NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|19113464|ref|NP_596672|]
View 

mitochondrial 54S ribosomal protein mL44 [Schizosaccharomyces pombe]

Protein Classification

ribonuclease III family protein( domain architecture ID 11426290)

ribonuclease III family protein similar to ribonuclease III, which digests double-stranded RNA in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S)

CATH:  1.10.1520.10
EC:  3.1.26.3
Gene Ontology:  GO:0004525|GO:0006396
PubMed:  18047582|24124076|17194582
SCOP:  4002876

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DSRM_MRPL3_like cd19873
double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal ...
 204-287 2.80e-39

double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal protein L3 (MRPL3) and similar proteins; MRPL3 (also called mitochondrial large ribosomal subunit protein mL44) is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. MRPL3 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


:

Pssm-ID: 380702  Cd Length: 84  Bit Score: 133.50  E-value: 2.80e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464 204 KQLDPRTMLQLQWPRRQLSRLCKRLSLKEPVYRIIAETGRKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLIS 283
Cdd:cd19873   1 RPLDISDLIKLENPKRTLSALLKREGLEPPVSRLLKESGRASHTPTFVVGVYSGSQKLGEGAGSSIKMAEIRAARDALRK 80


                ....
gi 19113464 284 YYIH 287
Cdd:cd19873  81 HYLY 84
RIBOc smart00535
Ribonuclease III family;
65-209 7.22e-25

Ribonuclease III family;


:

Pssm-ID: 197778  Cd Length: 129  Bit Score: 97.29  E-value: 7.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464     65 LVQALIDKTVvQNPQYSNEKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLEVQRReegl 144
Cdd:smart00535   3 LLRALTHASY-SNEHEHNERLEFLGDAVLELVVTEYLYKKYPDLSEGDLSRLRSALVSNETLARLAKKLGLGEFIR---- 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113464    145 qesfgkvLAKRADPEMLRKPGEIYKDeaarrAILAILGGVYLHQGFNDTKKFINDHILsKQLDPR 209
Cdd:smart00535  78 -------LGRGEAISGGRDKPKILAD-----VFEALIGAIYLDSGLEAAREFIRDLLG-PRLDEL 129
 
Name Accession Description Interval E-value
DSRM_MRPL3_like cd19873
double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal ...
 204-287 2.80e-39

double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal protein L3 (MRPL3) and similar proteins; MRPL3 (also called mitochondrial large ribosomal subunit protein mL44) is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. MRPL3 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380702  Cd Length: 84  Bit Score: 133.50  E-value: 2.80e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464 204 KQLDPRTMLQLQWPRRQLSRLCKRLSLKEPVYRIIAETGRKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLIS 283
Cdd:cd19873   1 RPLDISDLIKLENPKRTLSALLKREGLEPPVSRLLKESGRASHTPTFVVGVYSGSQKLGEGAGSSIKMAEIRAARDALRK 80


                ....
gi 19113464 284 YYIH 287
Cdd:cd19873  81 HYLY 84
RIBOc smart00535
Ribonuclease III family;
65-209 7.22e-25

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 97.29  E-value: 7.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464     65 LVQALIDKTVvQNPQYSNEKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLEVQRReegl 144
Cdd:smart00535   3 LLRALTHASY-SNEHEHNERLEFLGDAVLELVVTEYLYKKYPDLSEGDLSRLRSALVSNETLARLAKKLGLGEFIR---- 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113464    145 qesfgkvLAKRADPEMLRKPGEIYKDeaarrAILAILGGVYLHQGFNDTKKFINDHILsKQLDPR 209
Cdd:smart00535  78 -------LGRGEAISGGRDKPKILAD-----VFEALIGAIYLDSGLEAAREFIRDLLG-PRLDEL 129
Rnc COG0571
dsRNA-specific ribonuclease [Transcription];
164-281 5.23e-15

dsRNA-specific ribonuclease [Transcription];


Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 72.82  E-value: 5.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464 164 PGEIYKDEAARRAIL-----AILGGVYLHQGFNDTKKFINDHILSK---------QLDPRTMLQ--LQwprrqlsrlckR 227
Cdd:COG0571 101 KGEEKSGGRRRPSILadafeALIGAIYLDGGLEAARKFVLRLFEPRleeiapggaGKDYKTALQewLQ-----------A 169

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 19113464 228 LSLKEPVYRIIAETGrKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSL 281
Cdd:COG0571 170 RGLPLPEYEVVEEEG-PDHAKTFTVEVLVGGKVLGEGTGRSKKEAEQAAAKAAL 222
RIBOc cd00593
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and ...
 63-202 6.97e-15

RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing.


Pssm-ID: 238333  Cd Length: 133  Bit Score: 70.33  E-value: 6.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464  63 KVLVQALIDKTVVQN-PQYSNEKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLevqrre 141
Cdd:cd00593   1 SLLLEALTHPSYANEhGRFNNERLEFLGDAVLELVVTEYLFKKFPDLSEGDLTRLRSALVSNETLARLARELGL------ 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19113464 142 eglqesfgkvlakraDPEMLRKPGEIYKDEAARRAIL-----AILGGVYLHQGFNDTKKFINDHIL 202
Cdd:cd00593  75 ---------------GKYLRLGKGEEKSGGRLRPKILadvfeALIGAIYLDGGFEAARKFLLRLLG 125
DSRM smart00358
Double-stranded RNA binding motif;
217-285 9.29e-10

Double-stranded RNA binding motif;


Pssm-ID: 214634 [Multi-domain]  Cd Length: 67  Bit Score: 54.19  E-value: 9.29e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113464    217 PRRQLSRLCKRLSLkEPVYRIIAETGRKSRePVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLISYY 285
Cdd:smart00358   1 PKSLLQELAQKRKL-PPEYELVKEEGPDHA-PRFTVTVKVGGKRTGEGEGSSKKEAKQRAAEAALRSLK 67
dsrm pfam00035
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ...
 217-281 5.97e-08

Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.


Pssm-ID: 425434 [Multi-domain]  Cd Length: 66  Bit Score: 48.77  E-value: 5.97e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113464   217 PRRQLSRLCKRLsLKEPVYRIIAETGrKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSL 281
Cdd:pfam00035   1 PKSLLQEYAQKN-GKPPPYEYVSEEG-PPHSPKFTVTVKVDGKLYGSGTGSSKKEAEQLAAEKAL 63
Ribonuclease_3 pfam00636
Ribonuclease III domain;
83-189 6.01e-08

Ribonuclease III domain;


Pssm-ID: 459883  Cd Length: 101  Bit Score: 49.97  E-value: 6.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464    83 EKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLEVQRREEGLQESFGKVLAKRADpemLR 162
Cdd:pfam00636   1 ERLEFLGDAVLELYVREYLFEKFPDLREGDLHRLRSALVSNEALAKLARKLGLEKFLTEEELDIRRRNNALGKGP---KR 77

                          90       100
                  ....*....|....*....|....*....
gi 19113464   163 KPGEIYK--DeaarrAILAILGGVYLHQG 189
Cdd:pfam00636  78 ADGKEKVlaD-----AFEALIGALYLDGG 101
 
Name Accession Description Interval E-value
DSRM_MRPL3_like cd19873
double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal ...
 204-287 2.80e-39

double-stranded RNA binding motif of Saccharomyces cerevisiae mitochondrial 54S ribosomal protein L3 (MRPL3) and similar proteins; MRPL3 (also called mitochondrial large ribosomal subunit protein mL44) is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. MRPL3 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380702  Cd Length: 84  Bit Score: 133.50  E-value: 2.80e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464 204 KQLDPRTMLQLQWPRRQLSRLCKRLSLKEPVYRIIAETGRKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLIS 283
Cdd:cd19873   1 RPLDISDLIKLENPKRTLSALLKREGLEPPVSRLLKESGRASHTPTFVVGVYSGSQKLGEGAGSSIKMAEIRAARDALRK 80


                ....
gi 19113464 284 YYIH 287
Cdd:cd19873  81 HYLY 84
RIBOc smart00535
Ribonuclease III family;
65-209 7.22e-25

Ribonuclease III family;


Pssm-ID: 197778  Cd Length: 129  Bit Score: 97.29  E-value: 7.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464     65 LVQALIDKTVvQNPQYSNEKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLEVQRReegl 144
Cdd:smart00535   3 LLRALTHASY-SNEHEHNERLEFLGDAVLELVVTEYLYKKYPDLSEGDLSRLRSALVSNETLARLAKKLGLGEFIR---- 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113464    145 qesfgkvLAKRADPEMLRKPGEIYKDeaarrAILAILGGVYLHQGFNDTKKFINDHILsKQLDPR 209
Cdd:smart00535  78 -------LGRGEAISGGRDKPKILAD-----VFEALIGAIYLDSGLEAAREFIRDLLG-PRLDEL 129
Rnc COG0571
dsRNA-specific ribonuclease [Transcription];
164-281 5.23e-15

dsRNA-specific ribonuclease [Transcription];


Pssm-ID: 440336 [Multi-domain]  Cd Length: 229  Bit Score: 72.82  E-value: 5.23e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464 164 PGEIYKDEAARRAIL-----AILGGVYLHQGFNDTKKFINDHILSK---------QLDPRTMLQ--LQwprrqlsrlckR 227
Cdd:COG0571 101 KGEEKSGGRRRPSILadafeALIGAIYLDGGLEAARKFVLRLFEPRleeiapggaGKDYKTALQewLQ-----------A 169

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 19113464 228 LSLKEPVYRIIAETGrKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSL 281
Cdd:COG0571 170 RGLPLPEYEVVEEEG-PDHAKTFTVEVLVGGKVLGEGTGRSKKEAEQAAAKAAL 222
RIBOc cd00593
RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and ...
 63-202 6.97e-15

RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional control of mRNA stability and translational efficiency. It is involved in the processing of ribosomal RNA precursors. Prokaryotic RNAse III also plays a role in the maturation of tRNA precursors and in the processing of phage and plasmid transcripts. Eukaryotic RNase III's participate (through direct cleavage) in rRNA processing, in processing of small nucleolar RNAs (snoRNAs) and snRNA's (components of the spliceosome). In eukaryotes RNase III or RNaseIII like enzymes such as Dicer are involved in RNAi (RNA interference) and miRNA (micro-RNA) gene silencing.


Pssm-ID: 238333  Cd Length: 133  Bit Score: 70.33  E-value: 6.97e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464  63 KVLVQALIDKTVVQN-PQYSNEKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLevqrre 141
Cdd:cd00593   1 SLLLEALTHPSYANEhGRFNNERLEFLGDAVLELVVTEYLFKKFPDLSEGDLTRLRSALVSNETLARLARELGL------ 74

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19113464 142 eglqesfgkvlakraDPEMLRKPGEIYKDEAARRAIL-----AILGGVYLHQGFNDTKKFINDHIL 202
Cdd:cd00593  75 ---------------GKYLRLGKGEEKSGGRLRPKILadvfeALIGAIYLDGGFEAARKFLLRLLG 125
DSRM_mL44_subfamily cd20315
double-stranded RNA binding motif of mL44 subfamily proteins; The mitochondrion-specific ...
 217-285 5.36e-14

double-stranded RNA binding motif of mL44 subfamily proteins; The mitochondrion-specific ribosomal protein mL44 subfamily is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). MRPL3 (also known as mitochondrial large ribosomal subunit protein mL44) is a component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. MRPL44 (also called L44mt, MRP-L44, or mitochondrial large ribosomal subunit protein mL44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. Members of this family contain a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380747  Cd Length: 71  Bit Score: 65.98  E-value: 5.36e-14
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113464 217 PRRQLSRLCKRLSLKEPVYRIIAETGRKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLISYY 285
Cdd:cd20315   3 PTRELAEILRREGIEKPVSRLIAESGRLTKSPVYIVGVYCDEETIGEGYGYSIKEAKAEAATDALMKLF 71
DSRM smart00358
Double-stranded RNA binding motif;
217-285 9.29e-10

Double-stranded RNA binding motif;


Pssm-ID: 214634 [Multi-domain]  Cd Length: 67  Bit Score: 54.19  E-value: 9.29e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 19113464    217 PRRQLSRLCKRLSLkEPVYRIIAETGRKSRePVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLISYY 285
Cdd:smart00358   1 PKSLLQELAQKRKL-PPEYELVKEEGPDHA-PRFTVTVKVGGKRTGEGEGSSKKEAKQRAAEAALRSLK 67
DSRM_MRPL44 cd19874
double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and ...
 221-285 1.06e-09

double-stranded RNA binding motif of mitochondrial 39S ribosomal protein L44 (MRPL44) and similar proteins; MRPL44 (also known as L44mt, MRP-L44, or mitochondrial large ribosomal subunit protein mL44) is a component of the 39S subunit of mitochondrial ribosome. It may play a role in the assembly/stability of nascent mitochondrial polypeptides exiting the ribosome. MRPL44 contains a RNase III-like domain and a double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380703  Cd Length: 84  Bit Score: 54.52  E-value: 1.06e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113464 221 LSRLCKRLSLKEPVYRIIAETGRKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSLISYY 285
Cdd:cd19874  18 LVEILQKRGLPPPEPRLIRQSGANTVLPVYFVGLYSDKKLIGEGPGESILIAEEMAARDALRRLF 82
DSRM_RNAse_III_family cd10845
double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase ...
 207-281 1.99e-09

double-stranded RNA binding motif of ribonuclease III (RNase III) and similar proteins; RNase III (EC 3.1.26.3; also known as ribonuclease 3) digests double-stranded RNA formed within single-strand substrates, but not RNA-DNA hybrids. It is involved in the processing of rRNA precursors, viral transcripts, some mRNAs, and at least 1 tRNA (metY, a minor form of tRNA-init-Met). It cleaves the 30S primary rRNA transcript to yield the immediate precursors to the 16S and 23S rRNAs. The cleavage can occur in assembled 30S, 50S, and even 70S subunits and is influenced by the presence of ribosomal proteins. The RNase III family also includes the mitochondrion-specific ribosomal protein mL44 subfamily, which is composed of mitochondrial 54S ribosomal protein L3 (MRPL3) and mitochondrial 39S ribosomal protein L44 (MRPL44). Members of this family contain an RNase III domain and a C-terminal double-stranded RNA binding motif (DSRM). DSRM is not sequence specific, but highly specific for dsRNAs of various origin and structure.


Pssm-ID: 380682 [Multi-domain]  Cd Length: 69  Bit Score: 53.27  E-value: 1.99e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113464 207 DPRTMLQlqwprrqlsRLCKRLSLKEPVYRIIAETGrKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSL 281
Cdd:cd10845   2 DYKTALQ---------EYLQKRGLPLPEYELVEEEG-PDHNKTFTVEVKVNGKVIGEGTGRSKKEAEQAAAKAAL 66
dsrm pfam00035
Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training ...
 217-281 5.97e-08

Double-stranded RNA binding motif; Sequences gathered for seed by HMM_iterative_training Putative motif shared by proteins that bind to dsRNA. At least some DSRM proteins seem to bind to specific RNA targets. Exemplified by Staufen, which is involved in localization of at least five different mRNAs in the early Drosophila embryo. Also by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA.


Pssm-ID: 425434 [Multi-domain]  Cd Length: 66  Bit Score: 48.77  E-value: 5.97e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 19113464   217 PRRQLSRLCKRLsLKEPVYRIIAETGrKSREPVFVIGAYSGHHLLGQGQASSLNLAEQQAAYNSL 281
Cdd:pfam00035   1 PKSLLQEYAQKN-GKPPPYEYVSEEG-PPHSPKFTVTVKVDGKLYGSGTGSSKKEAEQLAAEKAL 63
Ribonuclease_3 pfam00636
Ribonuclease III domain;
83-189 6.01e-08

Ribonuclease III domain;


Pssm-ID: 459883  Cd Length: 101  Bit Score: 49.97  E-value: 6.01e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19113464    83 EKLWSIGKVFGDFYVLEYIKCKYPRLPEEAVHGMQNGWMGSKALSQLATIWGLEVQRREEGLQESFGKVLAKRADpemLR 162
Cdd:pfam00636   1 ERLEFLGDAVLELYVREYLFEKFPDLREGDLHRLRSALVSNEALAKLARKLGLEKFLTEEELDIRRRNNALGKGP---KR 77

                          90       100
                  ....*....|....*....|....*....
gi 19113464   163 KPGEIYK--DeaarrAILAILGGVYLHQG 189
Cdd:pfam00636  78 ADGKEKVlaD-----AFEALIGALYLDGG 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH