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Conserved domains on  [gi|19112419|ref|NP_595627|]
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aminophospholipid translocase regulatory protein Ivn1 [Schizosaccharomyces pombe]

Protein Classification

CDC50/LEM3 family protein( domain architecture ID 10009045)

CDC50/LEM3 family protein similar to Saccharomyces cerevisiae cell division control protein 50, Alkylphosphocholine resistance protein LEM3 and phospholipid translocase non-catalytic subunit CRF1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CDC50 COG5035
Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal ...
1-368 0e+00

Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms];


:

Pssm-ID: 227368  Cd Length: 372  Bit Score: 597.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419   1 MSQTEIVKKPKHKRFKRPDKSRFVQQTLPAWQFIFTPWTVLPLLFLLGIVFAPLGAGMFVASRRVKELRIDYTDCMNIG- 79
Cdd:COG5035   6 KDKKAIVSKPSLLKSRRPPNTAFRQQRLKAWQPILSPRTVLPLLFLIGIVFAPLGGGLLVASSSVQELTIDYTDCMTLAs 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419  80 DEFKQVPSTNIEFQYKNVKNVTAMWKSSGD------VCTLRFQIPEEMTSPVFAFYRLKNFYQNHRRYTVSADMFQLLGE 153
Cdd:COG5035  86 DEFSDIPSEYIQFHFKKKVNVLPQWRFSTDeeddfqKCQIRFTVPSDMKKPVFIYYRLTNFYQNHRRYVKSFDEDQLRGE 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419 154 ARTVAQLKSygFCKPLEANEeGKPYYPCGIIANSLFNDSYSSLLRYESfDSSNslglYNMTTNGTAWPEDRERYKKTKYN 233
Cdd:COG5035 166 ALKSDDLKS--NCKPLSYNE-DKIIYPCGLIANSMFNDTFSSLLTGIE-DTSN----YNLTTKGIAWESDRHRYKKTKYN 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419 234 ASQIVPPPNWAKMFPNGYTDDNIPDVSTWDAFQIWMRAAALPTFSKLALRNVTTALQPGIYEMNITYNFPVTEYKGTKTI 313
Cdd:COG5035 238 ASDIVPPPNWAKMYPDGYTDDNIPDLSTWEEFQNWMRTAAFPKFSKLAMRNVNDVLPPGTYQLNITLNFPVLEFNGTKSI 317
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19112419 314 MFSTTSVIGGKNYFLGILYFVIGGLCAASGVILSIACLIKPRRVGDPRYLSWNRG 368
Cdd:COG5035 318 VLTTNSVIGGKNYFLGIVYLIVGGICALLGLIFLIKWLFKPRKMADHSYLNWNME 372
 
Name Accession Description Interval E-value
CDC50 COG5035
Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal ...
1-368 0e+00

Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms];


Pssm-ID: 227368  Cd Length: 372  Bit Score: 597.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419   1 MSQTEIVKKPKHKRFKRPDKSRFVQQTLPAWQFIFTPWTVLPLLFLLGIVFAPLGAGMFVASRRVKELRIDYTDCMNIG- 79
Cdd:COG5035   6 KDKKAIVSKPSLLKSRRPPNTAFRQQRLKAWQPILSPRTVLPLLFLIGIVFAPLGGGLLVASSSVQELTIDYTDCMTLAs 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419  80 DEFKQVPSTNIEFQYKNVKNVTAMWKSSGD------VCTLRFQIPEEMTSPVFAFYRLKNFYQNHRRYTVSADMFQLLGE 153
Cdd:COG5035  86 DEFSDIPSEYIQFHFKKKVNVLPQWRFSTDeeddfqKCQIRFTVPSDMKKPVFIYYRLTNFYQNHRRYVKSFDEDQLRGE 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419 154 ARTVAQLKSygFCKPLEANEeGKPYYPCGIIANSLFNDSYSSLLRYESfDSSNslglYNMTTNGTAWPEDRERYKKTKYN 233
Cdd:COG5035 166 ALKSDDLKS--NCKPLSYNE-DKIIYPCGLIANSMFNDTFSSLLTGIE-DTSN----YNLTTKGIAWESDRHRYKKTKYN 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419 234 ASQIVPPPNWAKMFPNGYTDDNIPDVSTWDAFQIWMRAAALPTFSKLALRNVTTALQPGIYEMNITYNFPVTEYKGTKTI 313
Cdd:COG5035 238 ASDIVPPPNWAKMYPDGYTDDNIPDLSTWEEFQNWMRTAAFPKFSKLAMRNVNDVLPPGTYQLNITLNFPVLEFNGTKSI 317
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19112419 314 MFSTTSVIGGKNYFLGILYFVIGGLCAASGVILSIACLIKPRRVGDPRYLSWNRG 368
Cdd:COG5035 318 VLTTNSVIGGKNYFLGIVYLIVGGICALLGLIFLIKWLFKPRKMADHSYLNWNME 372
CDC50 pfam03381
LEM3 (ligand-effect modulator 3) family / CDC50 family; Members of this family have been ...
58-356 3.11e-136

LEM3 (ligand-effect modulator 3) family / CDC50 family; Members of this family have been predicted to contain transmembrane helices. The family member LEM3 is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells. The products of genes YNR048w, YNL323w and YCR094w (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.


Pssm-ID: 460906  Cd Length: 292  Bit Score: 390.04  E-value: 3.11e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419    58 MFVASRRVKELRIDYT-DCMNIGDEFKQVPSTNIEfqyknvknvtamWKSSGDVCTLRFQIPEEMTSPVFAFYRLKNFYQ 136
Cdd:pfam03381   1 LLYASNNVQEIVIDYTdDCATLAPTDNFNPIDYIQ------------NSNETKTCTIQFTIPKDMKGPVYLYYKLTNFYQ 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419   137 NHRRYTVSADMFQLLGEARTVAQLKSYgfCKPL---EANEEGKPYYPCGIIANSLFNDSYSSLLRYESFDSSNSLGLYNM 213
Cdd:pfam03381  69 NHRRYVKSRDDDQLKGKAVSALLSGSS--CKPLrynGARDDGKPIYPCGLIANSMFNDTFTLYNNSSPLLLNVGTSTYPL 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419   214 TTNGTAWPEDRE-RYK-KTKYNASQIVPPPNWAKMFPNGYTDDNIPDVSTWDAFQIWMRAAALPTFSKLALR-NVTTALQ 290
Cdd:pfam03381 147 TKKGIAWPSDKEhKFKnPTKYNASDIVPPPNWQKRYPNGYTEDNIPNLSENEDFIVWMRTAALPTFRKLYRRiNDTDGLP 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19112419   291 PGIYEMNITYNFPVTEYKGTKTIMFSTTSVIGGKNYFLGILYFVIGGLCAASGVILSIACLIKPRR 356
Cdd:pfam03381 227 AGTYTIDIGYNYPVTSFGGTKSIVLSTTSWIGGKNPFLGIAYLVVGGICLLLGIVFLIIHLIKPRK 292
 
Name Accession Description Interval E-value
CDC50 COG5035
Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal ...
1-368 0e+00

Cell cycle control protein [Cell division and chromosome partitioning / Transcription / Signal transduction mechanisms];


