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Conserved domains on  [gi|19113306|ref|NP_596514|]
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histone lysine methyltransferase Set6 [Schizosaccharomyces pombe]

Protein Classification

SET and MYND domain-containing protein( domain architecture ID 15871832)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) and MYND (myeloid, Nervy, and DEAF-1) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
169-254 4.67e-27

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


:

Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 105.15  E-value: 4.67e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 169 NAMNLvTSSFDSLGMCLDTILCRLNHSCDPNCQIIFDGA-IVQLVSKRDIKKDEQLFISYIDIRLPKSIRQKQLLKKYFF 247
Cdd:cd20071  37 NSFSL-TDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYIDPLLPRTERRRELLEKYGF 115

                ....*..
gi 19113306 248 SCYCPRC 254
Cdd:cd20071 116 TCSCPRC 122
zf-MYND pfam01753
MYND finger;
49-87 2.55e-13

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 2.55e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19113306    49 CSTCTEEKVKTQRCAACKIIHYCSKGCQKADWPFHKLEC 87
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
 
Name Accession Description Interval E-value
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
169-254 4.67e-27

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 105.15  E-value: 4.67e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 169 NAMNLvTSSFDSLGMCLDTILCRLNHSCDPNCQIIFDGA-IVQLVSKRDIKKDEQLFISYIDIRLPKSIRQKQLLKKYFF 247
Cdd:cd20071  37 NSFSL-TDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYIDPLLPRTERRRELLEKYGF 115

                ....*..
gi 19113306 248 SCYCPRC 254
Cdd:cd20071 116 TCSCPRC 122
zf-MYND pfam01753
MYND finger;
49-87 2.55e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 2.55e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19113306    49 CSTCTEEKVKTQRCAACKIIHYCSKGCQKADWPFHKLEC 87
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
142-227 4.44e-11

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 59.84  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306   142 LIASAASHYTQIYQAELFQKLFCRLAVNAMNLVTSSFDSLGMCLDTILCRLNHSCDPNCQIIFD----GAIVQLVSKRDI 217
Cdd:pfam00856  25 ITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFINHSCDPNCEVRVVyvngGPRIVIFALRDI 104
                          90
                  ....*....|
gi 19113306   218 KKDEQLFISY 227
Cdd:pfam00856 105 KPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
192-254 5.53e-11

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 59.98  E-value: 5.53e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19113306 192 LNHSCDPNCQIIFDGAIVQLVSKRDIKKDEQLFISY---IDIRLpksirqkqllkkyfFSCYCPRC 254
Cdd:COG2940  80 INHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYgldYDEEE--------------YPCRCPNC 131
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
182-234 3.78e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 57.34  E-value: 3.78e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19113306    182 GMCLDT-----ILCRLNHSCDPNCQIIF----DGAIVQLVSKRDIKKDEQLFISYIDIRLPK 234
Cdd:smart00317  63 DLCIDArrkgnLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
 
Name Accession Description Interval E-value
SET_SMYD cd20071
SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing ...
169-254 4.67e-27

SET domain (including SET domain and post-SET domain) found in SET and MYND domain-containing protein, and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1-SYMD5. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions.


Pssm-ID: 380997 [Multi-domain]  Cd Length: 122  Bit Score: 105.15  E-value: 4.67e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 169 NAMNLvTSSFDSLGMCLDTILCRLNHSCDPNCQIIFDGA-IVQLVSKRDIKKDEQLFISYIDIRLPKSIRQKQLLKKYFF 247
Cdd:cd20071  37 NSFSL-TDGLNEIGVGLFPLASLLNHSCDPNAVVVFDGNgTLRVRALRDIKAGEELTISYIDPLLPRTERRRELLEKYGF 115

                ....*..
gi 19113306 248 SCYCPRC 254
Cdd:cd20071 116 TCSCPRC 122
SET_SMYD3 cd19203
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 ...
79-256 3.26e-23

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 3 (SMYD3) and similar proteins; SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex. It is overexpressed in colorectal, breast, prostate, and hepatocellular tumors, and has been implicated as an oncogene in human malignancies. Methylation of MEKK2 by SMYD3 is important for regulation of the MEK/ERK pathway, suggesting the possibility of selectively targeting SMYD3 in RAS-driven cancers.


Pssm-ID: 380980 [Multi-domain]  Cd Length: 210  Bit Score: 97.44  E-value: 3.26e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306  79 DWPFHKLECKALQASkqngiLPSVCRLLIRLY----LLWQKNPAIIEPMEGhQNEFQAVSSSWSDAELI-ASAASHYTQI 153
Cdd:cd19203  40 PPDSVRLEGRIIFKL-----LDKAPSESEKLYsfydLQSNINKLSEDRKEG-LRQLAMVLQHYLREEIQdASQLPPAFDI 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 154 YQaelfqkLFCRLAVNAMNLVTSSFDSLGMCLDTILCRLNHSCDPNCQIIFDGAIVQLVSKRDIKKDEQLFISYIDIRLP 233
Cdd:cd19203 114 FE------LFAKVTCNSFTICDAEMQEVGVGLYPSASLLNHSCDPNCVIVFNGPHLLLRAIREIEVGEELTISYIDMLMP 187
                       170       180
                ....*....|....*....|...
gi 19113306 234 KSIRQKQLLKKYFFSCYCPRCEN 256
Cdd:cd19203 188 SEERRKQLRDQYCFECDCFRCQD 210
SET_SMYD1_2_3-like cd19167
SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, ...
138-256 8.69e-22

SET domain (including post-SET domain) found in SET and MYND domain-containing proteins, SMYD1, SMYD2, SMYD3 and similar proteins; The family includes SET and MYND domain-containing proteins, SMYD1, SMYD2 and SMYD3. SMYD1 (EC 2.1.1.43; also termed BOP) is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD2 (also termed HSKM-B, or lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). SMYD3 (also termed zinc finger MYND domain-containing protein 1) functions as a histone methyltransferase that specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. It also methylates 'Lys-5' of histone H4. SMYD3 plays an important role in transcriptional activation as a member of an RNA polymerase complex.


Pssm-ID: 380944 [Multi-domain]  Cd Length: 205  Bit Score: 93.26  E-value: 8.69e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 138 SDAELIASAASHYTQIYQAELFQKLFCRLAVNAMNLVTSSFDSLGMCLDTILCRLNHSCDPNCQIIFDGAIVQLVSKRDI 217
Cdd:cd19167  87 SDVATLHQFMSKDLQLPDAAYLVELFGKVNCNGFTISDEELQHVGVGIYPQAALLNHSCCPNCIVTFNGPNIEVRAVQEI 166
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 19113306 218 KKDEQLFISYIDIRLPKSIRQKQLLKKYFFSCYCPRCEN 256
Cdd:cd19167 167 EPGEEVFHSYIDLLYPTEERRDQLRDQYFFLCQCADCQT 205
SET_SMYD1 cd10526
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 ...
189-256 1.62e-14

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 1 (SMYD1) and similar proteins; SMYD1 (EC 2.1.1.43), also termed BOP, is a heart and muscle specific SET-MYND domain containing protein, which functions as a histone methyltransferase and regulates downstream gene transcription. It methylates histone H3 at 'Lys-4' (H3K4me), seems able to perform both mono-, di-, and trimethylation. SMYD1 plays a critical role in cardiomyocyte differentiation, cardiac morphogenesis and myofibril organization, as well as in the regulation of endothelial cells (ECs). It is expressed in vascular endothelial cells, it has beenshown that knockdown of SMYD1 in endothelial cells impairs EC migration and tube formation.


Pssm-ID: 380924 [Multi-domain]  Cd Length: 210  Bit Score: 72.45  E-value: 1.62e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19113306 189 LCRLNHSCDPNCQIIFDGAIVQLVSKRDIKKDEQLFISYIDIRLPKSIRQKQLLKKYFFSCYCPRCEN 256
Cdd:cd10526 143 LCLVNHDCWPNCTVIFNNGRIELRALGKISEGDELTVSYIDFLNTSEDRKEQLKKQYYFDCTCEHCTK 210
SET_SMYD4 cd10536
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
175-254 1.76e-14

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation.


Pssm-ID: 380934 [Multi-domain]  Cd Length: 218  Bit Score: 72.33  E-value: 1.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 175 TSSFDSLGMCLDTILCRLNHSCDPNCQIIFDGAIVQLVSKRDIKKDEQLFISY--IDIRLPKSIRQKQLLKKYFFSCYCP 252
Cdd:cd10536 137 TSKQVRIATAIYPTLSLLNHSCDPNTIRSFYGNTIVVRATRPIKKGEEITICYgpHFSRMKRSERQRLLKEQYFFDCSCE 216

                ..
gi 19113306 253 RC 254
Cdd:cd10536 217 AC 218
zf-MYND pfam01753
MYND finger;
49-87 2.55e-13

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 63.98  E-value: 2.55e-13
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 19113306    49 CSTCTEEKVKTQRCAACKIIHYCSKGCQKADWPFHKLEC 87
Cdd:pfam01753   1 CAVCGKEALKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
SET_SMYD5 cd10521
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ...
193-255 6.84e-12

SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 5 (SMYD5) and similar proteins; SMYD5 (also termed protein NN8-4AG, or retinoic acid-induced protein 15) functions as histone lysine methyltransferase that mediates H4K20me3 at heterochromatin regions. It plays an important role in chromosome integrity by regulating heterochromatin and repressing endogenous repetitive DNA elements during differentiation. In zebrafish embryogenesis, it plays pivotal roles in both primitive and definitive hematopoiesis.


Pssm-ID: 380919 [Multi-domain]  Cd Length: 282  Bit Score: 65.79  E-value: 6.84e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 19113306 193 NHSCDPNCQIIFDG--AIVQLVSKRDIKKDEQLFISYID---IRLPKSIRQKQLLKKYFFSCYCPRCE 255
Cdd:cd10521 213 NHSCVPNAEITFPEnnFTLSLKALRDIQEGEEICISYLDecqRERSRHSRQKILRENYLFICNCPKCE 280
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
142-227 4.44e-11

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 59.84  E-value: 4.44e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306   142 LIASAASHYTQIYQAELFQKLFCRLAVNAMNLVTSSFDSLGMCLDTILCRLNHSCDPNCQIIFD----GAIVQLVSKRDI 217
Cdd:pfam00856  25 ITKEEADKRELLYYDKLELRLWGPYLFTLDEDSEYCIDARALYYGNWARFINHSCDPNCEVRVVyvngGPRIVIFALRDI 104
                          90
                  ....*....|
gi 19113306   218 KKDEQLFISY 227
Cdd:pfam00856 105 KPGEELTIDY 114
SET COG2940
SET domain-containing protein (function unknown) [General function prediction only];
192-254 5.53e-11

SET domain-containing protein (function unknown) [General function prediction only];


Pssm-ID: 442183 [Multi-domain]  Cd Length: 134  Bit Score: 59.98  E-value: 5.53e-11
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19113306 192 LNHSCDPNCQIIFDGAIVQLVSKRDIKKDEQLFISY---IDIRLpksirqkqllkkyfFSCYCPRC 254
Cdd:COG2940  80 INHSCDPNCEADEEDGRIFIVALRDIAAGEELTYDYgldYDEEE--------------YPCRCPNC 131
SET_SMYD2 cd19202
SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 ...
162-254 6.28e-11

SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins; SMYD2 (also termed HSKM-B, lysine N-methyltransferase 3C (KMT3C)) functions as a histone methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. It specifically methylates histone H3 'Lys-4' (H3K4me) and dimethylates histone H3 'Lys-36' (H3K36me2). It plays a role in myofilament organization in both skeletal and cardiac muscles via Hsp90 methylation. SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas. It regulates leukemia cell growth such that diminished SMYD2 expression upregulates SET7/9, thereby possibly shifting leukemia cells from growth to quiescence state associated with resistance to DNA damage associated with Acute Myeloid Leukemia (AML).


Pssm-ID: 380979 [Multi-domain]  Cd Length: 206  Bit Score: 61.76  E-value: 6.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 162 LFCRLAVNAMNLVTSSFDSLGMCLDTILCRLNHSCDPNCQIIFDGAIVQLVSKRDIKKDEQLFISYIDIRLPKSIRQKQL 241
Cdd:cd19202 112 LFAQVNCNGFTIEDEELSHLGSAIFPDVALMNHSCCPNVIVTYKGTLAEVRAVQEIKPGEEVFTSYIDLLYPTEDRNDRL 191
                        90
                ....*....|...
gi 19113306 242 LKKYFFSCYCPRC 254
Cdd:cd19202 192 RDSYFFTCECQEC 204
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
182-234 3.78e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 57.34  E-value: 3.78e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 19113306    182 GMCLDT-----ILCRLNHSCDPNCQIIF----DGAIVQLVSKRDIKKDEQLFISYIDIRLPK 234
Cdd:smart00317  63 DLCIDArrkgnLARFINHSCEPNCELLFvevnGDDRIVIFALRDIKPGEELTIDYGSDYANE 124
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
193-227 8.31e-09

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 52.25  E-value: 8.31e-09
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 19113306 193 NHSCDPNCQIIFD----GAIVQLVSKRDIKKDEQLFISY 227
Cdd:cd08161  33 NHSCEPNCEFEEVyvggKPRVFIVALRDIKAGEELTVDY 71
SET_SETD4 cd19177
SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a ...
192-227 3.20e-05

SET domain found in SET domain-containing protein 4 (SETD4) and similar proteins; SETD4 is a cytosolic and nuclear functional lysine methyltransferase that plays a crucial role in breast carcinogenesis. However, its specific substrates and modification sites remain to be disclosed.


Pssm-ID: 380954 [Multi-domain]  Cd Length: 245  Bit Score: 45.37  E-value: 3.20e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 19113306 192 LNHSCDPNCQIIFD--GAIVQLVSKRDIKKDEQLFISY 227
Cdd:cd19177 192 LNHSPDVNVKAGFNksGKCYEIRTGTDYKKGEEVFISY 229
SET_LSMT cd10527
SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; ...
192-227 5.16e-05

SET domain found in Rubisco large subunit methyltransferase (LSMT) and similar proteins; Rubisco LSMT is a non-histone protein methyl transferase responsible for the trimethylation of lysine14 in the large subunit of Rubisco (ribulose-1,5-bisphosphate carboxylase/oxygenase). The family also includes SET domain-containing proteins, SETD3, SETD4 and SETD6, which belong to methyltransferase class VII that represents classical non-histone SET domain methyltransferases. Members in this family contain a SET domain and a C-terminal RubisCO LSMT substrate-binding (Rubis-subs-bind) domain.


Pssm-ID: 380925 [Multi-domain]  Cd Length: 236  Bit Score: 44.75  E-value: 5.16e-05
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 19113306 192 LNHSCD-PNCQIIFDGAI--VQLVSKRDIKKDEQLFISY 227
Cdd:cd10527 183 LNHSPDaPNVRYEYDEDEgsFVLVATRDIAAGEEVFISY 221
SET_SETD1-like cd10518
SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), ...
192-254 5.20e-05

SET domain (including post-SET domain) found in SET domain-containing proteins (SETD1A/SETD1B), histone-lysine N-methyltransferases (KMT2A/KMT2B/KMT2C/KMT2D) and similar proteins; This family includes SET domain-containing protein 1A (SETD1A), 1B (SETD1B), as well as histone-lysine N-methyltransferase 2A (KMT2A), 2B (KMT2B), 2C (KMT2C), 2D (KMT2D). These proteins are histone-lysine N-methyltransferases (EC 2.1.1.43) that specifically methylate 'Lys-4' of histone H3 (H3K4me).


Pssm-ID: 380916  Cd Length: 150  Bit Score: 43.35  E-value: 5.20e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113306 192 LNHSCDPNC---QIIFDGA--IVqLVSKRDIKKDEQLfiSYiDIRLPkSIRQKQLlkkyffSCYC--PRC 254
Cdd:cd10518  91 INHSCDPNCyakIITVDGEkhIV-IFAKRDIAPGEEL--TY-DYKFP-IEDEEKI------PCLCgaPNC 149
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
189-227 1.66e-04

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 41.17  E-value: 1.66e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 19113306 189 LCRL-NHSCDPNCQ--IIFDGAI--VQLVSKRDIKKDEQLFISY 227
Cdd:cd10522  73 LTRFiNHSDQPNLEliVRTLKGEqhIGFVAIRDIKPGEELFISY 116
SET_Suv4-20-like cd10524
SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of ...
192-255 1.68e-04

SET domain (including post-SET domain) found in Drosophila melanogaster suppressor of variegation 4-20 (Suv4-20) and similar proteins; Suv4-20 (also termed Su(var)4-20) is a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-20' of histone H4. It acts as a dominant suppressor of position-effect variegation. The family also includes Suv4-20 homologs, lysine N-methyltransferase 5B (KMT5B) and lysine N-methyltransferase 5C (KMT5C). Both KMT5B (also termed lysine-specific methyltransferase 5B, or suppressor of variegation 4-20 homolog 1, or Su(var)4-20 homolog 1, or Suv4-20h1) and KMT5C (also termed lysine-specific methyltransferase 5C, or suppressor of variegation 4-20 homolog 2, or Su(var)4-20 homolog 2, or Suv4-20h2) are histone methyltransferases that specifically trimethylate 'Lys-20' of histone H4 (H4K20me3). They play central roles in the establishment of constitutive heterochromatin in pericentric heterochromatin regions.


Pssm-ID: 380922 [Multi-domain]  Cd Length: 141  Bit Score: 41.50  E-value: 1.68e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 19113306 192 LNHSCDPNCQII---FDGAIVQLVskRDIKKDEQLFISYIDirlpksirqkqllkKYFFS----CYCPRCE 255
Cdd:cd10524  80 INHDCRPNCKFVptgKSTACVKVL--RDIEPGEEITVYYGD--------------NYFGEnneeCECETCE 134
SET_SpSet7-like cd10540
SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces ...
193-227 4.97e-04

SET domain found in Schizossacharomyces pombe Set7 and similar proteins; Schizosaccharomyces pombe Set7 is a novel histone-lysine N-methyltransferase. The family also includes a viral histone H3 lysine 27 methyltransferase from Paramecium bursaria Chlorella virus 1 (PBCV-1).


Pssm-ID: 380938  Cd Length: 112  Bit Score: 39.54  E-value: 4.97e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 19113306 193 NHSCDPNCQ--IIFDGAIVQLVSKRDIKKDEQLFISY 227
Cdd:cd10540  70 NHSYTPNAEyeIDFENQTIVFYALRDIEAGEELTINY 106
SET_EZH cd10519
SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar ...
193-227 1.35e-03

SET domain found in enhancer of zeste homolog 1 (EZH1), zeste homolog 2 (EZH2) and similar proteins; The family includes EZH1 and EZH2. EZH1 (EC 2.1.1.43; also termed ENX-2, or histone-lysine N-methyltransferase EZH1) is a catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. EZH2 (EC 2.1.1.43; also termed lysine N-methyltransferase 6, ENX-1, or histone-lysine N-methyltransferase EZH2) is a catalytic subunit of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. Both, EZH1 and EZH2, can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively.


Pssm-ID: 380917  Cd Length: 117  Bit Score: 38.38  E-value: 1.35e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 19113306 193 NHSCDPNCQiifdgAIVQLV---------SKRDIKKDEQLFISY 227
Cdd:cd10519  77 NHSSNPNCY-----AKVMMVngdhrigifAKRDIEAGEELFFDY 115
SET_SETD2 cd19172
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and ...
192-254 1.49e-03

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2) and similar proteins; SETD2 (also termed HIF-1, huntingtin yeast partner B, huntingtin-interacting protein 1 (HIP-1), huntingtin-interacting protein B, lysine N-methyltransferase 3A or protein-lysine N-methyltransferase SETD2) acts as histone-lysine N-methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. It has been shown that methylation is a posttranslational modification of dynamic microtubules and that SETD2 methylates alpha-tubulin at lysine 40, the same lysine that is marked by acetylation on microtubules. Methylation of microtubules occurs during mitosis and cytokinesis and can be ablated by SETD2 deletion, which causes mitotic spindle and cytokinesis defects, micronuclei, and polyploidy.


