|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
23-480 |
2.84e-161 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 462.86 E-value: 2.84e-161
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 23 ALLGSIGMAIVYGLKVNLSVAMVAMVNHTAIKAhgdggghgghgsvilsnasqvslveecNPPGGASNVTAKVEDGPFDW 102
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHD---------------------------NNNTSTDKDTLPVEAPEFDW 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 103 SEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRVLEGVGGGASFPAMH 182
Cdd:cd17318 54 SEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMH 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 183 VMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVqdnpnkqrfisleer 262
Cdd:cd17318 134 ALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV--------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 263 qmitsslgteqktehhpavpwgkvftsVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIF 342
Cdd:cd17318 199 ---------------------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWIC 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 343 SICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGFLSNHIDIAPNF 422
Cdd:cd17318 252 SIVGGYLADWLRSRGILSTTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNY 331
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 24580790 423 AGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIGAWRIIFGVTIVLFALEFLVFVFLG 480
Cdd:cd17318 332 AGTLMGITNTAATIAGIISPLIVGAIVKNDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
22-480 |
1.62e-94 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 292.45 E-value: 1.62e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 22 LALLGSIGMAIVYGLKVNLSVAMVAMVNHTaikahgdggghgghgSVILSNASQVSLVEECNPPGGASNVTAKVedgpFD 101
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSN---------------STLPSNNSSNACPEHSSSPSVEHNETGKK----YD 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 102 WSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRVLEGVGGGASFPAM 181
Cdd:cd17381 62 WDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAM 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 182 HVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVqdnpnkqrfislee 261
Cdd:cd17381 142 HAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV-------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 262 rqmitsslgteqktehhpavpwgkvftsVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMII 341
Cdd:cd17381 208 ----------------------------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWL 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 342 FSICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGFLSNHIDIAPN 421
Cdd:cd17381 260 FMILSGQIADNLREKQNFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPS 339
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*....
gi 24580790 422 FAGTLVALTNTAATLPGIVVPLFVGFVTKGNqNIGAWRIIFGVTIVLFALEFLVFVFLG 480
Cdd:cd17381 340 YAGILLGITNTFATIPGMVGPVIAKSLTHNN-TVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
100-480 |
1.99e-78 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 249.78 E-value: 1.99e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRVLEGVGGGASFP 179
Cdd:cd17380 29 FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVqdnpnkqrfisl 259
Cdd:cd17380 109 SMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL------------ 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 260 eerqmitsslgteqktehhpavpwgkvftsVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLkFNVASNAALSALPYFPM 339
Cdd:cd17380 177 ------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVM 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 340 IIFSICLGKLLDSLQAKGkITTTVARKTATSICTLIPGVCLLVLCYIgCRHYEAVSVMSVGIVAMGSMFSGFLSNHIDIA 419
Cdd:cd17380 226 FPSSNVAGWLADHLISRG-WTVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIA 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24580790 420 PNFAGTLVALTNTAATLPGIVVPLFVGFVTkgnQNIGAWRIIFGVTIVLFALEFLVFVFLG 480
Cdd:cd17380 304 PNYAGIVFGISNTAGTIPGIVGVYLTGYIL---EATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
19-489 |
7.83e-70 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 230.79 E-value: 7.83e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 19 RYVLALLGSIGMAIVYGLKVNLSVAMVAMVNHTaikahgdggghgghGSVILSNASQVSLVEEcnppggasnvtakVEDG 98
Cdd:TIGR00894 17 RLFLSFLLHICNVIIIAQRICLSLTMVAMVNKE--------------NSTDLACLSAENELDN-------------IKNP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 99 PFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRVLEGVGGGASF 178
Cdd:TIGR00894 70 NFKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVS 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 179 PAMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGV-CSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFI 257
Cdd:TIGR00894 150 PATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWlCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 258 SLEERQMITSSLgTEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYF 337
Cdd:TIGR00894 230 SKFEKKYINSSL-QGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 338 PMIIFSICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGFLSNHID 417
Cdd:TIGR00894 309 FAWLCSIFAGYLADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLD 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 418 IAPNFAGTLVALTNtaatLPGIVVPLFVGFVTKGNQNIGA---WRIIF------GVTIVLFALEFlvfvflGSGSEQPWN 488
Cdd:TIGR00894 389 LAPRFLGFIKGITG----LPGFIGGLIASTLAGNILSQDSknvWLIVFlimafvNILCVIFYLIF------GSAERQDWA 458
|
.
gi 24580790 489 K 489
Cdd:TIGR00894 459 K 459
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
23-462 |
5.26e-63 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 210.27 E-value: 5.26e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 23 ALLGSIGMAIVYGLKVNLSVAMVAMVNHTAIkahgdggghgghgsvilsnasqvslveecnppggASNVTAKVEDGPFDW 102
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTD----------------------------------AYGGKVIVHKAEFNW 46
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 103 SEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRVLEGVGGGASFPAMH 182
Cdd:cd17382 47 TPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACH 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 183 VMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWvilvqdnpnkqrfisleer 262
Cdd:cd17382 127 GIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW------------------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 263 qmitsslgteqktehhpavpwgkVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIF 342
Cdd:cd17382 188 -----------------------MLVSMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTII 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 343 SICLGKLLDSLQAKGKITTTVARKTATSICTLIPGVCLLVLCYigCRHYE-AVSVMSVGIVAMGSMFSGFLSNHIDIAPN 421
Cdd:cd17382 245 VPIGGQLADYLRSRGILSTTAVRKIFNCGGFGMEATFLLVVAF--SHSPTvAISFLVLAVGFSGFAISGFNVNHLDIAPR 322
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 24580790 422 FAGTLVALTNTAATLPGIVVPLFVGFVTKgNQNIGAWRIIF 462
Cdd:cd17382 323 YASILMGISNGIGTLSGMVCPVIVGALTK-HKTREEWQYVF 362
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
100-471 |
3.44e-38 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 143.09 E-value: 3.44e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELhyGGLILMRVLEGVGGGASFP 179
Cdd:cd17319 33 LGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL--TSLYVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDnpnkqrfisl 259
Cdd:cd17319 111 GAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ---------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 260 eerqmitsslgteqktehhpavpwgkvftsvpFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPM 339
Cdd:cd17319 181 --------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAG 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 340 IIFSICLGKLLDSLQakgkittTVARKTATSICTLIPGVCLLvLCYIGCRHYEAVSVMSVGIVAMGSMFSGFLSNHIDIA 419
Cdd:cd17319 229 AIGMILGGRLSDRLL-------RGARRLVIIIGLLLAAVGLL-LAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLL 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 24580790 420 P-NFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIGAWRIIFGVTIVLFAL 471
Cdd:cd17319 301 PgEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
100-480 |
4.40e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 137.31 E-value: 4.40e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTElhYGGLILMRVLEGVGGGASFP 179
Cdd:COG2271 40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATS--FWQLLLLRFLLGLGEAGFFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLwvilvqdnpnkqrfisl 259
Cdd:COG2271 118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 260 eerqmitsslgteqktehhpavpwgkvftsvPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPM 339
Cdd:COG2271 181 -------------------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAG 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 340 IIFSICLGKLLDSLQAKGKITTTvarktatsICTLIPGVCLLVLCYIGcRHYEAVSVMSVGIVAMGSMFSGFLSNHIDIA 419
Cdd:COG2271 230 IVGSLLGGWLSDRLGRRRKLVLA--------IGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24580790 420 P-NFAGTLVALTNTAATLPGIVVPLFVGFVTkgnqNIGAWRIIFGVTIVLFALEFLVFVFLG 480
Cdd:COG2271 301 PkKARGTASGLVNTFGFLGGALGPLLVGYLL----DATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
100-442 |
3.63e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 126.38 E-value: 3.63e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFP 179
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS--SLWLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVqDNPNKQRFISL 259
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPR-PPPESKRPKPA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 260 EERQMITsslgteqktehhpAVPWGKVFTSVPFWaILIAHTCSNFGWYMFLIEIPFYMkQVLKFNVASNAALSALPYFPM 339
Cdd:pfam07690 184 EEARLSL-------------IVAWKALLRDPVLW-LLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLG 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 340 IIFSICLGKLLDSLQAKGKITTTVarktatsICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIvAMGSMFSGFLSNHIDIA 419
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRRRRLLLAL-------LLLILAALGLLLLSLTLSSLWLLLALLLLGF-GFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 24580790 420 P-NFAGTLVALTNTAATLPGIVVP 442
Cdd:pfam07690 321 PkEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
100-471 |
1.82e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 119.45 E-value: 1.82e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFP 179
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP--SFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVC--SAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRfi 257
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESAR-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 258 sleerqmitssLGTEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYF 337
Cdd:cd06174 182 -----------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 338 PMIIFSICLGKLLDslqakgkitTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGFLSNHID 417
Cdd:cd06174 251 AGALGSLLLGLLSD---------RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAEL 321
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 24580790 418 IAPNFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIGAWRIIFGVTIVLFAL 471
Cdd:cd06174 322 FPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
100-479 |
3.87e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.97 E-value: 3.87e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFP 179
Cdd:COG2223 35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV--SYWLLLLLGLLLGIGGGGSFA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRfisl 259
Cdd:COG2223 113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA---- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 260 eerqmitsslgteqKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPM 339
Cdd:COG2223 189 --------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 340 IIFSICLGKLLDSlqakgkitttVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGFLSNHIDIA 419
Cdd:COG2223 255 ALGRPLGGWLSDR----------IGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24580790 420 P-NFAGTLVALTNTAATLPGIVVPLFVGFVtkgNQNIGAWRIIFGVTIVLFALEFLVFVFL 479
Cdd:COG2223 325 PtKNAGAVYGLVGAAGGLGGFLGPLLFGAL---LDATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-436 |
5.76e-26 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 108.52 E-value: 5.76e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFP 179
Cdd:COG2814 40 LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCI-WMLLWVILVQDNPNKQRfis 258
Cdd:COG2814 118 AALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAARA--- 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 259 leerqmitsslgteqktehHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFP 338
Cdd:COG2814 195 -------------------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLG 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 339 MIIFSICLGKLLDslqakgkittTVARKTATSICTLIPGVCLLVLCYIGcrhyeAVSVMSVGIVAMGSMFSGFLSNHIDI 418
Cdd:COG2814 256 GVLGALLAGRLAD----------RFGRRRLLLIGLLLLALGLLLLALAG-----SLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340
....*....|....*....|...
