NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|45550094|ref|NP_608581|]
View 

charon [Drosophila melanogaster]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
290-513 4.83e-13

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 4.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 290 AKMDINELLTRDGEDCLELALTNDTDTEIVSLILDARMMTDHLYENSNTALHLAVINHiNIESIRLLLRR-IDLNsllLT 368
Cdd:COG0666  41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG-DLEIVKLLLEAgADVN---AR 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 369 NDDGYTVLHLAVRNNQFLVVEAILDSiderelgetvyrrtleAANPNEWDEKGFAkYYDRACE--RLELNKTLLKNRAHk 446
Cdd:COG0666 117 DKDGETPLHLAAYNGNLEIVKLLLEA----------------GADVNAQDNDGNT-PLHLAAAngNLEIVKLLLEAGAD- 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45550094 447 rdvINAsEARGGNPPLFYAVEGEQEHLCYFLLAHLADPDEENLSGHSPKSYHYEYARTLRINLKVAR 513
Cdd:COG0666 179 ---VNA-RDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
290-513 4.83e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 4.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 290 AKMDINELLTRDGEDCLELALTNDTDTEIVSLILDARMMTDHLYENSNTALHLAVINHiNIESIRLLLRR-IDLNsllLT 368
Cdd:COG0666  41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG-DLEIVKLLLEAgADVN---AR 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 369 NDDGYTVLHLAVRNNQFLVVEAILDSiderelgetvyrrtleAANPNEWDEKGFAkYYDRACE--RLELNKTLLKNRAHk 446
Cdd:COG0666 117 DKDGETPLHLAAYNGNLEIVKLLLEA----------------GADVNAQDNDGNT-PLHLAAAngNLEIVKLLLEAGAD- 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45550094 447 rdvINAsEARGGNPPLFYAVEGEQEHLCYFLLAHLADPDEENLSGHSPKSYHYEYARTLRINLKVAR 513
Cdd:COG0666 179 ---VNA-RDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
Ank_2 pfam12796
Ankyrin repeats (3 copies);
315-394 3.27e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 3.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094   315 DTEIVSLILDARMMTDHLYENSNTALHLAVINHiNIESIRLLLRRIDLNSllltNDDGYTVLHLAVRNNQFLVVEAILDS 394
Cdd:pfam12796   9 NLELVKLLLENGADANLQDKNGRTALHLAAKNG-HLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEIVKLLLEK 83
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
290-513 4.83e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 69.60  E-value: 4.83e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 290 AKMDINELLTRDGEDCLELALTNDTDTEIVSLILDARMMTDHLYENSNTALHLAVINHiNIESIRLLLRR-IDLNsllLT 368
Cdd:COG0666  41 LLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG-DLEIVKLLLEAgADVN---AR 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 369 NDDGYTVLHLAVRNNQFLVVEAILDSiderelgetvyrrtleAANPNEWDEKGFAkYYDRACE--RLELNKTLLKNRAHk 446
Cdd:COG0666 117 DKDGETPLHLAAYNGNLEIVKLLLEA----------------GADVNAQDNDGNT-PLHLAAAngNLEIVKLLLEAGAD- 178

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45550094 447 rdvINAsEARGGNPPLFYAVEGEQEHLCYFLLAHLADPDEENLSGHSPKSYHYEYARTLRINLKVAR 513
Cdd:COG0666 179 ---VNA-RDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
Ank_2 pfam12796
Ankyrin repeats (3 copies);
315-394 3.27e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 3.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094   315 DTEIVSLILDARMMTDHLYENSNTALHLAVINHiNIESIRLLLRRIDLNSllltNDDGYTVLHLAVRNNQFLVVEAILDS 394
Cdd:pfam12796   9 NLELVKLLLENGADANLQDKNGRTALHLAAKNG-HLEIVKLLLEHADVNL----KDNGRTALHYAARSGHLEIVKLLLEK 83
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
289-494 6.04e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 6.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 289 HAKMDINELLTRDGEDCLELALTNDTDTEIVSLILDARMMTDHLYENSNTALHLAVINHINIESIRLLLRRIDLNsllLT 368
Cdd:COG0666   7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN---AK 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 369 NDDGYTVLHLAVRNNQFLVVEAILDSiderelgetvyrrtleAANPNEWDEKGF-AKYYDRACERLELNKTLLKNRAHkr 447
Cdd:COG0666  84 DDGGNTLLHAAARNGDLEIVKLLLEA----------------GADVNARDKDGEtPLHLAAYNGNLEIVKLLLEAGAD-- 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 45550094 448 dvINASEaRGGNPPLFYAVEGEQEHLCYFLLAHLADPDEENLSGHSP 494
Cdd:COG0666 146 --VNAQD-NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
290-442 1.37e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 49.95  E-value: 1.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45550094 290 AKMDINeLLTRDGEDCLELALTNDtDTEIVSLILDARMMTDHLYENSNTALHLAVINHiNIESIRLLLRR-IDLNsllLT 368
Cdd:COG0666 142 AGADVN-AQDNDGNTPLHLAAANG-NLEIVKLLLEAGADVNARDNDGETPLHLAAENG-HLEIVKLLLEAgADVN---AK 215

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45550094 369 NDDGYTVLHLAVRNNQFLVVEAILDSIDERELGETVYRRTLEAANPNEWDEKGFAKYYDRACERLELNKTLLKN 442
Cdd:COG0666 216 DNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
340-403 1.52e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.87  E-value: 1.52e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 45550094   340 LHLAVINHiNIESIRLLLR-RIDLNsllLTNDDGYTVLHLAVRNNQFLVVEAILD--SIDERELGET 403
Cdd:pfam12796   1 LHLAAKNG-NLELVKLLLEnGADAN---LQDKNGRTALHLAAKNGHLEIVKLLLEhaDVNLKDNGRT 63
Ank_4 pfam13637
Ankyrin repeats (many copies);
337-389 3.22e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.22e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 45550094   337 NTALHLAVINHiNIESIRLLL-RRIDLNsllLTNDDGYTVLHLAVRNNQFLVVE 389
Cdd:pfam13637   2 LTALHAAAASG-HLELLRLLLeKGADIN---AVDGNGETALHFAASNGNVEVLK 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH