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Conserved domains on  [gi|19115221|ref|NP_594309|]
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NatA N-acetyltransferase complex catalytic subunit Naa10 [Schizosaccharomyces pombe]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11418877)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 54-153 6.47e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


:

Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.21  E-value: 6.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221  54 GYVLAKMEEEPkdgiPHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEVyGAKYMSLHVRKSNRAAIHLYRdTLQFDVQG 133
Cdd:COG0456   1 GFALLGLVDGG----DEAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALYE-KLGFEEVG 74

                        90       100
                ....*....|....*....|
gi 19115221 134 IESKYYADgeDAYAMHKDFS 153
Cdd:COG0456  75 ERPNYYGD--DALVMEKELA 92
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 54-153 6.47e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.21  E-value: 6.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221  54 GYVLAKMEEEPkdgiPHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEVyGAKYMSLHVRKSNRAAIHLYRdTLQFDVQG 133
Cdd:COG0456   1 GFALLGLVDGG----DEAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALYE-KLGFEEVG 74

                        90       100
                ....*....|....*....|
gi 19115221 134 IESKYYADgeDAYAMHKDFS 153
Cdd:COG0456  75 ERPNYYGD--DALVMEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 50-124 2.81e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 60.22  E-value: 2.81e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115221    50 GRVVGYVLAKMEEEPkdgIPHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEvYGAKYMSLHVRKSNRAAIHLYR 124
Cdd:pfam00583  42 GELVGFASLSIIDDE---PPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERIFLEVAADNLAAIALYE 112
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-111 2.09e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.42  E-value: 2.09e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221  42 SYVATDpKGRVVGYVLAKMEEEPKDgipHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEvYGAKYMSLH 111
Cdd:cd04301   1 FLVAED-DGEIVGFASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEEARE-RGAKRLRLE 65
PRK03624 PRK03624
putative acetyltransferase; Provisional
 1-132 1.61e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 42.61  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221    1 MDIRPARISD----LTGMQNCNL---HNLPE-NYQLKyyLYHAiswPMLSYVATDPkGRVVGYVLAKMeeepkDGipH-G 71
Cdd:PRK03624   3 MEIRVFRQADfeavIALWERCDLtrpWNDPEmDIERK--LNHD---PSLFLVAEVG-GEVVGTVMGGY-----DG--HrG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19115221   72 HITSVSVMRSYRHLGLAKRLMVQSQRAMVEVyGAKYMSLHVRKSNRAAIHLYrDTLQFDVQ 132
Cdd:PRK03624  70 WAYYLAVHPDFRGRGIGRALVARLEKKLIAR-GCPKINLQVREDNDAVLGFY-EALGYEEQ 128
 
Name Accession Description Interval E-value
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 54-153 6.47e-13

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 61.21  E-value: 6.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221  54 GYVLAKMEEEPkdgiPHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEVyGAKYMSLHVRKSNRAAIHLYRdTLQFDVQG 133
Cdd:COG0456   1 GFALLGLVDGG----DEAEIEDLAVDPEYRGRGIGRALLEAALERARER-GARRLRLEVREDNEAAIALYE-KLGFEEVG 74

                        90       100
                ....*....|....*....|
gi 19115221 134 IESKYYADgeDAYAMHKDFS 153
Cdd:COG0456  75 ERPNYYGD--DALVMEKELA 92
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 50-124 2.81e-12

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 60.22  E-value: 2.81e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115221    50 GRVVGYVLAKMEEEPkdgIPHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEvYGAKYMSLHVRKSNRAAIHLYR 124
Cdd:pfam00583  42 GELVGFASLSIIDDE---PPVGEIEGLAVAPEYRGKGIGTALLQALLEWARE-RGCERIFLEVAADNLAAIALYE 112
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
1-151 2.37e-08

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 50.76  E-value: 2.37e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221   1 MDIRPARISDLTGMQ---NCNLHNLPENY--------QLKYYLYHAISWPMLSYVATDPkGRVVGYVLAkMEEEPKDGIP 69
Cdd:COG1247   2 MTIRPATPEDAPAIAaiyNEAIAEGTATFeteppseeEREAWFAAILAPGRPVLVAEED-GEVVGFASL-GPFRPRPAYR 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221  70 HGHITSVSVMRSYRHLGLAKRLMvqsqRAMVEV---YGAKYMSLHVRKSNRAAIHLYRDtLQFDVQGIESK-YYADGE-- 143
Cdd:COG1247  80 GTAEESIYVDPDARGRGIGRALL----EALIERaraRGYRRLVAVVLADNEASIALYEK-LGFEEVGTLPEvGFKFGRwl 154


                ....*...
gi 19115221 144 DAYAMHKD 151
Cdd:COG1247 155 DLVLMQKR 162
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 1-124 6.90e-08

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 48.83  E-value: 6.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221   1 MDIRPARISDLTGMQNcnLHNlpenyqlKYYLYHAISwpmLSYVATDpKGRVVGYV-LAKMEEEpkdgipHGHITSVSVM 79
Cdd:COG1246   1 MTIRPATPDDVPAILE--LIR-------PYALEEEIG---EFWVAEE-DGEIVGCAaLHPLDED------LAELRSLAVH 61

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19115221  80 RSYRHLGLAKRLMVQSQRAMVEvYGAKYMSLHvrkSNRAAIHLYR 124
Cdd:COG1246  62 PDYRGRGIGRRLLEALLAEARE-LGLKRLFLL---TTSAAIHFYE 102
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
51-124 1.27e-06

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 44.51  E-value: 1.27e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19115221  51 RVVGYVLAKMEEEPkdgipHGHITSVSVMRSYRHLGLAKRLMVQ-SQRAMVEvyGAKYMSLHVRKSNRAAIHLYR 124
Cdd:COG3393   1 ELVAMAGVRAESPG-----VAEISGVYTHPEYRGRGLASALVAAlAREALAR--GARTPFLYVDADNPAARRLYE 68
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 42-111 2.09e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 43.42  E-value: 2.09e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221  42 SYVATDpKGRVVGYVLAKMEEEPKDgipHGHITSVSVMRSYRHLGLAKRLMVQSQRAMVEvYGAKYMSLH 111
Cdd:cd04301   1 FLVAED-DGEIVGFASLSPDGSGGD---TAYIGDLAVLPEYRGKGIGSALLEAAEEEARE-RGAKRLRLE 65
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 43-124 6.23e-06

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 42.44  E-value: 6.23e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221    43 YVATDpKGRVVGYVLAkmeeEPKDGIPHGHITSVSVMRSYRHLGLAKRLMvqsqRAMVEVYGAKYMSLHVRKSNRAAIHL 122
Cdd:pfam13508   6 FVAED-DGKIVGFAAL----LPLDDEGALAELRLAVHPEYRGQGIGRALL----EAAEAAAKEGGIKLLELETTNRAAAF 76


                  ..
gi 19115221   123 YR 124
Cdd:pfam13508  77 YE 78
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
3-124 7.57e-06

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 43.54  E-value: 7.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221   3 IRPARISDLTGMQNCNLHNLPENY--QLKYYLYHAISWPmLSYVATDpKGRVVGYVLAkMEEEPKDGIPHGHITSVSVMR 80
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAFGPGReaELVDRLREDPAAG-LSLVAED-DGEIVGHVAL-SPVDIDGEGPALLLGPLAVDP 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 19115221  81 SYRHLGLAKRLMVQSQRAMVEVyGAKYMSLHvrkSNRAAIHLYR 124
Cdd:COG3153  78 EYRGQGIGRALMRAALEAARER-GARAVVLL---GDPSLLPFYE 117
PRK03624 PRK03624
putative acetyltransferase; Provisional
 1-132 1.61e-05

putative acetyltransferase; Provisional


Pssm-ID: 235142 [Multi-domain]  Cd Length: 140  Bit Score: 42.61  E-value: 1.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221    1 MDIRPARISD----LTGMQNCNL---HNLPE-NYQLKyyLYHAiswPMLSYVATDPkGRVVGYVLAKMeeepkDGipH-G 71
Cdd:PRK03624   3 MEIRVFRQADfeavIALWERCDLtrpWNDPEmDIERK--LNHD---PSLFLVAEVG-GEVVGTVMGGY-----DG--HrG 69

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19115221   72 HITSVSVMRSYRHLGLAKRLMVQSQRAMVEVyGAKYMSLHVRKSNRAAIHLYrDTLQFDVQ 132
Cdd:PRK03624  70 WAYYLAVHPDFRGRGIGRALVARLEKKLIAR-GCPKINLQVREDNDAVLGFY-EALGYEEQ 128
rimI PRK09491
ribosomal-protein-alanine N-acetyltransferase; Provisional
 110-148 1.65e-03

ribosomal-protein-alanine N-acetyltransferase; Provisional


Pssm-ID: 181904 [Multi-domain]  Cd Length: 146  Bit Score: 37.22  E-value: 1.65e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 19115221  110 LHVRKSNRAAIHLYrDTLQFDVQGIESKYY--ADG-EDAYAM 148
Cdd:PRK09491 102 LEVRASNAAAIALY-ESLGFNEVTIRRNYYptADGrEDAIIM 142
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
 3-124 4.99e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 36.13  E-value: 4.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221   3 IRPARISDLTGMqnCNLHNLPENYQ---------------LKYYLYHAISWPMLSYVATDP-KGRVVGYV-LAKMEEEPk 65
Cdd:COG1670  10 LRPLRPEDAEAL--AELLNDPEVARylpgppysleearawLERLLADWADGGALPFAIEDKeDGELIGVVgLYDIDRAN- 86

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115221  66 dgiPHGHItSVSVMRSYRHLGLAKRLMvqsqRAMV----EVYGAKYMSLHVRKSNRAAIHLYR 124
Cdd:COG1670  87 ---RSAEI-GYWLAPAYWGKGYATEAL----RALLdyafEELGLHRVEAEVDPDNTASIRVLE 141
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
50-153 8.81e-03

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 34.77  E-value: 8.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115221  50 GRVVGY--VLakmeeepKDGIPHGHITSVSVMRSYRHLGLAKRLMvqsQRAM--VEVYGAKYMSLHVRKSnraAIHLYRd 125
Cdd:COG2153  43 GELVATarLL-------PPGDGEAKIGRVAVLPEYRGQGLGRALM---EAAIeeARERGARRIVLSAQAH---AVGFYE- 108

                        90       100
                ....*....|....*....|....*...
gi 19115221 126 TLQFDVQGIEskYYADGEDAYAMHKDFS 153
Cdd:COG2153 109 KLGFVPVGEE--FLEAGIPHIDMRKPLS 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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