gi 24580790 419 A-----PNFAGTLVALTNTAATL 436
Cdd:COG2814 321 VaelapPEARGRASGLYNSAFFL 343
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
108-479 |
7.30e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 97.26 E-value: 7.30e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFPAMHVMIAS 187
Cdd:cd17325 34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFAT--SYWQLLLARFLQGLASAAVWPAAMALIAD 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 188 WAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRfisleerqmits 267
Cdd:cd17325 112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPN------------ 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 268 slgTEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSICLG 347
Cdd:cd17325 180 ---KRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAG 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 348 KLLDSLQAKGKITttvarktatsICTLIPGVCLLVLCYIGCRHYEAVsVMSVGIVAMGSMFSGFLSNHIDIAPNFA-GTL 426
Cdd:cd17325 257 KLSDRIGRKPLIL----------IGLLLSAVALLLLPLATSFWLLLL-LLALLGLGLGLVFPATLALLADIVPPEGrGTA 325
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 24580790 427 VALTNTAATLPGIVVPLFVGFVTkgnqNIGAWRIIFGVTIVLFALEFLVFVFL 479
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLY----DAFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
100-476 |
8.58e-16 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 78.75 E-value: 8.58e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFP 179
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAP--SFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTER-MVMSTIIyVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFIS 258
Cdd:cd17324 107 IAAAYAADLVPPEKRgRAIGLVF-SGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSL 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 259 LEERQmitsslgteqktehhpavpWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFP 338
Cdd:cd17324 186 GLLSS-------------------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 339 MIIFSICLGKLLDslqakgkittTVARKTATSICTLIpGVCLLVLCYIGCRHYEAVS---VMSVGIVAMGSMFSGFLSnh 415
Cdd:cd17324 247 GVVGSPLAGRLAD----------RGGRRALLIALLLL-AAALLLLTLLGPSPLLLLVglvLWGLGFFAAHSALQTRVL-- 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24580790 416 iDIAPNFAGTLVALTNTAATLPGIVVPLFVGFVTKGnqniGAWRIIFGVTIVLFALEFLVF 476
Cdd:cd17324 314 -RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH----GGWAGVGWVGAALLLLALLLA 369
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
95-451 |
1.16e-15 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 78.57 E-value: 1.16e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 95 VEDGPFDWSEplQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYggLILMRVLEGVGG 174
Cdd:TIGR00881 22 VEEIGLSKTD--LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWV--MAALWALNGIFQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 175 GASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQ-WGWESVFYVMGALSCIWMLLWVILVQDNPNK 253
Cdd:TIGR00881 98 GMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAElYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 254 QRFISLEErqMITSSLGTEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEI----PFYMKQVLKFNVASNA 329
Cdd:TIGR00881 178 CGLPPAEE--MPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIldwsPLYLTQEKGFSKEKAS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 330 ALSALPYFPMIIFSICLGKLLDSLQAKGKITTTVARKtatsictlipgvCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFS 409
Cdd:TIGR00881 256 WAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFM------------ALIIVSLLVYWLNPAANPLMDLICLFALGFL 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 24580790 410 GFLSNHI------DIAPNFA-GTLVALTNTAATLPGIVVPLFVGFVTKG 451
Cdd:TIGR00881 324 VYGPQMLigviasELAPKKAaGTAAGFVGFFAYLGGILAGLPLGYLADG 372
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
117-383 |
6.08e-13 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 70.34 E-value: 6.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 117 GYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMV 196
Cdd:cd17328 46 SYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 197 MSTIIYVGTSAGTALSILLAGVCSAQW-GWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERQMITSSLGTeqkt 275
Cdd:cd17328 124 ALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD---- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 276 ehhpavpWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSaLPYFPMIIFSICLGKLLdslqa 355
Cdd:cd17328 200 -------LKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVG-LIFGAITCIAGVLGVLL----- 266
|
250 260
....*....|....*....|....*...
gi 24580790 356 kGKITTTVARKTATSICTLIPGVCLLVL 383
Cdd:cd17328 267 -GGILADRLRRKTPRADPLVCAVGLLAA 293
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
100-246 |
2.75e-12 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 67.53 E-value: 2.75e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELhyGGLILMRVLEGVGGGASFP 179
Cdd:COG0477 44 LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSP--ELLIAARALQGIGAGGLMP 121
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVIL 246
Cdd:COG0477 122 GALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
108-242 |
1.04e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 66.07 E-value: 1.04e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHygGLILMRVLEGVGGGASFPAMHVMIAS 187
Cdd:cd17365 37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVL--QLALLRFLTGLGLGAAMPNAITLVSE 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 24580790 188 WAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLL 242
Cdd:cd17365 115 YAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
100-479 |
1.16e-11 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.42 E-value: 1.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFP 179
Cdd:COG0738 38 FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAP--SYPLLLLALFLLGLGLGLLDV 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMStIIYVGTSAGTALSILLAGVCSAQ---WGWESVFYVMGALSCIWMLLWVilvqdnpnkqrF 256
Cdd:COG0738 116 AANPYVAALGPETAASRLN-LLHAFFSLGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFL-----------R 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 257 ISLEErqmitssLGTEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPY 336
Cdd:COG0738 184 SKLPE-------IEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 337 FPMIIFSICLGKLLDslqakgkittTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIvAMGSMFSGFLSNHI 416
Cdd:COG0738 257 GGMTIGRFLGGFLLK----------RFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGL-GLSLMFPTIFSLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24580790 417 DIAPNFAGTLVALTNTAATLPGIVVPLFVGFVtkgNQNIGAwRIIFGVTIVLFALEFLVFVFL 479
Cdd:COG0738 326 DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL---ADAFGL-RAAFLVPLVCYLLILLLALAL 384
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
108-353 |
2.46e-10 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 62.37 E-value: 2.46e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTpVFTElHYGGLILMRVLEGVGGGASFPAMHVMIAS 187
Cdd:TIGR00895 55 GFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLC-ALAT-NVTQLLILRFLAGLGLGGLMPNLNALVSE 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 188 WAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIwmLLWVI----------LVQDNPNKQRF- 256
Cdd:TIGR00895 133 YAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL--LLLLLmrflpesidfLVSKRPETVRRi 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 257 ---ISLEERQMITSSLGTEQKTEHHPAVPWGKVFT------SVPFWAiliAHTCSNFGWYMFLIEIPFYMKQvLKFNVAS 327
Cdd:TIGR00895 211 vnaIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQgktariTVLLWL---LYFMLLVGVYFLTNWLPKLMVE-LGFSLSL 286
|
250 260
....*....|....*....|....*.
gi 24580790 328 NAALSALPYFPMIIFSICLGKLLDSL 353
Cdd:TIGR00895 287 AATGGALFNFGGVIGSIIFGWLADRL 312
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
109-442 |
2.70e-10 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 62.27 E-value: 2.70e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 109 TLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFPAMHVMIASW 188
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVK--NFGGLIALRFFLGLFESGVFPGFILYLGMW 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 189 APPTERMVMSTIIYVGTSAGTALSILLA-GVCSAQW-----GWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEER 262
Cdd:cd17327 123 YKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKILGvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEK 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 263 QMITSSLGTEQKTEHHPAVPWG---KVFTSVPFWAILIAHTCSN-----FGWYMFLI--EIPFYMKQVLKFNVASnAALS 332
Cdd:cd17327 203 ELAVERLRANQTGKGDQKFKWKqikEAFKDPRTWLLFLFFFCSQitnngISNFLPLIlkSLGFYSLQTNLLSVPI-GALG 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 333 ALpyfPMIIFSIclgkLLDSLQAKGKITTtvarktaTSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGFL 412
Cdd:cd17327 282 AV---SLLIAAL----LSDRFKKRGLFAI-------FACVLALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILLSWI 347
|
330 340 350
....*....|....*....|....*....|....*
gi 24580790 413 SNhidiapNFAG-----TLVALTNTAATLPGIVVP 442
Cdd:cd17327 348 SS------NCAGytkraTVLAIMLIFYNVGNIVAP 376
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
96-471 |
4.08e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 61.46 E-value: 4.08e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 96 EDGPFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTElhYGGLILMRVLEGVGGG 175
Cdd:cd17316 27 AEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPT--PILLLVLRFLQGIGIG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 176 ASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVC----SAQWGWESVFYVMGALSCIWMLLWVILVQdnp 251
Cdd:cd17316 105 GEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLipllSGDWGWRILFLIGALPALLALLLRRRTLL--- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 252 nkqrfisleerqmitsslgteqktehhpavpwgkvftsvpfwaILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAAL 331
Cdd:cd17316 182 -------------------------------------------LILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLY 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 332 SALPYFPMIIFSICLGKLLDslqakgkittTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGF 411
Cdd:cd17316 219 LLLISLGALVGALIAGLLSD----------RIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGA 288
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24580790 412 LSNHI-DIAP-NFAGTLVALTNTAATLPGIVVPLFVGFVTKGNQNIGAWRIIFGVTIVLFAL 471
Cdd:cd17316 289 LYAYLaELFPtEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
135-478 |
7.32e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.07 E-value: 7.32e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 135 KWVMLFSVAINVVCTLLTPVFTELHYGG----LILMRVLEGVGGGASFPAMHVMIASWAP-PTERMVMSTIIYVGTSAGT 209
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGkliyALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRLSSWRFAFAGLGG 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 210 ALSILLAGV------CSAQWGWESVFYVMGALSCIWMLLWVILVqdnpnKQRFISLEERQMITSSLGTeqktehhpavpw 283
Cdd:COG2211 161 LLASVLPPPlvaafgGDAALGYRLTALIFAVLGLLAFLLTFFGT-----KERPVPEEEKVSLKESLKA------------ 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 284 gkVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSICLGKLLDSLQakgkitttv 363
Cdd:COG2211 224 --LLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--------- 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 364 aRKTATSICTLIPGVCLLVLCYIGCRHYE----AVSVMSVGIVAMGSMFSGFLSNHIDIA-----PNFAGTLVALTNTAA 434
Cdd:COG2211 293 -KKKAFIIGLLLAALGLLLLFFLGPGNLWlllvLAALAGIGLGAILVLPWAMLADVVDYDewktgRRREGLYFGIFTFAI 371
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 24580790 435 TLPGIVVPLFV-------GFVTKGNQNIGA----WRIIFGVTIVLFALEFLVFVF 478
Cdd:COG2211 372 KLGQALAGALAglllalfGYVAGAAQSPSAltgiRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
108-247 |
2.86e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 58.74 E-value: 2.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFPAMHVMIAS 187
Cdd:cd17325 238 GLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLAT--SFWLLLLLLALLGLGLGLVFPATLALLAD 315
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 188 WAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILV 247
Cdd:cd17325 316 IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
127-471 |
3.06e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 58.78 E-value: 3.06e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 127 HVAENFSAKWVMLFSVAINVVCTLLTPVFTELhyGGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTS 206
Cdd:cd17329 57 RLADRFGRKPVMLAGLLLRALGFALLGFAHSP--WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAIN 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 207 AGTALSILLAGVcSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRfisleerqmitsslgteQKTEHHPAVPWGKV 286
Cdd:cd17329 135 LGVAIGPLLGGL-LLLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRR-----------------AAEKTEILRGYKIV 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 287 FTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSICLGKLLDSLQAKGKITTTVARK 366
Cdd:cd17329 197 LRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLF 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 367 TA-TSICTLIPGVCLLVLCYIgcrhyeavsVMSVGIVAMGSMFSGFLSnhiDIAP-NFAGTLVALTNTAATLPGIVVPLF 444
Cdd:cd17329 277 AIgFAVLAFANTLAVLILAMI---------VLTLGEMLVFPAVQTLVA---ALAPpDKRGSYMGFYALAWGLGRAIGPLV 344
|
330 340
....*....|....*....|....*..
gi 24580790 445 VGFVTKGNQNIGAWRIIFGVTIVLFAL 471
Cdd:cd17329 345 GGLLLDLLGPGLPWLILAALGLIAAAL 371
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
111-479 |
1.79e-08 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 56.43 E-value: 1.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 111 LSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTpVFTElHYGGLILMRVLEGVGGGASFPAMHVMIASWAP 190
Cdd:cd17320 40 LSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLC-ALAS-SIEQLLIARFLQGLGAAAGSVVARAIVRDLYS 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 191 PTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMgALSCIWMLLWVILVQDNPNKQRFISLEERQMITSslg 270
Cdd:cd17320 118 GAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL-ALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRA--- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 271 teqktehhpavpWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSICLGKLL 350
Cdd:cd17320 194 ------------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLV 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 351 dslqakGKITTTVARKTATSICTLIpGVCLLVLCYIGCRHYEA----VSVMSVGI-VAMGSMFSGFLSNHidiaPNFAGT 425
Cdd:cd17320 262 ------RRFGPRRLLRLGLLLLLAA-ALVLLLAALLGGLSLWPlvapLFLIFFGFgLIFPNATSLALEPF----PHVAGT 330
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 24580790 426 LVALTNTAATLPGIVVPLFVGFVtkgnQNIGAWriIFGVTIVLFALEFLVFVFL 479
Cdd:cd17320 331 ASALLGFLQFLIGALAGALVGLL----PNGTAL--PMGLLILVLGLLALLLLIL 378
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
117-457 |
2.24e-08 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 56.05 E-value: 2.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 117 GYLVSQ---IPL-AHVAENFSAKWVMLFSVAINVVCTL---LTPVFTELhygglILMRVLEGVGGGASFPAMHVMIASWA 189
Cdd:cd17503 39 SYLLALaimIPLsGWLADRFGTRRLFLTALALFTLGSLlcgLAPNLASL-----IIFRILQGFGGGVLIPLAQTILLRIY 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 190 PPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMgalsciwMLLWVILVQDNPnkqrFISLeerqmitssl 269
Cdd:cd17503 114 PPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN-------LPIGILALLLAP----LLDL---------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 270 gteqktehhpavpwgKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNvASNAALSALPY-FPMIIFSICLGK 348
Cdd:cd17503 173 ---------------RLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYS-AFESGLVLAPGgLASAILSPLVGR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 349 LLDSLQAKGKITttvarktatsICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMG-SMFSGFLSNHI--DIAPNFAGT 425
Cdd:cd17503 237 LLDKFGPRLLLL----------AGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGmGLVFMPLNTLAlnSLPPEQIGD 306
|
330 340 350
....*....|....*....|....*....|...
gi 24580790 426 LVALTNTAATLPG-IVVPLFVGFVTKGNQNIGA 457
Cdd:cd17503 307 ATALFNTIRQLGGsIGTALLATLLTNRTQFHHS 339
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
129-356 |
5.92e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 54.87 E-value: 5.92e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 129 AENFSAKWVMLFSVAINVVCTLLTPVFTELHYggLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAG 208
Cdd:cd17321 55 GDRFGRKRVFLIGLALFGLASLLCALAPSLAF--LIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIG 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 209 TALSILLAGVCSAQWGWESVFYVMGALSCIWMLLwvilvqdnpnkqrfisleerqmitsslgteqktehhpavpwgkvft 288
Cdd:cd17321 133 AALGPLLGGLLLELFGWRWIFLINVPIGLVALLL---------------------------------------------- 166
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 24580790 289 SVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNvASNAALSALPY-FPMIIFSICLGKLLDSLQAK 356
Cdd:cd17321 167 ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYS-PLQAGLALLPLaLAMLVAAPLAGRLADRFGPR 234
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
110-479 |
6.17e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 54.88 E-value: 6.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 110 LLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAI----NVVCTLLTPVFTelhyggLILMRVLEGVGGGASFP-AMHVM 184
Cdd:cd17474 39 LITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLfgigGLLCGLSDSFAL------LLAGRALQGIGAAGLGPlALTLI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 185 IASWAPPTERMVMSTIIyVGTSAGTALSILLAGVCsAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERQM 264
Cdd:cd17474 113 GDLFEGGERAKAMGLYE-AALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRD 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 265 itsslgteqktehhpavpWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSI 344
Cdd:cd17474 191 ------------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 345 CLGKLLdslqakgkiTTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIvAMGSMFSGFLSNHIDIAPNFA- 423
Cdd:cd17474 253 FVGRLL---------KKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL-GLGLNLPLLTTLVTELAPEEEr 322
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 24580790 424 GTLVALTNTAATLPGIVVPLFVGFVTKgnqnIGAWRIIFGVTIVLFALEFLVFVFL 479
Cdd:cd17474 323 GTASSLYNFVRFLGQAVGPLLFGLLLE----IFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
132-480 |
1.65e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 53.34 E-value: 1.65e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 132 FSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVM---STIIYVGTSAG 208
Cdd:COG2807 80 FGLERTLLLALLLLAAGLLLRSLAP--SVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDRVGLMTglyTAAMGLGAALA 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 209 TALSILLAGVcsaqWGWESVFYVMGALSCIWMLLWVILVQDNPnkqrfisleerqmitsslgtEQKTEHHPAVPWGKVFT 288
Cdd:COG2807 158 AGLTVPLAAA----LGWRGALAVWALLALLALLLWLPLLRRRP--------------------AAAAAAPAAASLRSLWR 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 289 SVPFWAILIAHTCSNFGWYMFLIEIPFYMKQvLKFNVASNAALSALPYFPMIIFSICLGKLLDSLQAKgkitttvaRKTA 368
Cdd:COG2807 214 SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR--------RPLL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 369 TSICTLipGVCLLVLCYIGCRHYEAVSVMSVGIvAMGSMFSGFLSNHIDIAPNF--AGTLVALTNTAATLPGIVVPLFVG 446
Cdd:COG2807 285 LLLGLL--GLAGLLGLLLAPGSLPWLWAVLLGL-GQGGLFPLALTLIGLRARTPaeAAALSGMAQSVGYLLAALGPLLVG 361
|
330 340 350
....*....|....*....|....*....|....
gi 24580790 447 FVtkgNQNIGAWRIIFGVTIVLFALEFLVFVFLG 480
Cdd:COG2807 362 AL---HDATGSWTAALLLLAALAVLMLVAGLLAG 392
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
100-351 |
2.46e-07 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 53.04 E-value: 2.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHyGGLILMRVLEGVGGGASFP 179
Cdd:cd17355 33 FGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLW-QLYLLWGLLGGGGAGTLAA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWML-LWVILVQDNPNKQrfis 258
Cdd:cd17355 112 VAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVpVLLLLRRRPADLA---- 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 259 leerqmitsSLGTEQKTEHHPAVPWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQvLKFNVASNAALSALPYFP 338
Cdd:cd17355 188 ---------LRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLF 257
|
250
....*....|...
gi 24580790 339 MIIFSICLGKLLD 351
Cdd:cd17355 258 NIVGRLLSGWLGD 270
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
95-251 |
2.64e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 52.66 E-value: 2.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 95 VEDGPFDWSEplQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILmrVLEGVGG 174
Cdd:cd17312 30 VEEIGLSKDD--LGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLW--GLNGLFQ 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 24580790 175 GASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNP 251
Cdd:cd17312 106 SMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
137-353 |
5.32e-06 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 48.84 E-value: 5.32e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 137 VMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAG----TALS 212
Cdd:cd17371 66 VLVITILLFAVFTLLCGFAQ--NYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGwllaTLLA 143
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 213 ILLAGVCSAQWGWESVFY--VMGALSCIWMLLWVilvqdnpnkqrfislEERQMITSSLGTEQKTEHHPAVPWGKVFTSV 290
Cdd:cd17371 144 ALLFPLLPPEIAWRVLFLlgALPALLVLFIRRFV---------------KEPPQWQAARAARRHFADRPSLRELFSPPLL 208
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24580790 291 P---FWAILIahTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSICLGKLLDSL 353
Cdd:cd17371 209 RttlLASLLA--TGALGGYYGITTWLPSYLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRI 272
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
112-471 |
9.65e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 48.09 E-value: 9.65e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 112 SCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTpVFTElHYGGLILMRVLEGVGGGASFPAMHVMIASWAPP 191
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLT-AFSP-NYTVFLVFRLLVGMGIGGIWVQAVVLNTEFLPK 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 192 TERMVMSTIIYVGTSAGTalsILLAGVCSA--QWGWESVFYVMGALSCIWMLLWVI------LVQDNPNK-----QRFIS 258
Cdd:TIGR00898 212 KQRAIVGTLIQVFFSLGL---VLLPLVAYFipDWRWLQLAVSLPTFLFFLLSWFVPesprwlISQGRIEEalkilQRIAK 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 259 LEERQMITSSL-------GTEQKTEHHPAV----PWGKVFTSVpFWAILIAHTCSNFGWYMFLieipfymkQVLKFNVAS 327
Cdd:TIGR00898 289 INGKKLPAEVLslslekdLSSSKKQYSFLDlfrtPNLRKTTLC-LMMLWFTTAFSYYGLVLDL--------GNLGGNIYL 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 328 NAALSALPYFPmiifsiclGKLLDSLqakgkITTTVARKTATSICTLIPGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSM 407
Cdd:TIGR00898 360 DLFISGLVELP--------AKLITLL-----LIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITS 426
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 408 -FSGFLSNHIDIAPNFAGTL-VALTNTAATLPGIVVPLFVgfvtkgnQNIGAWR----IIFGVTIVLFAL 471
Cdd:TIGR00898 427 aFQMVYLYTAELYPTVVRNLgVGVCSTMARVGSIISPFLV-------YLGEKWLflplVLFGGLALLAGI 489
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
108-383 |
1.05e-05 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 47.62 E-value: 1.05e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVM-LFSVAINVVCTLLTPVFTelhYGGLILMRVLEGVGGGASFPAMHVMIA 186
Cdd:cd17475 34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLaVGLLLMGAAALLMALVGS---YPVLLVLLFLVGAGYGSVQPGGGRAIM 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 187 SWAPPTER-MVMStIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRfisLEERQMI 265
Cdd:cd17475 111 RWFPPRERgLAMG-IRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASA---ATESAST 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 266 TSSLGTEqktehhpavpwgkVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSIC 345
Cdd:cd17475 187 LLRSLKE-------------VLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIG 253
|
250 260 270
....*....|....*....|....*....|....*...
gi 24580790 346 LGKLLDSLQAKgkitttvARKTATSICTLIPGVCLLVL 383
Cdd:cd17475 254 LGRVSDRVFGG-------RRRPVLVITAAIAAAALLVL 284
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
108-479 |
2.07e-05 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 46.79 E-value: 2.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYL----VSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELhyGGLILMRVLEGVGGGASFPAMHV 183
Cdd:cd17502 29 LSLVSWVGTAYLltstAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNM--TMLIVGRAIQGIGGGGLMSLAFI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 184 MIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYV---MGALSCIwmllwvilvqdnpnkqrfisle 260
Cdd:cd17502 107 IIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYInlpIGGLALA---------------------- 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 261 erqMITSslgteqktehhpavpwgkvftsvpFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNvASNAALSALPY-FPM 339
Cdd:cd17502 165 ---LLRT------------------------ILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDS-ATKSGVRLLPLiIGL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 340 IIFSICLGKLldslqakgkITTTVARKTATSICTLIPGVCLLVLCYIgcrHYEAVSVMSVGIVAMGSMFSGFLsnhidia 419
Cdd:cd17502 217 VIGSIISGAL---------ISKTGRYKPLIVIGTILMSVGAGLLTTL---TLDTSKWLLIGYLILLGLGLGIG------- 277
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24580790 420 pnFAGTLVALTNTAAtlpgivvPLFVGFVTKGN---QNIG-----AWRIIFGVTIVLFALEFLVFVFL 479
Cdd:cd17502 278 --FQQPLVAVQNAVP-------PADVGVATATNtffRSLGgtlgvAITDVFLVALALAALAFLLSLFL 336
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
111-444 |
3.76e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 46.03 E-value: 3.76e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 111 LSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGasfPAMHVMIASWA- 189
Cdd:cd17323 40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP--NIAMLIILRFLQGFFGS---SPLAIGAGTIAd 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 190 --PPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQdnpnkqrfisleerqmits 267
Cdd:cd17323 115 lfTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAIISGFCLILIFLFLP------------------- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 268 slgteqktehhpavpwgKVFTSVPFWAILIAHtcsnfgWYMFLIEIPFYMKQVLKFNVasnaALSALPYFP----MIIFS 343
Cdd:cd17323 176 -----------------IVLLLGLYVGLVYAI------LYLFLTAFPYVFGEVYGFSP----GEVGLMYLPigigALIGS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 344 ICLGKLLD-----SLQAKGKITTTVARKTATSI-CTLIPgVCLLVLCYIGCRHYE-AVSVMSVGIVAMGSMFSGFLSNH- 415
Cdd:cd17323 229 IIGGRLSDyyyrrLKKKNGGKPEPEARLPPAFIgAFLFP-IGLFIFGWTIYPHIHwIVPIIGSAFFGFGLMLIFQSSLTy 307
|
330 340 350
....*....|....*....|....*....|....*
gi 24580790 416 -IDIAPNFAGTLVALTN-----TAATLPGIVVPLF 444
Cdd:cd17323 308 lVDSYPKYAASALAANTlvrsiFAAIFPLFAQPMF 342
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
117-476 |
4.35e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 45.76 E-value: 4.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 117 GYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTElhYGGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMV 196
