NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19115892|ref|NP_594980|]
View 

histone lysine H3-K36 methyltransferase Set2 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 179-320 3.54e-90

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


:

Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 279.85  E-value: 3.54e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 179 FAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19172   1 YAKVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEIIDATKKGNLSRFIN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIG 320
Cdd:cd19172  81 HSCEPNCETQKWTVNGELRVGFFAKRDIPAGEELTFDYQFERYGKEAQKCYCGSPNCRGYIG 142
AWS smart00570
associated with SET domains; subdomain of PRESET
 125-179 6.23e-17

associated with SET domains; subdomain of PRESET


:

Pssm-ID: 197795  Cd Length: 50  Bit Score: 75.13  E-value: 6.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 19115892    125 EAMICDCRPHWVDgvNVACGhgSNCINRMTSIECTDeDNVCGPSCQNQRFQRHEF 179
Cdd:smart00570   1 DIMTCECKPTDDD--ETACG--SDCLNRMLFIECSS-SCPCGSYCSNQRFQKRQY 50
SRI pfam08236
SRI (Set2 Rpb1 interacting) domain; The SRI (Set2 Rpb1 interacting) domain mediates RNA ...
 699-776 2.21e-12

SRI (Set2 Rpb1 interacting) domain; The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilizes the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.


:

Pssm-ID: 462404  Cd Length: 83  Bit Score: 63.29  E-value: 2.21e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115892   699 FKAVLAKFFANKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEkalPDELSDSQQRKLRVWAFRYLDTVVSR 776
Cdd:pfam08236   8 FEKTLAPHVVNVLNKYRKKLGKEDFKRLAKELTKILVAKELKKCPNRDP---PEELSEKKKKKVKEFVKDYMEKFGAK 82
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 440-489 7.31e-04

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


:

Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 38.27  E-value: 7.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19115892   440 ILRSIKTMlswpRLTRNKIQDSNIEPVVQEFCDH-ENEEVKDHAKTLLKEW 489
Cdd:pfam08711   2 LLKKLEKL----PVTLELLKSTGIGKVVNKLRKHkENPEIKKLAKELVKKW 48
 
Name Accession Description Interval E-value
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 179-320 3.54e-90

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 279.85  E-value: 3.54e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 179 FAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19172   1 YAKVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEIIDATKKGNLSRFIN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIG 320
Cdd:cd19172  81 HSCEPNCETQKWTVNGELRVGFFAKRDIPAGEELTFDYQFERYGKEAQKCYCGSPNCRGYIG 142
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 180-303 4.76e-45

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 157.50  E-value: 4.76e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892    180 AKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNH 259
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 19115892    260 SCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGA 303
Cdd:smart00317  81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
187-317 1.10e-28

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 111.59  E-value: 1.10e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 187 TEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRmrqYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCY 266
Cdd:COG2940  13 SPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERR---EPHKEPLHTYLFELDDDGVIDGALGGNPARFINHSCDPNCE 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 19115892 267 VDKwmvgDKLRMGIFCKRDIIRGEELTFDYNVDrYGAQAQPCYCgePCCVG 317
Cdd:COG2940  90 ADE----EDGRIFIVALRDIAAGEELTYDYGLD-YDEEEYPCRC--PNCRG 133
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 191-297 4.94e-27

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 106.07  E-value: 4.94e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892   191 GFGLRADANLPKDTFVYEYIGE-VIPEQKFRKRMRQYDSEGI---KHFYFMMLQKGE--YIDAT--KRGSLARFCNHSCR 262
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLElrlWGPYLFTLDEDSeyCIDARalYYGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 19115892   263 PNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYN 297
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
AWS smart00570
associated with SET domains; subdomain of PRESET
 125-179 6.23e-17

associated with SET domains; subdomain of PRESET


Pssm-ID: 197795  Cd Length: 50  Bit Score: 75.13  E-value: 6.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 19115892    125 EAMICDCRPHWVDgvNVACGhgSNCINRMTSIECTDeDNVCGPSCQNQRFQRHEF 179
Cdd:smart00570   1 DIMTCECKPTDDD--ETACG--SDCLNRMLFIECSS-SCPCGSYCSNQRFQKRQY 50
SRI pfam08236
SRI (Set2 Rpb1 interacting) domain; The SRI (Set2 Rpb1 interacting) domain mediates RNA ...
 699-776 2.21e-12

SRI (Set2 Rpb1 interacting) domain; The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilizes the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.


Pssm-ID: 462404  Cd Length: 83  Bit Score: 63.29  E-value: 2.21e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115892   699 FKAVLAKFFANKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEkalPDELSDSQQRKLRVWAFRYLDTVVSR 776
Cdd:pfam08236   8 FEKTLAPHVVNVLNKYRKKLGKEDFKRLAKELTKILVAKELKKCPNRDP---PEELSEKKKKKVKEFVKDYMEKFGAK 82
AWS pfam17907
AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc ...
 143-177 3.27e-12

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc binding domain. The full AWS domain contains 8 cysteines. This entry represents the N-terminal part of the domain, with the C-terminal part interwoven with the SET domain.


Pssm-ID: 465559  Cd Length: 39  Bit Score: 61.29  E-value: 3.27e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19115892   143 CGHGSNCINRMTSIECTDEDNVCGPSCQNQRFQRH 177
Cdd:pfam17907   5 CGCGSDCINRMLFVECTPKTCPCGESCQNQRFQRK 39
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 440-489 7.31e-04

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 38.27  E-value: 7.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19115892   440 ILRSIKTMlswpRLTRNKIQDSNIEPVVQEFCDH-ENEEVKDHAKTLLKEW 489
Cdd:pfam08711   2 LLKKLEKL----PVTLELLKSTGIGKVVNKLRKHkENPEIKKLAKELVKKW 48
 
Name Accession Description Interval E-value
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
 179-320 3.54e-90

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 279.85  E-value: 3.54e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 179 FAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19172   1 YAKVEVFRTEKKGWGLRAAEDLPKGTFVIEYVGEVLDEKEFKRRMKEYAREGNRHYYFMALKSDEIIDATKKGNLSRFIN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIG 320
Cdd:cd19172  81 HSCEPNCETQKWTVNGELRVGFFAKRDIPAGEELTFDYQFERYGKEAQKCYCGSPNCRGYIG 142
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
 181-315 7.49e-53

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 179.76  E-value: 7.49e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 181 KVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHS 260
Cdd:cd10531   1 KLELFRTEKKGWGVKAKEDIQKGEFIIEYVGEVIDKKEFKERLDEYEELGKSNFYILSLSDDVVIDATRKGNLSRFINHS 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19115892 261 CRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCC 315
Cdd:cd10531  81 CEPNCETQKWIVNGEYRIGIFALRDIPAGEELTFDYNFVNYNEAKQVCLCGAQNC 135
SET_ASH1L cd19174
SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ...
 181-321 9.10e-52

SET domain (including post-SET domain) found in ASH1-like protein (ASH1L) and similar proteins; ASH1L (EC 2.1.1.43; also termed absent small and homeotic disks protein 1 homolog, KMT2H, or lysine N-methyltransferase 2H) acts as histone-lysine N-methyltransferase that specifically methylates 'Lys-36' of histone H3 (H3K36me). It plays important roles in development; heterozygous mutation of ASH1L is associated with severe intellectual disability (ID) and multiple congenital anomaly (MCA).


Pssm-ID: 380951 [Multi-domain]  Cd Length: 141  Bit Score: 177.10  E-value: 9.10e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 181 KVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRM-RQYDSEgiKHFYFMMLQKGEYIDATKRGSLARFCNH 259
Cdd:cd19174   1 GLERFRTEDKGWGVRTKEPIKAGQFIIEYVGEVVSEQEFRRRMiEQYHNH--SHHYCLNLDSGMVIDGYRMGNEARFVNH 78

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 19115892 260 SCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQA-QPCYCGEPCCVGYIGG 321
Cdd:cd19174  79 SCDPNCEMQKWSVNGVYRIGLFALKDIPAGEELTYDYNFHSFNVEKqQPCKCGSPNCRGVIGG 141
SET_NSD cd19173
SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, ...
 179-320 3.59e-50

SET domain (including post-SET domain) found in nuclear SET domain-containing proteins, NSD1, NSD2, NSD3 and similar proteins; The nuclear receptor-binding SET Domain (NSD) family of histone H3 lysine 36 methyltransferases is comprised of NSD1, NSD2, and NSD3, which are primarily known to be involved in chromatin integrity and gene expression through mono-, di-, or tri-methylating lysine 36 of histone H3 (H3K36), respectively. NSD1 (EC 2.1.1.43; also termed histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B) or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-27' (H3K27me) methyltransferase activity. NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3.


Pssm-ID: 380950 [Multi-domain]  Cd Length: 142  Bit Score: 172.50  E-value: 3.59e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 179 FAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19173   1 YPPTEPFKTGDRGWGLRTKRDIKKGDFVIEYVGELIDEEECRRRLKKAHENNITNFYMLTLDKDRIIDAGPKGNLSRFMN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIG 320
Cdd:cd19173  81 HSCQPNCETQKWTVNGDTRVGLFAVRDIPAGEELTFNYNLDCLGNEKKVCRCGAPNCSGFLG 142
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 180-303 4.76e-45

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 157.50  E-value: 4.76e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892    180 AKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNH 259
Cdd:smart00317   1 NKLEVFKSPGKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAYDTDGAKAFYLFDIDSDLCIDARRKGNLARFINH 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 19115892    260 SCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGA 303
Cdd:smart00317  81 SCEPNCELLFVEVNGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
 181-320 5.47e-44

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 155.27  E-value: 5.47e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 181 KVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHS 260
Cdd:cd19175   1 KMKLVKTEKCGWGLVADEDINAGEFIIEYVGEVIDDKTCEERLWDMKHKGEKNFYMCEIDKDMVIDATFKGNLSRFINHS 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 261 CRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQpCYCGEPCCVGYIG 320
Cdd:cd19175  81 CDPNCELQKWQVDGETRIGVFAIRDIKKGEELTYDYQFVQFGADQD-CHCGSKNCRGKLG 139
SET_NSD3 cd19212
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 179-320 6.87e-40

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 3 (NSD3) and similar proteins; NSD3 (EC 2.1.1.43; also termed protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine, Wolf-Hirschhorn syndrome candidate 1-like protein 1 (WHSC1L1), or WHSC1-like protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. NSD3 is amplified and overexpressed in multiple cancer types, including acute myeloid leukemia (AML), breast, lung, pancreatic and bladder cancers, as well as squamous cell carcinoma of the head and neck (SCCHN). NSD3 contributes to tumorigenesis by interacting with bromodomain-containing protein 4 (BRD4), the bromodomain and extraterminal (BET) protein, which is a potential therapeutic target in acute myeloid leukemia (AML). NSD3 is amplified in primary tumors and cell lines from breast carcinoma, and can promote the cell viability of small-cell lung cancer and pancreatic ductal adenocarcinoma. High NSD3 expression is implicated in poor grade and heavy smoking history in SCCHN. Thus, NSD3 may serve as a potential druggable target for selective cancer therapy.


Pssm-ID: 380989 [Multi-domain]  Cd Length: 142  Bit Score: 143.91  E-value: 6.87e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 179 FAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19212   1 YPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIG 320
Cdd:cd19212  81 HSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLG 142
SET_NSD2 cd19211
SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) ...
 179-320 1.51e-39

SET domain (including post-SET domain) found in nuclear SET domain-containing protein 2 (NSD2) and similar proteins; NSD2 (EC 2.1.1.43; also termed multiple myeloma SET domain-containing protein (MMSET), protein trithorax-5 (TRX5), or wolf-Hirschhorn syndrome candidate 1 protein (WHSC1)) acts as histone-lysine N-methyltransferase with histone H3 'Lys-36' (H3K36me) methyltransferase activity. NSD2 has been shown to mediate di- and trimethylation of H3K36 and dimethylation of H4K20 in different systems, and has been characterized as a transcriptional repressor interacting with histone deacetylase HDAC1 and histone demethylase LSD1. NSD2 mediates constitutive NF-kappaB signaling for cancer cell proliferation, survival and tumor growth. It is highly overexpressed in several types of human cancers, including small-cell lung cancers, neuroblastoma, carcinomas of stomach and colon, and bladder cancers, and its overexpression tends to be associated with tumor aggressiveness. WHSC1 is frequently deleted in Wolf-Hirschhorn syndrome (WHS).


Pssm-ID: 380988 [Multi-domain]  Cd Length: 142  Bit Score: 142.82  E-value: 1.51e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 179 FAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19211   1 YPETKIIKTEGKGWGLIAKRDIKKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFMN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIG 320
Cdd:cd19211  81 HSCQPNCETQKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGAPNCSGFLG 142
SET_NSD1 cd19210
SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing ...
 179-320 1.18e-38

SET domain (including post-SET domain) found in nuclear receptor-binding SET domain-containing protein 1 (NSD1) and similar proteins; NSD1 (EC 2.1.1.43; also termed Histone-lysine N-methyltransferase H3 lysine-36 and H4 lysine-20 specific, androgen receptor coactivator 267 kDa protein (ARA267), androgen receptor-associated protein of 267 kDa, H3-K36-HMTase, H4-K20-HMTase, lysine N-methyltransferase 3B (KMT3B), or NR-binding SET domain-containing protein 1) functions as a histone-lysine N-methyltransferase that preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4. NSD1 is altered in approximately 10% of head and neck cancer patients with 55% decrease in risk of death in NSD1-mutated versus non-mutated patients; its disruption promotes favorable chemotherapeutic responses linked to hypomethylation.


Pssm-ID: 380987 [Multi-domain]  Cd Length: 142  Bit Score: 140.45  E-value: 1.18e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 179 FAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19210   1 YPEVEIFRTLGRGWGLRCKTDIKKGEFVNEYVGELIDEEECRARIRYAQEHDITNFYMLTLDKDRIIDAGPKGNYARFMN 80

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCCVGYIG 320
Cdd:cd19210  81 HCCQPNCETQKWTVNGDTRVGLFALCDIKAGTELTFNYNLECLGNGKTVCKCGAPNCSGFLG 142
SET_SETMAR cd10544
SET domain (including pre-SET and post-SET domains) found in SET domain and mariner ...
 112-318 2.55e-33

SET domain (including pre-SET and post-SET domains) found in SET domain and mariner transposase fusion protein (SETMAR) and similar proteins; SETMAR (also termed metnase) is a DNA-binding protein that is indirectly recruited to sites of DNA damage through protein-protein interactions. It has a sequence-specific DNA-binding activity recognizing the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element and displays a DNA nicking and end joining activity. SETMAR also acts as a histone-lysine N-methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3. It specifically mediates dimethylation of H3 'Lys-36' at sites of DNA double-strand break and may recruit proteins required for efficient DSB repair through non-homologous end-joining.


