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Conserved domains on  [gi|19112136|ref|NP_595344|]
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WD repeat-containing protein [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-297 2.20e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 2.20e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  16 PINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRRLG 95
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  96 GHLAQINTIRYNEDSSILASGSFDSKVRLWDcrSNSFSPIQVLADAKDSVSSIDIAE--HLIVTGSTDGTLRTYDIRKGT 173
Cdd:cd00200  91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPdgTFVASSSQDGTIKLWDLRTGK 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 174 LSSDYFSH--PITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGlknMEYRVRS-SFNQSETIVFSGSEDGKVYL 250
Cdd:cd00200 169 CVATLTGHtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNSvAFSPDGYLLASGSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112136 251 WDLENETqiTSTSVVG-TPIVTDISCHPtmDDFIIATVHGDLFIYQYN 297
Cdd:cd00200 246 WDLRTGE--CVQTLSGhTNSVTSLAWSP--DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-297 2.20e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 2.20e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  16 PINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRRLG 95
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  96 GHLAQINTIRYNEDSSILASGSFDSKVRLWDcrSNSFSPIQVLADAKDSVSSIDIAE--HLIVTGSTDGTLRTYDIRKGT 173
Cdd:cd00200  91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPdgTFVASSSQDGTIKLWDLRTGK 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 174 LSSDYFSH--PITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGlknMEYRVRS-SFNQSETIVFSGSEDGKVYL 250
Cdd:cd00200 169 CVATLTGHtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNSvAFSPDGYLLASGSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112136 251 WDLENETqiTSTSVVG-TPIVTDISCHPtmDDFIIATVHGDLFIYQYN 297
Cdd:cd00200 246 WDLRTGE--CVQTLSGhTNSVTSLAWSP--DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
14-290 7.05e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 7.05e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  14 KEPINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRR 93
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  94 LGGHLAQINTIRYNEDSSILASGSFDSKVRLWDCRSNsfSPIQVLADAKDSVSSIDIA--EHLIVTGSTDGTLRTYDIRK 171
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 172 GTL--SSDYFSHPITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGLKNMEYRVrsSFNQSETIVFSGSEDGKVY 249
Cdd:COG2319 278 GELlrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 19112136 250 LWDLENETQITsTSVVGTPIVTDISCHPtmDDFIIATVHGD 290
Cdd:COG2319 356 LWDLATGELLR-TLTGHTGAVTSVAFSP--DGRTLASGSAD 393
PTZ00421 PTZ00421
coronin; Provisional
 72-129 4.46e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 4.46e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19112136   72 ASCGGDKFIQVWDVNTGKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWDCRS 129
Cdd:PTZ00421 142 ASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 87-126 1.29e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.29e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19112136     87 TGKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWD 126
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
88-126 1.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19112136    88 GKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWD 126
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 16-297 2.20e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.49  E-value: 2.20e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  16 PINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRRLG 95
Cdd:cd00200  11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  96 GHLAQINTIRYNEDSSILASGSFDSKVRLWDcrSNSFSPIQVLADAKDSVSSIDIAE--HLIVTGSTDGTLRTYDIRKGT 173
Cdd:cd00200  91 GHTSYVSSVAFSPDGRILSSSSRDKTIKVWD--VETGKCLTTLRGHTDWVNSVAFSPdgTFVASSSQDGTIKLWDLRTGK 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 174 LSSDYFSH--PITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGlknMEYRVRS-SFNQSETIVFSGSEDGKVYL 250
Cdd:cd00200 169 CVATLTGHtgEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNSvAFSPDGYLLASGSEDGTIRV 245

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 19112136 251 WDLENETqiTSTSVVG-TPIVTDISCHPtmDDFIIATVHGDLFIYQYN 297
Cdd:cd00200 246 WDLRTGE--CVQTLSGhTNSVTSLAWSP--DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
14-290 7.05e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.60  E-value: 7.05e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  14 KEPINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRR 93
Cdd:COG2319 120 TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRT 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  94 LGGHLAQINTIRYNEDSSILASGSFDSKVRLWDCRSNsfSPIQVLADAKDSVSSIDIA--EHLIVTGSTDGTLRTYDIRK 171
Cdd:COG2319 200 LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG--KLLRTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLWDLAT 277

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 172 GTL--SSDYFSHPITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGLKNMEYRVrsSFNQSETIVFSGSEDGKVY 249
Cdd:COG2319 278 GELlrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFSPDGKTLASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 19112136 250 LWDLENETQITsTSVVGTPIVTDISCHPtmDDFIIATVHGD 290
Cdd:COG2319 356 LWDLATGELLR-TLTGHTGAVTSVAFSP--DGRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-252 1.56e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 139.78  E-value: 1.56e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  14 KEPINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRR 93
Cdd:cd00200  51 TGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTT 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  94 LGGHLAQINTIRYNEDSSILASGSFDSKVRLWDcrSNSFSPIQVLADAKDSVSSIDIA--EHLIVTGSTDGTLRTYDIRK 171
Cdd:cd00200 131 LRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWD--LRTGKCVATLTGHTGEVNSVAFSpdGEKLLSSSSDGTIKLWDLST 208

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 172 GTLSSDYFSH--PITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGLKNmeyRVRS-SFNQSETIVFSGSEDGKV 248
Cdd:cd00200 209 GKCLGTLRGHenGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN---SVTSlAWSPDGKRLASGSADGTI 285


                ....
gi 19112136 249 YLWD 252
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
14-255 4.43e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.43e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  14 KEPINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRR 93
Cdd:COG2319 162 SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRT 241

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  94 LGGHLAQINTIRYNEDSSILASGSFDSKVRLWDcrSNSFSPIQVLADAKDSVSSIDIA--EHLIVTGSTDGTLRTYDIRK 171
Cdd:COG2319 242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD--LATGELLRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLAT 319

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 172 GTLSSDYFSH--PITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGLKNmeyRVRS-SFNQSETIVFSGSEDGKV 248
Cdd:COG2319 320 GKLLRTLTGHtgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTG---AVTSvAFSPDGRTLASGSADGTV 396


                ....*..
gi 19112136 249 YLWDLEN 255
Cdd:COG2319 397 RLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
16-290 6.32e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 133.11  E-value: 6.32e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  16 PINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRRLG 95
Cdd:COG2319  80 AVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  96 GHLAQINTIRYNEDSSILASGSFDSKVRLWDCRSNsfSPIQVLADAKDSVSSIDIA--EHLIVTGSTDGTLRTYDIRKGT 173
Cdd:COG2319 160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG--KLLRTLTGHTGAVRSVAFSpdGKLLASGSADGTVRLWDLATGK 237

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 174 LSSDYFSH--PITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGLKNmeyRVRS-SFNQSETIVFSGSEDGKVYL 250
Cdd:COG2319 238 LLRTLTGHsgSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG---GVNSvAFSPDGKLLASGSDDGTVRL 314

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 19112136 251 WDLENETQITsTSVVGTPIVTDISCHPtmDDFIIATVHGD 290
Cdd:COG2319 315 WDLATGKLLR-TLTGHTGAVRSVAFSP--DGKTLASGSDD 351
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-259 2.26e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 2.26e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  48 CIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWDc 127
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 128 rSNSFSPIQVLADAKDSVSSIDI--AEHLIVTGSTDGTLRTYDIRKGTLSSDYFSH--PITSVKTSKSASFSLISSLNSS 203
Cdd:cd00200  80 -LETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLTTLRGHtdWVNSVAFSPDGTFVASSSQDGT 158

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 19112136 204 IHLLDQETGKILKSYIGLKNmeyRVRS-SFNQSETIVFSGSEDGKVYLWDLENETQI 259
Cdd:cd00200 159 IKLWDLRTGKCVATLTGHTG---EVNSvAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 COG2319
WD40 repeat [General function prediction only];
2-290 3.50e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 111.93  E-value: 3.50e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136   2 RLEAKTKLSSKAKEPINVVKYNRTGKYVLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQ 81
Cdd:COG2319  24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  82 VWDVNTGKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWDcrSNSFSPIQVLADAKDSVSSIDIA--EHLIVTGS 159
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWD--LATGKLLRTLTGHSGAVTSVAFSpdGKLLASGS 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 160 TDGTLRTYDIRKGTLSSDYFSH--PITSVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGLknmEYRVRS-SFNQSE 236
Cdd:COG2319 182 DDGTVRLWDLATGKLLRTLTGHtgAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGH---SGSVRSvAFSPDG 258