Pssm-ID: 227368  Cd Length: 372  Bit Score: 597.24  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419   1 MSQTEIVKKPKHKRFKRPDKSRFVQQTLPAWQFIFTPWTVLPLLFLLGIVFAPLGAGMFVASRRVKELRIDYTDCMNIG- 79
Cdd:COG5035   6 KDKKAIVSKPSLLKSRRPPNTAFRQQRLKAWQPILSPRTVLPLLFLIGIVFAPLGGGLLVASSSVQELTIDYTDCMTLAs 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419  80 DEFKQVPSTNIEFQYKNVKNVTAMWKSSGD------VCTLRFQIPEEMTSPVFAFYRLKNFYQNHRRYTVSADMFQLLGE 153
Cdd:COG5035  86 DEFSDIPSEYIQFHFKKKVNVLPQWRFSTDeeddfqKCQIRFTVPSDMKKPVFIYYRLTNFYQNHRRYVKSFDEDQLRGE 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419 154 ARTVAQLKSygFCKPLEANEeGKPYYPCGIIANSLFNDSYSSLLRYESfDSSNslglYNMTTNGTAWPEDRERYKKTKYN 233
Cdd:COG5035 166 ALKSDDLKS--NCKPLSYNE-DKIIYPCGLIANSMFNDTFSSLLTGIE-DTSN----YNLTTKGIAWESDRHRYKKTKYN 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419 234 ASQIVPPPNWAKMFPNGYTDDNIPDVSTWDAFQIWMRAAALPTFSKLALRNVTTALQPGIYEMNITYNFPVTEYKGTKTI 313
Cdd:COG5035 238 ASDIVPPPNWAKMYPDGYTDDNIPDLSTWEEFQNWMRTAAFPKFSKLAMRNVNDVLPPGTYQLNITLNFPVLEFNGTKSI 317
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*
gi 19112419 314 MFSTTSVIGGKNYFLGILYFVIGGLCAASGVILSIACLIKPRRVGDPRYLSWNRG 368
Cdd:COG5035 318 VLTTNSVIGGKNYFLGIVYLIVGGICALLGLIFLIKWLFKPRKMADHSYLNWNME 372
CDC50 pfam03381
LEM3 (ligand-effect modulator 3) family / CDC50 family; Members of this family have been ...
58-356 3.11e-136

LEM3 (ligand-effect modulator 3) family / CDC50 family; Members of this family have been predicted to contain transmembrane helices. The family member LEM3 is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells. The products of genes YNR048w, YNL323w and YCR094w (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.


Pssm-ID: 460906  Cd Length: 292  Bit Score: 390.04  E-value: 3.11e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419    58 MFVASRRVKELRIDYT-DCMNIGDEFKQVPSTNIEfqyknvknvtamWKSSGDVCTLRFQIPEEMTSPVFAFYRLKNFYQ 136
Cdd:pfam03381   1 LLYASNNVQEIVIDYTdDCATLAPTDNFNPIDYIQ------------NSNETKTCTIQFTIPKDMKGPVYLYYKLTNFYQ 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419   137 NHRRYTVSADMFQLLGEARTVAQLKSYgfCKPL---EANEEGKPYYPCGIIANSLFNDSYSSLLRYESFDSSNSLGLYNM 213
Cdd:pfam03381  69 NHRRYVKSRDDDQLKGKAVSALLSGSS--CKPLrynGARDDGKPIYPCGLIANSMFNDTFTLYNNSSPLLLNVGTSTYPL 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19112419   214 TTNGTAWPEDRE-RYK-KTKYNASQIVPPPNWAKMFPNGYTDDNIPDVSTWDAFQIWMRAAALPTFSKLALR-NVTTALQ 290
Cdd:pfam03381 147 TKKGIAWPSDKEhKFKnPTKYNASDIVPPPNWQKRYPNGYTEDNIPNLSENEDFIVWMRTAALPTFRKLYRRiNDTDGLP 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19112419   291 PGIYEMNITYNFPVTEYKGTKTIMFSTTSVIGGKNYFLGILYFVIGGLCAASGVILSIACLIKPRR 356
Cdd:pfam03381 227 AGTYTIDIGYNYPVTSFGGTKSIVLSTTSWIGGKNPFLGIAYLVVGGICLLLGIVFLIIHLIKPRK 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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