Cdd:cd06180 46 GYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSG--FAALLALRFLAGAASAFVFVFGSNLVLHHATAAGRGH 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 197 MSTIIYVGTSAGTALSILL-AGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEERqmitsslgteqkt 275
Cdd:cd06180 124 LIGLLFAGVGLGIALSGLLvPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEASAAES------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 276 ehhpavpwgKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQvlkfnvASNAALSALPYFPMIIFSICLG-----KLL 350
Cdd:cd06180 191 ---------APGLNRPLWRLALAYGLFGFGYIITATFLPLIARE------TGAGSLLAGLLWSLFGLAAVPScflwgALS 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 351 DSLQAKGKITTTVA-RKTATSICTLIPGVCLLVLCYIGCrhyeAVSVMsvGIVAMGSMFSGFLsnhidiAPNFAGTLVAL 429
Cdd:cd06180 256 DRWGTRRALAANLLvQAVGVLLPLLSPGPAGLVLSAVLF----GGTFM--AITALVMALAREL------APPAAPRALAL 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 24580790 430 TNTAATLPGIVVPLFVGFVTKGNQNIGAWRIIFGVTIVLFALEFLVF 476
Cdd:cd06180 324 MTASFGVGQILGPLLAGWLADATGGFAPALILAAAALVVAALLALLV 370
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
108-479 |
5.18e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 45.70 E-value: 5.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVF--TELHYGGLILMRVLEGVGGGASFPAMHVMI 185
Cdd:cd17345 41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVpsATSSVGLMFILLFLNGWFQGMGWPPSGRTM 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 186 ASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWG---WESVFYVMGALSCIWMLLWVILVQDNPNKQRFISLEER 262
Cdd:cd17345 121 VHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEY 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 263 QMITSSLGTEQKTEHHPAVP---WGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPM 339
Cdd:cd17345 201 KGDYPEEADGEEEEQELSAWeifVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAA 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 340 IIFSICLGKLLDSLQAKGKITTTVARKTATSICTLI------PGVCLLVLCYIGCRHYeaVSVMSVGIVAMgsmfsgfls 413
Cdd:cd17345 281 IPGTLLAGWLSDKLFKGRRAPTGIIFMILVIVALIVywlapnVLVDLIALIALGFLIY--GPVMLIGLQAL--------- 349
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24580790 414 nhiDIAPNFA-GTLVALTNTAATLPGIVVP-LFVGFVTkgnQNIGaWriiFGVTIVLFALEFLVFVFL 479
Cdd:cd17345 350 ---ELVPKKAaGTAAGLTGLFGYLGGSVLAtALIGIIV---DHFG-W---NGGFIVLLASCILAIIFL 407
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
92-251 |
7.13e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 45.34 E-value: 7.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 92 TAKVEDGPFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTEL-HYGGLILMRVLE 170
Cdd:pfam00083 33 GLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKwSVYQLIVGRVLV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 171 GVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAG---TALSILLAGVCSAQWGWEsvfyVMGALSCIW---MLLWV 244
Cdd:pfam00083 113 GIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGillAYIFGLGLNKTSNSDGWR----IPLGLQLVPallLIIGL 188
|
....*..
gi 24580790 245 ILVQDNP 251
Cdd:pfam00083 189 LFLPESP 195
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
108-246 |
7.16e-05 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.91 E-value: 7.16e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELhyGGLILMRVLEGVGGGASFPAMHVMIAS 187
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSL--WLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 24580790 188 WAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVIL 246
Cdd:cd06173 325 RVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
100-212 |
1.82e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.81 E-value: 1.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 100 FDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTelHYGGLILMRVLEGVGGGASFP 179
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGLLFP 315
|
90 100 110
....*....|....*....|....*....|...
gi 24580790 180 AMHVMIASWAPPTERMVMSTIIYVGTSAGTALS 212
Cdd:COG2814 316 LLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
99-265 |
1.84e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.78 E-value: 1.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 99 PFDWSEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTElHYGGLILMRVLEGVGGgASF 178
Cdd:cd17341 28 DLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVS-SYWGLLVLGFLLGFAG-ANF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 179 PAMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQW-------GWESVFYVMGALSCIWMLLWVILVQDNP 251
Cdd:cd17341 106 ASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIvfdggfvGWRNAFFVPGILLAIAAVLVLLFGDDLP 185
|
170
....*....|....
gi 24580790 252 NKQRFISLEERQMI 265
Cdd:cd17341 186 TGKASALEFLKVQL 199
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
128-251 |
2.37e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 43.41 E-value: 2.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 128 VAENFSAKWVMLFSVAINVVCTLLTPVFTELHygGLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSA 207
Cdd:PRK11551 73 LADRIGRKRILIVSVALFGLFSLATAQAWDFP--SLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPF 150
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 24580790 208 GTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLWVILVQDNP 251
Cdd:PRK11551 151 GGALASVIGVLAAGDAAWRHIFYVGGVGPLLLVPLLMRWLPESR 194
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
108-243 |
3.02e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 42.93 E-value: 3.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 108 GTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRVLEGVGGGAsFPAMHVMIAS 187
Cdd:cd17477 226 ALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPL-YTLALALAGD 304
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 24580790 188 WAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALSCIWMLLW 243
Cdd:cd17477 305 RLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
103-245 |
5.11e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.58 E-value: 5.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 103 SEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRVLEGVGGGASFPAMH 182
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPW 341
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 24580790 183 VMIASWAPPTER--------MVMStIIYVGTSAGTALSILLAGVCSAQWGWES-VFYVMGALSCIWMLLWVI 245
Cdd:COG2211 342 AMLADVVDYDEWktgrrregLYFG-IFTFAIKLGQALAGALAGLLLALFGYVAgAAQSPSALTGIRLLFFLL 412
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
293-479 |
6.01e-04 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 42.26 E-value: 6.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 293 WAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVA--SNAALSALPYFPMIIFSI-CLGKLLDSLQAkGKITTTVARKTAT 369
Cdd:pfam00083 1 VALVAALGGFLFGYDTGVIGAFLTLIDFFKNFGLskSVSSLAALSVLSGLIVSIfSVGCFIGSLFA-GKLGDRFGRKKSL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 370 SICTLIpgVCLLVLCYIGCRHYEAVSVMSVGIVAMGsMFSGFLSNHI-----DIAP-NFAGTLVALTNTAATLpGIVVPL 443
Cdd:pfam00083 80 LIANVL--FVIGAVLQGAAKGKWSVYQLIVGRVLVG-IGVGGASVLApmyisEIAPkKLRGALGSLYQLAITF-GILLAY 155
|
170 180 190
....*....|....*....|....*....|....*.
gi 24580790 444 FVGFVTKGNQNIGAWRIIFGVTIVLFALEFLVFVFL 479
Cdd:pfam00083 156 IFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFL 191
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
124-475 |
1.17e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 41.40 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 124 PLA-HVAENFSAKWVMLFSVAINVVCTLLtPVFTELHYGgLILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIY 202
Cdd:cd17473 53 PLAgWLADRFGRKRLLIAGLLLYGIGGVA-GLFLDSLYA-LLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 203 VGTSAGTALSILLAGVCsAQWGWESVFYVMGALSCIWMLLWvilvqdnpnkqrfISLEERQmitsslgTEQKTEHHPAVP 282
Cdd:cd17473 131 AAMSLGGVVFLLLGGAL-AEIGWRAPFLVYLLALPVLILVL-------------LFLPEPA-------RKSKSAASPGAA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 283 WGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSICLGKLLDSLqakGKITTT 362
Cdd:cd17473 190 TAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL---GKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 363 VArktatsictlipGVCLLVLCYIGCRHYEAVSVMSVGIVAMGSMFSGFLSNHIDIA-----PNFAGTLVALTNTAATLP 437
Cdd:cd17473 267 AI------------GFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAmslvpPELRGRAMGIVTSAFFLG 334
|
330 340 350
....*....|....*....|....*....|....*....
gi 24580790 438 GIVVPLFVGFVTKGNQNI-GAWRIIFGVTIVLFALEFLV 475
Cdd:cd17473 335 QFLSPLVLGPLVNLTGGLsGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
120-246 |
1.80e-03 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 40.69 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 120 VSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELhyGGLILMRVLEGVGGGASFpAMHVMIASWAPPTERMVMST 199
Cdd:cd06179 47 VLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSV--NMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQG 123
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 24580790 200 IIYVGTSAGTALSILLAG--VCSAQWGWESVFYVMGALSCIWMLLWVIL 246
Cdd:cd06179 124 VVNLVASPGSALGPLIAGalVEANAAGWRWIFYINAIFNALALILLFFF 172
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
295-494 |
3.04e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 295 ILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSALPYFPMIIFSICLGKLLDslqakgkittTVARKTATSICTL 374
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD----------RFGRRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 375 IPGVCLLVLCYIGcrhyeAVSVMSVGIVAMGSMFSGFLSNHIDIAPNFA-----GTLVALTNTAATLPGIVVPLFVGFVT 449
Cdd:pfam07690 71 LFALGLLLLLFAS-----SLWLLLVLRVLQGLGAGALFPAALALIADWFppeerGRALGLVSAGFGLGAALGPLLGGLLA 145
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 24580790 450 KgnqnIGAWRIIFGVTIVLFALEFLVFVFLGSGSEQPWNKAGTPK 494
Cdd:pfam07690 146 S----LFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEA 186
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
163-251 |
3.18e-03 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 39.70 E-value: 3.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 163 LILMRVLEGVGGGASFPAMHVMIASWAPPTERMVMSTIIYVGTSAGTALSILLAGVCSAQWGWESVFYVMGALsCIWMLL 242
Cdd:cd17488 94 FAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGMYVPGII-AILMGI 172
|
90
....*....|
gi 24580790 243 WVIL-VQDNP 251
Cdd:cd17488 173 VLCWrLRDRP 182
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
103-245 |
3.83e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.50 E-value: 3.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 103 SEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELhyGGLILMRVLEGVGGGASFPAMH 182
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSV--ALLLVLRLIHGIGWGAFTTAAA 106
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24580790 183 VMIASWAPPTERMV----MSTIIYVGTSAGTALSILLAGVCSAQWgwesVFYVMGALSCI-WMLLWVI 245
Cdd:cd17489 107 TLVADIIPPSRRGEgigyYGLATTLAMALGPALGLFLYQHLGFAV----LFIVAAVLALLaLLLVFLV 170
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| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
103-383 |
8.35e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 38.37 E-value: 8.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 103 SEPLQGTLLSCYFWGYLVSQIPLAHVAENFSAKWVMLFSVAINVVCTLLTPVFTELHYGGLILMRV---LEGVGGGASFP 179
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVlafLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 180 AMHVMIASWAPPTERM----VMSTIIYVGTSAGTALSILLAGVCSAQWGW--ESVFYVMGALSCIWMLLWVILVQDNPNK 253
Cdd:cd06173 112 ARQALLPELVPKEQLVranaLNSLATQLARIIGPALGGLLVALLGPGGAFaiNALSFLLSALLLLFIRRPPPAAPGESSS 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24580790 254 QRFISLEERqmitsslgteqktehhpavpWGKVFTSVPFWAILIAHTCSNFGWYMFLIEIPFYMKQVLKFNVASNAALSA 333
Cdd:cd06173 192 LLLRDLREG--------------------LRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLA 251
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 24580790 334 LPYFPMIIFSICLGKLLDSLqakgkitttvARKTATSICTLIPGVCLLVL 383
Cdd:cd06173 252 AFGVGALLGALLLGRLSKRR----------RRGRLLLIGALLLGLALLVL 291
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