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 19112136 237 TIVFSGSEDGKVYLWDLENETQITsTSVVGTPIVTDISCHPtmDDFIIATVHGD 290
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLR-TLTGHSGGVNSVAFSP--DGKLLASGSDD 309
WD40 COG2319
WD40 repeat [General function prediction only];
29-290 1.41e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 1.41e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136  29 VLAAGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRRLGGHLAQINTIRYNE 108
Cdd:COG2319   9 LAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 109 DSSILASGSFDSKVRLWDCRSNsfSPIQVLADAKDSVSSIDIAE--HLIVTGSTDGTLRTYDIRKGTLSSDYFSH--PIT 184
Cdd:COG2319  89 DGRLLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPdgKTLASGSADGTVRLWDLATGKLLRTLTGHsgAVT 166

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136 185 SVKTSKSASFSLISSLNSSIHLLDQETGKILKSYIGLKNmeyRVRS-SFNQSETIVFSGSEDGKVYLWDLENETQITSTS 263
Cdd:COG2319 167 SVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG---AVRSvAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT 243

                       250       260
                ....*....|....*....|....*..
gi 19112136 264 vVGTPIVTDISCHPtmDDFIIATVHGD 290
Cdd:COG2319 244 -GHSGSVRSVAFSP--DGRLLASGSAD 267
PTZ00421 PTZ00421
coronin; Provisional
 72-129 4.46e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 50.66  E-value: 4.46e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 19112136   72 ASCGGDKFIQVWDVNTGKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWDCRS 129
Cdd:PTZ00421 142 ASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRD 199
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 87-126 1.29e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 1.29e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19112136     87 TGKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWD 126
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
88-126 1.63e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19112136    88 GKVDRRLGGHLAQINTIRYNEDSSILASGSFDSKVRLWD 126
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 45-84 3.22e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.22e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 19112136     45 SGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWD 84
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 20-170 7.08e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 7.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136   20 VKYNRTGKYVLAAGNERVVRLWN----VKSGACIH----EYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVD 91
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFEcesiIKDGRDIHypvvELASRSKLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLV 568

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136   92 RRLGGHLAQINTIRYNE-DSSILASGSFDSKVRLWDCRSN-SFSPIQVLADAKDSVSSIDIAEHLIVtGSTDGTLRTYDI 169
Cdd:PLN00181 569 TEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGvSIGTIKTKANICCVQFPSESGRSLAF-GSADHKVYYYDL 647


                 .
gi 19112136  170 R 170
Cdd:PLN00181 648 R 648
PTZ00421 PTZ00421
coronin; Provisional
 19-180 2.69e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.19  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136   19 VVKYNRTGKYVLA-AGNERVVRLWNVKSGACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWDVNTGKVDRRLGGH 97
Cdd:PTZ00421 130 IVSFHPSAMNVLAsAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136   98 LAQ-----INTIRYNEDSSILASGSFDSKVRLWDCRSNSfSPIQVLADAKDSVSSIDIAEH----LIVTGSTDGTLRTYD 168
Cdd:PTZ00421 210 ASAksqrcLWAKRKDLIITLGCSKSQQRQIMLWDTRKMA-SPYSTVDLDQSSALFIPFFDEdtnlLYIGSKGEGNIRCFE 288

                        170
                 ....*....|....
gi 19112136  169 IRKGTL--SSDYFS 180
Cdd:PTZ00421 289 LMNERLtfCSSYSS 302
WD40 pfam00400
WD domain, G-beta repeat;
46-84 2.77e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 2.77e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19112136    46 GACIHEYAGHGHEILDLDLVYDSTKFASCGGDKFIQVWD 84
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 66-181 2.07e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.49  E-value: 2.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112136   66 YDSTKFASCGGDKFIQVWDV-------NTGKVDRRLGGHLAQINTIRYNEDS-SILASGSFDSKVRLWDCrsNSFSPIQV 137
Cdd:PTZ00421  86 FDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDV--ERGKAVEV 163

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 19112136  138 LADAKDSVSSID--IAEHLIVTGSTDGTLRTYDIRKGTLSSDYFSH 181
Cdd:PTZ00421 164 IKCHSDQITSLEwnLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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