|
Name |
Accession |
Description |
Interval |
E-value |
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
119-1000 |
1.28e-161 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 494.84 E-value: 1.28e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 119 AKTYPFELDPFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYRELLSEFG--DVG 196
Cdd:COG4581 19 AEERGFELDPFQEEAILALEAGRSVLVAAPTGSGKTLVAEFAIFLALARGRRSFYTAPIKALSNQKFFDLVERFGaeNVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 197 LMTGDVSINPSASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILLPDAIRFIFLSATLPNAL 276
Cdd:COG4581 99 LLTGDASVNPDAPIVVMTTEILRNMLYREGADLEDVGVVVMDEFHYLADPDRGWVWEEPIIHLPARVQLVLLSATVGNAE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 277 QFARWISEIHkQPCHVVYTDYRPTPL-QHFIYPqgaDGIYMLvdeknkfktenFKKVLEVLDHSTRQEnysksskkvkks 355
Cdd:COG4581 179 EFAEWLTRVR-GETAVVVSEERPVPLeFHYLVT---PRLFPL-----------FRVNPELLRPPSRHE------------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 356 sslerIINMVLSNRYDPIIVFCFSKKECEINAHQFGKLDLNDTENKELVTEIFDSAinqlsEEDRGLRQFEEMRSLLLRG 435
Cdd:COG4581 232 -----VIEELDRGGLLPAIVFIFSRRGCDEAAQQLLSARLTTKEERAEIREAIDEF-----AEDFSVLFGKTLSRLLRRG 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 436 IGIHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLFTKAQKFSGNNFRWLTSGEYMQMSGRAGRRGIDT 515
Cdd:COG4581 302 IAVHHAGMLPKYRRLVEELFQAGLLKVVFATDTLAVGINMPARTVVFTKLSKFDGERHRPLTAREFHQIAGRAGRRGIDT 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 516 KGLSIVILDQSIDEQAARCLMNGQADVLNSAFHLSYGMILNLmrIEEISPE---DILKKSFYQFQNMESLPLIKEELMQL 592
Cdd:COG4581 382 EGHVVVLAPEHDDPKKFARLASARPEPLRSSFRPSYNMVLNL--LARPGLErarELLEDSFAQFQADRSVVGLARRAREL 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 593 KNEetsinipnetavkefhdlklqLEKYGEEIqkvmtHPDncLPYLQSgrliqiklggiifpwgvlvnvikrefDPNTRE 672
Cdd:COG4581 460 ERA---------------------LAGVVERL-----ACD--LGDLQE--------------------------YFALRQ 485
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 673 QVAPHE-------TYVLDVLLPISsnsmsnhkvnpSILVPPRPnetplyeivsVLLTAvcnissiriymprelnsneskL 745
Cdd:COG4581 486 PLSPLEalerespAYALDVVSVPE-----------ATLEDPRP----------VLLAQ---------------------D 523
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 746 RAYRRvnEVIEEFK-EIPYLDPLEhmhiesstlslSLRklEILEPK-LFDSPYYKDSKHRAEYHEFRKKLNLRaqikdis 823
Cdd:COG4581 524 RRARG--EAAAAMKaAIEYDERME-----------RLE--EVLRPHpLHECPLERAFELYRETHPWVRDIELR------- 581
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 824 tkiTNTEAiiqlRELKIRQRVLRRLGFCTLENVIDiKGRVACEITSgdellLVELIFQGFFNQMPPEEIAAALSCFVYED 903
Cdd:COG4581 582 ---PKSVA----RDFDRFCELLREYGYLDDLTLTS-EGLLLRYLYD-----AAEALRQGVPDDLDPEELAALISWLVEEV 648
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 904 KSEVSTLNLKEPFKKmyltIIEAakRIATVSLESKLQFNESDylHQFKPDIMEPVSLWINGASFQEICIVSKLYEGSIVR 983
Cdd:COG4581 649 RRVDSSEWERLPSPA----NRRA--FVLVNALFRRLELLERR--HGLPELDPGLAGAWASGADLAEVLDATDLDAGDFVR 720
|
890 900
....*....|....*....|
gi 19114484 984 TFRRL---DELLKQLEHAAI 1000
Cdd:COG4581 721 WVRQVidpDPELRRTARAAV 740
|
|
| DEXHc_Mtr4-like |
cd18024 |
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or ... |
94-298 |
7.65e-156 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase Mtr4; Mtr4 (also known as DOB1 or SKIV2L2) is a type II DEAD box helicase that plays a role in the processing of structured RNAs, including the maturation of 5.8S ribosomal RNA (rRNA)and is part of the TRAMP complex that is involved in exosome-mediated degradation of aberrant RNAs. Mtr4 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350782 [Multi-domain] Cd Length: 205 Bit Score: 458.83 E-value: 7.65e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 94 ALHKVVVPDDYDYIPLNKHIPSDPPAKTYPFELDPFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIY 173
Cdd:cd18024 1 CTHEVALPPDYDYTPISAHKPPGNPARTYPFTLDPFQKTAIACIERNESVLVSAHTSAGKTVVAEYAIAQSLRDKQRVIY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 174 TSPIKSLSNQKYRELLSEFGDVGLMTGDVSINPSASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWE 253
Cdd:cd18024 81 TSPIKALSNQKYRELQEEFGDVGLMTGDVTINPNASCLVMTTEILRSMLYRGSEIMREVAWVIFDEIHYMRDKERGVVWE 160
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 19114484 254 ETLILLPDAIRFIFLSATLPNALQFARWISEIHKQPCHVVYTDYR 298
Cdd:cd18024 161 ETIILLPDKVRYVFLSATIPNARQFAEWICKIHKQPCHVVYTDYR 205
|
|
| DEXHc_SKIV2L |
cd18027 |
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also ... |
118-295 |
3.53e-86 |
|
DEXH-box helicase domain of SKIV2L; Superkiller viralicidic activity 2-like (SKIV2L, also called SKI2 or DHX13) plays a role in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. SKIV2L belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350785 [Multi-domain] Cd Length: 179 Bit Score: 274.91 E-value: 3.53e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 118 PAKTYPFELDPFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYRELLSEFGDVGL 197
Cdd:cd18027 1 PAFKWPFELDVFQKQAILHLEAGDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSNQKFRDFKNTFGDVGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 198 MTGDVSINPSASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILLPDAIRFIFLSATLPNALQ 277
Cdd:cd18027 81 ITGDVQLNPEASCLIMTTEILRSMLYNGSDVIRDLEWVIFDEVHYINDAERGVVWEEVLIMLPDHVSIILLSATVPNTVE 160
|
170
....*....|....*...
gi 19114484 278 FARWISEIHKQPCHVVYT 295
Cdd:cd18027 161 FADWIGRIKKKNIYVIST 178
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
119-596 |
2.70e-73 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 252.12 E-value: 2.70e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 119 AKTYPFELDPFQSTAI-KCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYREL---LSEFG- 193
Cdd:COG1204 16 KERGIEELYPPQAEALeAGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGKALYIVPLRALASEKYREFkrdFEELGi 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 194 DVGLMTGDVSINP----SASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWE---ETLILLPDAIRFI 266
Cdd:COG1204 96 KVGVSTGDYDSDDewlgRYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDESRGPTLEvllARLRRLNPEAQIV 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 267 FLSATLPNALQFARWIseihkqPCHVVYTDYRPTPLQHFIYpqgadgiymlVDEKNKFKTENFKKVLEVLDhstrqenys 346
Cdd:COG1204 176 ALSATIGNAEEIAEWL------DAELVKSDWRPVPLNEGVL----------YDGVLRFDDGSRRSKDPTLA--------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 347 ksskkvkkssslerIINMVLSNRyDPIIVFCFSKKECEINAHQFGKLdLNDTENKELVTEIfDSAINQLSEEDRGLRQFE 426
Cdd:COG1204 231 --------------LALDLLEEG-GQVLVFVSSRRDAESLAKKLADE-LKRRLTPEEREEL-EELAEELLEVSEETHTNE 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 427 EMRSLLLRGIGIHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLFTKAQKFSGNnfrWLTSGEYMQMSG 506
Cdd:COG1204 294 KLADCLEKGVAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKRGGMV---PIPVLEFKQMAG 370
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 507 RAGRRGIDTKGLSIVILDQS--IDEQAARCLmNGQADVLNSAFHLSYGMILNLMRI---------EEIspEDILKKSFYQ 575
Cdd:COG1204 371 RAGRPGYDPYGEAILVAKSSdeADELFERYI-LGEPEPIRSKLANESALRTHLLALiasgfansrEEL--LDFLENTFYA 447
|
490 500
....*....|....*....|...
gi 19114484 576 FQNMESLP--LIKEELMQLKNEE 596
Cdd:COG1204 448 YQYDKGDLeeVVDDALEFLLENG 470
|
|
| rRNA_proc-arch |
pfam13234 |
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating ... |
566-826 |
2.61e-72 |
|
rRNA-processing arch domain; Mtr4 is the essential RNA helicase, and is an exosome-activating cofactor. This arch domain is carried in Mtr4 and Ski2 (the cytosolic homolog of Mtr4). The arch domain is required for proper 5.8S rRNA processing, and appears to function independently of canonical helicase activity.
Pssm-ID: 463813 Cd Length: 267 Bit Score: 240.65 E-value: 2.61e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 566 EDILKKSFYQFQNMESLPLIKEELMQLKNEETSINIPNETAVKEFHDLKLQLEKYGEEIQKVMTHPDNCLPYLQSGRLIQ 645
Cdd:pfam13234 1 EYMLKRSFSQFQNQASLPELEKKLKELEKELASIKIPDEEDIKEYYDLRQQLEKLNEDIREVILHPPYGLPFLQPGRLVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 646 IKL-GGIIFPWGVLVNVIKRefdPNTREQVAPHETYVLDVLLPISSNSM-----SNHKVNPSILVPPRPNETPLYEIVSV 719
Cdd:pfam13234 81 VKDnGDQDFGWGVVVNFKKR---KKNGKAEPPQESYIVDVLLVLALVSSpedldKFNDVNPEGFRPAPPGEKGEMEVVPV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 720 LLTAVCNISSIRIYMPRELNSNESKLRAYRRVNEVIEEFKE-IPYLDPLEHMHIESSTLSLSLRKLEILEPKLFDSPYYK 798
Cdd:pfam13234 158 PLSDIEAISSVRLKLPKDLRPAEAREAVLKALQELKRRFPDgIPLLDPIEDMKIKDDEFKELLRKIEVLESRLESHPLHK 237
|
250 260
....*....|....*....|....*...
gi 19114484 799 DSKHRAEYHEFRKKLNLRAQIKDISTKI 826
Cdd:pfam13234 238 SPRLEELYALYHEKVELQEEIKELKKEI 265
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
125-286 |
7.47e-57 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 194.02 E-value: 7.47e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 125 ELDPFQSTAIKCV-ERMESVLVSAHTSAGKTVIAEYAIAQAL-KNRQRVIYTSPIKSLSNQKYRELLSEFG----DVGLM 198
Cdd:cd17921 1 LLNPIQREALRALyLSGDSVLVSAPTSSGKTLIAELAILRALaTSGGKAVYIAPTRALVNQKEADLRERFGplgkNVGLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 199 TGDVSINPS----ASCLIMTTEILRAMLYKNSE-IMHEIAWVIFDEVHYMRDKDRGVVWEETLILLP---DAIRFIFLSA 270
Cdd:cd17921 81 TGDPSVNKLllaeADILVATPEKLDLLLRNGGErLIQDVRLVVVDEAHLIGDGERGVVLELLLSRLLrinKNARFVGLSA 160
|
170
....*....|....*.
gi 19114484 271 TLPNALQFARWISEIH 286
Cdd:cd17921 161 TLPNAEDLAEWLGVED 176
|
|
| DSHCT |
pfam08148 |
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box ... |
855-1023 |
1.49e-53 |
|
DSHCT (NUC185) domain; This C terminal domain is found in DOB1/SK12/helY-like DEAD box helicases.
Pssm-ID: 462374 Cd Length: 154 Bit Score: 183.81 E-value: 1.49e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 855 NVIDIKGRVACEITSGDELLLVELIFQGFFNQMPPEEIAAALSCFVYEDKSEVSTLnLKEPFKKMYLTIIEAAKRIATVS 934
Cdd:pfam08148 1 DVVTLKGRVACEIRSENELLLTELLFSGVFDDLDPEELAALLSAFVFEEKRREPYL-PSPELAEALRLLEEIAHRIAVSR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 935 LesklqfnesdylhqFKPDIMEPVSLWINGASFQEICIVSKLYEGSIVRTFRRLDELLKQLEHAAIVLGNNELKEKSVLT 1014
Cdd:pfam08148 80 F--------------LDFGLMEVVYAWARGASFAEICKLTDLDEGDIVRLIRRLDELLRQIANAAKIIGDPELREKAEEA 145
|
....*....
gi 19114484 1015 EQKLHRDII 1023
Cdd:pfam08148 146 IELIKRDIV 154
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
298-522 |
3.91e-53 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 182.37 E-value: 3.91e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 298 RPTPLQHFIYPQGADGIYMLVDEKNKFKTENFKKVlevldhstrqenysksskkvkkssslerIINMVLSNRydPIIVFC 377
Cdd:cd18795 1 RPVPLEEYVLGFNGLGIKLRVDVMNKFDSDIIVLL----------------------------KIETVSEGK--PVLVFC 50
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 378 FSKKECEINAhqfgkldlndtenkelvteifdsainqlseedrglrqfeemrsLLLRGIGIHHSGLLPILKELVEILFQE 457
Cdd:cd18795 51 SSRKECEKTA-------------------------------------------KDLAGIAFHHAGLTREDRELVEELFRE 87
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19114484 458 GLVRILFATETFSIGLNMPARTVLFTKAQKFSGNNFRWLTSGEYMQMSGRAGRRGIDTKGLSIVI 522
Cdd:cd18795 88 GLIKVLVATSTLAAGVNLPARTVIIKGTQRYDGKGYRELSPLEYLQMIGRAGRPGFDTRGEAIIM 152
|
|
| KOW_Mtr4 |
cd13154 |
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a ... |
637-765 |
4.00e-48 |
|
KOW_Mtr4 is an inserted domain in Mtr4 globular domain; Mtr4 is a conserved helicase with a core DExH region that cooperates with the eukaryotic nuclear exosome in RNA processing and degradation. KOW_Mtr4 motif might be involved in presenting RNA substrates to the helicase core. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. KOW motif is located at the extended insertion of Mtr4 protein.
Pssm-ID: 240518 Cd Length: 129 Bit Score: 167.37 E-value: 4.00e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 637 YLQSGRLIQIKLGGIIFPWGVLVNVIKREFDPNTREQVAPHETYVLDVLLPISSNSMSNhKVNPSILVPPRPNETPLYEI 716
Cdd:cd13154 1 FLQPGRLVKVKVGDDDFGWGVVVNFQKRPNKKNGSENSPPQESYVVDVLLNCSSGSSIN-NGSPSGIRPPGPGEKGEMEV 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 19114484 717 VSVLLTAVCNISSIRIYMPRELNSNESKLRAYRRVNEVIEEFKE-IPYLD 765
Cdd:cd13154 80 VPVLLSLIQAISSIRLYLPKDLRSADARQSVGKSLQEVKRRFPDgLPLLD 129
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
124-582 |
9.17e-37 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 148.49 E-value: 9.17e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 124 FELDPFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYREL--LSEFG-DVGLMTG 200
Cdd:PRK01172 21 FELYDHQRMAIEQLRKGENVIVSVPTAAGKTLIAYSAIYETFLAGLKSIYIVPLRSLAMEKYEELsrLRSLGmRVKISIG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 201 DVSINPS----ASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETL----ILLPDAiRFIFLSATL 272
Cdd:PRK01172 101 DYDDPPDfikrYDVVILTSEKADSLIHHDPYIINDVGLIVADEIHIIGDEDRGPTLETVLssarYVNPDA-RILALSATV 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 273 PNALQFARWISeihkqpCHVVYTDYRPTPLQHFIypqgadgIY---MLVDEKNKFKTENFKKVLEVLDHSTRqenyskss 349
Cdd:PRK01172 180 SNANELAQWLN------ASLIKSNFRPVPLKLGI-------LYrkrLILDGYERSQVDINSLIKETVNDGGQ-------- 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 350 kkvkksssleriinmvlsnrydpIIVFCFSKKECEINAHQFGKL--DLNDTENKELVTEIFDSAINQlseedrglrqfee 427
Cdd:PRK01172 239 -----------------------VLVFVSSRKNAEDYAEMLIQHfpEFNDFKVSSENNNVYDDSLNE------------- 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 428 mrsLLLRGIGIHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLFTKAQKFSGNNFRWLTSGEYMQMSGR 507
Cdd:PRK01172 283 ---MLPHGVAFHHAGLSNEQRRFIEEMFRNRYIKVIVATPTLAAGVNLPARLVIVRDITRYGNGGIRYLSNMEIKQMIGR 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 508 AGRRGIDTKGLSIVILDQSIDEQAARCLMNGQADVLNSAFHLSYGMILNLMRIEEI----SPEDILK---KSFYQFQNME 580
Cdd:PRK01172 360 AGRPGYDQYGIGYIYAASPASYDAAKKYLSGEPEPVISYMGSQRKVRFNTLAAISMglasSMEDLILfynETLMAIQNGV 439
|
..
gi 19114484 581 SL 582
Cdd:PRK01172 440 DE 441
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
125-529 |
3.88e-32 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 134.70 E-value: 3.88e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 125 ELDPFQSTAI-KCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYREL--LSEFG-DVGLMTG 200
Cdd:PRK02362 23 ELYPPQAEAVeAGLLDGKNLLAAIPTASGKTLIAELAMLKAIARGGKALYIVPLRALASEKFEEFerFEELGvRVGISTG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 201 D-------VSINpsaSCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILL----PDaIRFIFLS 269
Cdd:PRK02362 103 DydsrdewLGDN---DIIVATSEKVDSLLRNGAPWLDDITCVVVDEVHLIDSANRGPTLEVTLAKLrrlnPD-LQVVALS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 270 ATLPNALQFARWI-SEIhkqpchvVYTDYRPTPLQHFIYPQGAdgIYmLVDEKNKFKTENFKKVLevldhstrqenysks 348
Cdd:PRK02362 179 ATIGNADELADWLdAEL-------VDSEWRPIDLREGVFYGGA--IH-FDDSQREVEVPSKDDTL--------------- 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 349 skkvkksssleriiNMVLsnryDPI------IVFCFSKKECEINAHQFGKLdlndteNKELVTEIFDSAINQLSEEDRGL 422
Cdd:PRK02362 234 --------------NLVL----DTLeeggqcLVFVSSRRNAEGFAKRAASA------LKKTLTAAERAELAELAEEIREV 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 423 RQFEEMRSL---LLRGIGIHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLFTKAQKFSGN-NFRWLTS 498
Cdd:PRK02362 290 SDTETSKDLadcVAKGAAFHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRDYRRYDGGaGMQPIPV 369
|
410 420 430
....*....|....*....|....*....|.
gi 19114484 499 GEYMQMSGRAGRRGIDTKGLSiVILDQSIDE 529
Cdd:PRK02362 370 LEYHQMAGRAGRPGLDPYGEA-VLLAKSYDE 399
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
128-277 |
1.53e-30 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 118.50 E-value: 1.53e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 128 PFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQ---RVIYTSPIKSLSNQKYRELLSEFGDVGL----MTG 200
Cdd:pfam00270 2 PIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDngpQALVLAPTRELAEQIYEELKKLGKGLGLkvasLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 201 DVSINP------SASCLIMTTEILRAMLyKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILLPDAIRFIFLSATLPN 274
Cdd:pfam00270 82 GDSRKEqleklkGPDILVGTPGRLLDLL-QERKLLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLSATLPR 160
|
...
