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Conserved domains on  [gi|19115055|ref|NP_594143|]
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U3 snoRNP-associated protein Rrp9 [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-439 3.65e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 3.65e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 207 HVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIE 286
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 287 TLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLvfrsggtsmkATAGYMEGSVDCVAMI-DEDHFVTGSDNG 365
Cdd:cd00200 172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL----------GTLRGHENGVNSVAFSpDGYLLASGSEDG 241

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115055 366 VIALWSVQRKKPLFTYPLahgldpilapgrHSAetspdpvtippqprWITSLAAIPYSNLFASGSWDGNIRLWK 439
Cdd:cd00200 242 TIRVWDLRTGECVQTLSG------------HTN--------------SVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-439 3.65e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 3.65e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 207 HVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIE 286
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 287 TLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLvfrsggtsmkATAGYMEGSVDCVAMI-DEDHFVTGSDNG 365
Cdd:cd00200 172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL----------GTLRGHENGVNSVAFSpDGYLLASGSEDG 241

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115055 366 VIALWSVQRKKPLFTYPLahgldpilapgrHSAetspdpvtippqprWITSLAAIPYSNLFASGSWDGNIRLWK 439
Cdd:cd00200 242 TIRVWDLRTGECVQTLSG------------HTN--------------SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
207-441 1.04e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 1.04e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 207 HVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIE 286
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 287 TLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKiVEESQLVFRSGGTSmkatagymeGSVDCVAMI-DEDHFVTGSDNG 365
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-LATGELLRTLTGHS---------GGVNSVAFSpDGKLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 366 VIALWSVQRKKPLFTYPlAHGLDP----------ILAPGRH-------SAETSPDPVTIPPQPRWITSLAAIPYSNLFAS 428
Cdd:COG2319 311 TVRLWDLATGKLLRTLT-GHTGAVrsvafspdgkTLASGSDdgtvrlwDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                       250
                ....*....|...
gi 19115055 429 GSWDGNIRLWKIA 441
Cdd:COG2319 390 GSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 406-439 4.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19115055    406 TIPPQPRWITSLAAIPYSNLFASGSWDGNIRLWK 439
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
406-438 1.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 19115055   406 TIPPQPRWITSLAAIPYSNLFASGSWDGNIRLW 438
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-439 3.65e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 124.75  E-value: 3.65e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 207 HVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIE 286
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 287 TLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLvfrsggtsmkATAGYMEGSVDCVAMI-DEDHFVTGSDNG 365
Cdd:cd00200 172 TLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL----------GTLRGHENGVNSVAFSpDGYLLASGSEDG 241

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115055 366 VIALWSVQRKKPLFTYPLahgldpilapgrHSAetspdpvtippqprWITSLAAIPYSNLFASGSWDGNIRLWK 439
Cdd:cd00200 242 TIRVWDLRTGECVQTLSG------------HTN--------------SVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
207-441 1.04e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 1.04e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 207 HVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIE 286
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLR 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 287 TLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKiVEESQLVFRSGGTSmkatagymeGSVDCVAMI-DEDHFVTGSDNG 365
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-LATGELLRTLTGHS---------GGVNSVAFSpDGKLLASGSDDG 310

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 366 VIALWSVQRKKPLFTYPlAHGLDP----------ILAPGRH-------SAETSPDPVTIPPQPRWITSLAAIPYSNLFAS 428
Cdd:COG2319 311 TVRLWDLATGKLLRTLT-GHTGAVrsvafspdgkTLASGSDdgtvrlwDLATGELLRTLTGHTGAVTSVAFSPDGRTLAS 389

                       250
                ....*....|...
gi 19115055 429 GSWDGNIRLWKIA 441
Cdd:COG2319 390 GSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
198-495 4.41e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 124.64  E-value: 4.41e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 198 SRSRRGENDHVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVW 277
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 278 SLDQMSYIETLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKiVEESQLVFRSGGTSmkatagymeGSVDCVAM-IDED 356
Cdd:COG2319 190 DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD-LATGKLLRTLTGHS---------GSVRSVAFsPDGR 259

