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Conserved domains on  [gi|19115150|ref|NP_594238|]
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HSP chaperone complex subunit Cns1 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 200-348 7.51e-68

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


:

Pssm-ID: 439175  Cd Length: 150  Bit Score: 210.06  E-value: 7.51e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 200 KVIAAKTVLLALQERHIKTKTTEHPPDL-GDAMISLSTFDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVF 278
Cdd:cd21381   1 KERKKKTLKAALKARNITTRTTSQPPELlEDAKILLEDPLDPESQLIFPALLLYPLHLQSDFIKAFSELSTPQEHLEYVL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 279 QSPAPWDVHQLYNPDSLDVFATTDTLGLIKVGKNVPILKALTHPKVTLIDGLVQLHVVPHHLASDWISSW 348
Cdd:cd21381  81 PRPWDWDKHEEYTPKNVECYMETESGGLVKVGKKVPLLKVLSNGKVPLFDGLLRIYVVPKNKAAEWIKEW 150
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
35-194 7.55e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.39  E-value: 7.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  35 LEDVGDESENNVQLDALKALAYEGEPH---EVAQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAAC 111
Cdd:COG4785  41 LADLALALAAAALAAAALAAERIDRALalpDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEA----YNNRGLA 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 112 NLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRES 191
Cdd:COG4785 117 YLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALAL 196


                ...
gi 19115150 192 EKK 194
Cdd:COG4785 197 LLE 199
 
Name Accession Description Interval E-value
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 200-348 7.51e-68

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 210.06  E-value: 7.51e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 200 KVIAAKTVLLALQERHIKTKTTEHPPDL-GDAMISLSTFDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVF 278
Cdd:cd21381   1 KERKKKTLKAALKARNITTRTTSQPPELlEDAKILLEDPLDPESQLIFPALLLYPLHLQSDFIKAFSELSTPQEHLEYVL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 279 QSPAPWDVHQLYNPDSLDVFATTDTLGLIKVGKNVPILKALTHPKVTLIDGLVQLHVVPHHLASDWISSW 348
Cdd:cd21381  81 PRPWDWDKHEEYTPKNVECYMETESGGLVKVGKKVPLLKVLSNGKVPLFDGLLRIYVVPKNKAAEWIKEW 150
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 237-348 1.39e-53

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 172.41  E-value: 1.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150   237 FDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVFQSPAPWDVHQLYNPDSLDVFATTDTLGLIKVGKNVPIL 316
Cdd:pfam18972   2 PDDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMETRTGGLVKVGKKVPLR 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 19115150   317 KALTH-PKVTLIDGLVQLHVVPHHLASDWISSW 348
Cdd:pfam18972  82 KVLSSaPKVELVDGLLRIYVVPKGKAQKWIEDW 114
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
35-194 7.55e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.39  E-value: 7.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  35 LEDVGDESENNVQLDALKALAYEGEPH---EVAQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAAC 111
Cdd:COG4785  41 LADLALALAAAALAAAALAAERIDRALalpDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEA----YNNRGLA 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 112 NLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRES 191
Cdd:COG4785 117 YLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALAL 196


                ...
gi 19115150 192 EKK 194
Cdd:COG4785 197 LLE 199
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 57-155 1.28e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.53  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150    57 EGEPHEVAQNFREHGNECFASKRYKDAEEFYTKALAQKcgdkdIEIACYSNRAACNLLFENYRQVLNDCAQVLQRDSTHA 136
Cdd:TIGR00990 120 EEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECK-----PDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYS 194

                          90
                  ....*....|....*....
gi 19115150   137 KAYYRSAKALVALKRYDEA 155
Cdd:TIGR00990 195 KALNRRANAYDGLGKYADA 213
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 64-225 6.28e-07

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 50.56  E-value: 6.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150   64 AQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSA 143
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAEL----YADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  144 KALVALKRYDEAKECIRLCSLVHPNDPAIlalsKELQKKSDDFEKRESEKKRVAQEKVIAAKTVLLALQERHIKTKTTEH 223
Cdd:PLN03088  78 TACMKLEEYQTAKAALEKGASLAPGDSRF----TKLIKECDEKIAEEEKDLVQPVPSDLPSSVTAPPVEEADATPVVPPS 153


                 ..
gi 19115150  224 PP 225
Cdd:PLN03088 154 KP 155
TPR_19 pfam14559
Tetratricopeptide repeat;
116-175 7.71e-06

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 42.96  E-value: 7.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150   116 ENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILAL 175
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAAL 61
 
Name Accession Description Interval E-value
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 200-348 7.51e-68

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 210.06  E-value: 7.51e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 200 KVIAAKTVLLALQERHIKTKTTEHPPDL-GDAMISLSTFDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVF 278
Cdd:cd21381   1 KERKKKTLKAALKARNITTRTTSQPPELlEDAKILLEDPLDPESQLIFPALLLYPLHLQSDFIKAFSELSTPQEHLEYVL 80

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 279 QSPAPWDVHQLYNPDSLDVFATTDTLGLIKVGKNVPILKALTHPKVTLIDGLVQLHVVPHHLASDWISSW 348
Cdd:cd21381  81 PRPWDWDKHEEYTPKNVECYMETESGGLVKVGKKVPLLKVLSNGKVPLFDGLLRIYVVPKNKAAEWIKEW 150
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 237-348 1.39e-53

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 172.41  E-value: 1.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150   237 FDDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVFQSPAPWDVHQLYNPDSLDVFATTDTLGLIKVGKNVPIL 316
Cdd:pfam18972   2 PDDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMETRTGGLVKVGKKVPLR 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 19115150   317 KALTH-PKVTLIDGLVQLHVVPHHLASDWISSW 348
Cdd:pfam18972  82 KVLSSaPKVELVDGLLRIYVVPKGKAQKWIEDW 114
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 210-337 4.64e-22

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 91.08  E-value: 4.64e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 210 ALQERHIKTKTTE------------HPPDLGDAMISLstfdDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTV 277
Cdd:cd21380   6 AIKERGIKLEGSKkgesddlsllepCHPELSGARVHL----DEEGRLVWPVLFLYPEYKQSDFIQAFHEDTTFIDHLEVM 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19115150 278 FQSPAPWDVHQLYNPDSLDV-FATTDTLGLIKVGKNVPILKALTHPKVTLIDGLVQLHVVP 337
Cdd:cd21380  82 FEEPPPWDVEKKYTPDNLNVyFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLV 142
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 205-337 6.03e-21

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 88.16  E-value: 6.03e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 205 KTVLLALQERHIK-TKTTEHPPDLGDAMISLstfdDPKSELFFPTILLYPLVYQSDFVPSVSENCTPLELLKTVF---QS 280
Cdd:cd21377   1 KALLSALKSRGIKlGPPLYDEELTGERKPYL----DEDGELHWPVLLLYPEVGQSDFIEDFSEDDTLGDHLDVMFpepAP 76

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115150 281 PAPWDVHQLYNPDSLDVFATTDTL---------------GLIKVGKNVPILKALTHPKVTLIDGLVQLHVVP 337
Cdd:cd21377  77 PLPWDTEGEYTRDNLEVYYETNAVkplpsesskagpkekKWVRVDPDTTLGDVLAHPDYYVIPGIPVFYVVP 148
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
35-194 7.55e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 58.39  E-value: 7.55e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  35 LEDVGDESENNVQLDALKALAYEGEPH---EVAQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAAC 111
Cdd:COG4785  41 LADLALALAAAALAAAALAAERIDRALalpDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEA----YNNRGLA 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 112 NLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRES 191
Cdd:COG4785 117 YLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALAL 196


                ...
gi 19115150 192 EKK 194
Cdd:COG4785 197 LLE 199
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 47-173 1.13e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 1.13e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  47 QLDALKALAYEGEPHEVAQNFREHGNECFASKRYKDAEEFYTKALAQkcgDKDIEIAcYSNRAACNLLFENYRQVLNDCA 126
Cdd:COG3914  61 ALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALAL---NPDNAEA-LFNLGNLLLALGRLEEALAALR 136

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 19115150 127 QVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAIL 173
Cdd:COG3914 137 RALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL 183
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 43-213 1.55e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.24  E-value: 1.55e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  43 ENNVQLDALKALAYEGEPHEVAQNFRE--------------HGNECFASKRYKDAEEFYTKALAQKCGDkdieIACYSNR 108
Cdd:COG3914  77 LAALLELAALLLQALGRYEEALALYRRalalnpdnaealfnLGNLLLALGRLEEALAALRRALALNPDF----AEAYLNL 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 109 AacNLLFENYR--QVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILAL---SKELQKKS 183
Cdd:COG3914 153 G--EALRRLGRleEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNllfALRQACDW 230

                       170       180       190
                ....*....|....*....|....*....|
gi 19115150 184 DDFEKRESEKKRVAQEKVIAAKTVLLALQE 213
Cdd:COG3914 231 EVYDRFEELLAALARGPSELSPFALLYLPD 260
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
71-173 5.45e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 5.45e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  71 GNECFASKRYKDAEEFYTKALAQkcgDKDIEIAcYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALK 150
Cdd:COG0457  15 GLAYRRLGRYEEAIEDYEKALEL---DPDDAEA-LYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALG 90

                        90       100
                ....*....|....*....|...
gi 19115150 151 RYDEAKECIRLCSLVHPNDPAIL 173
Cdd:COG0457  91 RYEEALEDYDKALELDPDDAEAL 113
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
49-214 5.50e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 5.50e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  49 DALKAL--AYEGEPhEVAQNFREHGNECFASKRYKDAEEFYTKALAQKCGDkdieIACYSNRAACNLLFENYRQVLNDCA 126
Cdd:COG0457  26 EAIEDYekALELDP-DDAEALYNLGLAYLRLGRYEEALADYEQALELDPDD----AEALNNLGLALQALGRYEEALEDYD 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 127 QVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRESEKKRVAQEKVIAAKT 206
Cdd:COG0457 101 KALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLA 180


                ....*...
gi 19115150 207 VLLALQER 214
Cdd:COG0457 181 AALGEAAL 188
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 57-155 1.28e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.53  E-value: 1.28e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150    57 EGEPHEVAQNFREHGNECFASKRYKDAEEFYTKALAQKcgdkdIEIACYSNRAACNLLFENYRQVLNDCAQVLQRDSTHA 136
Cdd:TIGR00990 120 EEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIECK-----PDPVYYSNRAACHNALGDWEKVVEDTTAALELDPDYS 194

                          90
                  ....*....|....*....
gi 19115150   137 KAYYRSAKALVALKRYDEA 155
Cdd:TIGR00990 195 KALNRRANAYDGLGKYADA 213
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 75-181 5.44e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 5.44e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  75 FASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDE 154
Cdd:COG4235  28 LRLGRYDEALAAYEKALRLDPDNADA----LLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQGDYAE 103

                        90       100
                ....*....|....*....|....*..
gi 19115150 155 AKECIRLCSLVHPNDPAILALSKELQK 181
Cdd:COG4235 104 AIAAWQKLLALLPADAPARLLEASIAE 130
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
71-214 1.49e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.93  E-value: 1.49e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  71 GNECFASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALK 150
Cdd:COG0457  83 GLALQALGRYEEALEDYDKALELDPDDAEA----LYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLG 158

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115150 151 RYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRESEKKRVAQEKVIAAKTVLLALQER 214
Cdd:COG0457 159 RYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAEL 222
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 18-185 2.26e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 2.26e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  18 AEEMFNELNKV-PFFMQSLEDVGD--ESENNVQ--LDALKALAYEGEPHEVAQNfrEHGNECFASKRYKDAEEFYTKALA 92
Cdd:COG2956  95 AEELLEKLLELdPDDAEALRLLAEiyEQEGDWEkaIEVLERLLKLGPENAHAYC--ELAELYLEQGDYDEAIEALEKALK 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  93 QkcgDKDIEIAcYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAI 172
Cdd:COG2956 173 L---DPDCARA-LLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLL 248

                       170
                ....*....|...
gi 19115150 173 LALSKELQKKSDD 185
Cdd:COG2956 249 LALADLLERKEGL 261
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 64-225 6.28e-07

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 50.56  E-value: 6.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150   64 AQNFREHGNECFASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSA 143
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAIDLDPNNAEL----YADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  144 KALVALKRYDEAKECIRLCSLVHPNDPAIlalsKELQKKSDDFEKRESEKKRVAQEKVIAAKTVLLALQERHIKTKTTEH 223
Cdd:PLN03088  78 TACMKLEEYQTAKAALEKGASLAPGDSRF----TKLIKECDEKIAEEEKDLVQPVPSDLPSSVTAPPVEEADATPVVPPS 153


                 ..
gi 19115150  224 PP 225
Cdd:PLN03088 154 KP 155
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 62-200 2.80e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 2.80e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  62 EVAQNFREHGNECFASKRYKDAEEFYTKALAQKcgDKDIEIacYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYR 141
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELD--PDNPEA--FALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLN 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19115150 142 SAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRESEKKRVAQEK 200
Cdd:COG4783  78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELD 136
TPR_19 pfam14559
Tetratricopeptide repeat;
116-175 7.71e-06

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 42.96  E-value: 7.71e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150   116 ENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILAL 175
Cdd:pfam14559   2 GDYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAAL 61
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 75-160 3.19e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 43.80  E-value: 3.19e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  75 FASKRYKDAEEFYTKALAQKCGDKDIeiacYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDE 154
Cdd:COG5010  65 NKLGDFEESLALLEQALQLDPNNPEL----YYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDE 140


                ....*.
gi 19115150 155 AKECIR 160
Cdd:COG5010 141 AKAALQ 146
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 75-222 9.56e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.56  E-value: 9.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  75 FASKRYKDAEEFYTKALAqkcgDKDIEIACYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDE 154
Cdd:COG2956 121 EQEGDWEKAIEVLERLLK----LGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115150 155 AKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRESEKKRVAQEKviAAKTVLLALQERHIKTKTTE 222
Cdd:COG2956 197 AIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELD--PSDDLLLALADLLERKEGLE 262
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
104-173 1.17e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.07  E-value: 1.17e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 104 CYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAIL 173
Cdd:COG0457  10 AYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEAL 79
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
64-184 1.57e-04

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 42.56  E-value: 1.57e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  64 AQNFREHGNECFASKRYKDAEEFYTKALAQKCGDkDIEIAcySNRAACNLLFENYRQVLNDCAQVLQRDSTHAK-----A 138
Cdd:COG4700  89 VQNRVRLADALLELGRYDEAIELYEEALTGIFAD-DPHIL--LGLAQALFELGRYAEALETLEKLIAKNPDFKSsdahlL 165

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 19115150 139 YyrsAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSD 184
Cdd:COG4700 166 Y---ARALEALGDLEAAEAELEALARRYSGPEARYRYAKFLARQGR 208
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 75-169 2.91e-04

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 40.56  E-value: 2.91e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  75 FASKRYKDAEEFYTKALAQKcgDKDIEIacYSNRAACNLLFENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDE 154
Cdd:COG4783  49 LQLGDLDEAIVLLHEALELD--PDEPEA--RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDE 124

                        90
                ....*....|....*
gi 19115150 155 AKECIRLCSLVHPND 169
Cdd:COG4783 125 AIAALEKALELDPDD 139
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
75-168 4.28e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 39.00  E-value: 4.28e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  75 FASKRYKDAEEFYTKALAQkcgDKDIEIAcYSNRAACNLLFENYRQVLnDCAQVLQRDSTHAKAYYRSAKALVALKRYDE 154
Cdd:COG3063   3 LKLGDLEEAEEYYEKALEL---DPDNADA-LNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDE 77

                        90
                ....*....|....
gi 19115150 155 AKECIRLCSLVHPN 168
Cdd:COG3063  78 ALAYLERALELDPS 91
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 75-181 3.58e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 3.58e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150  75 FASKRYKDAEEFYTKALAQKCGDKDIEIACYsNRAACNLLFENYRQVLNDCAQVLQRDSTHAK---AYYRSAKALVALKR 151
Cdd:COG1729   4 LKAGDYDEAIAAFKAFLKRYPNSPLAPDALY-WLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGD 82

                        90       100       110
                ....*....|....*....|....*....|
gi 19115150 152 YDEAKECIRLCSLVHPNDPAILALSKELQK 181
Cdd:COG1729  83 YDKARATLEELIKKYPDSEAAKEARARLAR 112
TPR_8 pfam13181
Tetratricopeptide repeat;
136-162 6.48e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 33.91  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*..
gi 19115150   136 AKAYYRSAKALVALKRYDEAKECIRLC 162
Cdd:pfam13181   1 AEAYYNLGLIYLKLGDYEEAKEYYEKA 27
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 116-203 8.07e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 36.48  E-value: 8.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115150 116 ENYRQVLNDCAQVLQRDSTHAKAYYRSAKALVALKRYDEAKECIRLCSLVHPNDPAILALSKELQKKSDDFEKRESEKKR 195
Cdd:COG5010  68 GDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQR 147


                ....*...
gi 19115150 196 VAQEKVIA 203
Cdd:COG5010 148 ALGTSPLK 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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