gi 19114484 275 ALQ 277
Cdd:pfam00270 161 NLE 163
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
123-305 |
2.54e-30 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 119.13 E-value: 2.54e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 123 PFELDPFQSTAIKCV-ERMESVLVSAHTSAGKTVIAEYAIAQALKNRQ--RVIYTSPIKSLSNQKYRELLSEFGD----- 194
Cdd:smart00487 6 FEPLRPYQKEAIEALlSGLRDVILAAPTGSGKTLAALLPALEALKRGKggRVLVLVPTRELAEQWAEELKKLGPSlglkv 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 195 VGLMTGDVS-------INPSASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILLPDAIRFIF 267
Cdd:smart00487 86 VGLYGGDSKreqlrklESGKTDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKLLPKNVQLLL 165
|
170 180 190
....*....|....*....|....*....|....*...
gi 19114484 268 LSATLPNALQFARWisEIHKQPCHVVYTDYRPTPLQHF 305
Cdd:smart00487 166 LSATPPEEIENLLE--LFLNDPVFIDVGFTPLEPIEQF 201
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
127-298 |
9.82e-30 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 117.08 E-value: 9.82e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 127 DPFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALK--NRQRVIYTSPIKSLSNQKYRELLSEFGD---------V 195
Cdd:cd18025 3 DAWQRELLDIVDRRESALIVAPTSSGKTFISYYCMEKVLResDDGVVVYVAPTKALVNQVVAEVYARFSKkyppsgkslW 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 196 GLMTGDVSINPSASCLIMTT--EILRAMLY--KNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILLPdaIRFIFLSAT 271
Cdd:cd18025 83 GVFTRDYRHNNPMNCQVLITvpECLEILLLspHNASWVPRIKYVIFDEIHSIGQSEDGAVWEQLLLLIP--CPFLALSAT 160
|
170 180 190
....*....|....*....|....*....|
gi 19114484 272 LPNALQFARWISEI---HKQPCHVVYTDYR 298
Cdd:cd18025 161 IGNPQKFHEWLQSVqraRKAELKKIEHNHR 190
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
125-522 |
4.24e-28 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 121.85 E-value: 4.24e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 125 ELDPFQSTAIKC-VERMESVLVSAHTSAGKTVIAEYAIA-QALKNRQRVIYTSPIKSLSNQKYRELlSEFGDVGL----M 198
Cdd:PRK00254 23 ELYPPQAEALKSgVLEGKNLVLAIPTASGKTLVAEIVMVnKLLREGGKAVYLVPLKALAEEKYREF-KDWEKLGLrvamT 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 199 TGDVSINPS----ASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILLPDAIRFIFLSATLPN 274
Cdd:PRK00254 102 TGDYDSTDEwlgkYDIIIATAEKFDSLLRHGSSWIKDVKLVVADEIHLIGSYDRGATLEMILTHMLGRAQILGLSATVGN 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 275 ALQFARWISeihkqpCHVVYTDYRPTPLQHFIYPQG----ADGiymlvdeknkfKTENFKKVLEVLdhstrqenyskssk 350
Cdd:PRK00254 182 AEELAEWLN------AELVVSDWRPVKLRKGVFYQGflfwEDG-----------KIERFPNSWESL-------------- 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 351 kvkkssslerIINMVlsNRYDPIIVFCFSKKECEINAHQFGKLDLNDTENKELvteifdSAINQLSEEDRGLRQFEEMRS 430
Cdd:PRK00254 231 ----------VYDAV--KKGKGALVFVNTRRSAEKEALELAKKIKRFLTKPEL------RALKELADSLEENPTNEKLKK 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 431 LLLRGIGIHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLFTKAQKFSgnNFRW--LTSGEYMQMSGRA 508
Cdd:PRK00254 293 ALRGGVAFHHAGLGRTERVLIEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYS--NFGWedIPVLEIQQMMGRA 370
|
410
....*....|....
gi 19114484 509 GRRGIDTKGLSIVI 522
Cdd:PRK00254 371 GRPKYDEVGEAIIV 384
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
125-282 |
4.33e-25 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 103.18 E-value: 4.33e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 125 ELDPFQSTAI-KCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYREL--LSEFG-DVGLMTG 200
Cdd:cd18028 1 ELYPPQAEAVrAGLLKGENLLISIPTASGKTLIAEMAMVNTLLEGGKALYLVPLRALASEKYEEFkkLEEIGlKVGISTG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 201 DVSIN----PSASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLI---LLPDAIRFIFLSATLP 273
Cdd:cd18028 81 DYDEDdewlGDYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVArlrRLNPNTQIIGLSATIG 160
|
....*....
gi 19114484 274 NALQFARWI 282
Cdd:cd18028 161 NPDELAEWL 169
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
130-284 |
2.97e-22 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 95.89 E-value: 2.97e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 130 QSTAIK-CVERMESVLVSAHTSAGKTVIAEYAIAQALK-------NRQRVIYTSPIKSLSNQKYRELLSEFGDVGL---- 197
Cdd:cd18023 6 QSEVFPdLLYSDKNFVVSAPTGSGKTVLFELAILRLLKernplpwGNRKVVYIAPIKALCSEKYDDWKEKFGPLGLscae 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 198 MTGDVSINPS---ASC-LIMTT-EILRAMLYK---NSEIMHEIAWVIFDEVHYMRDKdRGVVWE-------------ETL 256
Cdd:cd18023 86 LTGDTEMDDTfeiQDAdIILTTpEKWDSMTRRwrdNGNLVQLVALVLIDEVHIIKEN-RGATLEvvvsrmktlssssELR 164
|
170 180
....*....|....*....|....*...
gi 19114484 257 ILLPDAIRFIFLSATLPNALQFARWISE 284
Cdd:cd18023 165 GSTVRPMRFVAVSATIPNIEDLAEWLGD 192
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
141-282 |
3.53e-17 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 79.93 E-value: 3.53e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 141 ESVLVSAHTSAGKTVIAEYAIAQALKNRQ----RVIYTSPIKSLSNQKYR---ELLSEFG---DVGLMTGDVS------- 203
Cdd:cd17922 2 RNVLIAAPTGSGKTEAAFLPALSSLADEPekgvQVLYISPLKALINDQERrleEPLDEIDleiPVAVRHGDTSqsekakq 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 204 -INPSaSCLIMTTEILRAMLY--KNSEIMHEIAWVIFDEVHYMRDKDRGVVWEETLILL-----PDAIRfIFLSATLPNA 275
Cdd:cd17922 82 lKNPP-GILITTPESLELLLVnkKLRELFAGLRYVVVDEIHALLGSKRGVQLELLLERLrkltgRPLRR-IGLSATLGNL 159
|
....*..
