NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|295444879|ref|NP_598892|]
View 

tumor necrosis factor alpha-induced protein 8 isoform 1 [Mus musculus]

Protein Classification

TNFAIP8 family protein( domain architecture ID 10527599)

tumor necrosis factor alpha-induced protein 8 (TNFAIP8) family protein is a DUF758 domain-containing protein similar to vertebrate TNFAIP8 that acts as a negative mediator of apoptosis and may play a role in tumor progression

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF758 pfam05527
Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, ...
 51-210 3.31e-89

Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.


:

Pssm-ID: 461672  Cd Length: 160  Bit Score: 259.04  E-value: 3.31e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444879   51 SIATTLIDDTSSEVLDELYRVTKEYTQNKKEAERVIKNLIKTVIKLAVLHRNNQFNQDELALMEKFKKKVHQLAMTVVSF 130
Cdd:pfam05527   1 SVAKLFIDDTSSELLDNLYRLAKEYTGNKKEAEKVVKNLIKIVVKVGVLYRNNQFSAEELALLEKFRRKFHQLAMTAISF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444879  131 HQVEYTFDRNVLSRLLNECRELLHEIIQRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGKFKPHLQKLCDGINKMLDEE 210
Cdd:pfam05527  81 YEVDFTFDKAVLAALLKECRDLLLQLVERHLTPKSHGRINHVFDFFADPEFLDALFSPDGPYREHLGKICDDLNKLLDEG 160
 
Name Accession Description Interval E-value
DUF758 pfam05527
Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, ...
 51-210 3.31e-89

Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.


Pssm-ID: 461672  Cd Length: 160  Bit Score: 259.04  E-value: 3.31e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444879   51 SIATTLIDDTSSEVLDELYRVTKEYTQNKKEAERVIKNLIKTVIKLAVLHRNNQFNQDELALMEKFKKKVHQLAMTVVSF 130
Cdd:pfam05527   1 SVAKLFIDDTSSELLDNLYRLAKEYTGNKKEAEKVVKNLIKIVVKVGVLYRNNQFSAEELALLEKFRRKFHQLAMTAISF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444879  131 HQVEYTFDRNVLSRLLNECRELLHEIIQRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGKFKPHLQKLCDGINKMLDEE 210
Cdd:pfam05527  81 YEVDFTFDKAVLAALLKECRDLLLQLVERHLTPKSHGRINHVFDFFADPEFLDALFSPDGPYREHLGKICDDLNKLLDEG 160
RicT_YaaT_fam NF041131
regulatory iron-sulfur-containing complex subunit RicT; RicT in Bacillus subtilis (originally ...
 67-140 2.63e-04

regulatory iron-sulfur-containing complex subunit RicT; RicT in Bacillus subtilis (originally YaaT) was described as stage 0 sporulation protein affecting phosphorelay signals. However, RicT belongs to a iron-sulfur containing regulatory complex that is conserved also in many non-sporulating species, together with homologs of YmcA (RicA) and YlbF (RicF).


Pssm-ID: 469054  Cd Length: 213  Bit Score: 40.56  E-value: 2.63e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 295444879  67 ELYRVTKEytqNKKEAERVIKNLIKTVIKLAV---LHRNNQFNQDELALMEKFKKKV--HQLAMTVVSfhqVEYTFDRN 140
Cdd:NF041131  12 ELGKVVLG---PKEVSEEELKKPLKPIIRKATeedLERYEENKEKEKEAFKICREKIaeHGLDMKLID---VEYTFDRS 84
 
Name Accession Description Interval E-value
DUF758 pfam05527
Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, ...
 51-210 3.31e-89

Domain of unknown function (DUF758); Family of eukaryotic proteins with unknown function, which are induced by tumour necrosis factor.


Pssm-ID: 461672  Cd Length: 160  Bit Score: 259.04  E-value: 3.31e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444879   51 SIATTLIDDTSSEVLDELYRVTKEYTQNKKEAERVIKNLIKTVIKLAVLHRNNQFNQDELALMEKFKKKVHQLAMTVVSF 130
Cdd:pfam05527   1 SVAKLFIDDTSSELLDNLYRLAKEYTGNKKEAEKVVKNLIKIVVKVGVLYRNNQFSAEELALLEKFRRKFHQLAMTAISF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 295444879  131 HQVEYTFDRNVLSRLLNECRELLHEIIQRHLTAKSHGRVNNVFDHFSDCDFLAALYNPFGKFKPHLQKLCDGINKMLDEE 210
Cdd:pfam05527  81 YEVDFTFDKAVLAALLKECRDLLLQLVERHLTPKSHGRINHVFDFFADPEFLDALFSPDGPYREHLGKICDDLNKLLDEG 160
RicT_YaaT_fam NF041131
regulatory iron-sulfur-containing complex subunit RicT; RicT in Bacillus subtilis (originally ...
 67-140 2.63e-04

regulatory iron-sulfur-containing complex subunit RicT; RicT in Bacillus subtilis (originally YaaT) was described as stage 0 sporulation protein affecting phosphorelay signals. However, RicT belongs to a iron-sulfur containing regulatory complex that is conserved also in many non-sporulating species, together with homologs of YmcA (RicA) and YlbF (RicF).


Pssm-ID: 469054  Cd Length: 213  Bit Score: 40.56  E-value: 2.63e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 295444879  67 ELYRVTKEytqNKKEAERVIKNLIKTVIKLAV---LHRNNQFNQDELALMEKFKKKV--HQLAMTVVSfhqVEYTFDRN 140
Cdd:NF041131  12 ELGKVVLG---PKEVSEEELKKPLKPIIRKATeedLERYEENKEKEKEAFKICREKIaeHGLDMKLID---VEYTFDRS 84
PSP1 pfam04468
PSP1 C-terminal conserved region; This region is present in both eukaryotes and eubacteria. ...
 91-142 4.62e-03

PSP1 C-terminal conserved region; This region is present in both eukaryotes and eubacteria. The yeast PSP1 protein is involved in suppressing mutations in the DNA polymerase alpha subunit in yeast.


Pssm-ID: 461321  Cd Length: 86  Bit Score: 35.06  E-value: 4.62e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 295444879   91 KTVIKLAV---LHRNNQFNQDELALMEKFKKKV--HQLAMTVVSfhqVEYTFDRNVL 142
Cdd:pfam04468   1 KKILRKATeedLERLEENREKEEEALEICREKIreHGLPMKLVD---VEYQFDGSKL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH