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Conserved domains on  [gi|19113351|ref|NP_596559|]
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bystin family U3 and U14 snoRNA associated protein [Schizosaccharomyces pombe]

Protein Classification

bystin family protein( domain architecture ID 10526307)

bystin family protein similar to human bystin that is required for processing of 20S pre-rRNA precursor and biogenesis of 40S ribosomal subunits

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Bystin pfam05291
Bystin; Trophinin and tastin form a cell adhesion molecule complex that potentially mediates ...
154-443 0e+00

Bystin; Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy. This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localized in the nucleus. It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesize 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits.


:

Pssm-ID: 461612  Cd Length: 290  Bit Score: 532.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   154 TTSLSDLIMQKINEAEARARGEYIPSAEEEENalPPLPPKVIEVYSKVGVLLSKYRSGKIPKAFKIIPTLSNWEDILYLT 233
Cdd:pfam05291   1 RRTLADLILEKIAEKEAEQSSQLSDGGPPEEP--VELDPKVVEVYTKVGELLSRYKSGKLPKAFKIIPSLPNWEDLLYLT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   234 RPDMWTPHACYEATRIFISNLKPVQAQHFLTVIILERVRDDIRENKKLNYHLYMALKKALYKPSSWFKGFLFPLVQE-NC 312
Cdd:pfam05291  79 EPENWTPHAMYEATRIFVSNLKAKQAQRFYELVLLPRVRDDIRENKKLNVHLYNALKKALYKPAAFFKGILFPLCESgTC 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   313 TLREAAIIGSILQKVSVPVLHSAAALLRLTEFDLSGATSVFIRILLDKKYALPYKVLDSLVFYFMRWKSL-ERPLAVLEH 391
Cdd:pfam05291 159 TLREAVIIGSVLAKVSIPVLHSAAALLKLAEMEYSGATSIFIRVLLDKKYALPYRVVDALVFHFLRFRNDtPRELPVLWH 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19113351   392 QSMLVFAQRYKFDITPEQKDALLEVVRLKGHYSIGPEIRRELLNSASRGEEI 443
Cdd:pfam05291 239 QSLLVFAQRYKNDITEDQKEALLDLLRVQGHHQITPEIRRELLASRGRGEEI 290
 
Name Accession Description Interval E-value
Bystin pfam05291
Bystin; Trophinin and tastin form a cell adhesion molecule complex that potentially mediates ...
154-443 0e+00

Bystin; Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy. This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localized in the nucleus. It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesize 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits.


Pssm-ID: 461612  Cd Length: 290  Bit Score: 532.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   154 TTSLSDLIMQKINEAEARARGEYIPSAEEEENalPPLPPKVIEVYSKVGVLLSKYRSGKIPKAFKIIPTLSNWEDILYLT 233
Cdd:pfam05291   1 RRTLADLILEKIAEKEAEQSSQLSDGGPPEEP--VELDPKVVEVYTKVGELLSRYKSGKLPKAFKIIPSLPNWEDLLYLT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   234 RPDMWTPHACYEATRIFISNLKPVQAQHFLTVIILERVRDDIRENKKLNYHLYMALKKALYKPSSWFKGFLFPLVQE-NC 312
Cdd:pfam05291  79 EPENWTPHAMYEATRIFVSNLKAKQAQRFYELVLLPRVRDDIRENKKLNVHLYNALKKALYKPAAFFKGILFPLCESgTC 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   313 TLREAAIIGSILQKVSVPVLHSAAALLRLTEFDLSGATSVFIRILLDKKYALPYKVLDSLVFYFMRWKSL-ERPLAVLEH 391
Cdd:pfam05291 159 TLREAVIIGSVLAKVSIPVLHSAAALLKLAEMEYSGATSIFIRVLLDKKYALPYRVVDALVFHFLRFRNDtPRELPVLWH 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19113351   392 QSMLVFAQRYKFDITPEQKDALLEVVRLKGHYSIGPEIRRELLNSASRGEEI 443
Cdd:pfam05291 239 QSLLVFAQRYKNDITEDQKEALLDLLRVQGHHQITPEIRRELLASRGRGEEI 290
 
Name Accession Description Interval E-value
Bystin pfam05291
Bystin; Trophinin and tastin form a cell adhesion molecule complex that potentially mediates ...
154-443 0e+00

Bystin; Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy. This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localized in the nucleus. It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesize 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits.


Pssm-ID: 461612  Cd Length: 290  Bit Score: 532.08  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   154 TTSLSDLIMQKINEAEARARGEYIPSAEEEENalPPLPPKVIEVYSKVGVLLSKYRSGKIPKAFKIIPTLSNWEDILYLT 233
Cdd:pfam05291   1 RRTLADLILEKIAEKEAEQSSQLSDGGPPEEP--VELDPKVVEVYTKVGELLSRYKSGKLPKAFKIIPSLPNWEDLLYLT 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   234 RPDMWTPHACYEATRIFISNLKPVQAQHFLTVIILERVRDDIRENKKLNYHLYMALKKALYKPSSWFKGFLFPLVQE-NC 312
Cdd:pfam05291  79 EPENWTPHAMYEATRIFVSNLKAKQAQRFYELVLLPRVRDDIRENKKLNVHLYNALKKALYKPAAFFKGILFPLCESgTC 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113351   313 TLREAAIIGSILQKVSVPVLHSAAALLRLTEFDLSGATSVFIRILLDKKYALPYKVLDSLVFYFMRWKSL-ERPLAVLEH 391
Cdd:pfam05291 159 TLREAVIIGSVLAKVSIPVLHSAAALLKLAEMEYSGATSIFIRVLLDKKYALPYRVVDALVFHFLRFRNDtPRELPVLWH 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 19113351   392 QSMLVFAQRYKFDITPEQKDALLEVVRLKGHYSIGPEIRRELLNSASRGEEI 443
Cdd:pfam05291 239 QSLLVFAQRYKNDITEDQKEALLDLLRVQGHHQITPEIRRELLASRGRGEEI 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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