gi 19114484 276 LQFARWI 282
Cdd:cd17922 160 EEAAAFL 166
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
125-510 |
4.79e-16 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 83.02 E-value: 4.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 125 ELDPFQSTAIK--CVERMESVLVSAhTSAGKTVIAEYA-IAQALKNRQRVIYTSPIKSLSNQKYRELLSEFG---DVGLM 198
Cdd:COG1202 209 ELLPVQSLAVEngLLEGKDQLVVSA-TATGKTLIGELAgIKNALEGKGKMLFLVPLVALANQKYEDFKDRYGdglDVSIR 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 199 TGDVSIN-------PSASCLIMTTE----ILRAmlyknSEIMHEIAWVIFDEVHYMRDKDRGVVWeETLI-----LLPDA 262
Cdd:COG1202 288 VGASRIRddgtrfdPNADIIVGTYEgidhALRT-----GRDLGDIGTVVIDEVHMLEDPERGHRL-DGLIarlkyYCPGA 361
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 263 iRFIFLSATLPNALQFARwiseihKQPCHVVYTDYRPTPLQ-HFIYpqgadgiymlVDEKNKfktenfkkvlevldhstr 341
Cdd:COG1202 362 -QWIYLSATVGNPEELAK------KLGAKLVEYEERPVPLErHLTF----------ADGREK------------------ 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 342 qenysksskkvkkssslERIINMVLSNRYDPI---------IVFCFSKKECEINAHQFGkldlndtenkelvteiFDSAi 412
Cdd:COG1202 407 -----------------IRIINKLVKREFDTKsskgyrgqtIIFTNSRRRCHEIARALG----------------YKAA- 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 413 nqlseedrglrqfeemrslllrgigIHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLF-TKAQkfsGN 491
Cdd:COG1202 453 -------------------------PYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFdSLAM---GI 504
|
410
....*....|....*....
gi 19114484 492 NfrWLTSGEYMQMSGRAGR 510
Cdd:COG1202 505 E--WLSVQEFHQMLGRAGR 521
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
141-271 |
6.84e-15 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 72.82 E-value: 6.84e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 141 ESVLVSAHTSAGKTVIAEYAIAQ-ALKNRQRVIYTSPIKSLSNQKYRELLSEFG---DVGLMTGDVS-------INPSAS 209
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLlLLKKGKKVLVLVPTKALALQTAERLRELFGpgiRVAVLVGGSSaeereknKLGDAD 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19114484 210 CLIMTTE-ILRAMLYKNSEIMHEIAWVIFDEVHyMRDKDRGVVWEETLIL----LPDAiRFIFLSAT 271
Cdd:cd00046 82 IIIATPDmLLNLLLREDRLFLKDLKLIIVDEAH-ALLIDSRGALILDLAVrkagLKNA-QVILLSAT 146
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
141-299 |
1.61e-13 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 70.32 E-value: 1.61e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 141 ESVLVSAHTSAGKTVIAEYAIAQALKNRQRV-IYTSPIKSLSNQKYRELLSEFGDVGL----MTGDVSINP-----SASC 210
Cdd:cd18026 34 RNLVYSLPTSGGKTLVAEILMLKRLLERRKKaLFVLPYVSIVQEKVDALSPLFEELGFrvegYAGNKGRSPpkrrkSLSV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 211 LIMTTEilRAMLYKNSEI----MHEIAWVIFDEVHYMRDKDRGVVWEETLILL----PDAIRFIFLSATLPNALQFARWI 282
Cdd:cd18026 114 AVCTIE--KANSLVNSLIeegrLDELGLVVVDELHMLGDGHRGALLELLLTKLlyaaQKNIQIVGMSATLPNLEELASWL 191
|
170
....*....|....*..
gi 19114484 283 SeihkqpCHVVYTDYRP 299
Cdd:cd18026 192 R------AELYTTNFRP 202
|
|
| DEXHc_Brr2_2 |
cd18021 |
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type ... |
128-282 |
3.57e-12 |
|
C-terminal D[D/E]X[H/Q]-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350779 [Multi-domain] Cd Length: 191 Bit Score: 66.13 E-value: 3.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 128 PFQSTAIKCVERM-ESVLVSAHTSAGKTVIAEYAIAQALKN--RQRVIYTSPIKSLSNQKYRELLSEFGDVG-----LMT 199
Cdd:cd18021 6 PIQTQVFNSLYNTdDNVFVGAPTGSGKTVCAELALLRHWRQnpKGRAVYIAPMQELVDARYKDWRAKFGPLLgkkvvKLT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 200 GDVSINP---SASCLIMTTEILRAML---YKNSEIMHEIAWVIFDEVHyMRDKDRGVVWEETL-------ILLPDAIRFI 266
Cdd:cd18021 86 GETSTDLkllAKSDVILATPEQWDVLsrrWKQRKNVQSVELFIADELH-LIGGENGPVYEVVVsrmryisSQLEKPIRIV 164
|
170
....*....|....*.
gi 19114484 267 FLSATLPNALQFARWI 282
Cdd:cd18021 165 GLSSSLANARDVGEWL 180
|
|
| DEXHc_ASCC3_2 |
cd18022 |
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
141-282 |
7.18e-12 |
|
C-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350780 [Multi-domain] Cd Length: 189 Bit Score: 65.47 E-value: 7.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 141 ESVLVSAHTSAGKTVIAEYAIAQALKNR--QRVIYTSPIKSLSNQKYRELLSEFGDV-GL----MTGDVSINP----SAS 209
Cdd:cd18022 18 NNVLLGAPTGSGKTIAAELAMFRAFNKYpgSKVVYIAPLKALVRERVDDWKKRFEEKlGKkvveLTGDVTPDMkalaDAD 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 210 CLIMTTE----ILRAmlYKNSEIMHEIAWVIFDEVHyMRDKDRGVVWEetLIL---------LPDAIRFIFLSATLPNAL 276
Cdd:cd18022 98 IIITTPEkwdgISRS--WQTREYVQQVSLIIIDEIH-LLGSDRGPVLE--VIVsrmnyissqTEKPVRLVGLSTALANAG 172
|
....*.