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 357 HFVTGSDNGVIALWSVQRKKPLFTypLAHGLDPILA----P-GRH-------------SAETSPDPVTIPPQPRWITSLA 418
Cdd:COG2319 260 LLASGSADGTVRLWDLATGELLRT--LTGHSGGVNSvafsPdGKLlasgsddgtvrlwDLATGKLLRTLTGHTGAVRSVA 337

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 19115055 419 AIPYSNLFASGSWDGNIRLWKIAEGLRsfepltIATPLSVYGCINSLSLSLQGkgkqsevRVFAACGRETRVGRWKT 495
Cdd:COG2319 338 FSPDGKTLASGSDDGTVRLWDLATGEL------LRTLTGHTGAVTSVAFSPDG-------RTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-443 2.65e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 2.65e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 207 HVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIE 286
Cdd:cd00200   8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 287 TLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQlvfrsggtsmKATAGYMEGSVDCVAMIDEDHFVT-GSDNG 365
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKC----------LTTLRGHTDWVNSVAFSPDGTFVAsSSQDG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 366 VIALWSVQRKKPLFTYPlAHgLDPILA-----PGRHSAETSPDPV-------------TIPPQPRWITSLAAIPYSNLFA 427
Cdd:cd00200 158 TIKLWDLRTGKCVATLT-GH-TGEVNSvafspDGEKLLSSSSDGTiklwdlstgkclgTLRGHENGVNSVAFSPDGYLLA 235

                       250
                ....*....|....*.
gi 19115055 428 SGSWDGNIRLWKIAEG 443
Cdd:cd00200 236 SGSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
207-472 7.79e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.62  E-value: 7.79e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 207 HVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIE 286
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 287 TLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLVFRSGGTsmkatagymeGSVDCVAMI-DEDHFVTGSDNG 365
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHT----------GAVRSVAFSpDGKLLASGSADG 226

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 366 VIALWSVQRKKPLFTypLAHGLDPILAP-----GRH-------------SAETSPDPVTIPPQPRWITSLAAIPYSNLFA 427
Cdd:COG2319 227 TVRLWDLATGKLLRT--LTGHSGSVRSVafspdGRLlasgsadgtvrlwDLATGELLRTLTGHSGGVNSVAFSPDGKLLA 304

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 19115055 428 SGSWDGNIRLWKIAEG--LRSFEPLTIAtplsvygcINSLSLSLQGK 472
Cdd:COG2319 305 SGSDDGTVRLWDLATGklLRTLTGHTGA--------VRSVAFSPDGK 343
WD40 COG2319
WD40 repeat [General function prediction only];
205-373 2.72e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.05  E-value: 2.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 205 NDHVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSY 284
Cdd:COG2319 243 TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKL 322

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 285 IETLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIVEESQLVFRSGGTsmkatagymeGSVDCVAM-IDEDHFVTGSD 363
Cdd:COG2319 323 LRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT----------GAVTSVAFsPDGRTLASGSA 392

                       170
                ....*....|
gi 19115055 364 NGVIALWSVQ 373
Cdd:COG2319 393 DGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 244-498 4.65e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.47  E-value: 4.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 244 HCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIETLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIve 323
Cdd:cd00200   3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL-- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 324 esqlvfrsggtSMKATAGYMEG---SVDCVAMIDEDHFVTGS-DNGVIALWSVQRKKPLFTYPlAHgldpilapgrhsae 399
Cdd:cd00200  81 -----------ETGECVRTLTGhtsYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLR-GH-------------- 134

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 400 tspdpvtippqPRWITSLAAIPYSNLFASGSWDGNIRLWKIAEG--LRSFEPLTiatplsvyGCINSLSLSLQGKGkqse 477
Cdd:cd00200 135 -----------TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGkcVATLTGHT--------GEVNSVAFSPDGEK---- 191

                       250       260
                ....*....|....*....|....*....
gi 19115055 478 vrvFAACGRETRVGRW--------KTLRG 498
Cdd:cd00200 192 ---LLSSSSDGTIKLWdlstgkclGTLRG 217
WD40 COG2319
WD40 repeat [General function prediction only];
214-498 7.76e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 7.76e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 214 LAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIETLFGHQD 293
Cdd:COG2319  42 LAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTG 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 294 VIFGVDALARERCVSVGGRDRTSRLWKiVEESQLVFRSGGTSmkatagymeGSVDCVAMI-DEDHFVTGSDNGVIALWSV 372
Cdd:COG2319 122 AVRSVAFSPDGKTLASGSADGTVRLWD-LATGKLLRTLTGHS---------GAVTSVAFSpDGKLLASGSDDGTVRLWDL 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 373 QRKKPLFTYPlAHGlDPILA----P-GRH-------------SAETSPDPVTIPPQPRWITSLAAIPYSNLFASGSWDGN 434
Cdd:COG2319 192 ATGKLLRTLT-GHT-GAVRSvafsPdGKLlasgsadgtvrlwDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGT 269

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115055 435 IRLWKIAEGlrsfEPLTIATPLSvyGCINSLSLSLQGkgkqsevRVFAACGRETRVGRWKTLRG 498
Cdd:COG2319 270 VRLWDLATG----ELLRTLTGHS--GGVNSVAFSPDG-------KLLASGSDDGTVRLWDLATG 320
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-371 7.46e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 78.15  E-value: 7.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 186 KAIKLH-FRPIKFSRSRRGendHVKEITCLAISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNE 264
Cdd:cd00200 115 KTIKVWdVETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEK 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 265 MFSCSADRSIKVWSLDQMSYIETLFGHQDVIFGVDALARERCVSVGGRDRTSRLWKIveesqlvfRSGGTSMKATAGymE 344
Cdd:cd00200 192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL--------RTGECVQTLSGH--T 261

                       170       180
                ....*....|....*....|....*...
gi 19115055 345 GSVDCVAMI-DEDHFVTGSDNGVIALWS 371
Cdd:cd00200 262 NSVTSLAWSpDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
215-493 6.51e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.49  E-value: 6.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 215 AISNDGRWIVTGGLDHRIVIRDSVTLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWSLDQMSYIETLFGHQDV 294
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 295 IFGVDALARERCVSVGGRDRTSRLWKIVEESQLVFRSGGTsmkatagymeGSVDCVAM-IDEDHFVTGSDNGVIALWSVQ 373
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT----------GAVRSVAFsPDGKTLASGSADGTVRLWDLA 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 374 RKKPLFTypLAHGLDPILA----P-GRHSAETSPD-------------PVTIPPQPRWITSLAAIPYSNLFASGSWDGNI 435
Cdd:COG2319 151 TGKLLRT--LTGHSGAVTSvafsPdGKLLASGSDDgtvrlwdlatgklLRTLTGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115055 436 RLWKIAEG--LRSFEPLTiatplsvyGCINSLSLSLQGkgkqsevRVFAACGRETRVGRW 493
Cdd:COG2319 229 RLWDLATGklLRTLTGHS--------GSVRSVAFSPDG-------RLLASGSADGTVRLW 273
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 406-439 4.20e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 4.20e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 19115055    406 TIPPQPRWITSLAAIPYSNLFASGSWDGNIRLWK 439
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 239-278 1.55e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.55e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19115055    239 TLEPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWS 278
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
406-438 1.60e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.60e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 19115055   406 TIPPQPRWITSLAAIPYSNLFASGSWDGNIRLW 438
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
207-236 2.03e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 2.03e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 19115055   207 HVKEITCLAISNDGRWIVTGGLDHRIVIRD 236
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 205-236 3.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.47e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 19115055    205 NDHVKEITCLAISNDGRWIVTGGLDHRIVIRD 236
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
241-278 1.18e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.18e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 19115055   241 EPQHCWKHHRDAVMGLAMRRGTNEMFSCSADRSIKVWS 278
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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