Pssm-ID: 380942 [Multi-domain]  Cd Length: 254  Bit Score: 128.96  E-value: 2.55e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 112 QYASANIGKP----PENEAMI--CDCRPHWVDGVNVAC--GHGSN-----CINRMTS------IECTDEdNVCGPSCQNQ 172
Cdd:cd10544   4 QYTPENVPGPgadtDPNEITFpgCDCKTSSCEPETCSClrKYGPNydddgCLLDFDGkysgpvFECNSM-CKCSESCQNR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 173 RFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQY---DSEGI----KHFYFMMLQKgEYI 245
Cdd:cd10544  83 VVQNGLQFKLQVFKTPKKGWGLRTLEFIPKGRFVCEYAGEVIGFEEARRRTKSQtkgDMNYIivlrEHLSSGKVLE-TFV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 246 DATKRGSLARFCNHSCRPNCY-----VDKwMVGdklRMGIFCKRDIIRGEELTFDY-------------NVDRYGAQAQP 307
Cdd:cd10544 162 DPTYIGNIGRFLNHSCEPNLFmvpvrVDS-MVP---KLALFAARDIVAGEELSFDYsgefsnsvesvtlARQDESKSRKP 237

                       250
                ....*....|.
gi 19115892 308 CYCGEPCCVGY 318
Cdd:cd10544 238 CLCGAENCRGF 248
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
 191-315 4.66e-32

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 121.55  E-value: 4.66e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 191 GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKW 270
Cdd:cd10518  25 GWGLFAKRPIAAGEMVIEYVGEVIRPIVADKREKRYDEEGGGGTYMFRIDEDLVIDATKKGNIARFINHSCDPNCYAKII 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19115892 271 MVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCGEPCC 315
Cdd:cd10518 105 TVDGEKHIVIFAKRDIAPGEELTYDYKFPIEDEEKIPCLCGAPNC 149
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 165-319 2.20e-29

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 117.39  E-value: 2.20e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLT-EKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKG- 242
Cdd:cd10542  72 CGPDCPNRVVQRGRKVPLCIFRTsNGRGWGVKTLEDIKKGTFVMEYVGEIITSEEAERRGKIYDANGRTYLFDLDYNDDd 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 243 -EY-IDATKRGSLARFCNHSCRPN-----CYVDkwmVGDKL--RMGIFCKRDIIRGEELTFDYN-VDRYGAQAQ------ 306
Cdd:cd10542 152 cEYtVDAAYYGNISHFINHSCDPNlavyaVWIN---HLDPRlpRIAFFAKRDIKAGEELTFDYLmTGTGGSSEStipkpk 228

                       170
                ....*....|....*..
gi 19115892 307 ----PCYCGEPCCVGYI 319
Cdd:cd10542 229 dvrvPCLCGSKNCRKYL 245
SET_SET1 cd20072
SET domain (including post-SET domain) found in catalytic component of the Saccharomyces ...
 192-315 6.35e-29

SET domain (including post-SET domain) found in catalytic component of the Saccharomyces cerevisiae COMPASS complex and similar proteins; The family contains mostly fungal SET domains, including SET1 found in the catalytic component of the Saccharomyces cerevisiae COMPASS (complex of proteins associated with Set1). SET1 is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex. The activity of this catalytic domain is established through forming a complex with a set of core proteins; it is extensively contacted by Cps60 (Bre2), Cps50 (Swd1), and Cps30 (Swd3).


Pssm-ID: 380998  Cd Length: 148  Bit Score: 112.90  E-value: 6.35e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 192 FGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWM 271
Cdd:cd20072  25 WGLYAMENISAKDMVIEYVGEVIRQQVADEREKRYLRQGIGSSYLFRIDDDTVVDATKKGNIARFINHCCDPNCTAKIIK 104

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 19115892 272 VGDKLRMGIFCKRDIIRGEELTFDYNVDRyGAQAQPCYCGEPCC 315
Cdd:cd20072 105 VEGEKRIVIYAKRDIAAGEELTYDYKFPR-EEDKIPCLCGAPNC 147
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
187-317 1.10e-28

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 111.59  E-value: 1.10e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 187 TEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRmrqYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCY 266
Cdd:COG2940  13 SPIHGRGVFATRDIPKGTLIGEYPGEVITWAEAERR---EPHKEPLHTYLFELDDDGVIDGALGGNPARFINHSCDPNCE 89

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 19115892 267 VDKwmvgDKLRMGIFCKRDIIRGEELTFDYNVDrYGAQAQPCYCgePCCVG 317
Cdd:COG2940  90 ADE----EDGRIFIVALRDIAAGEELTYDYGLD-YDEEEYPCRC--PNCRG 133
SET_SETD1 cd19169
SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and ...
 191-315 5.63e-28

SET domain (including post-SET domain) found in SET domain-containing protein 1 (SETD1) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A) and SET domain-containing protein 1B (SETD1B). These proteins are histone-lysine N-methyltransferases that specifically methylate 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated.


Pssm-ID: 380946  Cd Length: 148  Bit Score: 110.12  E-value: 5.63e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 191 GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKW 270
Cdd:cd19169  24 DWGLFALEPIAADEMVIEYVGQVIRQSVADEREKRYEAIGIGSSYLFRVDDDTIIDATKCGNLARFINHSCNPNCYAKII 103

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 19115892 271 MVGDKLRMGIFCKRDIIRGEELTFDYNVDrYGAQAQPCYCGEPCC 315
Cdd:cd19169 104 TVESQKKIVIYSKRPIAVNEEITYDYKFP-IEDEKIPCLCGAPQC 147
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 191-297 4.94e-27

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 106.07  E-value: 4.94e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892   191 GFGLRADANLPKDTFVYEYIGE-VIPEQKFRKRMRQYDSEGI---KHFYFMMLQKGE--YIDAT--KRGSLARFCNHSCR 262
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVlLITKEEADKRELLYYDKLElrlWGPYLFTLDEDSeyCIDARalYYGNWARFINHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 19115892   263 PNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYN 297
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDYG 115
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 165-297 6.35e-27

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 109.38  E-value: 6.35e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEG------IKHFYFMM 238
Cdd:cd10538  74 CDDDCKNRVVQRGLQARLQVFRTSKKGWGVRSLEFIPKGSFVCEYVGEVITTSEADRRGKIYDKSGgsylfdLDEFSDSD 153

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115892 239 LQKGEY-IDATKRGSLARFCNHSCRPNCYVDK-WMVGDKL---RMGIFCKRDIIRGEELTFDYN 297
Cdd:cd10538 154 GDGEELcVDATFCGNVSRFINHSCDPNLFPFNvVIDHDDLrypRIALFATRDILPGEELTFDYG 217
SET_KMT2C_2D cd19171
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), ...
 181-319 1.97e-26

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C), 2D (KMT2D) and similar proteins; This family includes KMT2C and KMT2D. Both, KMT2C (also termed HALR or MLL3) and KMT2D (also termed ALR or MLL2), act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me). They are subunits of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380948 [Multi-domain]  Cd Length: 153  Bit Score: 105.59  E-value: 1.97e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 181 KVDVFLTEKK--GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSE--GIkhfYFMMLQKGEYIDATKRGSLARF 256
Cdd:cd19171  13 RSNVYLARSRiqGLGLYAARDIEKHTMVIEYIGEIIRNEVANRREKIYESQnrGI---YMFRIDNDWVIDATMTGGPARY 89