Pssm-ID: 380949 [Multi-domain]  Cd Length: 142  Bit Score: 39.10  E-value: 1.49e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113306 192 LNHSCDPNCQI---IFDGAI-VQLVSKRDIKKDEQLFISYIDIRLPKSIrQKqllkkyffsCYC--PRC 254
Cdd:cd19172  79 INHSCEPNCETqkwTVNGELrVGFFAKRDIPAGEELTFDYQFERYGKEA-QK---------CYCgsPNC 137
SET_ASHR3-like cd19175
SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 ...
192-227 2.34e-03

SET domain (including post-SET domain) found in Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins; This family includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3, also termed protein SET DOMAIN GROUP 4 or protein stamen loss), ASH1 homolog 3 (ASHH3, also termed protein SET DOMAIN GROUP 7) and homolog 4 (ASHH4, also termed protein SET DOMAIN GROUP 24). They all function as histone-lysine N-methyltransferases (EC 2.1.1.43).


Pssm-ID: 380952 [Multi-domain]  Cd Length: 139  Bit Score: 38.17  E-value: 2.34e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 19113306 192 LNHSCDPNCQI---IFDGAI-VQLVSKRDIKKDEQLFISY 227
Cdd:cd19175  77 INHSCDPNCELqkwQVDGETrIGVFAIRDIKKGEELTYDY 116
SET_SUV39H cd10542
SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 ...
192-251 2.79e-03

SET domain (including pre-SET and post-SET domains) found in suppressor of variegation 3-9 homologs, SUV39H1, SUV39H2 and similar proteins; This family includes SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. Also included are Schizosaccharomyces pombe H3K9 methyltransferase Clr4 (SUV39H homolog) and Neurospora crassa DIM-5, both of which also methylate 'Lys-9' of histone H3.


Pssm-ID: 380940 [Multi-domain]  Cd Length: 245  Bit Score: 39.58  E-value: 2.79e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113306 192 LNHSCDPNCQIIF------DGAIVQLV--SKRDIKKDEQLFISYIDIRLPKSIRQKQLLKKYFF-SCYC 251
Cdd:cd10542 168 INHSCDPNLAVYAvwinhlDPRLPRIAffAKRDIKAGEELTFDYLMTGTGGSSESTIPKPKDVRvPCLC 236
SET_SETD2-like cd10531
SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), ...
191-232 2.82e-03

SET domain (including post-SET domain) found in SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2), ASH1-like protein (ASH1L) and similar proteins; This family includes SET domain-containing protein 2 (SETD2), nuclear SETD2 (NSD2) and ASH1-like protein (ASH1L), which function as histone-lysine N-methyltransferases. SETD2 specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using demethylated 'Lys-36' (H3K36me2) as substrate. NSD2 shows histone H3 'Lys-27' (H3K27me) methyltransferase activity. ASH1L specifically methylates 'Lys-36' of histone H3 (H3K36me). The family also includes Arabidopsis thaliana ASH1-related protein 3 (ASHR3) and similar proteins.


Pssm-ID: 380929  Cd Length: 136  Bit Score: 38.00  E-value: 2.82e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 19113306 191 RLNHSCDPNCQI---IFDGAI-VQLVSKRDIKKDEQLFISYIDIRL 232
Cdd:cd10531  76 FINHSCEPNCETqkwIVNGEYrIGIFALRDIPAGEELTFDYNFVNY 121
SET_SETD6 cd19178
SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a ...
192-247 3.49e-03

SET domain found in SET domain-containing protein 6 (SETD6) and similar proteins; SETD6 is a lysine N-methyltransferase that monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. It also monomethylates 'Lys-8' of H2AZ (H2AZK8me1).


Pssm-ID: 380955 [Multi-domain]  Cd Length: 250  Bit Score: 39.21  E-value: 3.49e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 19113306 192 LNHSCDPNCQIIFDGAIVQLVSKRDIKKDEQLFISYIDirLPKSirqkQLLKKYFF 247
Cdd:cd19178 198 LNHIANNNARLEFDPDCLRMIATRDIKKGEEIFNTYGE--LANW----ELLHMYGF 247
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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