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Conserved domains on  [gi|19114792|ref|NP_593880|]
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splicing factor Cdc5 [Schizosaccharomyces pombe]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein( domain architecture ID 11473979)

SANT/Myb-like DNA-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-535 8.33e-151

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


:

Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 449.62  E-value: 8.33e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792   1 MVVLKGGAWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQW 80
Cdd:COG5147  15 QTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792  81 RTIAPIV-GRTATQCLERYQKLLDDLEakeneqlglisgegaeaAAPVNDPNSRLRFGEAEPNLETLPALPDAIDMDEDE 159
Cdd:COG5147  95 STIADYKdRRTAQQCVERYVNTLEDLS-----------------STHDSKLQRRNEFDKIDPFNENSARRPDIYEDELLE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 160 KEMLSEARARLANTQGKKAKRKDREKQLELTRRLSHLQKRRELKAAGINIKLFRRKKNEMDynasipfeKKPAIGFYDTS 239
Cdd:COG5147 158 REVNREASYRLRVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEIN--------KAFKKGETLAL 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 240 EEDRQNFREKREADQKIIENGIRNNemESEGRKFGHFEKPKPIDRVKKPNKDAQEEKMRRLAEAEQMSKRRKLNLPSPTV 319
Cdd:COG5147 230 EQEINEYKEKKGLSRKQFCERIWST--DRDEDKFWPNIYKKLPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVV 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 320 SQDELDKVVKLGFAGDRARAMtdttpDANYSTNLLGkytqierATPLRTPISGELEGREDSVTIEVRNQLMRNREQSSLL 399
Cdd:COG5147 308 EHGGSWTEIGKLLGRMPNDCR-----DRWRDYVKCG-------DTLKRNRWSIEEEELLDKVVNEMRLEAQQSSRILWLL 375

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 400 GQESIP--LQPGGTGYTGVTPSHAANGSALAAPQATPFRTPRDTFSINAAAERAGRLASERENKIRLKALRELLAKLPKP 477
Cdd:COG5147 376 IAQNIRnrLQHHCRDKYGVLISNSSPFDAGAAIWLIERYSNRKIQNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTP 455

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19114792 478 KNDYELMEPRFADETDVEATVGVLEEDATDRErRIQERIAEKERLAKARRSQVIQRDL 535
Cdd:COG5147 456 DYNKSSLERIKKSAIDDGKKVLSLTLRELNKE-SSPERNYISDFKDSATAFIIIQRLC 512
 
Name Accession Description Interval E-value
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-535 8.33e-151

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 449.62  E-value: 8.33e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792   1 MVVLKGGAWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQW 80
Cdd:COG5147  15 QTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792  81 RTIAPIV-GRTATQCLERYQKLLDDLEakeneqlglisgegaeaAAPVNDPNSRLRFGEAEPNLETLPALPDAIDMDEDE 159
Cdd:COG5147  95 STIADYKdRRTAQQCVERYVNTLEDLS-----------------STHDSKLQRRNEFDKIDPFNENSARRPDIYEDELLE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 160 KEMLSEARARLANTQGKKAKRKDREKQLELTRRLSHLQKRRELKAAGINIKLFRRKKNEMDynasipfeKKPAIGFYDTS 239
Cdd:COG5147 158 REVNREASYRLRVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEIN--------KAFKKGETLAL 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 240 EEDRQNFREKREADQKIIENGIRNNemESEGRKFGHFEKPKPIDRVKKPNKDAQEEKMRRLAEAEQMSKRRKLNLPSPTV 319
Cdd:COG5147 230 EQEINEYKEKKGLSRKQFCERIWST--DRDEDKFWPNIYKKLPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVV 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 320 SQDELDKVVKLGFAGDRARAMtdttpDANYSTNLLGkytqierATPLRTPISGELEGREDSVTIEVRNQLMRNREQSSLL 399
Cdd:COG5147 308 EHGGSWTEIGKLLGRMPNDCR-----DRWRDYVKCG-------DTLKRNRWSIEEEELLDKVVNEMRLEAQQSSRILWLL 375

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 400 GQESIP--LQPGGTGYTGVTPSHAANGSALAAPQATPFRTPRDTFSINAAAERAGRLASERENKIRLKALRELLAKLPKP 477
Cdd:COG5147 376 IAQNIRnrLQHHCRDKYGVLISNSSPFDAGAAIWLIERYSNRKIQNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTP 455

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19114792 478 KNDYELMEPRFADETDVEATVGVLEEDATDRErRIQERIAEKERLAKARRSQVIQRDL 535
Cdd:COG5147 456 DYNKSSLERIKKSAIDDGKKVLSLTLRELNKE-SSPERNYISDFKDSATAFIIIQRLC 512
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 414-608 6.68e-39

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


Pssm-ID: 463366  Cd Length: 227  Bit Score: 143.95  E-value: 6.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792   414 TGVTPSHAANGSALAAPQ----ATPFRTP-RDTFSINAAAERAG----RLASERENKIRLkALRELLAKLPKPKNDYELM 484
Cdd:pfam11831   4 PLATPFRTGNGGVGATPRrgfgATPLRTPlRDKLNINPEDGMLVgetpRDEKQRQKEAKE-QLRSGLASLPKPKNDFEIV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792   485 EPRFADETDVEATVGVLEEDATDRERRIQERIAEKERLAKARRSQVIQRDLIRPSVTQPEKWKRSLENEDPTA-----NV 559
Cdd:pfam11831  83 LPEEEEEESETEAVEDSEEDAAERDAREQAEREAEEEKELARRSQVVQRGLPRPSEVNLDVLRPANDEPPLTDlqpaeEL 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 19114792   560 LLKEMIALISSDAINYPF-GNSKVKGTANKVPDLSNEEIERCRLLLKKEI 608
Cdd:pfam11831 163 IKKEMATLLHHDALKYPLpGAAQPYLEASPYEDFSDEELAAAKELIAAEM 212
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 54-103 1.62e-29

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 110.86  E-value: 1.62e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 19114792  54 PSIKKTEWSREEDEKLLHLAKLLPTQWRTIAPIVGRTATQCLERYQKLLD 103
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLD 50
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
6-54 3.22e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.77  E-value: 3.22e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 19114792      6 GGAWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWIDP 54
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 4-93 3.99e-09

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 58.16  E-value: 3.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792    4 LKGGAWKNTEDEILKAAVSKYGKNQWARI---SSLLvrKTPKQCKARWYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQW 80
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLpkrAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRW 100

                         90
                 ....*....|....
gi 19114792   81 RTIA-PIVGRTATQ 93
Cdd:PLN03212 101 SLIAgRIPGRTDNE 114
 
Name Accession Description Interval E-value
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 1-535 8.33e-151

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 449.62  E-value: 8.33e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792   1 MVVLKGGAWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQW 80
Cdd:COG5147  15 QTKRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQW 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792  81 RTIAPIV-GRTATQCLERYQKLLDDLEakeneqlglisgegaeaAAPVNDPNSRLRFGEAEPNLETLPALPDAIDMDEDE 159
Cdd:COG5147  95 STIADYKdRRTAQQCVERYVNTLEDLS-----------------STHDSKLQRRNEFDKIDPFNENSARRPDIYEDELLE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 160 KEMLSEARARLANTQGKKAKRKDREKQLELTRRLSHLQKRRELKAAGINIKLFRRKKNEMDynasipfeKKPAIGFYDTS 239
Cdd:COG5147 158 REVNREASYRLRVPRVSKADVKPREKGEENNPDIEDLQEMKELKSASITRHLILPSKSEIN--------KAFKKGETLAL 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 240 EEDRQNFREKREADQKIIENGIRNNemESEGRKFGHFEKPKPIDRVKKPNKDAQEEKMRRLAEAEQMSKRRKLNLPSPTV 319
Cdd:COG5147 230 EQEINEYKEKKGLSRKQFCERIWST--DRDEDKFWPNIYKKLPYRDKKSIYKHLRRKYNIFEQRGKWTKEEEQELAKLVV 307

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 320 SQDELDKVVKLGFAGDRARAMtdttpDANYSTNLLGkytqierATPLRTPISGELEGREDSVTIEVRNQLMRNREQSSLL 399
Cdd:COG5147 308 EHGGSWTEIGKLLGRMPNDCR-----DRWRDYVKCG-------DTLKRNRWSIEEEELLDKVVNEMRLEAQQSSRILWLL 375

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792 400 GQESIP--LQPGGTGYTGVTPSHAANGSALAAPQATPFRTPRDTFSINAAAERAGRLASERENKIRLKALRELLAKLPKP 477
Cdd:COG5147 376 IAQNIRnrLQHHCRDKYGVLISNSSPFDAGAAIWLIERYSNRKIQNGDLIKWRNSVLDSARRRMRDLKDLPEYALLLRTP 455

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19114792 478 KNDYELMEPRFADETDVEATVGVLEEDATDRErRIQERIAEKERLAKARRSQVIQRDL 535
Cdd:COG5147 456 DYNKSSLERIKKSAIDDGKKVLSLTLRELNKE-SSPERNYISDFKDSATAFIIIQRLC 512
Myb_Cef pfam11831
pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 ...
 414-608 6.68e-39

pre-mRNA splicing factor component; This family is a region of the Myb-Related Cdc5p/Cef1 proteins, in fungi, and is part of the pre-mRNA splicing factor complex.


Pssm-ID: 463366  Cd Length: 227  Bit Score: 143.95  E-value: 6.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792   414 TGVTPSHAANGSALAAPQ----ATPFRTP-RDTFSINAAAERAG----RLASERENKIRLkALRELLAKLPKPKNDYELM 484
Cdd:pfam11831   4 PLATPFRTGNGGVGATPRrgfgATPLRTPlRDKLNINPEDGMLVgetpRDEKQRQKEAKE-QLRSGLASLPKPKNDFEIV 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792   485 EPRFADETDVEATVGVLEEDATDRERRIQERIAEKERLAKARRSQVIQRDLIRPSVTQPEKWKRSLENEDPTA-----NV 559
Cdd:pfam11831  83 LPEEEEEESETEAVEDSEEDAAERDAREQAEREAEEEKELARRSQVVQRGLPRPSEVNLDVLRPANDEPPLTDlqpaeEL 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 19114792   560 LLKEMIALISSDAINYPF-GNSKVKGTANKVPDLSNEEIERCRLLLKKEI 608
Cdd:pfam11831 163 IKKEMATLLHHDALKYPLpGAAQPYLEASPYEDFSDEELAAAKELIAAEM 212
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 54-103 1.62e-29

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 110.86  E-value: 1.62e-29
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 19114792  54 PSIKKTEWSREEDEKLLHLAKLLPTQWRTIAPIVGRTATQCLERYQKLLD 103
Cdd:cd11659   1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIVGRTAQQCLERYNKLLD 50
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 9-69 5.24e-12

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 61.17  E-value: 5.24e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19114792     9 WKNTEDEILKAAVSKYGkNQWARISSLLVRKTPKQCKARWYEWIDPSIKKTEWSREEDEKL 69
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 8-52 3.12e-11

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 58.74  E-value: 3.12e-11
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 19114792   8 AWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWI 52
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
6-54 3.22e-11

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 58.77  E-value: 3.22e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 19114792      6 GGAWKNTEDEILKAAVSKYGKNQWARISSLLVRKTPKQCKARWYEWIDP 54
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 7-52 3.09e-10

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 55.97  E-value: 3.09e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 19114792     7 GAWKNTEDEILKAAVSKYGkNQWARISSLLVRKTPKQCKARWYEWI 52
Cdd:pfam00249   2 GPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 4-93 3.99e-09

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 58.16  E-value: 3.99e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792    4 LKGGAWKNTEDEILKAAVSKYGKNQWARI---SSLLvrKTPKQCKARWYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQW 80
Cdd:PLN03212  23 MKRGPWTVEEDEILVSFIKKEGEGRWRSLpkrAGLL--RCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRW 100

                         90
                 ....*....|....
gi 19114792   81 RTIA-PIVGRTATQ 93
Cdd:PLN03212 101 SLIAgRIPGRTDNE 114
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 58-102 1.50e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 50.97  E-value: 1.50e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 19114792    58 KTEWSREEDEKLLHLAKLLPTQWRTIAPIV-GRTATQCLERYQKLL 102
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLpGRTDNQCKNRWQNYL 46
PLN03091 PLN03091
hypothetical protein; Provisional
 4-90 2.25e-07

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 54.21  E-value: 2.25e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19114792    4 LKGGAWKNTEDEILKAAVSKYGKNQWARISSLL-VRKTPKQCKARWYEWIDPSIKKTEWSREEDEKLLHLAKLLPTQWRT 82
Cdd:PLN03091  12 LRKGLWSPEEDEKLLRHITKYGHGCWSSVPKQAgLQRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRWSQ 91


                 ....*....
gi 19114792   83 IAP-IVGRT 90
Cdd:PLN03091  92 IAAqLPGRT 100
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
58-102 1.67e-06

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 45.29  E-value: 1.67e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 19114792     58 KTEWSREEDEKLLHLAKLLPT-QWRTIAPIVG-RTATQCLERYQKLL 102
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKnNWEKIAKELPgRTAEQCRERWRNLL 47
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 60-102 3.69e-06

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 44.49  E-value: 3.69e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 19114792  60 EWSREEDEKLLHLAKLLPT-QWRTIAPIVG-RTATQCLERYQKLL 102
Cdd:cd00167   1 PWTEEEDELLLEAVKKYGKnNWEKIAKELPgRTPKQCRERWRNLL 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 9-48 7.60e-05

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 40.63  E-value: 7.60e-05
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 19114792   9 WKNTEDEILKAAVSKYGKNQWARI---SSLLVRKTPKQCKARW 48
Cdd:cd11660   3 WTDEEDEALVEGVEKYGVGNWAKIlkdYFFVNNRTSVDLKDKW 45
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 61-103 1.09e-03

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 37.67  E-value: 1.09e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 19114792    61 WSREEDEKLLHLAKLLPTQWRTIAPIVG-RTATQCLERYQKLLD 103
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGrRTPKQCFDRWRRKLN 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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