gi 19114484 277 QFARWI 282
Cdd:cd18022 173 DLANWL 178
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
435-512 |
4.27e-11 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 59.92 E-value: 4.27e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19114484 435 GIGIHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMP-ARTVLFTKAqkfsgnnfrWLTSGEYMQMSGRAGRRG 512
Cdd:smart00490 13 KVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDL---------PWSPASYIQRIGRAGRAG 82
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
128-301 |
9.12e-11 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 66.28 E-value: 9.12e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 128 PFQSTAIKCVERMESVLVSAHTSAGKT------VIAEYA---IAQALKNRQRVIYTSPIKSLSNQKYREL---LSEFGD- 194
Cdd:COG1201 27 PPQREAWPAIAAGESTLLIAPTGSGKTlaaflpALDELArrpRPGELPDGLRVLYISPLKALANDIERNLrapLEEIGEa 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 195 ---------VGLMTGDVSI--------NPsASCLIMTTEILRAML-YKNS-EIMHEIAWVIFDEVHYMRDKDRGVVWEET 255
Cdd:COG1201 107 aglplpeirVGVRTGDTPAserqrqrrRP-PHILITTPESLALLLtSPDArELLRGVRTVIVDEIHALAGSKRGVHLALS 185
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 19114484 256 L----ILLPDAIRFIFLSATLPNALQFARWIS-EIHKQPCHVVYTDYRPTP 301
Cdd:COG1201 186 LerlrALAPRPLQRIGLSATVGPLEEVARFLVgYEDPRPVTIVDAGAGKKP 236
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
130-280 |
1.84e-10 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 61.06 E-value: 1.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 130 QSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQAL--KNRQRVIYTSPIKSLSN---QKYRELLSEFG---DVGLMTGD 201
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILEALlrDPGSRALYLYPTKALAQdqlRSLRELLEQLGlgiRVATYDGD 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 202 VSINPS-------ASCLIMTTEILRAMLYKNSEIMHEIA----WVIFDEVHYMRdkdrGVVWEETLILL----------P 260
Cdd:cd17923 85 TPREERraiirnpPRILLTNPDMLHYALLPHHDRWARFLrnlrYVVLDEAHTYR----GVFGSHVALLLrrlrrlcrryG 160
|
170 180
....*....|....*....|
gi 19114484 261 DAIRFIFLSATLPNALQFAR 280
Cdd:cd17923 161 ADPQFILTSATIGNPAEHAR 180
|
|
| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
141-282 |
8.64e-10 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 59.37 E-value: 8.64e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 141 ESVLVSAHTSAGKTVIAEYAIAQALKNRQR-----------VIYTSPIKSLSNQ---KYRELLSEFG-DVGLMTGDVSIN 205
Cdd:cd18020 18 ENMLICAPTGAGKTNIAMLTILHEIRQHVNqggvikkddfkIVYIAPMKALAAEmveKFSKRLAPLGiKVKELTGDMQLT 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 206 PS---ASCLIMTT-EILRAMLYKNS---EIMHEIAWVIFDEVHYMRDkDRGVVWE----ETLILLPDA---IRFIFLSAT 271
Cdd:cd18020 98 KKeiaETQIIVTTpEKWDVVTRKSSgdvALSQLVRLLIIDEVHLLHD-DRGPVIEslvaRTLRQVESTqsmIRIVGLSAT 176
|
170
....*....|.
gi 19114484 272 LPNALQFARWI 282
Cdd:cd18020 177 LPNYLDVADFL 187
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
119-279 |
1.25e-09 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 58.58 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 119 AKTYPFELDPFQSTAIKCV-------ERMESvLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYRELLSE 191
Cdd:cd17918 9 CKSLPFSLTKDQAQAIKDIekdlhspEPMDR-LLSGDVGSGKTLVALGAALLAYKNGKQVAILVPTEILAHQHYEEARKF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 192 FGD--VGLMTGDV--SINPSASCLIMTTEILRAmlyknSEIMHEIAWVIFDEVHYMrdkdrGVVWEETLILLpDAIRFIF 267
Cdd:cd17918 88 LPFinVELVTGGTkaQILSGISLLVGTHALLHL-----DVKFKNLDLVIVDEQHRF-----GVAQREALYNL-GATHFLE 156
|
170
....*....|...
gi 19114484 268 LSAT-LPNALQFA 279
Cdd:cd17918 157 ATATpIPRTLALA 169
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
50-271 |
1.76e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 61.58 E-value: 1.76e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 50 IIENLSDSSVNKEYAKNSLKLSDAVSESKYLNPLLKDKRHDRSFALHKVVVPDDYDYIPLNKHIPSDPPAKTYPFELDPF 129
Cdd:COG1061 5 GIAERGADKLRSSLLLLDLERLELSLLRNLVEARRLAIKEGTREDGRRLPEEDTERELAEAEALEAGDEASGTSFELRPY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 130 QSTAIKCVERMES------VLVSAhTSAGKTVIAeYAIAQALKNRQRVIYTSPIKSLSNQKYRELLSEFGDVGlmTGDVS 203
Cdd:COG1061 85 QQEALEALLAALErgggrgLVVAP-TGTGKTVLA-LALAAELLRGKRVLVLVPRRELLEQWAEELRRFLGDPL--AGGGK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19114484 204 INPSASCLIMTTEILRAMLYKNsEIMHEIAWVIFDEVHYMRDKdrgvVWEETLILLPDAIRfIFLSAT 271
Cdd:COG1061 161 KDSDAPITVATYQSLARRAHLD-ELGDRFGLVIIDEAHHAGAP----SYRRILEAFPAAYR-LGLTAT 222
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
126-274 |
4.18e-09 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 57.77 E-value: 4.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 126 LDPFQSTAIKC-VERMESVLVSAHTSAGKTVIAEYAIAQAL-KNRQR----------VIYTSPIKSLSNQKYREL---LS 190
Cdd:cd18019 18 LNRIQSKLFPAaFETDENLLLCAPTGAGKTNVALLTILREIgKHRNPdgtinldafkIVYIAPMKALVQEMVGNFskrLA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 191 EFG-DVGLMTGDVSINP---SASCLIMTT-EILRAMLYKNSEIMHE--IAWVIFDEVHYMRDkDRGVVWE-------ETL 256
Cdd:cd18019 98 PYGiTVAELTGDQQLTKeqiSETQIIVTTpEKWDIITRKSGDRTYTqlVRLIIIDEIHLLHD-DRGPVLEsivartiRQI 176
|
170
....*....|....*...
gi 19114484 257 ILLPDAIRFIFLSATLPN 274
Cdd:cd18019 177 EQTQEYVRLVGLSATLPN 194
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
111-525 |
5.10e-09 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 60.23 E-value: 5.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 111 KHIPSdPPAKTYPFE--LDP----------------FQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQA-LKNRQ-R 170
Cdd:COG1205 25 RTIPA-REARYAPWPdwLPPelraalkkrgierlysHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAlLEDPGaT 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 171 VIYTSPIKSLSN---QKYRELLSEFG---DVGLMTGDVS------INPSASCLIMTTEIL-RAMLYknseimHEIAW--- 234
Cdd:COG1205 104 ALYLYPTKALARdqlRRLRELAEALGlgvRVATYDGDTPpeerrwIREHPDIVLTNPDMLhYGLLP------HHTRWarf 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 235 ------VIFDEVH-YmrdkdRGV----VweeTLIL---------LPDAIRFIFLSATLPNALQFARWISEihkQPCHVVY 294
Cdd:COG1205 178 frnlryVVIDEAHtY-----RGVfgshV---ANVLrrlrricrhYGSDPQFILASATIGNPAEHAERLTG---RPVTVVD 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 295 TDYRPTPLQHFIY---PQGADGIYmlvdeknkfktenfkkvlevldHSTRQEnysksskkvkksssLERIINMVLSNRYd 371
Cdd:COG1205 247 EDGSPRGERTFVLwnpPLVDDGIR----------------------RSALAE--------------AARLLADLVREGL- 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 372 PIIVFCFSKKECEInahqfgkldlndtenkelvteIFDSAINQLSEEDRGLRqfeemrslllrgIGIHHSGLLPILKELV 451
Cdd:COG1205 290 RTLVFTRSRRGAEL---------------------LARYARRALREPDLADR------------VAAYRAGYLPEERREI 336
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 452 EILFQEGLVRILFATETFSIGLNMP---ArTVLftkaqkfSGNnfrwltSGEYM---QMSGRAGRRGIDtkGLSIVI--- 522
Cdd:COG1205 337 ERGLRSGELLGVVSTNALELGIDIGgldA-VVL-------AGY------PGTRAsfwQQAGRAGRRGQD--SLVVLVagd 400
|
....*
gi 19114484 523 --LDQ 525
Cdd:COG1205 401 dpLDQ 405
|
|
| SF2_C_suv3 |
cd18805 |
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene ... |
462-514 |
6.46e-08 |
|
C-terminal helicase domain of ATP-dependent RNA helicase; The SUV3 (suppressor of Var 3) gene encodes a DNA and RNA helicase, which is localized in mitochondria and is a subunit of the degradosome complex involved in regulation of RNA surveillance and turnover. SUV3 exhibits DNA and RNA-dependent ATPase, DNA and RNA-binding and DNA and RNA unwinding activities. SUV3 is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350192 [Multi-domain] Cd Length: 135 Bit Score: 52.56 E-value: 6.46e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 19114484 462 ILFATETFSIGLNMPARTVLFTKAQKFSGNNFRWLTSGEYMQMSGRAGRRGID 514
Cdd:cd18805 73 VLVASDAIGMGLNLNIRRVIFSSLSKFDGNEMRPLSPSEVKQIAGRAGRFGSH 125
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
125-250 |
3.28e-07 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 54.51 E-value: 3.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 125 ELDPFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAI---------AQALKNRQRVIYTSPIKSLSNQKYR--------- 186
Cdd:PRK13767 32 TFTPPQRYAIPLIHEGKNVLISSPTGSGKTLAAFLAIidelfrlgrEGELEDKVYCLYVSPLRALNNDIHRnleepltei 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 187 -ELLSEFGD------VGLMTGDVSINPSAS-------CLIMTTEILRAMLY--KNSEIMHEIAWVIFDEVHYMRDKDRGV 250
Cdd:PRK13767 112 rEIAKERGEelpeirVAIRTGDTSSYEKQKmlkkpphILITTPESLAILLNspKFREKLRTVKWVIVDEIHSLAENKRGV 191
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
358-512 |
4.07e-06 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 46.43 E-value: 4.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 358 LERIINMVLSNRYDPIIVFCFSKKECEInahqfgkldlndtenkelvteifdsainqlseedrglrqfEEMRSLLLRGIG 437
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEA----------------------------------------ELLLEKEGIKVA 42
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19114484 438 IHHSGLLPILKELVEILFQEGLVRILFATETFSIGLNMPARTVLFtkaqkfsgnNFR-WLTSGEYMQMSGRAGRRG 512
Cdd:pfam00271 43 RLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVI---------NYDlPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
143-281 |
4.09e-06 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 48.10 E-value: 4.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 143 VLVSAHTSAGKTVIAEYAIAQALKNR-QRVIYTSP----IKSLSNQKYRELLSEFGD-VGL-MTGDVSINPSASCLIMTT 215
Cdd:cd17990 20 VVLEAPPGAGKTTRVPLALLAELWIAgGKIIVLEPrrvaARAAARRLATLLGEAPGEtVGYrVRGESRVGRRTRVEVVTE 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 216 EILRAMLYKNSEiMHEIAWVIFDEVHyMRDKDR----GVVWEETLILLPDaIRFIFLSATLPNALQFARW 281
Cdd:cd17990 100 GVLLRRLQRDPE-LSGVGAVILDEFH-ERSLDAdlalALLLEVQQLLRDD-LRLLAMSATLDGDGLAALL 166
|
|
| DEXQc_Suv3 |
cd17913 |
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA ... |
149-252 |
8.03e-06 |
|
DEXQ-box helicase domain of Suv3; Suppressor of var1 3-like protein (Suv3) is a DNA/RNA unwinding enzyme belonging to the class of DexH-box helicases. It localizes predominantly in the mitochondria, where it forms an RNA-degrading complex called mitochondrial degradosome (mtEXO) with exonuclease PNP (polynucleotide phosphorylase), that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Suv3 plays a role in the RNA surveillance system in mitochondria; it regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. It also confers salinity and drought stress tolerance by maintaining both photosynthesis and antioxidant machinery, probably via an increase in plant hormone levels such as gibberellic acid (GA3), the cytokinin zeatin (Z), and indole-3-acetic acid (IAA). Suv3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350671 [Multi-domain] Cd Length: 142 Bit Score: 46.40 E-value: 8.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 149 TSAGKTviaeYAIAQALKNRQRVIYTSPIKSLSNQKYRELLSEFGDVGLMTGD-VSINPSASCLIMTTEilraMLYKNSE 227
Cdd:cd17913 10 TNSGKT----YHALQRLKSAKSGVYCGPLRLLAWEVYERLNAEGVPCDLVTGQeRREVEGATHVSCTVE----MASISEP 81
|
90 100
....*....|....*....|....*
gi 19114484 228 ImhEIAwVIfDEVHYMRDKDRGVVW 252
Cdd:cd17913 82 Y--DVA-VI-DEIQMIGDPQRGWAW 102
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
144-272 |
1.02e-05 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 46.53 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 144 LVSAHTSAGKTVIAEYAIAQALKnrQRVIYTSPIKSLSNQKYRELLSEFGD--VGLMTGDVSI-NPSASCLIMTTEILRA 220
Cdd:cd17926 22 ILVLPTGSGKTLTALALIAYLKE--LRTLIVVPTDALLDQWKERFEDFLGDssIGLIGGGKKKdFDDANVVVATYQSLSN 99
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 19114484 221 MLYKNSEIMHEIAWVIFDEVHYMrdkdRGVVWEETLILLPDAIRFiFLSATL 272
Cdd:cd17926 100 LAEEEKDLFDQFGLLIVDEAHHL----PAKTFSEILKELNAKYRL-GLTATP 146
|
|
| DEXHc_cas3 |
cd17930 |
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase ... |
143-276 |
3.33e-05 |
|
DEXH/Q-box helicase domain of Cas3; CRISPR-associated (Cas) 3 is a nuclease-helicase responsible for degradation of dsDNA. The two enzymatic units of Cas3, a histidine-aspartate (HD) nuclease and a Superfamily 2 (SF2) helicase, may be expressed from separate genes as Cas3' (SF2 helicase) and Cas3'' (HD nuclease) or may be fused as a single HD-SF2 polypeptide. The nucleolytic activity of most Cas3 enzymes is transition metal ion-dependent. Cas3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350688 [Multi-domain] Cd Length: 186 Bit Score: 45.75 E-value: 3.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 143 VLVSAHTSAGKTviaEYAIAQALKNR-----QRVIYTSPIKSLSNQ---KYRELLSEFGD---VGLMTGDVSIN------ 205
Cdd:cd17930 4 VILEAPTGSGKT---EAALLWALKLAarggkRRIIYALPTRATINQmyeRIREILGRLDDedkVLLLHSKAALEllesde 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 206 -PSASCLIMTTEILRAMLYKNSEIM---------------------HEIAW--VIFDEVH-----YMRdkdrGVVweETL 256
Cdd:cd17930 81 ePDDDPVEAVDWALLLKRSWLAPIVvttidqllesllkykhferrlHGLANsvVVLDEVQaydpeYMA----LLL--KAL 154
|
170 180
....*....|....*....|..
gi 19114484 257 ILLPDA--IRFIFLSATLPNAL 276
Cdd:cd17930 155 LELLGElgGPVVLMTATLPALL 176
|
|
| PRK09751 |
PRK09751 |
putative ATP-dependent helicase Lhr; Provisional |
145-282 |
5.05e-05 |
|
putative ATP-dependent helicase Lhr; Provisional
Pssm-ID: 137505 [Multi-domain] Cd Length: 1490 Bit Score: 47.61 E-value: 5.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 145 VSAHTSAGKTVIA-EYAIAQALKNR------------QRVIYTSPIKSLSNQKYREL---LSEFGD-------------V 195
Cdd:PRK09751 1 VIAPTGSGKTLAAfLYALDRLFREGgedtreahkrktSRILYISPIKALGTDVQRNLqipLKGIADerrrrgetevnlrV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 196 GLMTGDVSINPSA-------SCLIMTTEILRAMLY-KNSEIMHEIAWVIFDEVHYMRDKDRG----VVWEETLILLPDAI 263
Cdd:PRK09751 81 GIRTGDTPAQERSkltrnppDILITTPESLYLMLTsRARETLRGVETVIIDEVHAVAGSKRGahlaLSLERLDALLHTSA 160
|
170
....*....|....*....
gi 19114484 264 RFIFLSATLPNALQFARWI 282
Cdd:PRK09751 161 QRIGLSATVRSASDVAAFL 179
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
368-512 |
6.71e-05 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 43.74 E-value: 6.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 368 NRYDPIIVFCFSKKECEinahqfgkldlndtenkelvteifdsainQLSEEdrglrqfeemrsllLRGIGIH----HSGL 443
Cdd:cd18794 28 HLGGSGIIYCLSRKECE-----------------------------QVAAR--------------LQSKGISaaayHAGL 64
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 444 LPILKELVEILFQEGLVRILFATETFSIGLNMP-ARTVLFTKAQKfsgnnfrwlTSGEYMQMSGRAGRRG 512
Cdd:cd18794 65 EPSDRRDVQRKWLRDKIQVIVATVAFGMGIDKPdVRFVIHYSLPK---------SMESYYQESGRAGRDG 125
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
141-241 |
8.03e-04 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 43.57 E-value: 8.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 141 ESVLVSAHTSAGKTVIAEYAIAQALKNRQ-RVIYTSPIKSLSNQ---KYRELLS-EFGDVGLMTGDVSINP------SAS 209
Cdd:COG1111 18 KNTLVVLPTGLGKTAVALLVIAERLHKKGgKVLFLAPTKPLVEQhaeFFKEALNiPEDEIVVFTGEVSPEKrkelweKAR 97
|
90 100 110
....*....|....*....|....*....|..
gi 19114484 210 CLIMTTEILRAMLYKNSEIMHEIAWVIFDEVH 241
Cdd:COG1111 98 IIVATPQVIENDLIAGRIDLDDVSLLIFDEAH 129
|
|
| DEXDc_ComFA |
cd17925 |
DEXD-box helicase domain of ComFA; ATP-dependent helicase ComFA (also called ComF operon ... |
133-240 |
2.36e-03 |
|
DEXD-box helicase domain of ComFA; ATP-dependent helicase ComFA (also called ComF operon protein 1) is part of the complex mediating the binding and uptake of single-stranded DNA. ComFA is required for DNA uptake but not for binding. It belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350683 [Multi-domain] Cd Length: 143 Bit Score: 39.59 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 133 AIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQRVIYTSPIKSLSNQKYRELLSEFG--DVGLMTGDVSINPSASC 210
Cdd:cd17925 9 LVETIDAKEDLLVWAVTGAGKTEMLFPAIAQALRQGGRVAIASPRIDVCLELAPRLKAAFPgaAIVLLHGGSEDQYQRSP 88
|
90 100 110
....*....|....*....|....*....|..
gi 19114484 211 L-IMTT-EILRamlYKnseimHEIAWVIFDEV 240
Cdd:cd17925 89 LvIATThQLLR---FY-----RAFDLLIIDEV 112
|
|
| Cas3_I |
cd09639 |
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short ... |
143-276 |
5.71e-03 |
|
CRISPR/Cas system-associated protein Cas3; CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; DEAD/DEAH box helicase DNA helicase cas3'; Often but not always is fused to HD nuclease domain; signature gene for Type I
Pssm-ID: 187770 [Multi-domain] Cd Length: 353 Bit Score: 40.11 E-value: 5.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 143 VLVSAHTSAGKTVIAEYAIAQALKNRQ--RVIYTSPIKSLSNQKYRELLSEFGDVGLmtGDVSINPSASCLIMTTE---I 217
Cdd:cd09639 2 LVIEAPTGYGKTEAALLWALHSLKSQKadRVIIALPTRATINAMYRRAKEAFGETGL--YHSSILSSRIKEMGDSEefeH 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 218 LRAMLYKNS--------------EIM---------HEI-------AWVIFDEVHYMRDKDRGVVWEETLILLPDAIRFIF 267
Cdd:cd09639 80 LFPLYIHSNdtlfldpitvctidQVLksvfgefghYEFtlasianSLLIFDEVHFYDEYTLALILAVLEVLKDNDVPILL 159
|
....*....
gi 19114484 268 LSATLPNAL 276
Cdd:cd09639 160 MSATLPKFL 168
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
128-273 |
8.41e-03 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 38.72 E-value: 8.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 128 PFQSTAIKCVERMESVLVSAHTSAGKTVIAEYAIAQALKNRQ-----RVIYTSPIKSLSNQKYRE-------------LL 189
Cdd:cd17957 15 PIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKLGKPRkkkglRALILAPTRELASQIYREllklskgtglrivLL 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114484 190 SEFGDVGLMTGDVSINpSASCLIMTTEILRAMLYKNSEIMHEIAWVIFDEVhymrDK--DRGVVwEETLILL-----PDA 262
Cdd:cd17957 95 SKSLEAKAKDGPKSIT-KYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEA----DKlfEPGFR-EQTDEILaactnPNL 168
|
170
....*....|.
gi 19114484 263 IRFIFlSATLP 273
Cdd:cd17957 169 QRSLF-SATIP 178
|
|
| |