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115892 257 CNHSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQ-PCYCGEPCCVGYI 319
Cdd:cd19171  90 INHSCNPNCVAEVVTFDKEKKIIIISNRRIAKGEELTYDYKFDFEDDQHKiPCLCGAPNCRKWM 153
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
 191-296 1.04e-25

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 102.32  E-value: 1.04e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 191 GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKhfYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKW 270
Cdd:cd10519  12 GWGLFLKEPIKKDEFIGEYTGELISQDEADRRGKIYDKYNSS--YLFNLNDQFVVDATRKGNKIRFANHSSNPNCYAKVM 89

                        90       100
                ....*....|....*....|....*.
gi 19115892 271 MVGDKLRMGIFCKRDIIRGEELTFDY 296
Cdd:cd10519  90 MVNGDHRIGIFAKRDIEAGEELFFDY 115
SET_KMT2A_2B cd19170
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), ...
 182-319 2.81e-25

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B) and similar proteins; This family includes KMT2A and KMT2B. Both KMT2A (also termed ALL-1 or CXXC7 or MLL or MLL1 or TRX1 or HRX) and KMT2B (also termed MLL4 or TRX2) act as histone methyltransferases that methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380947 [Multi-domain]  Cd Length: 152  Bit Score: 102.47  E-value: 2.81e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 182 VDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMlQKGEYIDATKRGSLARFCNHSC 261
Cdd:cd19170  16 VGVYRSPIHGRGLFCKRNIDAGEMVIEYAGEVIRSVLTDKREKYYESKGIGCYMFRI-DDDEVVDATMHGNAARFINHSC 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19115892 262 RPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAqPCYCGEPCCVGYI 319
Cdd:cd19170  95 EPNCYSRVVNIDGKKHIVIFALRRILRGEELTYDYKFPIEDVKI-PCTCGSKKCRKYL 151
SET_SETDB1 cd10517
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 165-317 1.04e-24

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes.


Pssm-ID: 380915 [Multi-domain]  Cd Length: 288  Bit Score: 105.06  E-value: 1.04e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEgikhfYFMML----- 239
Cdd:cd10517 114 CDKRCYNRVVQNGLQVRLQVFKTEKKGWGIRCLDDIPKGSFVCIYAGQILTEDEANEEGLQYGDE-----YFAELdyiev 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 240 ---QKGEY----------IDATKRGSLARFCNHSCRPNCYVDKWMVGDK-LRM---GIFCKRDIIRGEELTFDYN--VDR 300
Cdd:cd10517 189 vekLKEGYesdveehcyiIDAKSEGNLGRYLNHSCSPNLFVQNVFVDTHdLRFpwvAFFASRYIRAGTELTWDYNyeVGS 268

                       170
                ....*....|....*..
gi 19115892 301 YGAQAQPCYCGEPCCVG 317
Cdd:cd10517 269 VPGKVLYCYCGSSNCRG 285
SET_SUV39H2 cd10532
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 145-319 7.01e-24

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 2 (SUV39H2) and similar proteins; SUV39H2 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B (KMT1B), or Su(var)3-9 homolog 2) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380930 [Multi-domain]  Cd Length: 243  Bit Score: 101.51  E-value: 7.01e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 145 HGSNCINRMTSI-ECTDEDNvCGPSCQNQRFQRHEFAKVDVFLTEK-KGFGLRADANLPKDTFVYEYIGEVIPEQKFRKR 222
Cdd:cd10532  49 HGQLKIPPGTPIyECNSRCK-CGPDCPNRVVQKGTQYSLCIFRTSNgRGWGVKTLQKIKKNSFVMEYVGEVITSEEAERR 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 223 MRQYDSEGIKHFYFMMLQKGEY-IDATKRGSLARFCNHSCRPNCYVDKWMVgDKL-----RMGIFCKRDIIRGEELTFDY 296
Cdd:cd10532 128 GQFYDSKGITYLFDLDYESDEFtVDAARYGNVSHFVNHSCDPNLQVFNVFI-DNLdtrlpRIALFSTRTIKAGEELTFDY 206

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 19115892 297 NVDRYG------AQAQP--------CYCGEPCCVGYI 319
Cdd:cd10532 207 QMKGSGdlssdsIDNSPakkrvrtvCKCGAVTCRGYL 243
SET_SUV39H_Clr4-like cd20073
SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 ...
 157-319 1.19e-22

SET domain (including pre-SET and post-SET domains) found in of Schizosaccharomyces pombe H3K9 methyltransferase Clr4, and similar proteins; This subfamily contains fission yeast Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (also known as Suv39h), the sole homolog of the mammalian SUV39H1 and SUV39H2 enzymes, that has a critical role in preventing aberrant heterochromatin formation. It is known to di- and tri-methylate Lys-9 of histone H3, a central heterochromatic histone modification, with its specificity profile most similar to that of the human SUV39H2 homolog.


Pssm-ID: 380999 [Multi-domain]  Cd Length: 259  Bit Score: 98.03  E-value: 1.19e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 157 ECtDEDNVCGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFY- 235
Cdd:cd20073  71 EC-NENCDCGINCPNRVVQRGRKLPLEIFKTKHKGWGLRCPRFIKAGTFIGVYLGEVITQSEAEIRGKKYDNVGVTYLFd 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 236 --FMMLQKGEY--IDATKRGSLARFCNHSCRPNCYVDKWMVGDKLR----MGIFCKRDIIRGEELTFDY----NVDRYGA 303
Cdd:cd20073 150 ldLFEDQVDEYytVDAQYCGDVTRFINHSCDPNLAIYSVLRDKSDSkiydLAFFAIKDIPALEELTFDYsgrnNFDQLGF 229

                       170       180
                ....*....|....*....|....*....
gi 19115892 304 QA-------------QPCYCGEPCCVGYI 319
Cdd:cd20073 230 IGnrsnskyinlknkRPCYCGSANCRGWL 258
SET_SUV39H1 cd10525
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
 165-319 1.01e-21

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homolog 1 (SUV39H1) and similar proteins; SUV39H1 (EC 2.1.1.43; also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A (KMT1A), position-effect variegation 3-9 homolog (SUV39H), or Su(var)3-9 homolog 1) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. It mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions.


Pssm-ID: 380923 [Multi-domain]  Cd Length: 255  Bit Score: 95.34  E-value: 1.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLTEK-KGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGE 243
Cdd:cd10525  71 CGPDCPNRVVQKGIQYDLCIFRTDNgRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDV 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 244 Y-IDATKRGSLARFCNHSCRPNCYVDKWMVgDKL-----RMGIFCKRDIIRGEELTFDYN--VD--------------RY 301
Cdd:cd10525 151 YtVDAAYYGNISHFVNHSCDPNLQVYNVFI-DNLderlpRIALFATRTIRAGEELTFDYNmqVDpvdaestkmdsnfgLA 229

                       170       180
                ....*....|....*....|....*
gi 19115892 302 GAQAQP-------CYCGEPCCVGYI 319
Cdd:cd10525 230 GLPGSPkkrvrieCKCGVRSCRKYL 254
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 190-301 2.38e-21

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 90.09  E-value: 2.38e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 190 KGFGLRADANLPKDTFVYEYIGEVIPEQKFRKR--MRQYDSegikhfYFMMLQKGE-YIDATKRGSLARFCNHSCRPNCY 266
Cdd:cd10522  13 NGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDsvYHYDPL------YPFDLNGDIlVIDAGKKGNLTRFINHSDQPNLE 86

                        90       100       110
                ....*....|....*....|....*....|....*
gi 19115892 267 VDKWMVGDKLRMGIFCKRDIIRGEELTFDYNvDRY 301
Cdd:cd10522  87 LIVRTLKGEQHIGFVAIRDIKPGEELFISYG-PKY 120
SET_KMT2A cd19206
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) ...
 182-315 1.53e-20

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2A (KMT2A) and similar proteins; KMT2A (EC2.1.1.43; also termed lysine N-methyltransferase 2A, ALL-1, CXXC-type zinc finger protein 7 (CXXC7), myeloid/lymphoid or mixed-lineage leukemia (MLL), myeloid/lymphoid or mixed-lineage leukemia protein 1 (MLL1), trithorax-like protein (TRX1), or zinc finger protein HRX) acts as a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac).


Pssm-ID: 380983 [Multi-domain]  Cd Length: 154  Bit Score: 88.93  E-value: 1.53e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 182 VDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMmLQKGEYIDATKRGSLARFCNHSC 261
Cdd:cd19206  16 VGVYRSPIHGRGLFCKRNIDAGEMVIEYSGNVIRSILTDKREKYYDSKGIGCYMFR-IDDSEVVDATMHGNAARFINHSC 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19115892 262 RPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQ-PCYCGEPCC 315
Cdd:cd19206  95 EPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKlPCNCGAKKC 149
SET_SETD8 cd10528
SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2. ...
 187-298 1.76e-20

SET domain found in SET domain-containing protein 8 (SETD8) and similar proteins; SETD8 (EC 2.1.1.43; also termed N-lysine methyltransferase KMT5A, H4-K20-HMTase KMT5A, lysine N-methyltransferase 5A, lysine-specific methylase 5A, PR/SET domain-containing protein 07, PR-Set7 or PR/SET07) is a nucleosomal histone-lysine N-methyltransferase that specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). It plays a central role in the silencing of euchromatic genes.


Pssm-ID: 380926 [Multi-domain]  Cd Length: 141  Bit Score: 88.40  E-value: 1.76e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 187 TEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQY--DSEGIKH-FYFMMLQKGEYIDATKR-GSLARFCNHSCR 262
Cdd:cd10528  24 IDGKGRGVIATRPFEKGDFVVEYHGDLITITEAKKREALYakDPSTGCYmYYFQYKGKTYCVDATKEsGRLGRLINHSKK 103

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 19115892 263 -PNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNV 298
Cdd:cd10528 104 kPNLKTKLLVIDGVPHLILVAKRDIKPGEELLYDYGD 140
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 165-315 1.74e-19

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 88.07  E-value: 1.74e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKfrKRMRQYDSegikHFYFMMLQKGEY 244
Cdd:cd10535  76 CWRNCRNRVVQNGLRARLQLYRTRDMGWGVRSLQDIPPGTFVCEYVGELISDSE--ADVREEDS----YLFDLDNKDGEV 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 245 --IDATKRGSLARFCNHSCRPNCY-VDKWMVGDKL---RMGIFCKRDIIRGEELTFDYNvDRY---GAQAQPCYCGEPCC 315
Cdd:cd10535 150 ycIDARFYGNVSRFINHHCEPNLVpVRVFMAHQDLrfpRIAFFSTRLIEAGEQLGFDYG-ERFwdiKGKLFSCRCGSPKC 228
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 157-315 1.95e-19

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 88.16  E-value: 1.95e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 157 ECTDEDNvCGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKrmRQYDSegikhFYF 236
Cdd:cd10543  69 ECNRACS-CWRNCRNRVVQNGIRYRLQLFRTRGMGWGVRALQDIPKGTFVCEYIGELISDSEADS--REDDS-----YLF 140

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 237 MMLQK-GEY--IDATKRGSLARFCNHSCRPNCYVDKWMVGDK----LRMGIFCKRDIIRGEELTFDYNvDRYGA---QAQ 306
Cdd:cd10543 141 DLDNKdGETycIDARRYGNISRFINHLCEPNLIPVRVFVEHQdlrfPRIAFFASRDIKAGEELGFDYG-EKFWRikgKYF 219


                ....*....
gi 19115892 307 PCYCGEPCC 315
Cdd:cd10543 220 TCRCGSPKC 228
SET_EZH2 cd19218
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43) ...
 191-296 2.77e-19

SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins; EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380995  Cd Length: 120  Bit Score: 84.19  E-value: 2.77e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 191 GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEgIKHFYFMmLQKGEYIDATKRGSLARFCNHSCRPNCYVDKW 270
Cdd:cd19218  15 GWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKY-MCSFLFN-LNNDFVVDATRKGNKIRFANHSVNPNCYAKVM 92

                        90       100
                ....*....|....*....|....*.
gi 19115892 271 MVGDKLRMGIFCKRDIIRGEELTFDY 296
Cdd:cd19218  93 MVNGDHRIGIFAKRAIQTGEELFFDY 118
SET_SETDB2 cd10523
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) ...
 165-319 2.55e-18

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 2 (SETDB2) and similar proteins; SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380921 [Multi-domain]  Cd Length: 266  Bit Score: 85.65  E-value: 2.55e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSC-------QNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVI-----PEQKFRKRMR----QYDS 228
Cdd:cd10523  86 CNVSCkcnrmlcQNRVVQHGLQVRLQVFKTEKKGWGVRCLDDIDKGTFVCIYAGRVLsrarsPTEPLPPKLElpseNEVE 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 229 EGIKHFYFMMLQKGE----YIDATKRGSLARFCNHSCRPNCYVDKWMVGDKLR----MGIFCKRDIIRGEELTFDYNVDR 300
Cdd:cd10523 166 VVTSWLILSKKRKLRenvcFLDASKEGNVGRFLNHSCCPNLFVQNVFVDTHDKnfpwVAFFTNRVVKAGTELTWDYSYDA 245

                       170       180
                ....*....|....*....|.
gi 19115892 301 YGAQAQ--PCYCGEPCCVGYI 319
Cdd:cd10523 246 GTSPEQeiPCLCGVNKCQKKI 266
SET_SETD1A cd19204
SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and ...
 192-317 2.60e-18

SET domain (including post-SET domain) found in SET domain-containing protein 1A (SETD1A) and similar proteins; SETD1A (EC2.1.1.43), also termed lysine N-methyltransferase 2F, or Set1/Ash2 histone methyltransferase complex subunit SET1, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me), when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Human SET domain containing protein 1A (hSETD1A) expression occurs at a high rate in hepatocellular carcinoma patients and controls tumor metastasis in breast cancer by activating MMP expression.


Pssm-ID: 380981 [Multi-domain]  Cd Length: 153  Bit Score: 82.38  E-value: 2.60e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 192 FGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWM 271
Cdd:cd19204  26 WGLFAMEPIAADEMVIEYVGQNIRQVVADMREKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVIT 105

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 19115892 272 VGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAqPCYCGEPCCVG 317
Cdd:cd19204 106 IESQKKIVIYSKQPIGVNEEITYDYKFPIEDNKI-PCLCGTENCRG 150
SET_KMT2D cd19209
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) ...
 181-315 8.97e-18

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2D (KMT2D) and similar proteins; KMT2D (EC2.1.1.43; also termed lysine N-methyltransferase 2D, ALL1-related protein (ALR), or myeloid/lymphoid or mixed-lineage leukemia protein 2 (MLL2)), acts as histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. KMT2D is a subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation.


Pssm-ID: 380986 [Multi-domain]  Cd Length: 155  Bit Score: 80.90  E-value: 8.97e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 181 KVDVFLTEKK--GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGiKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19209  15 KNNVYLARSRiqGLGLYAAKDLEKHTMVIEYIGTIIRNEVANRREKIYEEQN-RGIYMFRINNEHVIDATLTGGPARYIN 93

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQ-PCYCGEPCC 315
Cdd:cd19209  94 HSCAPNCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHKiPCHCGAWNC 151
SET_KMT2B cd19207
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) ...
 182-315 1.00e-17

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2B (KMT2B) and similar proteins; KMT2B (EC2.1.1.43; also termed lysine N-methyltransferase 2B, myeloid/lymphoid or mixed-lineage leukemia protein 4 (MLL2/MLL4), trithorax homolog 2 (TRX2), or WW domain-binding protein 7 (WBP-7)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me). It is required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that precedes resumption of meiosis, oocyte survival and normal zygotic genome activation.


Pssm-ID: 380984 [Multi-domain]  Cd Length: 154  Bit Score: 80.84  E-value: 1.00e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 182 VDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMlQKGEYIDATKRGSLARFCNHSC 261
Cdd:cd19207  16 VGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDSKGIGCYMFRI-DDFDVVDATMHGNAARFINHSC 94

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19115892 262 RPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQ-PCYCGEPCC 315
Cdd:cd19207  95 EPNCYSRVIHVEGQKHIVIFALRKIYRGEELTYDYKFPIEDASNKlPCNCGAKRC 149
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 192-297 1.86e-17

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 79.24  E-value: 1.86e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 192 FGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGikhfYFMMLQKGE-----YIDATKRGSLARFCNHSCRPNCY 266
Cdd:cd10529  17 KGLVATEDISPGEPILEYKGEVSLRSEFKEDNGFFKRPS----PFVFFYDGFeglplCVDARKYGNEARFIRRSCRPNAE 92

                        90       100       110
                ....*....|....*....|....*....|....
gi 19115892 267 VDKWMVGD-KLRMGIFCKRDIIRGEELT--FDYN 297
Cdd:cd10529  93 LRHVVVSNgELRLFIFALKDIRKGTEITipFDYD 126
SET_KMT2C cd19208
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) ...
 181-315 2.19e-17

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 2C (KMT2C) and similar proteins; KMT2C (EC2.1.1.43; also termed lysine N-methyltransferase 2C, homologous to ALR protein (HALR) myeloid/lymphoid, or mixed-lineage leukemia protein 3 (MLL3)), acts as a histone methyltransferase that methylates 'Lys-4' of histone H3 (H3K4me) and may be involved in leukemogenesis and developmental disorder. KMT2C is a catalytic subunit of MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. Overexpression of KMT2C is associated with estrogen receptor-positive breast cancer; KMT2C mediates the estrogen dependence of breast cancer through regulation of estrogen receptor alpha (ERalpha) enhancer function. KMT2C is frequently mutated in certain populations with diffuse-type gastric adenocarcinomas (DGA); its loss promotes epithelial-to-mesenchymal transition (EMT) and is associated with worse overall survival.


Pssm-ID: 380985 [Multi-domain]  Cd Length: 154  Bit Score: 80.06  E-value: 2.19e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 181 KVDVFLTEK--KGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGiKHFYFMMLQKGEYIDATKRGSLARFCN 258
Cdd:cd19208  14 KSNVYLARSriQGLGLYAARDIEKHTMVIEYIGTIIRNEVANRKEKLYESQN-RGVYMFRIDNDHVIDATLTGGPARYIN 92

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 19115892 259 HSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQ-PCYCGEPCC 315
Cdd:cd19208  93 HSCAPNCVAEVVTFEKGHKIIISSSRRIQKGEELCYDYKFDFEDDQHKiPCHCGAVNC 150
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 165-298 2.23e-17

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 82.07  E-value: 2.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRM----------RQYDSEGIKHF 234
Cdd:cd10545  71 CPPSCYNRVTQKGLRYRLEVFKTAERGWGVRSWDSIPAGSFICEYVGELLDTSEADTRSgnddylfdidNRQTNRGWDGG 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 235 YFMMLQKG-------------EY-IDATKRGSLARFCNHSCRPNCYVDKWMV--GDKL--RMGIFCKRDIIRGEELTFDY 296
Cdd:cd10545 151 QRLDVGMSdgerssaedeessEFtIDAGSFGNVARFINHSCSPNLFVQCVLYdhNDLRlpRVMLFAADNIPPLQELTYDY 230


                ..
gi 19115892 297 NV 298
Cdd:cd10545 231 GY 232
SET_SETD1B cd19205
SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and ...
 192-317 3.26e-17

SET domain (including post-SET domain) found in SET domain-containing protein 1B (SETD1B) and similar proteins; SETD1B (EC2.1.1.43), also termed lysine N-methyltransferase 2G, is a histone-lysine N-methyltransferase that specifically methylates 'Lys-4' of histone H3 (H3K4me) when part of the SET1 histone methyltransferase (HMT) complex, but not if the neighboring 'Lys-9' residue is already methylated. Loss of SETD1B occurs in up to half the gastric and colorectal cancers, most commonly via SETD1B mutations, while de novo variants in SETD1B are associated with intellectual disability, epilepsy and autism.


Pssm-ID: 380982 [Multi-domain]  Cd Length: 153  Bit Score: 79.33  E-value: 3.26e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 192 FGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRPNCYVDKWM 271
Cdd:cd19205  26 WGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVIT 105

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 19115892 272 VGDKLRMGIFCKRDIIRGEELTFDYNVDrYGAQAQPCYCGEPCCVG 317
Cdd:cd19205 106 VESQKKIVIYSKQHINVNEEITYDYKFP-IEDVKIPCLCGSENCRG 150
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 165-315 4.71e-17

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 81.22  E-value: 4.71e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKfrKRMRQYDSegikHFYFMMLQKGEY 244
Cdd:cd10533  76 CWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEYVGELISDAE--ADVREDDS----YLFDLDNKDGEV 149

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 245 --IDATKRGSLARFCNHSCRPNCY-VDKWMVGDKL---RMGIFCKRDIIRGEELTFDYNvDRY---GAQAQPCYCGEPCC 315
Cdd:cd10533 150 ycIDARYYGNISRFINHLCDPNIIpVRVFMLHQDLrfpRIAFFSSRDIRTGEELGFDYG-DRFwdiKSKYFTCQCGSEKC 228
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 239-297 4.87e-17

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 76.14  E-value: 4.87e-17
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 19115892 239 LQKGEYIdatkrgSLARFCNHSCRPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYN 297
Cdd:cd08161  20 IPKGEVI------GLARFINHSCEPNCEFEEVYVGGKPRVFIVALRDIKAGEELTVDYG 72
AWS smart00570
associated with SET domains; subdomain of PRESET
 125-179 6.23e-17

associated with SET domains; subdomain of PRESET


Pssm-ID: 197795  Cd Length: 50  Bit Score: 75.13  E-value: 6.23e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 19115892    125 EAMICDCRPHWVDgvNVACGhgSNCINRMTSIECTDeDNVCGPSCQNQRFQRHEF 179
Cdd:smart00570   1 DIMTCECKPTDDD--ETACG--SDCLNRMLFIECSS-SCPCGSYCSNQRFQKRQY 50
SET_EZH1 cd19217
SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43) ...
 191-296 1.32e-16

SET domain found in enhancer of zeste homolog 1 (EZH1) and similar proteins; EZH1 (EC 2.1.1.43), also termed ENX-2, or histone-lysine N-methyltransferase EZH1, is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380994  Cd Length: 136  Bit Score: 77.03  E-value: 1.32e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 191 GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEgIKHFYFMmLQKGEYIDATKRGSLARFCNHSCRPNCYVDKW 270
Cdd:cd19217  17 GWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKY-MSSFLFN-LNNDFVVDATRKGNKIRFANHSVNPNCYAKVV 94

                        90       100
                ....*....|....*....|....*.
gi 19115892 271 MVGDKLRMGIFCKRDIIRGEELTFDY 296
Cdd:cd19217  95 MVNGDHRIGIFAKRAIQQGEELFFDY 120
SET_SETDB cd10541
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), ...
 165-319 1.15e-15

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1), SET domain bifurcated 2 (SETDB2), and similar proteins; SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis.


Pssm-ID: 380939 [Multi-domain]  Cd Length: 236  Bit Score: 77.20  E-value: 1.15e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPS-CQNQRFQRHEFAKVDVFLTEKKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEgikhfYFMMLQKGE 243
Cdd:cd10541  76 CDPNmCQNRLVQHGLQVRLQLFKTQNKGWGIRCLDDIAKGTFVCIYAGKILTDDFADKEGLEMGDE-----YFANLDHIE 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 244 ----YIDATKRGSLARFCNHSCRPNCYVDKWMVGDKLR----MGIFCKRDIIRGEELTFDYNvdrYGAQAQP-----CYC 310
Cdd:cd10541 151 escyIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLrfpwVAFFASKRIKAGTELTWDYN---YEVGSVEgkellCCC 227


                ....*....
gi 19115892 311 GEPCCVGYI 319
Cdd:cd10541 228 GSNECRGRL 236
SET_SUV39H_DIM5-like cd19473
SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; ...
 165-318 1.18e-14

SET domain (including pre-SET domain) found in Neurospora crassa (DIM-5) and similar proteins; This subfamily contains Neurospora crassa DIM-5 (also termed H3-K9-HMTase dim-5, or HKMT) which functions as histone-lysine N-methyltransferase that specifically trimethylates histone H3 to form H3K9me3.


Pssm-ID: 380996 [Multi-domain]  Cd Length: 274  Bit Score: 75.05  E-value: 1.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 165 CGPSCQNQRFQRHEFAKVDVFLTE-KKGFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSEGIKHFYFMMLQK-- 241
Cdd:cd19473  90 CSDDCPNRVVERGRKVPLQIFRTSdGRGWGVRSTVDIKRGQFVDCYVGEIITPEEAQRRRDAATIAQRKDVYLFALDKfs 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 242 -GEYIDATKRGSL-----------ARFCNHSCRPNC--------YVDKWMVGdklrMGIFCKRDIIRGEELTFDY----- 296
Cdd:cd19473 170 dPDSLDPRLRGDPyeidgefmsgpTRFINHSCDPNLrifarvgdHADKHIHD----LAFFAIKDIPRGTELTFDYvdgvt 245

                       170       180
                ....*....|....*....|....*...
gi 19115892 297 ------NVDRYGAQAQPCYCGEPCCVGY 318
Cdd:cd19473 246 gldddaGDEEKEKEMTKCLCGSPKCRGY 273
SRI pfam08236
SRI (Set2 Rpb1 interacting) domain; The SRI (Set2 Rpb1 interacting) domain mediates RNA ...
 699-776 2.21e-12

SRI (Set2 Rpb1 interacting) domain; The SRI (Set2 Rpb1 interacting) domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. This domain is conserved from yeast to humans. Members of this family form a compact, closed three-helix bundle, with an up-down-up topology. The first and second helices are antiparallel to each other and are of similar length; the third helix, which is packed across helices alpha1 and alpha2 is slightly shorter, consisting of only 15 amino acids. Most conserved hydrophobic residues are largely buried in the interior of the structure and form an extensive and contiguous hydrophobic core that stabilizes the packing of the three-helix bundle. This domain mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.


Pssm-ID: 462404  Cd Length: 83  Bit Score: 63.29  E-value: 2.21e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19115892   699 FKAVLAKFFANKTARYQEKLGKAEFKLRVKKMTEIILKKHIQLVLSKKEkalPDELSDSQQRKLRVWAFRYLDTVVSR 776
Cdd:pfam08236   8 FEKTLAPHVVNVLNKYRKKLGKEDFKRLAKELTKILVAKELKKCPNRDP---PEELSEKKKKKVKEFVKDYMEKFGAK 82
SET_EZH-like cd19168
SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb ...
 191-301 2.59e-12

SET domain found in enhancer of zeste homolog 1 (EZH1) and zeste homolog 2 (EZH2) of polycomb repressive complex 2 (PRC2), and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both EZH1 and EZH2 can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.


Pssm-ID: 380945  Cd Length: 124  Bit Score: 64.52  E-value: 2.59e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 191 GFGLRADANLPKDTFVYEYIGEVIPEQKFRKRMRQYDSegIKHFYFMMLQKGEYIDATKRGSLARFCNHSCRP----NCY 266
Cdd:cd19168  13 GLGLFAAEDIKEGEFVIEYTGELISHDEGVRREHRRGD--VSYLYLFEEQEGIWVDAAIYGNLSRYINHATDKvktgNCM 90

                        90       100       110
                ....*....|....*....|....*....|....*
gi 19115892 267 VDKWMVGDKLRMGIFCKRDIIRGEELTFDYNvDRY 301
Cdd:cd19168  91 PKIMYVNHEWRIKFTAIKDIKIGEELFFNYG-DNF 124
AWS pfam17907
AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc ...
 143-177 3.27e-12

AWS domain; This entry represents the AWS (associated with SET domain) domain. This is a zinc binding domain. The full AWS domain contains 8 cysteines. This entry represents the N-terminal part of the domain, with the C-terminal part interwoven with the SET domain.


Pssm-ID: 465559  Cd Length: 39  Bit Score: 61.29  E-value: 3.27e-12
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 19115892   143 CGHGSNCINRMTSIECTDEDNVCGPSCQNQRFQRH 177
Cdd:pfam17907   5 CGCGSDCINRMLFVECTPKTCPCGESCQNQRFQRK 39
SET_SpSET3-like cd19183
SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET ...
 192-299 6.40e-12

SET domain (including post-SET domain) found in Schizosaccharomyces pombe SET domain-containing protein 3 (SETD3) and similar proteins; Schizosaccharomyces pombe SETD3 functions as a transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. It is required for both, gene activation and repression.


Pssm-ID: 380960  Cd Length: 173  Bit Score: 64.73  E-value: 6.40e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 192 FGLRADANLPKDTFVYEYIGEVipeqkfrKRMRQYDSEGIKHFYFMMLQKGE---------YIDATKRGSLARFCNHSCR 262
Cdd:cd19183  14 FGLFADRPIPAGDPIQELLGEI-------GLQSEYIADPENQYQILGAPKPHvffhpqsplYIDTRRSGSVARFIRRSCR 86

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 19115892 263 PNCYVDKWMVGD--KLRMGIFCKRDIIRGEELTFDYNVD 299
Cdd:cd19183  87 PNAELVTVASDSgsVLKFVLYASRDISPGEEITIGWDWD 125
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
 253-296 4.11e-08

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 52.38  E-value: 4.11e-08
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 19115892 253 LARFCNHSCRPNCYvdkWMVGDKLRMGIFCKRDIIRGEELTFDY 296
Cdd:cd20071  55 LASLLNHSCDPNAV---VVFDGNGTLRVRALRDIKAGEELTISY 95
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
 181-299 4.21e-08

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 51.87  E-value: 4.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 181 KVDVFLTEKKGFGLRADANLPKDTFVyeyigEVIPEQKFRKRMRQYDSEG-IKHFYFMMlQKGEYIDATKRGSLArfcNH 259
Cdd:cd10540   1 RLEVKPSTLKGRGVFATRPIKKGEVI-----EEAPVIVLPKEEYQHLCKTvLDHYVFSW-GDGCLALALGYGSMF---NH 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 19115892 260 SCRPNCYvdKWMVGDKLRMGIFCKRDIIRGEELTFDYNVD 299
Cdd:cd10540  72 SYTPNAE--YEIDFENQTIVFYALRDIEAGEELTINYGDD 109
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
 254-314 1.93e-07

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 50.74  E-value: 1.93e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19115892 254 ARFCNHSCRPNCyvdKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYCgEPC 314
Cdd:cd10524  77 AAFINHDCRPNC---KFVPTGKSTACVKVLRDIEPGEEITVYYGDNYFGENNEECEC-ETC 133
SET_ATXR5_6-like cd10539
SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The ...
 189-297 8.04e-07

SET domain found in fungal protein lysine methyltransferase SET5 and similar protein; The family includes Arabidopsis thaliana ATXR5 and ATXR6. Both ATXR5 (also termed protein SET DOMAIN GROUP 15, or TRX-related protein 5) and ATXR6 (also termed protein SET DOMAIN GROUP 34, or TRX-related protein 6) function as histone methyltransferase that specifically monomethylates 'Lys-37' of histone H3 (H3K27me1). They are required for chromatin structure and gene silencing.


Pssm-ID: 380937  Cd Length: 138  Bit Score: 48.95  E-value: 8.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 189 KKGFGLRADANLPKDTFVYEYIGEVipeQKFRKRMRqYDSEGIkhfyfMML------QKGEYIDATKRGSLARFC----N 258
Cdd:cd10539  13 REGFTVEADGFIKDLTIIAEYTGDV---DYIRNREF-DDNDSI-----MTLllagdpSKSLVICPDKRGNIARFIsginN 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 19115892 259 HSC----RPNCYVDKWMVGDKLRMGIFCKRDIIRGEELTFDYN 297
Cdd:cd10539  84 HTKdgkkKQNCKCVRYSINGEARVLLVATRDIAKGERLYYDYN 126
SET_KMT2E cd19182
SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar ...
 194-302 1.84e-05

SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; KMT2E (also termed inactive lysine N-methyltransferase 2E, myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) plays a key role in hematopoiesis, spermatogenesis and cell cycle progression. It associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Lack of key residues in the SET domain as well as the presence of an unusually large loop in the SET-I subdomain preclude the interaction of MLL5 SET with its cofactor and substrate thus making MLL5 devoid of any in vitro methyltransferase activity on full-length histones and histone H3 peptide.


Pssm-ID: 380959  Cd Length: 129  Bit Score: 44.88  E-value: 1.84e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 194 LRADANLPKDTFVYEYIGevipeqKFRKRmRQYDSEG--IKHFYFMMLQKGEY------IDATKRGSLARFCNHSCRPNC 265
Cdd:cd19182  21 LKAAKDLPPDTLIIEYRG------KFMLR-EQFEANGyfFKRPYPFVLFYSKFhglemcVDARTFGNEARFIRRSCTPNA 93

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 19115892 266 YVDKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDrYG 302
Cdd:cd19182  94 EVRHVIEDGTIHLYIYSIRSIPKGTEITIAFDFD-YG 129
SET_SETD5 cd19181
SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and ...
 194-297 2.30e-05

SET domain (including post-SET domain) found in SET domain-containing protein 5 (SETD5) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. SETD5 loss-of-function mutations are a likely cause of a familial syndromic intellectual disability with variable phenotypic expression.


Pssm-ID: 380958  Cd Length: 150  Bit Score: 45.00  E-value: 2.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19115892 194 LRADANLPKDTFVYEYIGEVIPEQKFrkrmrQYDSEGIKHFYFMMLQKGEY------IDATKRGSLARFCNHSCRPNCYV 267
Cdd:cd19181  21 LRAARDLALDTLIIEYRGKVMLRQQF-----EVNGHFFKRPYPFVLFYSKFngvemcVDARTFGNDARFIRRSCTPNAEV 95

                        90       100       110
                ....*....|....*....|....*....|..
gi 19115892 268 DKWMVGDKLRMGIFCKRDIIRGEELT--FDYN 297
Cdd:cd19181  96 RHMIADGMIHLCIYAVAAIAKDAEVTiaFDYE 127
SET_KMT5C cd19185
SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) ...
 254-310 5.17e-04

SET domain (including post-SET domain) found in histone-lysine N-methyltransferase 5C (KMT5C) and similar proteins; KMT5C (also termed lysine N-methyltransferase 5C, lysine-specific methyltransferase 5C, suppressor of variegation 4-20 homolog 2, Su(var)4-20 homolog 2 or Suv4-20h2) is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 (H4K20me3). It plays a central role in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380962  Cd Length: 142  Bit Score: 41.18  E-value: 5.17e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19115892 254 ARFCNHSCRPNCyvdKWMVGDKLRMGIFCKRDIIRGEELTFDYNVDRYGAQAQPCYC 310
Cdd:cd19185  77 AAFINHDCKPNC---KFVPADGNAACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCEC 130
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 440-489 7.31e-04

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 38.27  E-value: 7.31e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 19115892   440 ILRSIKTMlswpRLTRNKIQDSNIEPVVQEFCDH-ENEEVKDHAKTLLKEW 489
Cdd:pfam08711   2 LLKKLEKL----PVTLELLKSTGIGKVVNKLRKHkENPEIKKLAKELVKKW 48
PostSET smart00508
Cysteine-rich motif following a subset of SET domains;
304-320 1.51e-03

Cysteine-rich motif following a subset of SET domains;


Pssm-ID: 214703  Cd Length: 17  Bit Score: 36.61  E-value: 1.51e-03
                           10
                   ....*....|....*..
gi 19115892    304 QAQPCYCGEPCCVGYIG 320
Cdd:smart00508   1 KKQPCLCGAPNCRGFLG 17
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
 242-298 3.23e-03

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 39.97  E-value: 3.23e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 19115892 242 GEYIDATKRGSLAR-------FCNHSCRPNCyvDKWMVGDKLrmGIFCKRDIIRGEELTFDYNV 298
Cdd:cd10536 132 GSQVDTSKQVRIATaiyptlsLLNHSCDPNT--IRSFYGNTI--VVRATRPIKKGEEITICYGP 191
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH