NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|158534071|ref|NP_596871|]
View 

interleukin-4 receptor subunit alpha precursor [Rattus norvegicus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10557929)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
 28-121 5.09e-52

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


:

Pssm-ID: 462720  Cd Length: 94  Bit Score: 176.02  E-value: 5.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071   28 VLGDPTCFSDYIRTSTCEWQLDSTVDCSSQLLLDYRLLFEFSENLTCTPKNSADTVCVCQMAIEEPIQADTYWLELWSER 107
Cdd:pfam09238   1 VLQEPTCFSDYISTSTCEWKMDSPTNCSSELLLSYQLDFEFSENLTCVPENSEDAVCVCKMLMDDFVSADTYSLELWAGG 80

                          90
                  ....*....|....
gi 158534071  108 GQLWQGSFKPSDNV 121
Cdd:pfam09238  81 QLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-220 8.99e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 8.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071 123 PPAPDNLTLHTNVSNALLLMWSNPYPSNNFLHKGLICMvnisREDNPAEFKVYNVTYTePKLSFPVNTLTSGVRYRARVR 202
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEY----REKGSGDWKEVEVTPG-SETSYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*...
gi 158534071 203 VLSQSFPGIWSEWSPSIT 220
Cdd:cd00063   76 AVNGGGESPPSESVTVTT 93
 
Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
 28-121 5.09e-52

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


Pssm-ID: 462720  Cd Length: 94  Bit Score: 176.02  E-value: 5.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071   28 VLGDPTCFSDYIRTSTCEWQLDSTVDCSSQLLLDYRLLFEFSENLTCTPKNSADTVCVCQMAIEEPIQADTYWLELWSER 107
Cdd:pfam09238   1 VLQEPTCFSDYISTSTCEWKMDSPTNCSSELLLSYQLDFEFSENLTCVPENSEDAVCVCKMLMDDFVSADTYSLELWAGG 80

                          90
                  ....*....|....
gi 158534071  108 GQLWQGSFKPSDNV 121
Cdd:pfam09238  81 QLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-220 8.99e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 8.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071 123 PPAPDNLTLHTNVSNALLLMWSNPYPSNNFLHKGLICMvnisREDNPAEFKVYNVTYTePKLSFPVNTLTSGVRYRARVR 202
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEY----REKGSGDWKEVEVTPG-SETSYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*...
gi 158534071 203 VLSQSFPGIWSEWSPSIT 220
Cdd:cd00063   76 AVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 123-210 1.18e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071   123 PPAPDNLTLHTNVSNALLLMWSNPYPSNNFLHKglicmVNISREDNPAEFKVYNVTYTEPKLSFPVNTLTSGVRYRARVR 202
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYI-----VGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                   ....*...
gi 158534071   203 VLSQSFPG 210
Cdd:smart00060  76 AVNGAGEG 83
 
Name Accession Description Interval E-value
IL4Ra_N pfam09238
Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall ...
 28-121 5.09e-52

Interleukin-4 receptor alpha chain, N-terminal; Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.


Pssm-ID: 462720  Cd Length: 94  Bit Score: 176.02  E-value: 5.09e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071   28 VLGDPTCFSDYIRTSTCEWQLDSTVDCSSQLLLDYRLLFEFSENLTCTPKNSADTVCVCQMAIEEPIQADTYWLELWSER 107
Cdd:pfam09238   1 VLQEPTCFSDYISTSTCEWKMDSPTNCSSELLLSYQLDFEFSENLTCVPENSEDAVCVCKMLMDDFVSADTYSLELWAGG 80

                          90
                  ....*....|....
gi 158534071  108 GQLWQGSFKPSDNV 121
Cdd:pfam09238  81 QLLWQGSFKPSEHV 94
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 123-220 8.99e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 8.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071 123 PPAPDNLTLHTNVSNALLLMWSNPYPSNNFLHKGLICMvnisREDNPAEFKVYNVTYTePKLSFPVNTLTSGVRYRARVR 202
Cdd:cd00063    1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEY----REKGSGDWKEVEVTPG-SETSYTLTGLKPGTEYEFRVR 75

                         90
                 ....*....|....*...
gi 158534071 203 VLSQSFPGIWSEWSPSIT 220
Cdd:cd00063   76 AVNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 123-210 1.18e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 41.45  E-value: 1.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 158534071   123 PPAPDNLTLHTNVSNALLLMWSNPYPSNNFLHKglicmVNISREDNPAEFKVYNVTYTEPKLSFPVNTLTSGVRYRARVR 202
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYI-----VGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75


                   ....*...
gi 158534071   203 VLSQSFPG 210
Cdd:smart00060  76 AVNGAGEG 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH