAAAAAKAEKTTPEKPKAAAPTPEPPAASKpTPPAAAKPPEPAPAAKPPPTPVARADPRETR 191
PTZ00121 PTZ00121
MAEBL; Provisional
 397-599 2.82e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   397 ESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKpttpsasKVEEpsKKRDEDNHQ 476
Cdd:PTZ00121 1173 EDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVK-------KAEE--AKKDAEEAK 1243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   477 KEETVTQPKREKTPVEKSFPKPASSPVTFSEDVKKEPSEEKKLEVSDEAPKAAPLAESKKVEEKEPFYVSKDKKDISAVN 556
Cdd:PTZ00121 1244 KAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKK 1323

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 19114087   557 LADLNKRFEGFEKRYEEELAIRDWKIAQlEDKLAKLTEAIKEK 599
Cdd:PTZ00121 1324 AEEAKKKADAAKKKAEEAKKAAEAAKAE-AEAAADEAEAAEEK 1365
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
 422-497 3.04e-03

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 468201 [Multi-domain]  Cd Length: 684  Bit Score: 40.77  E-value: 3.04e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114087  422 EEKV-ETPKPEAQPVSKPKESAEEQKPSKEPEV-KPTTPSASKVEEPSKKRDEDNHQKeETVTQPKREKTPVEKSFPK 497
Cdd:NF033838 409 EDKVkEKPAEQPQPAPAPQPEKPAPKPEKPAEQpKAEKPADQQAEEDYARRSEEEYNR-LTQQQPPKTEKPAQPSTPK 485
PTZ00121 PTZ00121
MAEBL; Provisional
 376-598 3.23e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 3.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   376 AEEWASGKDAQPDLLDMSTLYESKGTVEKAVSATVPSAGAQVQKHNEE---KVETPKPEAQPVskpKESAEEQKPSKEpe 452
Cdd:PTZ00121 1440 AEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEakkKAEEAKKKADEA---KKAAEAKKKADE-- 1514

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   453 vkpttpsASKVEEpSKKRDEDNHQKEETVTQPKREKTPVEKSFPKPASSPVTFSEDVKKepSEEKKLEVSDEAPKAAPLA 532
Cdd:PTZ00121 1515 -------AKKAEE-AKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKK--AEEAKKAEEDKNMALRKAE 1584

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087   533 ESKKVEEKEPFYVSKDKKDISAVNLADLNK----RFEGFEKRYEEELAIRDWKIAQLEDKLAKLTEAIKE 598
Cdd:PTZ00121 1585 EAKKAEEARIEEVMKLYEEEKKMKAEEAKKaeeaKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKK 1654
PRK10819 PRK10819
transport protein TonB; Provisional
 395-501 3.87e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 39.28  E-value: 3.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  395 LYESKGTVEKAVSATVPSAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVEEPSKKRDEDN 474
Cdd:PRK10819  31 LYTSVHQVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIPKPEPKPKPKPKPKPKPV 110

                         90       100
                 ....*....|....*....|....*..
gi 19114087  475 HQKEEtvtQPKREKTPVEksfPKPASS 501
Cdd:PRK10819 111 KKVEE---QPKREVKPVE---PRPASP 131
PRK13108 PRK13108
prolipoprotein diacylglyceryl transferase; Reviewed
 332-492 5.39e-03

prolipoprotein diacylglyceryl transferase; Reviewed


Pssm-ID: 237284 [Multi-domain]  Cd Length: 460  Bit Score: 39.58  E-value: 5.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  332 EVMRAYKSVNDSIIEPISFIVPRRSESFQSDIYPPAPSGKPSLTAEEWASGKDAQPDLLDMSTLyESKGTVEKAVSATVP 411
Cdd:PRK13108 283 GALRGSEYVVDEALEREPAELAAAAVASAASAVGPVGPGEPNQPDDVAEAVKAEVAEVTDEVAA-ESVVQVADRDGESTP 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  412 ----SAGAQVQKHNEEKVETPKPEAQPVSKPKESAEEQKPSKEPevkPTTPSASKVEEPSKKRDEDNHQKEETVTQPKRE 487
Cdd:PRK13108 362 aveeTSEADIEREQPGDLAGQAPAAHQVDAEAASAAPEEPAALA---SEAHDETEPEVPEKAAPIPDPAKPDELAVAGPG 438


                 ....*
gi 19114087  488 KTPVE 492
Cdd:PRK13108 439 DDPAE 443
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 423-537 8.30e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 39.02  E-value: 8.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114087  423 EKVETPKPEAQPVSKPKESAEEQKPSKEPEVKPTTPSASKVeePSKKrdednhqkeetvtqPKREKTPVEKSFPKPASSP 502
Cdd:PRK14950 357 EALLVPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANI--PPKE--------------PVRETATPPPVPPRPVAPP 420

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 19114087  503 V-TFSEDVKKEPSEEKKLEVSDEAPKAAPLAESKKV 537
Cdd:PRK14950 421 VpHTPESAPKLTRAAIPVDEKPKYTPPAPPKEEEKA 456
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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