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Conserved domains on  [gi|21717703|ref|NP_598951|]
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vomeronasal 1 receptor 229 [Mus musculus]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
8-299 2.53e-70

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd13949:

Pssm-ID: 475119  Cd Length: 295  Bit Score: 219.83  E-value: 2.53e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   8 MGIVLSLQSALGILGNFSLLFYYLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNdLFDDVGCKLIMYV 87
Cdd:cd13949   3 IRITFFSEVGVGISANSILLLFHIFMFFRGHRPRSTDLIIGHLSLIHLLLLLTMGIIATDAFFSWG-GWDDITCKFLIYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703  88 RRVSRSMSISMTCLLSVFQAITISTRNSCWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKDIEF 167
Cdd:cd13949  82 HRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMLISSHLLVSIIATPNLTSNNFIYVTQS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703 168 CHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHASPRTSAENRATQTILILVCTFLAFY 247
Cdd:cd13949 162 CSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQHLHSTSLSPKASPEQRATQTILLLMSFFVVMY 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 21717703 248 TLSSVLQGYVALSHDPSWWVMNITTIISMGFPAIGPFV-MSRDFTVSRFCFTC 299
Cdd:cd13949 242 ILDSIVFYSRTKFKNDSILYCVQIIVSHSYATVSPFVFlMTEKHIIKFLRSMC 294
 
Name Accession Description Interval E-value
7tm_V1R_pheromone cd13949
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G ...
8-299 2.53e-70

vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily; This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.


Pssm-ID: 320087  Cd Length: 295  Bit Score: 219.83  E-value: 2.53e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   8 MGIVLSLQSALGILGNFSLLFYYLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNdLFDDVGCKLIMYV 87
Cdd:cd13949   3 IRITFFSEVGVGISANSILLLFHIFMFFRGHRPRSTDLIIGHLSLIHLLLLLTMGIIATDAFFSWG-GWDDITCKFLIYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703  88 RRVSRSMSISMTCLLSVFQAITISTRNSCWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKDIEF 167
Cdd:cd13949  82 HRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMLISSHLLVSIIATPNLTSNNFIYVTQS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703 168 CHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHASPRTSAENRATQTILILVCTFLAFY 247
Cdd:cd13949 162 CSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQHLHSTSLSPKASPEQRATQTILLLMSFFVVMY 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 21717703 248 TLSSVLQGYVALSHDPSWWVMNITTIISMGFPAIGPFV-MSRDFTVSRFCFTC 299
Cdd:cd13949 242 ILDSIVFYSRTKFKNDSILYCVQIIVSHSYATVSPFVFlMTEKHIIKFLRSMC 294
V1R pfam03402
Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known ...
7-297 9.51e-64

Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known vomeronasal organ receptor families, the V1R family.


Pssm-ID: 460912  Cd Length: 292  Bit Score: 202.95  E-value: 9.51e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703     7 AMGIVLSLQSALGILGNFSLLFYYLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLpEVLAVFGWNDLFDDVGCKLIMY 86
Cdd:pfam03402   2 NIGIIFFSEVGVGISANSILLLFHIFMFFTGHRLRPTDLIIGHLSLIHLLMLLTMGI-IAMDAFGSQGRWDDTTCKFLIY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703    87 VRRVSRSMSISMTCLLSVFQAITISTRNSCWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKDIE 166
Cdd:pfam03402  81 LHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMSISSHLLLSIIATPNLTSSSFIYVTQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   167 FCHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHASPRTSAENRATQTILILVCTFLAF 246
Cdd:pfam03402 161 SCSILPMSYSMQSLFSTLLASRDVFLIGLMVLSSGYMVALLCRHKKQAQHLHGTSLSPKASPEQRATRTILLLMSFFVVM 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 21717703   247 YTLSSVLQGYVALSHDPSWWVmNITTIISMGFPAIGPFV-MSRDFTVSRFCF 297
Cdd:pfam03402 241 YILDSIVSYSRTMFKNDSIFY-CVQILVSHSYATVSPFVlISTEKRIIKFLR 291
 
Name Accession Description Interval E-value
7tm_V1R_pheromone cd13949
vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G ...
8-299 2.53e-70

vomeronasal organ pheromone receptor type-1 family, member of the seven-transmembrane G protein-coupled receptor superfamily; This family represents vomeronasal type-1 receptors (V1Rs) that are specifically expressed in the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes and monkeys. The VNO detects pheromones, chemicals released from animals that can influence social and reproductive behaviors, such as male-male aggression or sexual mating, in other members of the same species. On the other hand, the olfactory epithelium, which contains olfactory receptor neurons inside the nasal cavity, is responsible for detecting odor molecules (smells). There are two types of vertebrate pheromones: (1) small volatile molecules such as 2-heptanone, a substance in the urine of both male and female that extends estrous cycle length in female mice; and (2) water-soluble molecules such as the major histocompatibility complex (HMC) class-I peptide, which can induce the pregnancy block effect, the tendency for female rodents to abort their pregnancies upon exposure to the scent of an unknown male. While V1Rs and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO, V2Rs (type-2 vomeronasal receptors) and G-alpha(o) protein are coexpressed in the basal layer of the VNO. Activation of V1R or V2R causes stimulation of phospholipase pathway, generating diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3). V1Rs have a short N-terminal extracellular domain, whereas V2Rs contain a long N-terminal extracellular domain, which is believed to bind pheromones. Although V1Rs share the seven-transmembrane domain structure with V1Rs and olfactory receptors, they share little sequence similarity with each other.


Pssm-ID: 320087  Cd Length: 295  Bit Score: 219.83  E-value: 2.53e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   8 MGIVLSLQSALGILGNFSLLFYYLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNdLFDDVGCKLIMYV 87
Cdd:cd13949   3 IRITFFSEVGVGISANSILLLFHIFMFFRGHRPRSTDLIIGHLSLIHLLLLLTMGIIATDAFFSWG-GWDDITCKFLIYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703  88 RRVSRSMSISMTCLLSVFQAITISTRNSCWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKDIEF 167
Cdd:cd13949  82 HRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMLISSHLLVSIIATPNLTSNNFIYVTQS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703 168 CHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHASPRTSAENRATQTILILVCTFLAFY 247
Cdd:cd13949 162 CSILPMSYSMQSLFSTLLAFRDVFLIGLMLLSSGYMVALLHRHKKQVQHLHSTSLSPKASPEQRATQTILLLMSFFVVMY 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 21717703 248 TLSSVLQGYVALSHDPSWWVMNITTIISMGFPAIGPFV-MSRDFTVSRFCFTC 299
Cdd:cd13949 242 ILDSIVFYSRTKFKNDSILYCVQIIVSHSYATVSPFVFlMTEKHIIKFLRSMC 294
V1R pfam03402
Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known ...
7-297 9.51e-64

Vomeronasal organ pheromone receptor family, V1R; This family represents one of two known vomeronasal organ receptor families, the V1R family.


Pssm-ID: 460912  Cd Length: 292  Bit Score: 202.95  E-value: 9.51e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703     7 AMGIVLSLQSALGILGNFSLLFYYLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLpEVLAVFGWNDLFDDVGCKLIMY 86
Cdd:pfam03402   2 NIGIIFFSEVGVGISANSILLLFHIFMFFTGHRLRPTDLIIGHLSLIHLLMLLTMGI-IAMDAFGSQGRWDDTTCKFLIY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703    87 VRRVSRSMSISMTCLLSVFQAITISTRNSCWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKDIE 166
Cdd:pfam03402  81 LHRVLRGLSLCTTCLLSVLQAITLSPRSSCLAKFKHKSPHHISGAFLFLWVLYMSISSHLLLSIIATPNLTSSSFIYVTQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   167 FCHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHASPRTSAENRATQTILILVCTFLAF 246
Cdd:pfam03402 161 SCSILPMSYSMQSLFSTLLASRDVFLIGLMVLSSGYMVALLCRHKKQAQHLHGTSLSPKASPEQRATRTILLLMSFFVVM 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 21717703   247 YTLSSVLQGYVALSHDPSWWVmNITTIISMGFPAIGPFV-MSRDFTVSRFCF 297
Cdd:pfam03402 241 YILDSIVSYSRTMFKNDSIFY-CVQILVSHSYATVSPFVlISTEKRIIKFLR 291
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
8-288 1.42e-14

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 72.08  E-value: 1.42e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   8 MGIVLSLQSALGILGNFSLLfyyLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNDLFDDVGCKLIMYV 87
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVL---LSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703  88 RRVSRSMSISMTCLLSVFQAITISTRNscwKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTSTNRNSKNKTQKKdief 167
Cdd:cd14964  78 WYGANLASIWTTLVLTYHRYFALCGPL---KYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGSC---- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703 168 chsvgRDKMVDIMYTAFCVFpeVLFSLLIVSSSTTMIVILYGHKKRVQHILHTHaSPRTSAENRATQTILILVCTFLAFY 247
Cdd:cd14964 151 -----YLICTTIYLTWGFLL--VSFLLPLVAFLVIFSRIVLRLRRRVRAIRSAA-SLNTDKNLKATKSLLILVITFLLCW 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 21717703 248 TLSSVLQGYVALSHD--PSWWVMNITTIISMGFPAIGPFVMSR 288
Cdd:cd14964 223 LPFSIVFILHALVAAgqGLNLLSILANLLAVLASTLNPFIYCL 265
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
8-285 4.84e-08

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 53.06  E-value: 4.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   8 MGIVLSLQSALGILGNFSLLfyyLVLYNKERTLKIIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNDLFDDVGCKLIMYV 87
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVI---LVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703  88 RRVSRSMSISMTCLLSV--FQAITISTRNSCWkefkeQTAKFMGLFISLCWILFMLVNMLFPVYTSTNrnsknktQKKDI 165
Cdd:cd00637  78 QSVSLLASILTLTAISVdrYLAIVHPLRYRRR-----FTRRRAKLLIALIWLLSLLLALPPLLGWGVY-------DYGGY 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703 166 EFCHSVGRDKMVDIMYTAFCVFPEVLFSLLIVSSS-TTMIVILYGHKKRVQ-HILHTHASPRTSAENRATQTILILVCTF 243
Cdd:cd00637 146 CCCCLCWPDLTLSKAYTIFLFVLLFLLPLLVIIVCyVRIFRKLRRHRRRIRsSSSNSSRRRRRRRERKVTKTLLIVVVVF 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 21717703 244 LAFYT---LSSVLQGYVALSHDPSWWVMNITTIISMGFPAIGPFV 285
Cdd:cd00637 226 LLCWLpyfILLLLDVFGPDPSPLPRILYFLALLLAYLNSAINPII 270
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
68-276 8.48e-05

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 43.05  E-value: 8.48e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703    68 AVFGWNDLFDDVGCKLIMYVRRVSRSMSISMTCLLSV--FQAITISTRNSCWkefkeQTAKFMGLFISLCWILFMLVNML 145
Cdd:pfam00001  45 YLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISIdrYLAIVHPLRYKRR-----RTPRRAKVLILVIWVLALLLSLP 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703   146 FPVYTSTNRNSKNKTQKKDIEFCHSVGRDKMVDIMYTaFCVFpeVLFSLLIVSSSTTMIVILYGHKKRVQHilhthaSPR 225
Cdd:pfam00001 120 PLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYTLLIS-VLGF--LLPLLVILVCYTLIIRTLRKSASKQKS------SER 190
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 21717703   226 TSAENRATQTILILVCTFLAFYT--LSSVLQGYVALSHDPSWWVMNITTIISM 276
Cdd:pfam00001 191 TQRRRKALKTLAVVVVVFILCWLpyHIVNLLDSLALDCELSRLLDKALSVTLW 243
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
10-207 8.47e-03

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 37.10  E-value: 8.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703  10 IVLSLQSALGILGNFSLLFYYLVLYNKERTlkiIDIILIHVFTSNSLIIFSKGLPEVLAVFGWNDLFDDVGCKLIMYVRR 89
Cdd:cd15921   5 TAYILIFILGLTGNSISVYVFLSQYRSQTP---VSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21717703  90 VSRSMSISMTCLLSVFQAITISTRnscWKEFKEQTAKFMGLFISLCWILFMLVNMLFPVYTStnrNSKNKTQKKDIEFCH 169
Cdd:cd15921  82 VNMYSSIYFLTALSVFRYLALVWP---YLYLRVQTHSVAGIICGLIWILMGLASSPLLFAKS---KQHDEGSTRCLELAH 155
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 21717703 170 SvGRDKMVDIMYTAFCVFPEVLFSLLIVSSSTTMIVIL 207
Cdd:cd15921 156 D-AVDKLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLL 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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